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Article: Endovascular management of acute and subacute venous thoracic outlet syndrome.

Davies, Mark G / Hart, Joseph P

2024 Volume 11, Page(s) 1302568

Abstract: Approximately 3% of all patients presenting with Thoracic Outlet Syndrome have a venous etiology (vTOS), which is considered "effort thrombosis". These patients will present with symptomatic deep venous thrombosis or focal subclavian vein (SCV) stenosis. ...

Abstract	Approximately 3% of all patients presenting with Thoracic Outlet Syndrome have a venous etiology (vTOS), which is considered "effort thrombosis". These patients will present with symptomatic deep venous thrombosis or focal subclavian vein (SCV) stenosis. Endovascular management of vTOS occurs in several phases: diagnostic, preoperative therapeutic intervention before decompression, postoperative interventions after decompression, and delayed interventions in the follow-up after decompression. In the diagnostic phase, dynamic SCV venography can establish functional vTOS. Approximately 4,000 patients have been treated for vTOS and reported in the literature since 1970. Declotting of the SCV was followed by surgical decompression in 53% of patients, while in the remainder, surgical decompression alone (18%), endovascular intervention alone (15%), or conservative therapy with anticoagulation (15%) was performed. The initial intervention was predominantly catheter-directed thrombolysis, with <10% of cases undergoing concomitant balloon angioplasty. 93% of cases were successful. In the postoperative phase, balloon angioplasty was performed to correct residual intrinsic SCV disease after vTOS decompression in under 15% of cases. Stents were rarely deployed. Symptom relief was reported as 94 ± 12% (mean ± SD) and 90 ± 23%, respectively for declotting with decompression and declotting alone. In the delayed phase, balloon angioplasty was performed in under 15% of cases to re-establish patency.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2024.1302568
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Article ; Online: Extra-corporal Membrane Oxygenation (ECMO) in Massive Pulmonary Embolism.

Davies, Mark G / Hart, Joseph P

Annals of vascular surgery

2024

Abstract: Background: Massive pulmonary embolism (MPE) carries significant 30-day mortality, and a change in societal guidelines has promoted the increasing use of extracorporeal membrane oxygenation (ECMO) in the immediate management of MPE-associated ... ...

Abstract	Background: Massive pulmonary embolism (MPE) carries significant 30-day mortality, and a change in societal guidelines has promoted the increasing use of extracorporeal membrane oxygenation (ECMO) in the immediate management of MPE-associated cardiovascular shock. This narrative review examines the current status of ECMO in MPE. Methods: A literature review was performed from 1982 to 2022 search for the terms Pulmonary embolism and ECMO and refined by examining those publications that covered MPE RESULTS: In the patient with MPE, veno-arterial-ECMO is now recommended as a bridge to interventional therapy. It can reliably decrease right ventricular overload, improve RV function, and allow hemodynamic stability and restoration of tissue oxygenation. The use of ECMO in MPE has been associated with lower mortality in registry reviews, but there has been no significant difference in outcomes between patients treated with and without ECMO in meta-analyses. Applying ECMO is also associated with substantial multisystem morbidity due to systemic inflammatory response, bleeding with coagulopathy, hemorrhagic stroke, renal dysfunction, and acute limb ischemia, which must be factored into the outcomes. Conclusions: The application of ECMO in MPE should be combined with an aggressive interventional pulmonary interventional program and should strictly adhere to the current selection criteria.
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2024.02.015
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Article: Venous thoracic outlet syndrome and hemodialysis.

Davies, Mark G / Hart, Joseph P

Frontiers in surgery

2023 Volume 10, Page(s) 1149644

Abstract: Central venous stenotic disease is reported in 7%-40% of patients needing a central venous catheter for dialysis and in 19%-41% of hemodialysis patients who have had a prior central venous catheter. Half of these patients will be asymptomatic. Venous ... ...

Abstract	Central venous stenotic disease is reported in 7%-40% of patients needing a central venous catheter for dialysis and in 19%-41% of hemodialysis patients who have had a prior central venous catheter. Half of these patients will be asymptomatic. Venous Thoracic Outlet syndrome in hemodialysis (hdTOS) is part of this spectrum of disease. The extrinsic mechanical compression of the subclavian vein at the costoclavicular triangle between the clavicle and 1st rib results in an area of external compression with a predisposition to intrinsic mural disease in the vein. The enhanced flow induced by the presence of a distal arteriovenous access in all patients exacerbates the subclavian vein's response to ongoing extrinsic and intrinsic injury. Repeated endovascular interventions during the maintenance of vascular access accelerates chronic untreatable occlusion of the subclavian vein in the long term. Similar to patients with central venous stenosis, patients with hdTOS can present immediately after access formation with ipsilateral edema or longitudinally with episodes of access dysfunction. hdTOS can be treated in an escalating manner with arteriovenous access flow reduction to <1,500 ml/min, endovascular management, surgical decompression by first rib resection in healthy patients and medial clavicle resection in less healthy patients followed by secondary venous interventions, or finally, a venous bypass. hdTOS represents a complex and evolving therapeutic conundrum for the dialysis community, and additional clinical investigations to establish robust algorithms are required.
Language	English
Publishing date	2023-03-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1149644
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Article: Current status of ECMO for massive pulmonary embolism.

