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  1. AU="Davies, Neville"
  2. AU="Wise, J.C."
  3. AU="Mazer, Benjamin L"
  4. AU="Vellore J. Karthikeyan"

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  1. Artikel: Knee joint dislocation: overview and current concepts.

    Anazor, Fitzgerald C / Baryeh, Kwaku / Davies, Neville C

    British journal of hospital medicine (London, England : 2005)

    2021  Band 82, Heft 12, Seite(n) 1–10

    Abstract: Knee joint dislocation is a relatively uncommon injury but its management is important because of the associated high risk of vascular, neurological and multi-ligamentous knee injuries. Clinicians must be aware that not all knee dislocations are ... ...

    Abstract Knee joint dislocation is a relatively uncommon injury but its management is important because of the associated high risk of vascular, neurological and multi-ligamentous knee injuries. Clinicians must be aware that not all knee dislocations are diagnosed on plain X-rays; a high index of suspicion is required based on clinical evaluation. Multidisciplinary specialist care is required in all cases to achieve best outcomes. Early one-stage or multiple staged ligament repair and reconstruction offer better outcomes, but most patients have some long-term functional limitation. This article provides insights into the epidemiology and management of this injury and its devastating effects.
    Mesh-Begriff(e) Humans ; Knee Dislocation/diagnosis ; Knee Dislocation/epidemiology ; Knee Dislocation/therapy ; Knee Injuries ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Radiography ; Soft Tissue Injuries
    Sprache Englisch
    Erscheinungsdatum 2021-12-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2021.0466
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A Virtual Fracture Clinic Pathway for Managing Suspected Paediatric Scaphoid Fractures.

    Aboelmagd, Karim / Aboelmagd, Tariq / Lane, Jennifer C / Morley, John / Middleton, Claire / El Khouly, Amr / Davies, Neville

    Cureus

    2022  Band 14, Heft 9, Seite(n) e29238

    Abstract: Introduction: The mismanagement of an occult scaphoid fracture is a significant concern in patients presenting with anatomical snuffbox tenderness and no radiographic signs of injury.: Aim: This study investigated whether a virtual fracture clinic ( ... ...

    Abstract Introduction: The mismanagement of an occult scaphoid fracture is a significant concern in patients presenting with anatomical snuffbox tenderness and no radiographic signs of injury.
    Aim: This study investigated whether a virtual fracture clinic (VFC) could improve care efficiency and expedite management decisions surrounding suspected pediatric scaphoid fractures.
    Method: Data was reviewed for patients referred via the VFC for suspected scaphoid fractures at a local trauma unit over 19 months. Patients received an "appointment" in VFC. Based on their notes and imaging, patients were referred to an outpatient clinic for repeat radiographs within two weeks (if initial radiographs demonstrated no fracture). Patients with unremarkable second x-rays were contacted and informed to mobilize and return if the pain persisted at four weeks.
    Results: The pathway received 175 referrals; 114 male, 61 female, mean age 14 years, range 9-17) with 42 scaphoid fractures diagnosed, 35 (83.3%) on first x-ray, and 7 (16.7%) occult fractures. The pathway managed all patients as intended; 71 patients were seen face-to-face in the clinic due to age or pathology picked up on the first x-ray, and 104 required repeat radiographs. Following the second radiograph, 78 patients were discharged directly. Twenty-six patients required further review in a face-to-face clinic after their second radiograph.
    Conclusion: VFC appears to be a safe and efficient method of managing patients with suspected scaphoid fractures on short-term follow-up analysis. This cohort presents no 'missed' injuries and therefore appears safe compared to conventional treatment pathways.
    Sprache Englisch
    Erscheinungsdatum 2022-09-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.29238
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Medical experts and the criminal courts. Clinical forensic medicine needs to become part of the syllabus.

    Davies, Neville

    BMJ (Clinical research ed.)

