LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article: Comparable Efficacy of Oral Bendamustine versus Intravenous Administration in Treating Hematologic Malignancies.

Cracchiolo, Megan J / Davis, Lisa / Matiatos, Andrew P / Davini, Dan W / Husnain, Muhammad / Simpson, Richard J / Voudouris, Vasilios / Katsanis, Emmanuel

Research square

2024

Abstract: Purpose: The purpose of this study was to analyze potential differences in antitumor efficacy and pharmacokinetics between intravenous (IV) bendamustine (BEN) and a novel orally administered bendamustine agent (PO) that is utilizing the beneficial ... ...

Abstract	Purpose: The purpose of this study was to analyze potential differences in antitumor efficacy and pharmacokinetics between intravenous (IV) bendamustine (BEN) and a novel orally administered bendamustine agent (PO) that is utilizing the beneficial properties of superstaturated solid dispersions formulated in nanoparticles. Methods: Pharmacokinetics of IV versus PO BEN were determined by analysis of plasma samples collected from NSG mice treated with either IV or PO BEN. Plasma samples were analyzed using liquid chromatography-mass spectrometry (LC/MS/MS) following a liquid-liquid extraction to determine peak BEN concentration (Cmax), area under the concentration-time curve (AUC) and the half-life (t1/2) Results: Bendamustine at a high dose Conclusions: The novel oral BEN agent tested exhibits good oral bioavailability and systemic exposure for
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3848777/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Multiagent Intratumoral Immunotherapy Can Be Effective in A20 Lymphoma Clearance and Generation of Systemic T Cell Immunity.

Gilman, Kristy E / Matiatos, Andrew P / Cracchiolo, Megan J / Moon, Amanda G / Davini, Dan W / Simpson, Richard J / Katsanis, Emmanuel

Cancers

2023 Volume 15, Issue 7

Abstract: The use of immunotherapies has shown promise against selective human cancers. Identifying novel combinations of innate and adaptive immune cell-activating agents that can work synergistically to suppress tumor growth and provide additional protection ... ...

Abstract	The use of immunotherapies has shown promise against selective human cancers. Identifying novel combinations of innate and adaptive immune cell-activating agents that can work synergistically to suppress tumor growth and provide additional protection against resistance or recurrence is critical. The A20 murine lymphoma model was used to evaluate the effect of various combination immunotherapies administered intratumorally. We show that single-modality treatment with Poly(I:C) or GM-CSF-secreting allogeneic cells only modestly controls tumor growth, whereas when given together there is an improved benefit, with 50% of animals clearing tumors and surviving long-term. Neither heat nor irradiation of GM-CSF-secreting cells enhanced the response over use of live cells. The use of a TIM-3 inhibitory antibody and an OX40 agonist in combination with Poly(I:C) allowed for improved tumor control, with 90% of animals clearing tumors with or without a combination of GM-CSF-secreting cells. Across all treatment groups, mice rejecting their primary A20 tumors were immune to subsequent challenge with A20, and this longstanding immunity was T-cell dependent. The results herein support the use of combinations of innate and adaptive immune activating agents for immunotherapy against lymphoma and should be investigated in other cancer types.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15071951
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Partially replacing cyclophosphamide with bendamustine in combination with cyclosporine A improves survival and reduces xenogeneic graft-versus-host-disease.

Gilman, Kristy E / Cracchiolo, Megan J / Matiatos, Andrew P / Davini, Dan W / Simpson, Richard J / Katsanis, Emmanuel

Frontiers in immunology

2023 Volume 13, Page(s) 1045710

Abstract: Introduction: The use of allogeneic hematopoietic cell transplantation (allo-HCT) for treating hematological disorders is increasing, but the development of graft-versus-host disease (GvHD) remains a major cause of morbidity and mortality. The use of ... ...