Davies, Mark G / Hart, Joseph P

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1298686

Abstract: Massive pulmonary embolism (MPE) carries significant 30-day mortality and is characterized by acute right ventricular failure, hypotension, and hypoxia, leading to cardiovascular collapse and cardiac arrest. Given the continued high mortality associated ... ...

Abstract	Massive pulmonary embolism (MPE) carries significant 30-day mortality and is characterized by acute right ventricular failure, hypotension, and hypoxia, leading to cardiovascular collapse and cardiac arrest. Given the continued high mortality associated with MPE, there has been ongoing interest in utilizing extracorporeal membrane oxygenation (ECMO) to provide oxygenation support to improve hypoxia and offload the right ventricular (RV) pressure in the belief that rapid reduction of hypoxia and RV pressure will improve outcomes. Two modalities can be employed: Veno-arterial-ECMO is a reliable process to decrease RV overload and improve RV function, thus allowing for hemodynamic stability and restoration of tissue oxygenation. Veno-venous ECMO can support oxygenation but is not designed to help circulation. Several societal guidelines now suggest using ECMO in MPE with interventional therapy. There are three strategies for ECMO utilization in MPE: bridge to definitive interventional therapy, sole therapy, and recovery after interventional treatment. The use of ECMO in MPE has been associated with lower mortality in registry reviews, but there has been no significant difference in outcomes between patients treated with and without ECMO in meta-analyses. Considerable heterogeneity in studies is a significant weakness of the available literature. Applying ECMO is also associated with substantial multisystem morbidity due to a systemic inflammatory response, hemorrhagic stroke, renal dysfunction, and bleeding, which must be factored into the outcomes. The application of ECMO in MPE should be combined with an aggressive pulmonary interventional program and should strictly adhere to the current selection criteria.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1298686
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Article ; Online: Comparison of Open and Endovascular Aneurysm Repair in Native Arteriovenous Fistulas.

Yan, Qi / Davies, Mark G

Annals of vascular surgery

2023 Volume 100, Page(s) 233–242

Abstract: Background: Arteriovenous accesses develop aneurysms (FA) during their active use, resulting in pain, erosion, bleeding, and difficulty in cannulation. This study aims to evaluate the outcomes of open and endovascular management of single FA in ... ...

Abstract	Background: Arteriovenous accesses develop aneurysms (FA) during their active use, resulting in pain, erosion, bleeding, and difficulty in cannulation. This study aims to evaluate the outcomes of open and endovascular management of single FA in arteriovenous fistulas (AVF). Methods: A retrospective review of all upper extremity primary AVFs over 12 years was undertaken at a single center. Patients undergoing elective open and endovascular repair of a single FA were identified. Thirty-day outcomes, cannulation failure, line placement, re-intervention, and functional dialysis (continuous hemodialysis) for 3 consecutive months were examined. Results: Three hundred and seventy nine patients presented with a single FA that met the requirements for intervention: 126 (33%) underwent endovascular repair, and the remainder 253 (67%) underwent open repair. Preoperative fistulogram identified anatomically significant issues in 91% of the cases, and these were treated by balloon angioplasty: 10% within the fistula tract, 44% within the outflow tract, and 47% in the central veins. In open repair, 57% underwent plication, 35% underwent resection and re-anastomosis, and the remainder (8%) underwent interposition grafting. In endovascular repair, successful placement of a stent was achieved in all cases with 1 ± 2 (mean ± standard deviation [SD]) covered stents (diameter: 6 -8 mm) placed, achieving successful exclusion of the FA. The combination of early thrombosis and cannulation failures led to the greater need for a tunneled central line in endovascular repair (6.5% vs. 2.4%; endovascular versus open repair; P = 0.04). As a result, the mean time for establishing renewed access in the index AVF was significantly higher in endovascular repair (2 ± 3 vs. 2 ± 2 weeks, mean ± SD; endovascular open repair versus open repair; P = 0.001). In follow-up, there were more secondary interventions per year in the endovascular compared to open repair groups (3.1 vs. 1.4 secondary interventions per year; endovascular versus open repair; P = 0.04). Median functional dialysis durations were superior in the open repair (48 ± 6%, mean + standard error) compared to the endovascular repair at 5 years. (26 ± 7%; P = 0.03). Conclusions: Open repair results in a more rapid return to access use, lower need for a tunneled central line, lower secondary re-intervention rates, and superior functional dialysis durations compared to endovascular repair. Open FA repair should be considered for symptomatic single FA repairs before endovascular FA repair.
MeSH term(s)	Humans ; Arteriovenous Shunt, Surgical/adverse effects ; Endovascular Aneurysm Repair ; Graft Occlusion, Vascular ; Vascular Patency ; Aortic Aneurysm, Abdominal/surgery ; Treatment Outcome ; Endovascular Procedures/adverse effects ; Blood Vessel Prosthesis Implantation/adverse effects ; Arteriovenous Fistula/surgery ; Angioplasty, Balloon ; Renal Dialysis ; Retrospective Studies
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2023.09.102
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Obesity drives secondary procedures to achieve access maturation in end-stage renal disease.

