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Article: Your ID, please? The effect of facemasks and makeup on perceptions of age of young adult female faces.

Davis, Hannah / Attard-Johnson, Janice

2022 Volume 36, Issue 2, Page(s) 453–459

Abstract: During the COVID-19 pandemic, wearing facemasks was mandatory in the United Kingdom except for individuals with medical exemptions. Facemasks cover the full lower half of the face; however, the effect of facemasks on age perception is not yet known. The ... ...

Abstract	During the COVID-19 pandemic, wearing facemasks was mandatory in the United Kingdom except for individuals with medical exemptions. Facemasks cover the full lower half of the face; however, the effect of facemasks on age perception is not yet known. The present study examined whether age estimation accuracy of unfamiliar young adult women is impaired when the target is wearing a facemask. This study also examined whether makeup, which has previously been shown to increase error bias, further impairs age estimation accuracy when paired with a facemask. The findings indicate that both facemasks and makeup tend to result in overestimation of the young women's age compared to neutral faces, but the combination of both is not additive. Individual level analysis also revealed large individual differences in age estimation accuracy ranging from estimates within 1 year of the target's actual age, and age estimates which deviated by up to 20 years.
Language	English
Publishing date	2022-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1477153-6
ISSN	1099-0720 ; 0888-4080
ISSN (online)	1099-0720
ISSN	0888-4080
DOI	10.1002/acp.3923
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Article ; Online: Droplet Digital PCR for Oncogenic KMT2A Fusion Detection.

Young, Andrew L / Davis, Hannah C / Challen, Grant A

The Journal of molecular diagnostics : JMD

2023 Volume 25, Issue 12, Page(s) 898–906

Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer diagnosed in approximately 120,000 individuals worldwide each year. During treatment for AML, detecting residual disease is essential for prognostication and treatment decision-making. Currently, ...

Abstract	Acute myeloid leukemia (AML) is an aggressive blood cancer diagnosed in approximately 120,000 individuals worldwide each year. During treatment for AML, detecting residual disease is essential for prognostication and treatment decision-making. Currently, methods for detecting residual AML are limited to identifying approximately 1:100 to 1:1000 leukemic cells (morphology and DNA sequencing) or are difficult to implement (flow cytometry). AML arising after chemotherapy or radiation exposure is termed therapy-related AML (t-AML) and is exceptionally aggressive and treatment resistant. t-AML is often driven by oncogenic fusions that result from prior treatments that introduce double-strand DNA breaks. The most common t-AML-associated translocations affect KMT2A. There are at least 80 known KMT2A fusion partners, but approximately 80% of fusions involve only five partners-AF9, AF6, AF4, ELL, and ENL. We present a novel droplet digital PCR assay targeting the most common KMT2A-rearrangements to enable detection of rare AML cells harboring these fusions. This assay was benchmarked in cell lines and patient samples harboring oncogenic KMT2A fusions and demonstrated a limit of detection of approximately 1:1,000,000 cells. Future application of this assay could improve disease detection and treatment decision-making for patients with t-AML with KMT2A fusions and premalignant oncogenic fusion detection in at-risk individuals after chemotherapy exposure.
MeSH term(s)	Humans ; Myeloid-Lymphoid Leukemia Protein/genetics ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Polymerase Chain Reaction ; Gene Rearrangement ; Oncogene Fusion ; Translocation, Genetic ; Oncogene Proteins, Fusion/genetics
Chemical Substances	Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Oncogene Proteins, Fusion
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2000060-1
ISSN	1943-7811 ; 1525-1578
ISSN (online)	1943-7811
ISSN	1525-1578
DOI	10.1016/j.jmoldx.2023.09.006
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Article ; Online: Mechanical compression regulates tumor spheroid invasion into a 3D collagen matrix.

Pandey, Mrinal / Suh, Young Joon / Kim, Minha / Davis, Hannah Jane / Segall, Jeffrey E / Wu, Mingming

Physical biology

2024 Volume 21, Issue 3

Abstract: Uncontrolled growth of tumor cells in confined spaces leads to the accumulation of compressive stress within the tumor. Although the effects of tension within 3D extracellular matrices (ECMs) on tumor growth and invasion are well established, the role of ...