Abstract	Introduction: The use of allogeneic hematopoietic cell transplantation (allo-HCT) for treating hematological disorders is increasing, but the development of graft-versus-host disease (GvHD) remains a major cause of morbidity and mortality. The use of post-transplant cyclophosphamide (CY) has significantly improved outcomes following allo-HCT, but complications of viral reactivation due to delayed immune reconstitution or relapse remain. Other laboratories are evaluating the potential benefit of lowering the dose of CY given post-transplant, whereas our laboratory has been focusing on whether partially replacing CY with another DNA alkylating agent, bendamustine (BEN) may be advantageous in improving outcomes with allo-HCT. Methods: Here, we utilized a xenogeneic GvHD (xGvHD) model in which immunodeficient NSG mice are infused with human peripheral blood mononuclear cells (PBMCs). Results: We show that a lower dose of CY (25 mg/kg) given on days +3 and +4 or CY (75 mg/kg) given on only day +3 post-PBMC infusion is not sufficient for improving survival from xGvHD, but can be improved with the addition of BEN (15 mg/kg) on day +4 to day +3 CY (75 mg/kg). CY/BEN treated mice when combined with cyclosporine A (CSA) (10mg/kg daily from days +5 to +18 and thrice weekly thereafter), had improved outcomes over CY/CY +CSA treated mice. Infiltration of GvHD target organs was reduced in both CY/CY and CY/BEN treatment groups versus those receiving no treatment. CY/CY +CSA mice exhibited more severe xGvHD at day 10, marked by decreased serum albumin and increased intestinal permeability. CY/BEN treated mice had reductions in naïve, effector memory and Th17 polarized T cells. RNAseq analysis of splenocytes isolated from CY/CY and CY/BEN treated animals revealed increased gene set enrichment in multiple KEGG pathways related to cell migration, proliferation/differentiation, and inflammatory pathways, among others with CY/BEN treatment. Conclusion: Together, we illustrate that the use of CY/BEN is safe and shows similar control of xGvHD to CY/CY, but when combined with CSA, survival with CY/BEN is significantly prolonged compared to CY/CY.
MeSH term(s)	Humans ; Animals ; Mice ; Cyclosporine/therapeutic use ; Bendamustine Hydrochloride ; Leukocytes, Mononuclear ; Cyclophosphamide/therapeutic use ; Graft vs Host Disease/drug therapy ; Graft vs Host Disease/etiology
Chemical Substances	Cyclosporine (83HN0GTJ6D) ; Bendamustine Hydrochloride (981Y8SX18M) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1045710
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.

Mullins, Genevieve N / Valentine, Kristen M / Al-Kuhlani, Mufadhal / Davini, Dan / Jensen, Kirk D C / Hoyer, Katrina K

Scientific reports

2020 Volume 10, Issue 1, Page(s) 21994

Abstract: IL-2Rα, in part, comprises the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. IL-2Rα deficient mice (IL-2Rα-KO) develop systemic autoimmune disease and die from severe anemia between 18 and 80 ... ...

Abstract	IL-2Rα, in part, comprises the high affinity receptor for IL-2, a cytokine important in immune proliferation, activation, and regulation. IL-2Rα deficient mice (IL-2Rα-KO) develop systemic autoimmune disease and die from severe anemia between 18 and 80 days of age. These mice develop kinetically distinct autoimmune progression, with approximately a quarter dying by 21 days of age and half dying after 30 days. This research aims to define immune parameters and cytokine signaling that distinguish cohorts of IL-2Rα-KO mice that develop early- versus late-stage autoimmune disease. To investigate these differences, we evaluated complete blood counts (CBC), antibody binding of RBCs, T cell numbers and activation, hematopoietic progenitor changes, and signaling kinetics, during autoimmune hemolytic anemia (AIHA) and bone marrow failure. We identified several alterations that, when combined, correlate to disease kinetics. Early onset disease correlates with anti-RBC antibodies, lower hematocrit, and reduced IL-7 signaling. CD8 regulatory T cells (Tregs) have enhanced apoptosis in early disease. Further, early and late end stage disease, while largely similar, had several differences suggesting distinct mechanisms drive autoimmune disease kinetics. Therefore, IL-2Rα-KO disease pathology rates, driven by T cell signaling, promote effector T cell activation and expansion and Treg dysfunction.
MeSH term(s)	Animals ; Apoptosis ; CD8-Positive T-Lymphocytes/immunology ; Cell Proliferation ; Erythrocytes/metabolism ; Immunologic Memory ; Interleukin-2/metabolism ; Interleukin-2 Receptor alpha Subunit/deficiency ; Interleukin-2 Receptor alpha Subunit/metabolism ; Kinetics ; Lymphocyte Activation/immunology ; Mice, Inbred BALB C ; Mice, Knockout ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; Thymus Gland/growth & development
Chemical Substances	Interleukin-2 ; Interleukin-2 Receptor alpha Subunit
Language	English
Publishing date	2020-12-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-78975-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: CD8