Yan, Qi / Davies, Mark G

Journal of vascular surgery

2023 Volume 78, Issue 6, Page(s) 1531–1540.e4

Abstract: Background: Establishing long-term arteriovenous access is an important component in the long-term care of a patient with end-stage renal disease. The increasing frequency of obesity is reported to impact the access management of end-stage renal disease ...

Abstract	Background: Establishing long-term arteriovenous access is an important component in the long-term care of a patient with end-stage renal disease. The increasing frequency of obesity is reported to impact the access management of end-stage renal disease patients. This study aims to evaluate the outcomes of arteriovenous fistulae (AVF) in obese and nonobese patients. Methods: A retrospective review of all patients over ten years with primary autogenous AVF (radiocephalic, brachiocephalic, and brachial-basilic) was undertaken at a single center. Patients were subcategorized by body mass index into nonobese, class I, II, and III obesity. Outcomes of maturation (successful progression to hemodialysis), reintervention, functional dialysis (continuous hemodialysis for 3 consecutive months), and patency were examined. Results: From January 1999 to December 2019, 2311 patients (67% female; mean age, 61 ± 15 years) underwent primary AVF placement (12% radiocephalic, 53% brachiocephalic, and 35% brachial basilic). Forty-one percent were nonobese, 29% had class I obesity, 19% had class II obesity, and 11% had class III obesity. The majority of patients were diabetic and Hispanic. The 30-day major adverse cardiovascular event rate was elevated in class II (0.20%) and class III (0.50%) obesity compared with class I obesity (0.15%) and nonobese (0.05%). The 30-day morbidity rate was higher in all classes of obesity (0.5% vs0.3% vs 0.2% vs 0.05% for class III vs class II vs class I obesity and nonobese, respectively). Early thrombosis was significantly increased in class II (9%) and class III obesity (12%) compared with class I obesity (5%) and nonobese (3%). There was a two-fold increase in procedures to effect maturation in class II (51%) and class III (74%) obesity compared with class I obesity (22%) and nonobese (34%). Secondary patency at 3 years was significantly lower in class III (62 ± 4%) and class II (79 ± 3%) compared with class I obesity (87 ± 2%) and nonobese (93 ± 4%). All classes of obesity required significantly more secondary Interventions per year compared with nonobese (3.9 vs 3.1 vs 2.5 vs 1.4 secondary interventions per year for class III vs class II vs class I obesity and nonobese, respectively). Conclusions: Advancing obesity class is associated with an increased number of procedures to achieve AVF maturation and is associated with poorer patency and functionality as the category of obesity advances.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Male ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/methods ; Treatment Outcome ; Vascular Patency ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/etiology ; Renal Dialysis ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Retrospective Studies
Language	English
Publishing date	2023-08-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2023.08.102
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Outcomes of one-stage and two-stage aneurysm repair in arteriovenous fistulae.

Yan, Qi / Davies, Mark G

Journal of vascular surgery

2023 Volume 79, Issue 3, Page(s) 662–670.e3

Abstract: Objective: Maintenance of long-term arteriovenous access is important in long-term care for patients with end-stage renal disease. Arteriovenous access is associated in the long term with the development of fistula aneurysms (FAs). This study aims to ... ...