Abstract	Uncontrolled growth of tumor cells in confined spaces leads to the accumulation of compressive stress within the tumor. Although the effects of tension within 3D extracellular matrices (ECMs) on tumor growth and invasion are well established, the role of compression in tumor mechanics and invasion is largely unexplored. In this study, we modified a Transwell assay such that it provides constant compressive loads to spheroids embedded within a collagen matrix. We used microscopic imaging to follow the single cell dynamics of the cells within the spheroids, as well as invasion into the 3D ECMs. Our experimental results showed that malignant breast tumor (MDA-MB-231) and non-tumorigenic epithelial (MCF10A) spheroids responded differently to a constant compression. Cells within the malignant spheroids became more motile within the spheroids and invaded more into the ECM under compression; whereas cells within non-tumorigenic MCF10A spheroids became less motile within the spheroids and did not display apparent detachment from the spheroids under compression. These findings suggest that compression may play differential roles in healthy and pathogenic epithelial tissues and highlight the importance of tumor mechanics and invasion.
MeSH term(s)	Humans ; Spheroids, Cellular ; Collagen ; Neoplasms ; Extracellular Matrix ; Cell Line, Tumor
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2133216-2
ISSN	1478-3975 ; 1478-3967
ISSN (online)	1478-3975
ISSN	1478-3967
DOI	10.1088/1478-3975/ad3ac5
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Article: Nutritional Benefits from Fatty Acids in Organic and Grass-Fed Beef.

Davis, Hannah / Magistrali, Amelia / Butler, Gillian / Stergiadis, Sokratis

Foods (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: Livestock production is under increasing scrutiny as a component of the food supply chain with a large impact on greenhouse gas emissions. Amidst growing calls to reduce industrial ruminant production, there is room to consider differences in meat ... ...

Abstract	Livestock production is under increasing scrutiny as a component of the food supply chain with a large impact on greenhouse gas emissions. Amidst growing calls to reduce industrial ruminant production, there is room to consider differences in meat quality and nutritional benefits of organic and/or pasture-based management systems. Access to forage, whether fresh or conserved, is a key influencing factor for meat fatty acid profile, and there is increasing evidence that pasture access is particularly beneficial for meat’s nutritional quality. These composition differences ultimately impact nutrient supply to consumers of conventional, organic and grass-fed meat. For this review, predicted fatty acid supply from three consumption scenarios were modelled: i. average UK population National Diet and Nutrition Survey (NDNS) (<128 g/week) red meat consumption, ii. red meat consumption suggested by the UK National Health Service (NHS) (<490 g/week) and iii. red meat consumption suggested by the Eat Lancet Report (<98 g/week). The results indicate average consumers would receive more of the beneficial fatty acids for human health (especially the essential omega-3, alpha-linolenic acid) from pasture-fed beef, produced either organically or conventionally.
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11050646
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Article ; Online: Tranexamic acid for treatment of symptomatic hemorrhagic conversion following administration of tenecteplase for acute ischemic stroke.

Hailu, Kirubel / Ragoonanan, David / Davis, Hannah

The American journal of emergency medicine

2022 Volume 59, Page(s) 216.e1–216.e5

MeSH term(s)	Brain Ischemia/drug therapy ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke ; Stroke/drug therapy ; Tenecteplase/therapeutic use ; Tissue Plasminogen Activator/therapeutic use ; Tranexamic Acid/therapeutic use ; Treatment Outcome
Chemical Substances	Fibrinolytic Agents ; Tranexamic Acid (6T84R30KC1) ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Tenecteplase (WGD229O42W)
Language	English
Publishing date	2022-06-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2022.06.022
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ab Jg. 2022: Lesesaal (EG)

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Article: Nutritional Benefits from Fatty Acids in Organic and Grass-Fed Beef

