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Article ; Online: Managing psychotic depression and diagnostic uncertainty in liaison psychiatry.

Davies, Joanne E / Johnson, Sarah

BMJ case reports

2019 Volume 12, Issue 1

Abstract: A middle-aged woman presented with a history of symptoms of depression with psychotic features severely affecting her physical health. Neuroimaging of her brain suggested pathological changes out of keeping with her age, leading to further investigations ...

Abstract	A middle-aged woman presented with a history of symptoms of depression with psychotic features severely affecting her physical health. Neuroimaging of her brain suggested pathological changes out of keeping with her age, leading to further investigations including genetic testing for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis was also considered as a differential diagnosis as an initial serum test for anti-NMDAR autoantibodies was positive. Her symptoms resolved following treatment with electroconvulsive therapy. Despite her initial neuroimaging, her genetic test for CADASIL was negative and her subsequent test for anti-NMDAR autoantibodies was negative, suggesting that the initial test may have been a false positive.
MeSH term(s)	Depression/diagnostic imaging ; Depression/etiology ; Depression/therapy ; Diagnosis, Differential ; Electroconvulsive Therapy ; Female ; Humans ; Middle Aged ; Neuroimaging ; Psychotic Disorders/diagnostic imaging ; Psychotic Disorders/etiology ; Psychotic Disorders/therapy ; Treatment Outcome
Language	English
Publishing date	2019-01-20
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2018-227606
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Article: A taste for expat life.

Davies, Joanne

Nursing standard (Royal College of Nursing (Great Britain) : 1987)

2012 Volume 26, Issue 52, Page(s) 61

MeSH term(s)	Career Choice ; Faculty, Nursing ; Humans ; Maternal-Child Nursing/education ; Qatar ; Travel ; United Kingdom
Language	English
Publishing date	2012-08
Publishing country	England
Document type	Journal Article
ZDB-ID	645016-7
ISSN	2047-9018 ; 0029-6570
ISSN (online)	2047-9018
ISSN	0029-6570
DOI	10.7748/ns2012.08.26.52.61.p9222
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Zs.A 2410: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 273: Show issues

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Article ; Online: Natural Protection From Type 1 Diabetes in NOD Mice Is Characterized by a Unique Pancreatic Islet Phenotype.

Boldison, Joanne / Thayer, Terri C / Davies, Joanne / Wong, F Susan

Diabetes

2021 Volume 70, Issue 4, Page(s) 955–965

Abstract: The NOD mouse develops spontaneous type 1 diabetes, with some features of disease that are very similar to the human disease. However, a proportion of NOD mice are naturally protected from developing diabetes, and currently, studies characterizing this ... ...

Abstract	The NOD mouse develops spontaneous type 1 diabetes, with some features of disease that are very similar to the human disease. However, a proportion of NOD mice are naturally protected from developing diabetes, and currently, studies characterizing this cohort are very limited. Here, using both immunofluorescence and multiparameter flow cytometry, we focus on the pancreatic islet morphology and immune infiltrate observed in naturally protected NOD mice. We show that naturally protected NOD mice are characterized by an increased frequency of insulin-containing, smaller-sized, pancreatic islets. Although mice remain diabetes free, florid immune infiltrate remains. However, this immune infiltrate is skewed toward a regulatory phenotype in both T- and B-cell compartments. Pancreatic islets have an increased frequency of IL-10-producing B cells and associated cell surface markers. Resident memory CD69
MeSH term(s)	Animals ; Antigens, CD/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; CTLA-4 Antigen/genetics ; CTLA-4 Antigen/metabolism ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Female ; Flow Cytometry ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Integrin alpha Chains/metabolism ; Islets of Langerhans/metabolism ; Mice
Chemical Substances	Antigens, CD ; CTLA-4 Antigen ; Ctla4 protein, mouse ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Integrin alpha Chains ; alpha E integrins
Language	English
Publishing date	2021-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db20-0945
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Article ; Online: Improving the provision of clinical skills teaching for undergraduate medical students during their psychiatry placement: a trainee-led quality improvement project.