Abstract	Objective: Maintenance of long-term arteriovenous access is important in long-term care for patients with end-stage renal disease. Arteriovenous access is associated in the long term with the development of fistula aneurysms (FAs). This study aims to evaluate the outcomes of staged FA treatment in dialysis access arteriovenous fistulae (AVF). Methods: A retrospective review of all patients over a 12-year period with primary autogenous AVF was undertaken at a single center. Patients undergoing elective open aneurysm repair were identified and were categorized into three groups: single FA repair (single, control group) and staged and unstaged repair of two FAs (staged and unstaged). A staged repair was a procedure in which the initial intent was to treat both aneurysms in the AVF and in which the most symptomatic aneurysm was treated first. When the incision from the first surgery had healed, the second symptomatic aneurysm in the AVF was treated. An unstaged repair was a procedure in which the initial intent was to repair both symptomatic aneurysms simultaneously. All patients had a fistulogram before the FA repair. Thirty-day outcomes, cannulation failure, line placement, reintervention, and functional dialysis (continuous hemodialysis for 3 consecutive months) were examined. Results: Five hundred twenty-seven patients presented with FA that met requirements for open intervention; 44% underwent single FA repair, whereas the remaining 34% and 22% underwent staged and unstaged repair of two FAs, respectively. The majority of patients were diabetic and Hispanic. Ninety-one percent of the patients required percutaneous interventions of the outflow tract (37%) and the central veins (54%). Thirty-day major adverse cardiovascular events were equivalent across all modalities. Thirty-day morbidity and early thrombosis (<18 days) were significantly higher in the unstaged group (4.3%) compared with the two other groups (1.3% and 2.1%, single and staged, respectively), which led to an increased need for a short-term tunneled catheter (8.9%) compared with the two other groups (3.4% and 4.4%, single and staged, respectively), Unstaged repair resulted in an increased incidence of secondary procedures (5.0%) compared with the two other groups (2.6% and 3.1%, single and staged, respectively). Functional dialysis at 5 years was equivalent in the single and staged groups but was significantly decreased in the unstaged group. Conclusions: Open interventions are successful therapeutic modalities for FAs, but unstaged rather than staged repair of two concurrent FAs results in a higher early thrombosis, an increased secondary intervention rate, and a need for a short-term tunneled central line. Staged and single FA repairs have equivalent results. In the setting of two symptomatic FAs, staged repair is recommended.
MeSH term(s)	Humans ; Arteriovenous Shunt, Surgical/adverse effects ; Treatment Outcome ; Veins/diagnostic imaging ; Veins/surgery ; Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Aneurysm/surgery ; Arteriovenous Fistula/complications ; Renal Dialysis/adverse effects ; Thrombosis/etiology ; Retrospective Studies ; Vascular Patency
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2023.10.057
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Article ; Online: MANAGEMENT OF DEPTH TO ACHIEVE TIMELY ARTERIO-VENOUS FISTULA UTILIZATION.

Cheun, Tracy J / Hart, Joseph P / Davies, Mark G

Journal of vascular surgery

2024

Abstract: Background: Failure to achieve timely arteriovenous fistulae (AVF) utilization due to excessive depth (>6mm) remains an ongoing concern for dialysis access. This study evaluates the outcomes of radio cephalic (RCF) and brachiocephalic (BCF) fistula ... ...

Abstract	Background: Failure to achieve timely arteriovenous fistulae (AVF) utilization due to excessive depth (>6mm) remains an ongoing concern for dialysis access. This study evaluates the outcomes of radio cephalic (RCF) and brachiocephalic (BCF) fistula elevation required for access utilization. Methods: A retrospective review of all patients undergoing first-time autologous access over 10 years was undertaken. RCF and BCF were analyzed, and cases of initial access failure due to depth alone were selected for study. Primary and staged brachio-basilic AVF were excluded. Outcomes of early thrombosis, Line placement, maturation (successful progression to HD), re-intervention, and functional dialysis (continuous HD for three consecutive months) were examined. Results: From January 2012 to December 2022, 1733 patients (67% female, age 61±14yrs; mean ± SD) underwent autologous AVF placement. 298 (17%) patients had depth-related AVF access issues (BCF - 71% and RCF - 29%). 19% of these AVFs underwent a primary balloon-assisted maturation (BAM), and 2% had side branch coil embolization before consideration for elevation. The average time to intervention for depth was 11±4 weeks (mean ± SD) after primary creation. During elevation, side branch ligation occurred in 38% of cases, and 15% underwent intraoperative balloon-assisted maturation, The pre-elevation depth was 8.2 ± 3.1mm, and the post-elevation depth was 4.7 ± 2.9mm (mean ± SD, P= .002). Early thrombosis (<18 days) occurred in 4% of cases. There was no mortality, and 30-day MACE was 2%, with a 30-day morbidity of 5%, which was driven by wound issues. 6% of the AVFs underwent follow-up BAM within three months. Maturation of the AVFs was 74±3% vs. 72±3% (mean ± SEM; P=.58) for Elevation vs. No-Elevation groups at 24 weeks, respectively. However, there was an increase in tunneled central line placement in pre-emptive fistula patients due to the delay in maturation (17% vs. 8 %, Elevation vs. No-Elevation; P=.008). Mean successful access time of 6±3 weeks after elevation (16±4 weeks after access creation). There was a median of 2.4 secondary Interventions per year after elevation compared to a median of 2,7 secondary Interventions per year without elevation. Access functionality was 68±8% vs. 75±8% at 3 years for Elevation vs. No-Elevation, respectively (mean ± SEM; P=.25). Conclusion: Elevation of deep BCF and RCF occurs late after placement but can be successfully achieved with low morbidity and satisfactory long-term functionality. It results in an increase in tunneled central line placement in pre-emptive fistula patients. Elevation is a valuable adjunct to AV fistula maturation and enhances an autologous access policy.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2024.03.445
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Article ; Online: PEDAL MEDIAL ARTERIAL CALCIFICATION INFLUENCES THE OUTCOMES OF ISOLATED INFRA-MALLEOLAR INTERVENTIONS FOR CHRONIC LIMB-THREATENING ISCHEMIA.

