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  1. Article ; Online: The genomics of sporadic and hereditary colorectal cancer.

    Sadien, I D / Davies, R J / Wheeler, Jmd

    Annals of the Royal College of Surgeons of England

    2024  Volume 106, Issue 4, Page(s) 313–320

    Abstract: Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, ... ...

    Abstract Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Over the past three decades, extensive efforts have sought to elucidate the genomic landscape of CRC. These studies reveal that CRC is highly heterogeneous at the molecular level, with different subtypes characterised by distinct somatic mutational profiles, epigenetic aberrations and transcriptomic signatures. This review summarises our current understanding of the genomic and epigenomic alterations implicated in CRC development and progression. Particular focus is given to how characterisation of CRC genomes is leading to more personalised approaches to diagnosis and treatment.
    MeSH term(s) Humans ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/therapy ; Microsatellite Instability ; Genomics ; Gene Expression Profiling
    Language English
    Publishing date 2024-03-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2024.0024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.234: Show issues Location:
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  2. Article ; Online: Dynamic baselines for the detection of water quality impacts - the case of shale gas development.

    Worrall, Fred / Davies, Richard J / Hart, Alwyn

    Environmental science. Processes & impacts

    2021  Volume 23, Issue 8, Page(s) 1116–1129

    Abstract: There is a need for the development of effective baselines against which the water quality impacts of new developments can be assessed. The specific conductance of flowback water from shale gas operations is typically many times the specific conductance ... ...

    Abstract There is a need for the development of effective baselines against which the water quality impacts of new developments can be assessed. The specific conductance of flowback water from shale gas operations is typically many times the specific conductance of surface water and near-surface groundwater. This contrast in specific conductance means that specific conductance could be the ideal determinand for detecting water quality impacts from shale gas extraction. If specific conductance is to be used for detecting the impacts of shale gas operations, then a baseline of specific conductance in water bodies is required. Here, Bayesian hierarchical modelling of specific conductance was applied across English groundwater. The modelling used existing, spot-sampled data from the years 2000 to 2018 from 537 unique borehole locations. When the differences between boreholes was considered, then the approach was sufficiently sensitive to detect 1% mixing of fracking fluid in groundwater at a 95% confidence interval. The Bayesian hierarchical modelling maximises the return on public investment and provides a means by which future observations can be judged.
    MeSH term(s) Bayes Theorem ; Groundwater ; Hydraulic Fracking ; Natural Gas ; Oil and Gas Fields ; Water Pollutants, Chemical/analysis ; Water Quality
    Chemical Substances Natural Gas ; Water Pollutants, Chemical
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2703814-2
    ISSN 2050-7895 ; 2050-7887
    ISSN (online) 2050-7895
    ISSN 2050-7887
    DOI 10.1039/d0em00440e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 7401: Show issues

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  3. Article ; Online: Does Prophylactic Negative-Pressure Wound Therapy Prevent Surgical Site Infection After Laparotomy? A Systematic Review and Meta-analysis of Randomized Controlled trials.

    Meyer, Jeremy / Roos, Elin / Davies, Richard Justin / Buchs, Nicolas Christian / Ris, Frédéric / Toso, Christian

    World journal of surgery

    2023  Volume 47, Issue 6, Page(s) 1464–1474

    Abstract: Background: Prophylactic negative-pressure wound therapy (pNPWT) may prevent surgical site infection (SSI) after laparotomy, but existing meta-analyses pooling only high-quality evidence have failed to confirm this effect. Recently, several randomized ... ...

    Abstract Background: Prophylactic negative-pressure wound therapy (pNPWT) may prevent surgical site infection (SSI) after laparotomy, but existing meta-analyses pooling only high-quality evidence have failed to confirm this effect. Recently, several randomized controlled trials (RCTs) have been published. We performed an updated systematic review and meta-analysis to determine if pNPWT reduces the incidence of SSI after laparotomy.
    Methods: MEDLINE, Embase, CENTRAL and Web of Science were searched on the 25.08.2021 for RCTs reporting on the incidence of SSI in patients who underwent laparotomy with and without pNPWT. The systematic review was compliant with the AMSTAR2 recommendation and registered into PROSPERO. Risk ratios (RR) for SSI in patients with pNPWT, and risk difference (RD) between control and pNPWT patients, were obtained using random effects models. Heterogeneity was quantified using the I
    Results: Eleven RCTs were included, representing 973 patients who received pNPWT and 970 patients who received standard wound dressing. Pooled RR and RD between patients with and without pNPWT were of, respectively, 0.665 (95% CI 0.49-0.91, I
    Conclusion: The protective effect of pNPWT against SSI after laparotomy is confirmed by high-quality pooled evidence.
    MeSH term(s) Humans ; Surgical Wound Infection/prevention & control ; Surgical Wound Infection/epidemiology ; Laparotomy/adverse effects ; Negative-Pressure Wound Therapy ; Randomized Controlled Trials as Topic ; Bandages
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-023-06908-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1336: Show issues Location:
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  4. Article ; Online: COVID-19 gastrointestinal symptoms mimicking surgical presentations

    Ashcroft, J. / Hudson, V.E. / Davies, R.J.