Davis, Hannah / Magistrali, Amelia / Butler, Gillian / Stergiadis, Sokratis

Foods. 2022 Feb. 23, v. 11, no. 5

2022

Abstract	Livestock production is under increasing scrutiny as a component of the food supply chain with a large impact on greenhouse gas emissions. Amidst growing calls to reduce industrial ruminant production, there is room to consider differences in meat quality and nutritional benefits of organic and/or pasture-based management systems. Access to forage, whether fresh or conserved, is a key influencing factor for meat fatty acid profile, and there is increasing evidence that pasture access is particularly beneficial for meat’s nutritional quality. These composition differences ultimately impact nutrient supply to consumers of conventional, organic and grass-fed meat. For this review, predicted fatty acid supply from three consumption scenarios were modelled: i. average UK population National Diet and Nutrition Survey (NDNS) (<128 g/week) red meat consumption, ii. red meat consumption suggested by the UK National Health Service (NHS) (<490 g/week) and iii. red meat consumption suggested by the Eat Lancet Report (<98 g/week). The results indicate average consumers would receive more of the beneficial fatty acids for human health (especially the essential omega-3, alpha-linolenic acid) from pasture-fed beef, produced either organically or conventionally.
Keywords	alpha-linolenic acid ; beef ; dietary surveys ; fatty acid composition ; food supply chain ; grass-fed livestock ; greenhouse gases ; health services ; human health ; livestock production ; meat consumption ; meat quality ; nutritive value ; pastures ; red meat ; ruminants
Language	English
Dates of publication	2022-0223
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11050646
Database	NAL-Catalogue (AGRICOLA)

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Thesis ; Online: Molecular Mechanisms Underlying Osteocyte Apoptosis and the Associated Osteoclastogenesis in Cx43-Deficiency and Aging

Davis, Hannah Marie

2019

Abstract: Old age is associated with increased bone fragility and risk of fracture as a result of skeletal alterations, including low bone density and cortical thinning. Further, apoptotic osteocytes accumulate in old mice and humans. We have previously shown that ...

Abstract	Old age is associated with increased bone fragility and risk of fracture as a result of skeletal alterations, including low bone density and cortical thinning. Further, apoptotic osteocytes accumulate in old mice and humans. We have previously shown that mice lacking osteocytic connexin (Cx) 43 (Cx43ΔOt) exhibit a phenotype similar to that of the aging skeleton, with elevated osteocyte apoptosis and an associated increase in osteoclastogenesis. These findings suggest that osteocyte apoptosis results in the release of factors that recruit osteoclasts to bone surfaces close to areas that contain apoptotic osteocytes. However, the specific chemotactic signals, the events mediating their release, and the mechanisms of their action remain unknown. Consistent with this notion, we also found that HMGB1 released by Cx43-deficient (Cx43def) MLO-Y4 osteocytic cells enhances osteoclastogenesis in part by increasing osteocytic RANKL, which promotes osteoclastogenesis, and, at the same time, directly stimulating osteoclastogenesis. Further, expression of the pro-survival microRNA (miR), miR21, is low in Cx43def cells and bones from old female mice, and low miR21 levels increase osteocyte apoptosis. However, surprisingly, mice lacking miR21 (miR21ΔOt) have decreased osteoclast number and activity even under conditions of elevated osteocyte apoptosis; suggesting that osteocytic miR21 may mediate osteoclast precursor recruitment/survival induced by apoptotic osteocytes. However, whether HMGB1/miR21 are released by osteocytes, and if the HMGB1 receptors, receptor for advanced glycation end products (RAGE) and/or toll-like receptor (TLR4) are involved in osteoclast recruitment in Cx43ΔOt and old mice is unknown. The overall objectives of this series of studies were to elucidate the mechanisms underlying osteocyte apoptosis in Cx43-deficiency and aging and identify the signaling molecules that link osteocyte apoptosis and osteoclast recruitment. We hypothesize that enhanced extracellular release of the signaling factors HMGB1 and miR21 recruits osteoclasts to areas containing apoptotic osteocytes and promotes osteoclast activity, leading to targeted bone resorption. Overall, these studies will provide insights into the mechanisms governing osteocyte apoptosis and the associated targeted osteoclast resorption, allowing for the development of novel therapeutics for preserving the structure and strength of the aging skeleton.
Keywords	Cellular biology\|Aging
Subject code	616
Language	ENG
Publishing date	2019-01-01 00:00:01.0
Publisher	Indiana University - Purdue University Indianapolis
Publishing country	us
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Milk Fatty Acids: The Impact of Grazing Diverse Pasture and the Potential to Predict Rumen-Derived Methane

Loza, Cecilia / Davis, Hannah / Malisch, Carsten / Taube, Freidhelm / Loges, Ralf / Magistrali, Amelia / Butler, Gillian

Agriculture. 2023 Jan. 11, v. 13, no. 1

2023

Abstract: The sustainability of dairying has been questioned, yet cattle exploit non-food resources (especially forages) and provide key nutrients for consumers’ health. This study, using different forage types, considered milk’s nutritional quality, focusing on ... ...