Cheun, Tracy J / Hart, Joseph P / Davies, Mark G

Journal of vascular surgery

2024

Abstract: Background: Infra-malleolar disease is present in most diabetic patients presenting with tissue loss. Infra-malleolar (pedal) artery disease and pedal medial arterial calcification (pMAC) are associated with major amputation in patients with chronic ... ...

Abstract	Background: Infra-malleolar disease is present in most diabetic patients presenting with tissue loss. Infra-malleolar (pedal) artery disease and pedal medial arterial calcification (pMAC) are associated with major amputation in patients with chronic limb-threatening ischemia (CLTI). This study aimed to examine the impact of pMAC on the outcomes after isolated infra-malleolar (pedal artery) interventions. Methods: A database of lower extremity endovascular intervention for tissue loss patients between 2007 and 2022 was retrospectively queried. Patients with CLTI were selected, and those undergoing isolated infra-malleolar intervention on the dorsalis pedis and medial and lateral tarsal arteries and who had foot x-rays were identified. X-rays were assessed blindly for pMAC and scored on a scale of 0-5. Patients with concomitant superficial femoral artery (SFA) and tibial interventions were excluded. Intention to treat analysis by the patient was performed. Amputation-free survival (AFS; survival without major amputation) was evaluated. Results: 223 patients (51% female, 87% Hispanic, average age 66 years; 323 vessels) underwent isolated infra-malleolar intervention for tissue loss. All patients had diabetes, 96% had hypertension, 79% had hyperlipidemia, and 63% had chronic renal insufficiency (55% of these were on hemodialysis). Most of the patients had WIfI stage 3 disease and had various stages of pMAC: severe (score=5) in 48%, moderate (score = 2-4) in 31%, and mild (score = 0-1) in 21% of the patients. Technical success was 94%, with a median of 1 vessel treated per patient. All failures were in severe pMAC. Overall, Major Adverse Cardiovascular Events (MACE) was 0.9% at 90 days after the procedure. Following the intervention, most patients underwent a planned forefoot amputation (single digit, multiple digits, ray amputation, or trans-metatarsal amputation). WIfI ischemic grade was improved by 51%. Wound healing at three months was 69%. Those not healing underwent below-knee amputations (BKA). The overall 5-yr-AFS rate was 35±9%. The severity of pMAC was associated with decreased AFS. Conclusions: PMAC influences the technical and long-term outcomes of Infra-malleolar intervention in diabetes. Severe pMAC is associated with amputation and should be considered as a variable in the shared decision-making of diabetic patients with CLTI.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2024.04.042
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Book: Chronic venous insufficiency

Davies, Mark G. / Lumsden, Alan B.

(Contemporary endovascular management ; 1)

2011

Author's details	ed. Mark G. Davies ; Alan B. Lumsden
Series title	Contemporary endovascular management ; 1
Collection
Language	English
Size	XIII, 222 S. : Ill., graph. Darst.
Publisher	Cardiotext Publ
Publishing place	Minneapolis, Minn
Publishing country	United States
Document type	Book
HBZ-ID	HT016928771
ISBN	978-1-935395-09-6 ; 1-935395-09-2
Database	Catalogue ZB MED Medicine, Health

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