Davies, Joanne / Churchhouse, Gabrielle / Buckley, Melissa

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

2019 Volume 28, Issue 1, Page(s) 101–105

Abstract: Objective: To increase the provision of clinical skills training during their psychiatry placement by providing a new teaching course to enhance both their clinical knowledge and communication skills.: Method: We delivered a pilot teaching course ... ...

Abstract	Objective: To increase the provision of clinical skills training during their psychiatry placement by providing a new teaching course to enhance both their clinical knowledge and communication skills. Method: We delivered a pilot teaching course consisting of five workshops (incorporating facilitated, 'near peer' role-play) during the students' psychiatry placement. Qualitative and quantitative feedback was collected pre- and post-course to allow for development of the course. Results: Data collected indicated that all students found the course a valuable addition to their usual teaching. They indicated that their confidence in their ability to assess patients with common clinical problems improved. Conclusions: This trainee-led course was easily integrated into the curriculum and received positive feedback from students. It may have enhanced students' confidence and readiness for exams but this will require further examination of objective assessments and ongoing research to establish this.
MeSH term(s)	Adult ; Clinical Competence ; Curriculum ; Education, Medical, Undergraduate/standards ; Female ; Humans ; Male ; Psychiatry/education ; Quality Improvement/standards ; Students, Medical ; Young Adult
Language	English
Publishing date	2019-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2213198-X
ISSN	1440-1665 ; 1039-8562
ISSN (online)	1440-1665
ISSN	1039-8562
DOI	10.1177/1039856219871874
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Zs.A 6220: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 581: Show issues

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Article: The Qatar Simulation Consortium (QSC): National Simulation Collaboration.

Pyburn, Renee R / Davies, Joanne L

Nursing education perspectives

2015 Volume 36, Issue 6, Page(s) 417–419

Abstract: This article describes the formation and work of a nationwide Qatar Simulation Consortium. In 2013, members included the schools of medicine, nursing, and allied health in Qatar, as well as the public health care system and a private, publicly funded ... ...

Abstract	This article describes the formation and work of a nationwide Qatar Simulation Consortium. In 2013, members included the schools of medicine, nursing, and allied health in Qatar, as well as the public health care system and a private, publicly funded hospital. The mission of the consortium is to foster simulation collaboration among health care and educational institutions and advance simulation education, research, and practice to align with current global standards.
MeSH term(s)	Allied Health Occupations/education ; Cooperative Behavior ; Education, Medical/methods ; Education, Medical/organization & administration ; Education, Nursing/methods ; Education, Nursing/organization & administration ; Education, Pharmacy/methods ; Education, Pharmacy/organization & administration ; Humans ; Interprofessional Relations ; Patient Simulation ; Qatar
Language	English
Publishing date	2015-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075410-3
ISSN	1943-4685 ; 1536-5026
ISSN (online)	1943-4685
ISSN	1536-5026
DOI	10.5480/15-1667
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Zs.A 3023: Show issues

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Article ; Online: Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes.

Boldison, Joanne / Hopkinson, Jessica R / Davies, Joanne / Pearson, James A / Leete, Pia / Richardson, Sarah / Morgan, Noel G / Wong, F Susan

Diabetologia

2022 Volume 66, Issue 3, Page(s) 551–566

Abstract: Aims/hypothesis: B cells play an important role in driving the development of type 1 diabetes; however, it remains unclear how they contribute to local beta cell destruction during disease progression. Here, we use gene expression profiling of B cell ... ...

Abstract	Aims/hypothesis: B cells play an important role in driving the development of type 1 diabetes; however, it remains unclear how they contribute to local beta cell destruction during disease progression. Here, we use gene expression profiling of B cell subsets identified in inflamed pancreatic tissue to explore their primary functional role during the progression of autoimmune diabetes. Methods: Transcriptional profiling was performed on FACS-sorted B cell subsets isolated from pancreatic islets and the pancreatic lymph nodes of NOD mice. Results: B cells are highly modified by the inflamed pancreatic tissue and can be distinguished by their transcriptional profile from those in the lymph nodes. We identified both a discrete and a core shared gene expression profile in islet CD19 Conclusions/interpretation: Our study provides a detailed transcriptional analysis of islet B cells. Specific gene signatures and interaction networks have been identified that point towards a functional role for B cells in driving autoimmune diabetes.
MeSH term(s)	Mice ; Animals ; Diabetes Mellitus, Type 1/metabolism ; Mice, Inbred NOD ; Pancreas/metabolism ; Islets of Langerhans/metabolism ; Gene Expression Profiling
Language	English
Publishing date	2022-12-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-022-05839-7
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Zs.A 279: Show issues

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Article ; Online: Novel engineered B lymphocytes targeting islet-specific T cells inhibit the development of type 1 diabetes in non-obese diabetic Scid mice.