Gravano, David M / Al-Kuhlani, Mufadhal / Davini, Dan / Sanders, P Dominick / Manilay, Jennifer O / Hoyer, Katrina K

Journal of autoimmunity

2016 Volume 75, Page(s) 58–67

Abstract: Bone marrow (BM) failure syndrome encompasses a group of disorders characterized by BM stem cell dysfunction, resulting in varying degrees of hypoplasia and blood pancytopenia, and in many patients is autoimmune and inflammatory in nature. The important ... ...

Abstract	Bone marrow (BM) failure syndrome encompasses a group of disorders characterized by BM stem cell dysfunction, resulting in varying degrees of hypoplasia and blood pancytopenia, and in many patients is autoimmune and inflammatory in nature. The important role of T helper 1 (Th1) polarized CD4
MeSH term(s)	Adoptive Transfer ; Anemia/genetics ; Anemia/immunology ; Anemia/metabolism ; Animals ; Autoimmunity/immunology ; Bone Marrow/immunology ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Bone Marrow Cells/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cell Proliferation ; Flow Cytometry ; Forkhead Transcription Factors ; Hematopoietic Stem Cells/immunology ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Interleukin-2/deficiency ; Interleukin-2/genetics ; Interleukin-2/immunology ; Mice, Inbred BALB C ; Mice, Knockout ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	Forkhead Transcription Factors ; Foxp3 protein, mouse ; Interleukin-2 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2016.07.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2368: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease.

Valentine, Kristen M / Davini, Dan / Lawrence, Travis J / Mullins, Genevieve N / Manansala, Miguel / Al-Kuhlani, Mufadhal / Pinney, James M / Davis, Jason K / Beaudin, Anna E / Sindi, Suzanne S / Gravano, David M / Hoyer, Katrina K

Journal of immunology (Baltimore, Md. : 1950)

2018 Volume 201, Issue 1, Page(s) 31–40

Abstract: CD8 T cells can play both a protective and pathogenic role in inflammation and autoimmune development. Recent studies have highlighted the ability of CD8 T cells to function as T follicular helper (Tfh) cells in the germinal center in the context of ... ...

Abstract	CD8 T cells can play both a protective and pathogenic role in inflammation and autoimmune development. Recent studies have highlighted the ability of CD8 T cells to function as T follicular helper (Tfh) cells in the germinal center in the context of infection. However, whether this phenomenon occurs in autoimmunity and contributes to autoimmune pathogenesis is largely unexplored. In this study, we show that CD8 T cells acquire a CD4 Tfh profile in the absence of functional regulatory T cells in both the IL-2-deficient and scurfy mouse models. Depletion of CD8 T cells mitigates autoimmune pathogenesis in IL-2-deficient mice. CD8 T cells express the B cell follicle-localizing chemokine receptor CXCR5, a principal Tfh transcription factor Bcl6, and the Tfh effector cytokine IL-21. CD8 T cells localize to the B cell follicle, express B cell costimulatory proteins, and promote B cell differentiation and Ab isotype class switching. These data reveal a novel contribution of autoreactive CD8 T cells to autoimmune disease, in part, through CD4 follicular-like differentiation and functionality.
MeSH term(s)	Anemia, Hemolytic, Autoimmune/immunology ; Anemia, Hemolytic, Autoimmune/pathology ; Animals ; Autoimmunity/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Differentiation/immunology ; Erythrocytes/immunology ; Female ; Immunoglobulin Class Switching/immunology ; Interleukin-2/genetics ; Interleukins/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Proto-Oncogene Proteins c-bcl-6/metabolism ; Receptors, CXCR5/metabolism ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Bcl6 protein, mouse ; CXCR5 protein, mouse ; Interleukin-2 ; Interleukins ; Proto-Oncogene Proteins c-bcl-6 ; Receptors, CXCR5 ; interleukin-21 (MKM3CA6LT1)
Language	English
Publishing date	2018-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1701079
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients.