    2003  Band 326, Heft 7397, Seite(n) 1037

    Mesh-Begriff(e) Curriculum ; Education, Medical, Undergraduate/organization & administration ; Forensic Medicine/education ; United Kingdom
    Sprache Englisch
    Erscheinungsdatum 2003-05-10
    Erscheinungsland England
    Dokumenttyp Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Experience with the Fassier-Duval telescopic rod: first 24 consecutive cases with a minimum of 1-year follow-up.

    Birke, Oliver / Davies, Neville / Latimer, Mark / Little, David Graham / Bellemore, Michael

    Journal of pediatric orthopedics

    2011  Band 31, Heft 4, Seite(n) 458–464

    Abstract: Background: The new Fassier-Duval Telescopic IM System (FD-rod) has the advantage of a single entry point over the traditional telescopic rods such as the Bailey-Dubow or Sheffield rods. Although encouraging early results were presented by the ... ...

    Abstract Background: The new Fassier-Duval Telescopic IM System (FD-rod) has the advantage of a single entry point over the traditional telescopic rods such as the Bailey-Dubow or Sheffield rods. Although encouraging early results were presented by the originators of the technique at international meetings, there is no formal publication in the literature as yet.
    Methods: We performed a chart and x-ray review of the first 24 consecutive FD-rod insertions in 15 patients (age, 1.5 to 12.5 y) with a minimum of 1-year follow up (1 to 2.4 y) after implantation of femoral and/or tibial FD-rods. Diagnoses included with osteogenesis imperfecta (OI) (15 cases, 9 patients), and other conditions such as congenital tibial pseudarthrosis (CPT) in neurofibromatosis type 1 (NF1) (2 cases), and epidermal naevus syndrome (1 case). In patients with hypophosphataemic rickets (6 cases, 2 patients) the FD-rods were combined with an Ilizarov frame.
    Results: We found the OI patient group associated with a 13% reoperation rate (2 of 15 cases) for proximal rod migration and a 40% complication rate (6 of 15 cases): rod migration and limited telescoping (5) and intraoperative joint intrusion (1). There were no infections. All the NF1 CPT (2) and epidermal naevus syndrome (1) cases required several reoperations for nonunion, loss of fixation, shortening (negative telescoping), migration, and/or joint intrusion-mainly due to the severe underlying pathology with insufficient longitudinal or torsional stability and diminished healing capacity. In hypophosphataemic rickets (combined with Ilizarov frame fixation) we found a 50% complication rate (3 of 6 cases) and a 17% reoperation rate (1 of 6): 2 FD-rods did not telescope and 1 case of peroneal neuropraxia required neurolysis.
    Conclusions: In our experience the technique of using FD rods is demanding and associated with some intraoperative and postoperative pitfalls. We are happy to continue its use in OI patients when there is longitudinal stability and sufficient bone healing. However, in circumstances of insufficient stability and bone healing potential, further stabilization that can be achieved with an Ilizarov frame may be beneficial.
    Mesh-Begriff(e) Bone Diseases/diagnostic imaging ; Bone Diseases/pathology ; Bone Diseases/surgery ; Child ; Child, Preschool ; Equipment Failure ; Familial Hypophosphatemic Rickets/diagnostic imaging ; Familial Hypophosphatemic Rickets/pathology ; Familial Hypophosphatemic Rickets/surgery ; Female ; Follow-Up Studies ; Fracture Fixation, Intramedullary/instrumentation ; Fracture Fixation, Intramedullary/methods ; Humans ; Ilizarov Technique ; Infant ; Male ; Orthopedic Fixation Devices ; Osteogenesis Imperfecta/diagnostic imaging ; Osteogenesis Imperfecta/pathology ; Osteogenesis Imperfecta/surgery ; Postoperative Complications ; Radiography ; Reoperation ; Retrospective Studies ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2011-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604642-3
    ISSN 1539-2570 ; 0271-6798
    ISSN (online) 1539-2570
    ISSN 0271-6798
    DOI 10.1097/BPO.0b013e31821bfb50
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1681: Hefte anzeigen Standort:
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  5. Artikel ; Online: The Oxford Ankle Foot Questionnaire for Children: review of development and potential applications.