Chen, Dawei / Kakabadse, Dimitri / Fishman, Sigal / Weinstein-Marom, Hadas / Davies, Joanne / Boldison, Joanne / Thayer, Terri C / Wen, Li / Gross, Gideon / Wong, F Susan

Frontiers in immunology

2023 Volume 14, Page(s) 1227133

Abstract: Introduction: In this study, we report a novel therapeutic approach using B lymphocytes to attract islet-specific T cells in the non-obese diabetic (NOD) mouse model and prevent the development of autoimmune diabetes. Rather than using the antibody ... ...

Abstract	Introduction: In this study, we report a novel therapeutic approach using B lymphocytes to attract islet-specific T cells in the non-obese diabetic (NOD) mouse model and prevent the development of autoimmune diabetes. Rather than using the antibody receptor of B cells, this approach utilizes their properties as antigen-presenting cells to T cells. Methods: Purified splenic B cells were treated with lipopolysaccharide, which increases regulatory B (Breg) cell function, then electroporated with mRNA encoding either chimeric MHC-I or MHC-II molecules covalently linked to antigenic peptides. Immunoregulatory functions of these engineered B cells (e-B cells) were tested by Results: The e-B cells expressing chimeric MHC-I-peptide inhibited antigen-specific CD8 Discussion: MHC-peptide chimeric e-B cells interacted with pathogenic T cells, and protected the host from autoimmune diabetes, in a mouse model. Thus, we have successfully expressed MHC-peptide constructs in B cells that selectively targeted antigen-specific cells, raising the possibility that this strategy could be used to endow different protective cell types to specifically regulate/remove pathogenic cells.
MeSH term(s)	Mice ; Animals ; Diabetes Mellitus, Type 1/prevention & control ; Mice, Inbred NOD ; Mice, SCID ; Islets of Langerhans ; Severe Combined Immunodeficiency ; B-Lymphocytes, Regulatory ; Histocompatibility Antigens Class II
Chemical Substances	Histocompatibility Antigens Class II
Language	English
Publishing date	2023-09-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1227133
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Article ; Online: Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8

Thayer, Terri C / Davies, Joanne / Pearson, James A / Hanna, Stephanie J / Wen, Li / Wong, F Susan

Diabetes

2020 Volume 70, Issue 2, Page(s) 529–537

Abstract: Lymph node stromal cells (LNSC) are essential for providing and maintaining peripheral self-tolerance of potentially autoreactive cells. In type 1 diabetes, proinsulin-specific ... ...

Abstract	Lymph node stromal cells (LNSC) are essential for providing and maintaining peripheral self-tolerance of potentially autoreactive cells. In type 1 diabetes, proinsulin-specific CD8
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/metabolism ; Dendritic Cells/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Histocompatibility Antigens Class II/metabolism ; Lymph Nodes/metabolism ; Mice ; Mice, Inbred NOD ; Proinsulin/metabolism ; Stromal Cells/metabolism
Chemical Substances	Histocompatibility Antigens Class II ; Proinsulin (9035-68-1)
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db19-1050
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Article ; Online: Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells.

Boldison, Joanne / Da Rosa, Larissa Camargo / Davies, Joanne / Wen, Li / Wong, F Susan

Cellular & molecular immunology

2019 Volume 17, Issue 8, Page(s) 843–855

Abstract: Regulatory B cells (Bregs) suppress and reduce autoimmune pathology. However, given the variety of Breg subsets, the role of Bregs in the pathogenesis of type 1 diabetes is still unclear. Here, we dissect this fundamental mechanism. We show that natural ... ...