Davini, Dan / Naeem, Fouzia / Phong, Aron / Al-Kuhlani, Mufadhal / Valentine, Kristen M / McCarty, James / Ojcius, David M / Gravano, David M / Hoyer, Katrina K

The Journal of allergy and clinical immunology

2018 Volume 142, Issue 6, Page(s) 1971–1974.e7

MeSH term(s)	Adolescent ; Blood Proteins/analysis ; Child ; Child, Preschool ; Chronic Disease ; Coccidioides ; Coccidioidomycosis/blood ; Coccidioidomycosis/immunology ; Cytokines/blood ; Female ; Humans ; Infant ; Male ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Blood Proteins ; Cytokines
Language	English
Publishing date	2018-10-26
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2018.10.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.92: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.

Bour-Jordan, Hélène / Thompson, Heather L / Giampaolo, Jennifer R / Davini, Dan / Rosenthal, Wendy / Bluestone, Jeffrey A

Journal of autoimmunity

2013 Volume 45, Page(s) 58–67

Abstract: The non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes but also multiple other autoimmune diseases. Over twenty susceptibility loci linked to diabetes have been identified in NOD mice and progress has been made in the ...

Abstract	The non-obese diabetic (NOD) mouse is susceptible to the development of autoimmune diabetes but also multiple other autoimmune diseases. Over twenty susceptibility loci linked to diabetes have been identified in NOD mice and progress has been made in the definition of candidate genes at many of these loci (termed Idd for insulin-dependent diabetes). The susceptibility to multiple autoimmune diseases in the NOD background is a unique opportunity to examine susceptibility genes that confer a general propensity for autoimmunity versus susceptibility genes that control individual autoimmune diseases. We previously showed that NOD mice deficient for the costimulatory molecule B7-2 (NOD-B7-2KO mice) were protected from diabetes but spontaneously developed an autoimmune peripheral neuropathy. Here, we took advantage of multiple NOD mouse strains congenic for Idd loci to test the role of these Idd loci the development of neuropathy and determine if B6 alleles at Idd loci that are protective for diabetes will also be for neuropathy. Thus, we generated NOD-B7-2KO strains congenic at Idd loci and examined the development of neuritis and clinical neuropathy. We found that the NOD-H-2(g7) MHC region is necessary for development of neuropathy in NOD-B7-2KO mice. In contrast, other Idd loci that significantly protect from diabetes did not affect neuropathy when considered individually. However, we found potent genetic interactions of some Idd loci that provided almost complete protection from neuritis and clinical neuropathy. In addition, defective immunoregulation by Tregs could supersede protection by some, but not other, Idd loci in a tissue-specific manner in a model where neuropathy and diabetes occurred concomitantly. Thus, our study helps identify Idd loci that control tissue-specific disease or confer general susceptibility to autoimmunity, and brings insight to the Treg-dependence of autoimmune processes influenced by given Idd region in the NOD background.
MeSH term(s)	Alleles ; Animals ; B7-2 Antigen/genetics ; Cells, Cultured ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Female ; Genetic Loci/genetics ; Genetic Predisposition to Disease/genetics ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/genetics ; Guillain-Barre Syndrome/immunology ; Histocompatibility Antigens Class II/genetics ; Interferon-gamma/metabolism ; Male ; Mice ; Mice, Congenic ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, Knockout ; Organ Specificity ; Sex Factors ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	B7-2 Antigen ; Histocompatibility Antigens Class II ; I-A g7 antigen ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2013-07-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639452-8
ISSN	1095-9157 ; 0896-8411
ISSN (online)	1095-9157
ISSN	0896-8411
DOI	10.1016/j.jaut.2013.06.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2368: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Maternal immune stimulation during pregnancy shapes the immunological phenotype of offspring.

Mandal, Mili / Donnelly, Robert / Elkabes, Stella / Zhang, Pan / Davini, Dan / David, Brian T / Ponzio, Nicholas M

Brain, behavior, and immunity

2013 Volume 33, Page(s) 33–45

Abstract: Epidemiological studies have associated infection during pregnancy with increased risk of neurodevelopmental disorders in children, which is modeled in rodents by stimulating the immune system of pregnant dams with microorganisms or their mimics, such as ...