    Morris, Christopher / Doll, Helen / Wainwright, Andrew / Davies, Neville / Theologis, Tim / Fitzpatrick, Ray

    Prosthetics and orthotics international

    2010  Band 34, Heft 3, Seite(n) 238–244

    Abstract: There is increasing recognition of the credibility and utility of patient reported outcome measures, both in research and as routine quality indicators. This paper reviews the development of a questionnaire for children with foot or ankle problems and ... ...

    Abstract There is increasing recognition of the credibility and utility of patient reported outcome measures, both in research and as routine quality indicators. This paper reviews the development of a questionnaire for children with foot or ankle problems and integrates the findings from three previously published studies in a cohesive way for the orthotic community. The Oxford Ankle Foot Questionnaire for Children was designed to evaluate the effectiveness of interventions. The development process was conducted in three phases. First the items were devised through focus groups with children affected by foot and ankle problems, and their parents. Second, test versions of child and parent questionnaires were evaluated to enable scales to be developed and tested for validity and reliability. Finally, findings from a prospective study assessing how scores changed over time and/or with treatment supported the longitudinal validity and responsiveness of the scales. The questionnaire offers an inexpensive and expedient means to evaluate the effectiveness of orthoses and other interventions used to treat children's foot or ankle problems. The Oxford Ankle Foot Questionnaire for Children has broad utility both in routine clinical settings, or applied research to evaluate treatment programmes and interventions used in paediatric orthopaedics, trauma and rheumatology.
    Mesh-Begriff(e) Adolescent ; Ankle Joint ; Child ; Child, Preschool ; Foot Joints ; Humans ; Orthotic Devices ; Reproducibility of Results ; Surveys and Questionnaires ; Treatment Outcome ; United Kingdom
    Sprache Englisch
    Erscheinungsdatum 2010-06-05
    Erscheinungsland France
    Dokumenttyp Journal Article ; Review
    ZDB-ID 753382-2
    ISSN 1746-1553 ; 0309-3646
    ISSN (online) 1746-1553
    ISSN 0309-3646
    DOI 10.3109/03093641003789300
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The Oxford Ankle Foot Questionnaire for children: responsiveness and longitudinal validity.

    Morris, Christopher / Doll, Helen / Davies, Neville / Wainwright, Andrew / Theologis, Tim / Willett, Keith / Fitzpatrick, Ray

    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

    2009  Band 18, Heft 10, Seite(n) 1367–1376

    Abstract: Purpose: To evaluate how scores from the Oxford Ankle Foot Questionnaire change over time and with treatment using both distribution-based and anchor-based approaches.: Methods: Eighty children aged 5-16 and their parent or career completed ... ...

    Abstract Purpose: To evaluate how scores from the Oxford Ankle Foot Questionnaire change over time and with treatment using both distribution-based and anchor-based approaches.
    Methods: Eighty children aged 5-16 and their parent or career completed questionnaires at orthopaedic or trauma outpatient clinics. They were asked to complete and return a second set of questionnaires again within 2 weeks (retest), and then mailed a third set of questionnaires to complete again after 2 months (follow-up). The follow-up questionnaires included a global rating of change 'transition' item.
    Results: Child- and parent-reported mean domain scores (Physical, School & Play, and Emotional) were all stable at retest, whereas positive mean changes were observed at follow-up. As we hypothesised, trauma patients had poorer scores than elective patients at baseline, and showed greater improvement at follow-up. For trauma patients, mean changes in per cent scores were large (scores improved between 40 and 56 for the Physical and School & Play domains, and 17 and 21 for Emotional); all effect sizes (ES) were large (>0.8). For elective patients, the mean improvement in per cent scores were more moderate (Physical: child 10, ES = 0.4, parent 11, ES = 0.5; School & Play child 0, ES = 0, parent 9 ES = 0.4; Emotional: child 6, ES = 0.2; parents 8, ES > 0.3). Minimal detectable change (MDC(90)), an indication of measurement error, ranged from 6 to 8. Half the standard deviation of baseline scores ranged from 11 to 18. Minimal important difference could only be calculated for elective patients (9 child and 13 parent ratings), these ranged from 7 to 17.
    Conclusions: The findings support the responsiveness and longitudinal validity of the scales. Changes in domain scores of, or exceeding, the MDC(90) (6-8) are likely to be beyond measurement error; further work is required to refine the estimate of change that can be considered important.
    Mesh-Begriff(e) Adolescent ; Ankle Joint/physiopathology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Foot/physiopathology ; Humans ; Longitudinal Studies ; Male ; Orthopedics ; Quality of Life ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2009-11-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 1161148-0
    ISSN 1573-2649 ; 0962-9343
    ISSN (online) 1573-2649
    ISSN 0962-9343
    DOI 10.1007/s11136-009-9550-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3796: Hefte anzeigen Standort:
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  7. Artikel: Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

    Davies, Lee A / Hannavy, Kevin / Davies, Neville / Pirrie, Alistair / Coffee, Ronald A / Hyde, Stephen C / Gill, Deborah R

    Pharmaceutical research

    2005  Band 22, Heft 8, Seite(n) 1294–1304

    Abstract: Purpose: Naked plasmid DNA (pDNA) is a potential gene transfer agent for lung gene therapies but cannot be aerosolised without degradation using conventional nebulisation devices. This study investigated the viability of an alternative nebulisation ... ...

    Abstract Purpose: Naked plasmid DNA (pDNA) is a potential gene transfer agent for lung gene therapies but cannot be aerosolised without degradation using conventional nebulisation devices. This study investigated the viability of an alternative nebulisation technique, electrohydrodynamic (EHD) comminution for the aerosol delivery of naked DNA in vivo.
    Methods: Naked pDNA was aerosolised using jet and ultrasonic nebulisers, and by EHD comminution. Degradation associated with the aerosolisation process was investigated using gel electrophoresis and by transfection studies in cell culture. Optimised formulations for EHD aerosolisation of pDNA were developed and in vivo deposition and reporter gene expression were investigated in mice.
    Results: Unlike conventional nebulisation devices, EHD comminution of plasmids up to 15 kb in size resulted in no detectable pDNA degradation. EHD formulations containing up to 1 mg/ml pDNA were developed and shown to produce monodisperse aerosols suitable for targeted lung delivery in humans. Aerosolisation studies in vivo demonstrated detectable levels of pDNA deposition and measurable luciferase reporter gene expression in the lungs of exposed mice.
    Conclusions: This study demonstrates for the first time that respirable aerosols of naked pDNA can be generated without plasmid degradation and that EHD comminution is an appropriate technique for the aerosolisation of delicate gene transfer agents.
    Mesh-Begriff(e) Aerosols ; Animals ; Chemistry, Pharmaceutical ; DNA/chemistry ; Electrochemistry ; Female ; Genes, Reporter/genetics ; Genetic Vectors ; Lung/metabolism ; Mice ; Mice, Inbred BALB C ; Molecular Conformation ; Nebulizers and Vaporizers ; Plasmids/chemistry ; Reverse Transcriptase Polymerase Chain Reaction
    Chemische Substanzen Aerosols ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2005-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 843063-9
    ISSN 1573-904X ; 0724-8741 ; 0739-0742
    ISSN (online) 1573-904X
    ISSN 0724-8741 ; 0739-0742
    DOI 10.1007/s11095-005-5268-6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1937: Hefte anzeigen Standort:
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