Abstract	Regulatory B cells (Bregs) suppress and reduce autoimmune pathology. However, given the variety of Breg subsets, the role of Bregs in the pathogenesis of type 1 diabetes is still unclear. Here, we dissect this fundamental mechanism. We show that natural protection from type 1 diabetes in nonobese diabetic (NOD) mice is associated with increased numbers of IL-10-producing B cells, while development of type 1 diabetes in NOD mice occurs in animals with compromised IL-10 production by B cells. However, B cells from diabetic mice regain IL-10 function if activated by the innate immune receptor TLR4 and can suppress insulin-specific CD8 T cells in a dendritic cell (DC)-dependent, IL-10-mediated fashion. Suppression of CD8 T cells is reliant on B-cell contact with DCs. This cell contact results in deactivation of DCs, inducing a tolerogenic state, which in turn can regulate pathogenic CD8 T cells. Our findings emphasize the importance of DC-Breg interactions during the development of type 1 diabetes.
MeSH term(s)	Animals ; Antigens, CD/metabolism ; B-Lymphocytes, Regulatory/drug effects ; B-Lymphocytes, Regulatory/immunology ; CD8-Positive T-Lymphocytes/drug effects ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/drug effects ; Cytokines/biosynthesis ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Diabetes Mellitus, Type 1/immunology ; Epitopes/immunology ; Immune Tolerance/drug effects ; Immunosuppression ; Insulin/pharmacology ; Interleukin-10/biosynthesis ; Lipopolysaccharides ; Mice, Inbred NOD ; Models, Immunological ; Phenotype
Chemical Substances	Antigens, CD ; Cytokines ; Epitopes ; Insulin ; Lipopolysaccharides ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2019-11-14
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2435097-7
ISSN	2042-0226 ; 1672-7681
ISSN (online)	2042-0226
ISSN	1672-7681
DOI	10.1038/s41423-019-0324-z
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Article ; Online: An Undergraduate Course Combining Interprofessional Education and Complementary Health Approaches Learning Objectives: Successful Integrative Learning that Improves Interest and Reduces Redundancy.

Kutt, Anastasia / Mayan, Maria / Bienko, Izabela / Davies, JoAnne / Bhatt, Hitesh / Vohra, Sunita

Explore (New York, N.Y.)

2019 Volume 15, Issue 4, Page(s) 273–282

Abstract: Background: Literature suggests interprofessional education (IPE) and education about complementary therapies for health sciences students may be effectively combined.: Methods: A novel 30-hour, 10-week course for interprofessional undergraduate ... ...

Abstract	Background: Literature suggests interprofessional education (IPE) and education about complementary therapies for health sciences students may be effectively combined. Methods: A novel 30-hour, 10-week course for interprofessional undergraduate health sciences students combining IPE and complementary therapies learning objectives was developed and offered in 2012 (N = 71), 2013 (N = 120) and 2014 (N = 140). Pre-post mixed methods measurement occurred in three groups: one taking combined IPE-complementary therapies curriculum, and two control groups (one following non-specialized IPE curriculum, and one following combined IPE-continuing care curriculum). The students' attitudinal changes towards IPE and complementary therapies, and their comfort collaborating with students in other health sciences programs were measured using scales. Qualitative evaluation was conducted via content analysis of team-based reflective essays of their opinions towards what they learned about IPE and complementary therapies, and how it changed during the course. Results: Quantitative results exhibited ceiling effects, revealing little change or difference between groups on all measures, with the exception of the Health Professional Collaborative Competency Perception Scale which indicated the students taking the IPE-complementary therapies course reported increased comfort collaborating in comparison with control groups. Qualitative results indicated students: increased their awareness and knowledge about complementary therapies, and were inspired to learn more, appreciated the need for collaboration and communication, desired to be more patient-centered, and wove concepts related to IPE and complementary therapies together. Conclusion: Combining IPE initiatives and basic complementary therapies education can save curricular time, and develop healthcare professionals who appear to be more ready to provide team-based, patient-centered care.
MeSH term(s)	Alberta ; Complementary Therapies/education ; Curriculum ; Health Occupations/education ; Humans ; Interprofessional Relations ; Learning ; Qualitative Research ; Students, Health Occupations/psychology
Language	English
Publishing date	2019-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2019.02.002
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