Abstract	Epidemiological studies have associated infection during pregnancy with increased risk of neurodevelopmental disorders in children, which is modeled in rodents by stimulating the immune system of pregnant dams with microorganisms or their mimics, such as poly(I:C) or LPS. In two prenatal mouse models, we show that in utero exposure of the fetus to cytokines/inflammatory mediators elicited by maternal immune stimulation with poly(I:C) yields offspring that exhibit a proinflammatory phenotype due to alterations in developmental programming of their immune system. Changes in the innate and adaptive immune elements of these pro-inflammatory offspring result in more robust responses following exposure to immune stimuli than those observed in control offspring from PBS-injected pregnant dams. In the first model, offspring from poly(I:C)-injected immunologically naïve dams showed heightened cellular and cytokine responses 4 h after injection of zymosan, a TLR2 agonist. In the second model, using dams with immunological memory, poly(I:C) injection during pregnancy produced offspring that showed preferential differentiation toward Th17 cell development, earlier onset of clinical symptoms of EAE, and more severe neurological deficits following immunization with MOG35-55. Such "fetal programming" in offspring from poly(I:C)-injected dams not only persists into neonatal and adult life, but also can have profound consequences on health and disease.
MeSH term(s)	Animals ; Cells, Cultured ; Encephalomyelitis, Autoimmune, Experimental/epidemiology ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/physiopathology ; Female ; Illness Behavior/physiology ; Immunomodulation/immunology ; Immunophenotyping ; Injections, Intraperitoneal ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mothers ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Peptide Fragments/administration & dosage ; Poly I-C/administration & dosage ; Poly I-C/adverse effects ; Pregnancy ; Th17 Cells/immunology ; Th17 Cells/metabolism ; Th17 Cells/pathology ; Zymosan/administration & dosage
Chemical Substances	Myelin-Oligodendrocyte Glycoprotein ; Peptide Fragments ; myelin oligodendrocyte glycoprotein (35-55) ; Zymosan (9010-72-4) ; Poly I-C (O84C90HH2L)
Language	English
Publishing date	2013-10
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2013.04.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

Order via subito

Details ▾

Article ; Online: Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy.

Su, Maureen A / Davini, Dan / Cheng, Philip / Giang, Karen / Fan, Una / DeVoss, Jason J / Johannes, Kellsey P A / Taylor, Lorelei / Shum, Anthony K / Valenzise, Mariella / Meloni, Antonella / Bour-Jordan, Helene / Anderson, Mark S

Journal of immunology (Baltimore, Md. : 1950)

2012 Volume 188, Issue 10, Page(s) 4906–4912

Abstract: Chronic inflammatory demyelinating polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the autoimmune response is initiated, identity of provoking Ags, and pathogenic effector ... ...

Abstract	Chronic inflammatory demyelinating polyneuropathy is a debilitating autoimmune disease characterized by peripheral nerve demyelination and dysfunction. How the autoimmune response is initiated, identity of provoking Ags, and pathogenic effector mechanisms are not well defined. The autoimmune regulator (Aire) plays a critical role in central tolerance by promoting thymic expression of self-Ags and deletion of self-reactive T cells. In this study, we used mice with hypomorphic Aire function and two patients with Aire mutations to define how Aire deficiency results in spontaneous autoimmune peripheral neuropathy. Autoimmunity against peripheral nerves in both mice and humans targets myelin protein zero, an Ag for which expression is Aire-regulated in the thymus. Consistent with a defect in thymic tolerance, CD4(+) T cells are sufficient to transfer disease in mice and produce IFN-γ in infiltrated peripheral nerves. Our findings suggest that defective Aire-mediated central tolerance to myelin protein zero initiates an autoimmune Th1 effector response toward peripheral nerves.
MeSH term(s)	Amino Acid Sequence ; Animals ; Autoantibodies/blood ; Disease Models, Animal ; Female ; Humans ; Immune Tolerance/genetics ; Mice ; Mice, Inbred NOD ; Mice, Mutant Strains ; Mice, SCID ; Molecular Sequence Data ; Myelin P0 Protein/deficiency ; Myelin P0 Protein/genetics ; Myelin P0 Protein/physiology ; Point Mutation ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/blood ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/genetics ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/immunology ; Transcription Factors/deficiency ; Transcription Factors/genetics ; Transcription Factors/physiology ; AIRE Protein
Chemical Substances	Autoantibodies ; Myelin P0 Protein ; Transcription Factors
Language	English
Publishing date	2012-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1200493
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito