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  1. Article ; Online: Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML.

    Kent, Andrew / Crump, Lyndsey S / Davila, Eduardo

    Frontiers in immunology

    2023  Volume 14, Page(s) 1202950

    Abstract: Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of ...

    Abstract Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of research in myeloid neoplasms given their remarkable success in other hematologic malignancies, particularly B-cell-derived acute lymphoid leukemia, myeloma, and lymphomas. Several limitations have hindered clinical application of adoptive cell therapies in AML including lack of leukemia-specific antigens, on-target-off-leukemic toxicity, immunosuppressive microenvironments, and leukemic stem cell populations elusive to immune recognition and destruction. While there are promising T cell-based therapies including chimeric antigen receptor (CAR)-T designs under development, other cytotoxic lymphocyte cell subsets have unique phenotypes and capabilities that might be of additional benefit in AML treatment. Of particular interest are the natural killer (NK) and unconventional T cells known as invariant natural killer T (iNKT) and gamma delta (γδ) T cells. NK, iNKT, and γδT cells exhibit intrinsic anti-malignant properties, potential for alloreactivity, and human leukocyte-antigen (HLA)-independent function. Here we review the biology of each of these unconventional cytotoxic lymphocyte cell types and compare and contrast their strengths and limitations as the basis for adoptive cell therapies for AML.
    MeSH term(s) Humans ; T-Lymphocytes ; Leukemia, Myeloid, Acute/therapy ; Cell- and Tissue-Based Therapy ; Gamma Rays ; Hematologic Neoplasms ; Tumor Microenvironment
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1202950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Robotic approach in complex ventral hernias: anterior component separation technique.

    Nogueira, Raquel / Lima, Diego Laurentino / ParraDavila, Eduardo / Malcher, Flavio

    Journal of minimally invasive surgery

    2023  Volume 26, Issue 2, Page(s) 88–92

    Abstract: Open onlay ventral hernia repair is still one of the most-used surgical techniques for the repair of hernias worldwide. The robotic anterior component separation technique uses the surgeon's usual anatomical expertise on onlay mesh placement with the ... ...

    Abstract Open onlay ventral hernia repair is still one of the most-used surgical techniques for the repair of hernias worldwide. The robotic anterior component separation technique uses the surgeon's usual anatomical expertise on onlay mesh placement with the manipulation and advantages of minimally invasive surgery. It maintains the precepts of reestablishment the midline integrity and insertion of mesh in the preaponeurotic space, without contact with the viscera. The use of this technique is simple and quite reproducible if you compare it with other techniques. Also, the time spent in surgery does not last long.
    Language English
    Publishing date 2023-05-17
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2234-5248
    ISSN (online) 2234-5248
    DOI 10.7602/jmis.2023.26.2.88
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  3. Article ; Online: Chimeric non-antigen receptors in T cell-based cancer therapy.

    Guo, Jitao / Kent, Andrew / Davila, Eduardo

    Journal for immunotherapy of cancer

    2021  Volume 9, Issue 8

    Abstract: Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through ... ...

    Abstract Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through selective expression of tumor-antigen specific T cell receptors or engineered antigen-recognition chimeric antigen receptors (CARs). While several CARs have been approved for treatment of hematopoietic malignancies, this kind of therapy has been less successful in the treatment of solid tumors, in part due to lack of suitable tumor-specific targets, the immunosuppressive tumor microenvironment, and the inability of adoptively transferred cells to maintain their therapeutic potentials. It is critical for therapeutic T cells to overcome immunosuppressive environmental triggers, mediating balanced antitumor immunity without causing unwanted inflammation or autoimmunity. To address these hurdles, chimeric receptors with distinct signaling properties are being engineered to function as allies of tumor antigen-specific receptors, modulating unique aspects of T cell function without directly binding to antigen themselves. In this review, we focus on the design and function of these chimeric non-antigen receptors, which fall into three broad categories: 'inhibitory-to-stimulatory' switch receptors that bind natural ligands, enhanced stimulatory receptors that interact with natural ligands, and synthetic receptor-ligand pairs. Our intent is to offer detailed descriptions that will help readers to understand the structure and function of these receptors, as well as inspire development of additional novel synthetic receptors to improve T cell-based cancer therapy.
    MeSH term(s) Cell Engineering/methods ; Humans ; Neoplasms/therapy ; Receptors, Chimeric Antigen/immunology
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-09-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2021-002628
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  4. Article ; Online: Naturally Occurring Genetic Alterations in Proximal TCR Signaling and Implications for Cancer Immunotherapy.

    Kent, Andrew / Longino, Natalie V / Christians, Allison / Davila, Eduardo

    Frontiers in immunology

    2021  Volume 12, Page(s) 658611

    Abstract: T cell-based immunotherapies including genetically engineered T cells, adoptive transfer of tumor-infiltrating lymphocytes, and immune checkpoint blockade highlight the impressive anti-tumor effects of T cells. These successes have provided new hope to ... ...

    Abstract T cell-based immunotherapies including genetically engineered T cells, adoptive transfer of tumor-infiltrating lymphocytes, and immune checkpoint blockade highlight the impressive anti-tumor effects of T cells. These successes have provided new hope to many cancer patients with otherwise poor prognoses. However, only a fraction of patients demonstrates durable responses to these forms of therapies and many develop significant immune-mediated toxicity. These heterogeneous clinical responses suggest that underlying nuances in T cell genetics, phenotypes, and activation states likely modulate the therapeutic impact of these approaches. To better characterize known genetic variations that may impact T cell function, we 1) review the function of early T cell receptor-specific signaling mediators, 2) offer a synopsis of known mutations and genetic alterations within the associated molecules, 3) discuss the link between these mutations and human disease and 4) review therapeutic strategies under development or in clinical testing that target each of these molecules for enhancing anti-tumor T cell activity. Finally, we discuss novel engineering approaches that could be designed based on our understanding of the function of these molecules in health and disease.
    MeSH term(s) Animals ; Biomarkers ; CD3 Complex/genetics ; CD3 Complex/metabolism ; Carrier Proteins/chemistry ; Carrier Proteins/metabolism ; Disease Management ; Disease Susceptibility ; Genetic Engineering ; Genetic Variation ; Humans ; Immunotherapy ; Immunotherapy, Adoptive ; Multiprotein Complexes ; Mutation ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, Antigen, T-Cell/chemistry ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Structure-Activity Relationship ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
    Chemical Substances Biomarkers ; CD3 Complex ; Carrier Proteins ; Multiprotein Complexes ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2021-05-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.658611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Safe Introduction of New Technologies and Techniques in Minimally Invasive Colorectal Surgery.

    Melani, Armando Geraldo Franchini / Romagnolo, Luis Gustavo Capochin / Davila, Eduardo Parra

    Clinics in colon and rectal surgery

    2021  Volume 34, Issue 3, Page(s) 181–185

    Abstract: In the past 20 years, colorectal surgery has experienced important advances as a result of new technologies that have increasingly transformed conventional open surgery into maximal usage of minimally invasive approaches. While many tools are being ... ...

    Abstract In the past 20 years, colorectal surgery has experienced important advances as a result of new technologies that have increasingly transformed conventional open surgery into maximal usage of minimally invasive approaches. While many tools are being developed to change the way that operations are being performed, quality must not suffer. We describe here some of the aspects to pursue to achieve optimal and safe outcomes while utilizing minimally invasive techniques such as robotic surgery, transanal total mesorectal excision, as well as the role of immunofluorescence.
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2048635-2
    ISSN 1531-0043
    ISSN 1531-0043
    DOI 10.1055/s-0040-1722764
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Book: Does size matter?

    Dávila, Eduardo / Walther, Ansgar

    bailouts with large and small banks

    (Working paper series / National Bureau of Economic Research ; 24132)

    2017  

    Author's details Eduardo Dávila, Ansgar Walther
    Series title Working paper series / National Bureau of Economic Research ; 24132
    Language English
    Size 54 Seiten, Illustrationen
    Publisher National Bureau of Economic Research
    Publishing place Cambridge, MA
    Document type Book
    Note Erscheint auch als Online-Ausgabe
    Database ECONomics Information System

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  7. Article ; Online: Enhancing antitumor immunity through checkpoint blockade as a therapeutic strategy in T-cell lymphomas.

    Neuwelt, Alexander / Al-Juhaishi, Taha / Davila, Eduardo / Haverkos, Bradley

    Blood advances

    2020  Volume 4, Issue 17, Page(s) 4256–4266

    Abstract: The majority of historical therapies for managing T-cell lymphomas (TCLs) have consisted of T-cell-depleting strategies. Unfortunately, these forms of therapies can hamper the ability to mount effective antitumor immune responses. Recently, the use of ... ...

    Abstract The majority of historical therapies for managing T-cell lymphomas (TCLs) have consisted of T-cell-depleting strategies. Unfortunately, these forms of therapies can hamper the ability to mount effective antitumor immune responses. Recently, the use of checkpoint inhibitors has revolutionized the therapy of solid and hematologic malignancies. The development of immunotherapies for the management of TCL has lagged behind other malignancies given 2 central reasons: (1) the competing balance of depleting malignant T cells while simultaneously enhancing an antitumor T-cell response and (2) concern for tumor hyperprogression by blocking inhibitory signals on the surface of the malignant T cell, thereby leading to further proliferation of the malignant cells. These challenges were highlighted with the discovery that programmed cell death protein 1 (PD-1) functions paradoxically as a haploinsufficient tumor suppressor in preclinical TCL models. In contrast, some preclinical and clinical evidence suggests that PD-1/programmed death ligand 1 may become an important therapeutic tool in the management of patients with TCL. Improved understanding of the immune landscape of TCL is necessary in order to identify subsets of patients most likely to benefit from checkpoint-inhibitor therapy. With increased preclinical research focus on the tumor microenvironment, substantial strides are being made in understanding how to harness the power of the immune system to treat TCLs. In this review, designed to be a "call to action," we discuss the challenges and opportunities of using immune-modulating therapies, with a focus on checkpoint inhibitors, for the treatment of patients with TCL.
    MeSH term(s) B7-H1 Antigen ; Humans ; Immunotherapy ; Lymphoma, T-Cell ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances B7-H1 Antigen
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020001966
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Producer T cells: Using genetically engineered T cells as vehicles to generate and deliver therapeutics to tumors.

    Tsai, Alexander K / Davila, Eduardo

    Oncoimmunology

    2016  Volume 5, Issue 5, Page(s) e1122158

    Abstract: Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel ... ...

    Abstract Adoptive cell transfer (ACT) is an emerging anticancer therapy that has shown promise in various malignancies. Redirecting antigen specificity by genetically engineering T cells to stably express receptors has become an effective variant of ACT. A novel extension of this approach is to utilize engineered T cells to produce and deliver anticancer therapeutics that enhance cytotoxic T cell function and simultaneously inhibit immunosuppressive processes. Here, we review the potential of using T cells as therapeutic-secreting vehicles for immunotherapies and present theoretical and established arguments in support of further development of this unique cell-based immunotherapy.
    Language English
    Publishing date 2016-01-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2015.1122158
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  9. Article: Editorial for special surgical issue.

    Kim, Keith / Parra-Davila, Eduardo

    Journal of robotic surgery

    2016  Volume 5, Issue 1, Page(s) 1

    Language English
    Publishing date 2016-06-07
    Publishing country England
    Document type Congress
    ZDB-ID 2268283-1
    ISSN 1863-2491 ; 1863-2483
    ISSN (online) 1863-2491
    ISSN 1863-2483
    DOI 10.1007/s11701-010-0241-8
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  10. Article ; Online: Hernia U: challenges and opportunities of an online platform for surgical education.

    Lima, Diego Laurentino / Lima, Raquel Nogueira C Laurentino / Parra-Davila, Eduardo / Morales-Conde, Salvador / Malcher, Flavio

    Revista do Colegio Brasileiro de Cirurgioes

    2021  Volume 48, Page(s) e20202873

    MeSH term(s) Hernia ; Herniorrhaphy ; Humans
    Language Portuguese
    Publishing date 2021-03-31
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2223714-8
    ISSN 1809-4546 ; 1809-4546
    ISSN (online) 1809-4546
    ISSN 1809-4546
    DOI 10.1590/0100-6991e-20202873
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