Abstract	The sustainability of dairying has been questioned, yet cattle exploit non-food resources (especially forages) and provide key nutrients for consumers’ health. This study, using different forage types, considered milk’s nutritional quality, focusing on fatty acid profiles alongside methane emissions—investigating whether methane can be predicted from milk fatty acids (FAs). Compared with grass/clover/maize silage, cows grazing grass/clover pasture produced milk 70% higher in beneficial omega-3 FAs, which increased by an additional 15% when grazing more diverse pasture. Milk from grazing also had less omega-6 FAs (compared with silage diets), and their ratio with omega-3 FAs fell from 2.5:1 on silage to 1.2:1 when grazing grass/clover and 1.1:1 on diverse pasture. Measured methane emissions (at 8.7 g/kg energy-corrected milk) were lower than published values, and existing models for estimating methane from lactating cows were poor predictors for this dataset. The multiple regression of methane against milk FAs in this study provided predictions with an R² of 0.56 for daily emissions and 0.65 relative to milk output. Grazing quality and a diverse pasture with productive cows were potentially beneficial to milk nutritional quality, and our results reinforce the theory that milk fat composition could be an accessible tool for methane prediction; however, they also suggest that more work is needed for alternative production systems.
Keywords	agriculture ; cattle ; corn silage ; data collection ; fatty acids ; grasses ; methane ; milk ; milk fat ; milk production ; nutritive value ; pastures ; prediction ; regression analysis
Language	English
Dates of publication	2023-0111
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13010181
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chill coma onset and recovery fail to reveal true variation in thermal performance among populations of Drosophila melanogaster.

Davis, Hannah E / Cheslock, Alexandra / MacMillan, Heath A

Scientific reports

2021 Volume 11, Issue 1, Page(s) 10876

Abstract: Species from colder climates tend to be more chill tolerant regardless of the chill tolerance trait measured, but for Drosophila melanogaster, population-level differences in chill tolerance among populations are not always found when a single trait is ... ...

Abstract	Species from colder climates tend to be more chill tolerant regardless of the chill tolerance trait measured, but for Drosophila melanogaster, population-level differences in chill tolerance among populations are not always found when a single trait is measured in the laboratory. We measured chill coma onset temperature, chill coma recovery time, and survival after chronic cold exposure in replicate lines derived from multiple paired African and European D. melanogaster populations. The populations in our study were previously found to differ in chronic cold survival ability, which is believed to have evolved independently in each population pair; however, they did not differ in chill coma onset temperature and chill coma recovery time in a manner that reflected their geographic origins, even though these traits are known to vary with origin latitude among Drosophila species and are among the most common metrics of thermal tolerance in insects. While it is common practice to measure only one chill tolerance trait when comparing chill tolerance among insect populations, our results emphasise the importance of measuring more than one thermal tolerance trait to minimize the risk of missing real adaptive variation in insect thermal tolerance.
MeSH term(s)	Animals ; Biological Variation, Population ; Cold Temperature ; Coma ; Drosophila melanogaster/physiology ; Female ; Phenotype ; Survival Analysis ; Temperature ; Thermogenesis
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-90401-5
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Article ; Online: Long COVID: major findings, mechanisms and recommendations.

Davis, Hannah E / McCorkell, Lisa / Vogel, Julia Moore / Topol, Eric J

Nature reviews. Microbiology

2023 Volume 21, Issue 3, Page(s) 133–146

Abstract: Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million ... ...

Abstract	Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process.
MeSH term(s)	Child ; Humans ; COVID-19 ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; COVID-19 Testing ; Biomedical Research
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2139054-X
ISSN	1740-1534 ; 1740-1526
ISSN (online)	1740-1534
ISSN	1740-1526
DOI	10.1038/s41579-022-00846-2
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Zs.MG 74: Show issues

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