    Annals of Medicine and Surgery

    2020  Volume 56, Page(s) 108–109

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.06.025
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Long-distance migration and venting of methane from the base of the hydrate stability zone

    Davies, Richard J. / Yang, Jinxiu / Ireland, Mark T. / Berndt, Christian / Maqueda, Miguel Ángel Morales / Huuse, Mads

    2024  

    Abstract: Marine methane hydrate is an ice-like substance that is stable in sediment around marine continental margins where water depths are greater than ~450–700 m. The release of methane due to melting of hydrates is considered to be a mechanism for past global ...

    Abstract Marine methane hydrate is an ice-like substance that is stable in sediment around marine continental margins where water depths are greater than ~450–700 m. The release of methane due to melting of hydrates is considered to be a mechanism for past global carbon-cycle perturbations and could exacerbate ongoing anthropogenic climate change. Increases in bottom-water temperature at the landward limit of marine hydrate around continental margins, where vulnerable hydrate exists at or below the seabed, cause methane to vent into the ocean. However, this setting represents only ~3.5% of the global hydrate reservoir. The potential for methane from hydrate in deeper water to reach the atmosphere was considered negligible. Here we use three-dimensional (3D) seismic imagery to show that, on the Mauritanian margin, methane migrated at least 40 km below the base of the hydrate stability zone and vented through 23 pockmarks at the shelf break, probably during warmer Quaternary interglacials. We demonstrate that, under suitable circumstances, some of the 96.5% of methane bound in deeper water distal hydrates can reach the seafloor and vent into the ocean beyond the landward limit of marine hydrate. This reservoir should therefore be considered for estimating climate change-induced methane release during a warming world.
    Subject code 550
    Language English
    Publisher Nature Research
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Ethical challenges for doctors working in immigration detention.

    Davies, Robert J

    The Medical journal of Australia

    2014  Volume 202, Issue 1, Page(s) 16

    MeSH term(s) Emigration and Immigration ; Ethics, Medical ; Humans
    Language English
    Publishing date 2014-05-13
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja14.01456
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.398: Show issues Location:
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  7. Article: COVID-19 gastrointestinal symptoms mimicking surgical presentations.

    Ashcroft, J / Hudson, V E / Davies, R J

    Annals of medicine and surgery (2012)

    2020  Volume 56, Page(s) 108–109

    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2020.06.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Intersphincteric epidermoid inclusion cyst: report of a rare case.

    Ashcroft, James / Mahler-Araujo, Betania / Davies, Richard J

    Journal of surgical case reports

    2020  Volume 2020, Issue 3, Page(s) rjaa004

    Abstract: Epidermoid inclusion cysts of the perineal region are a rare entity, which require appropriate diagnosis and management. Here we describe the unusual case of a large protruding epidermoid inclusion cyst originating from the intersphincteric anal plane, ... ...

    Abstract Epidermoid inclusion cysts of the perineal region are a rare entity, which require appropriate diagnosis and management. Here we describe the unusual case of a large protruding epidermoid inclusion cyst originating from the intersphincteric anal plane, which was mobilized and excised successfully. Essential investigations to ensure accurate diagnosis in addition to surgical technique to reduce recurrence and patient morbidity are described in this case report.
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Case Reports
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjaa004
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  9. Article: Facilitating resilience in the return to surgical practice.

    Ashcroft, J / Davies, R J / Brennan, P A

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2020  Volume 19, Issue 6, Page(s) 380–383

    MeSH term(s) COVID-19 ; Humans ; Resilience, Psychological
    Keywords covid19
    Language English
    Publishing date 2020-11-01
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2020.09.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5756: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Surgeons' view of the PREVENTT trial. Comment on Br J Anaesth 2021; 126: 9-11.

    Meyer, Jeremy / Di Saverio, Salomone / Ris, Frédéric / Davies, Richard J

    British journal of anaesthesia

    2021  Volume 126, Issue 3, Page(s) e84–e86

    MeSH term(s) Administration, Intravenous ; Anemia ; Humans ; Iron/therapeutic use ; Patient Readmission ; Surgeons
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-01-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.11.025
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