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  1. Book ; Online: Bladder cancer

    Lerner, Seth P. / Davis, Ian D.

    2018  

    Author's details Seth P. Lerner, Ian D. Davis
    Keywords Bladder/Cancer/Genetic aspects
    Subject code 616.99462042
    Language English
    Size 1 online resource (81 pages)
    Edition Third edition.
    Publisher Health Press
    Publishing place Place of publication not identified
    Document type Book ; Online
    ISBN 1-910797-66-9 ; 1-910797-64-2 ; 978-1-910797-66-2 ; 978-1-910797-64-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Be Careful Not To ARAMIS the Point.

    Davis, Ian D

    European urology

    2022  Volume 83, Issue 3, Page(s) 222–223

    Language English
    Publishing date 2022-10-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.09.019
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  3. Article: Combination therapy in metastatic hormone-sensitive prostate cancer: is three a crowd?

    Davis, Ian D

    Therapeutic advances in medical oncology

    2022  Volume 14, Page(s) 17588359221086827

    Abstract: The mainstay of treatment for metastatic prostate cancer is androgen deprivation therapy (ADT). Outcomes with ADT are variable but control of hormone-sensitive prostate cancer (HSPC) can often be achieved for many years. Death from prostate cancer is ... ...

    Abstract The mainstay of treatment for metastatic prostate cancer is androgen deprivation therapy (ADT). Outcomes with ADT are variable but control of hormone-sensitive prostate cancer (HSPC) can often be achieved for many years. Death from prostate cancer is usually due to the development of escape variants able to survive and proliferate in the setting of castrate levels of serum androgens (metastatic castration-resistant prostate cancer, mCRPC). Several agents can improve survival for patients with mCRPC, including chemotherapy, agents to reduce androgen receptor signalling, the radioisotope radium-223 dichloride, and cellular immunotherapy with sipuleucel-T. Some of these agents have been moved earlier in the disease course and have shown to improve survival in metastatic HSPC also, often to a much greater degree than when the same agents are used in mCRPC. Specifically, survival of metastatic HSPC can be improved with the addition to ADT of any one of docetaxel, abiraterone acetate/prednisone combination, apalutamide, enzalutamide, or darolutamide in combination with docetaxel. Factors affecting outcomes include the volume or burden of disease, timing of metastases relative to the original diagnosis, and patient factors determining the appropriateness of therapy. Unfortunately, uptake of this information by the clinical community remains suboptimal, with many men potentially suitable for combination therapy still receiving only ADT. Some trials have examined the effects of 'triplet' therapies although few were designed specifically to address this question. The best evidence to date suggests that triplet therapy with ADT + abiraterone + docetaxel or ADT + darolutamide + docetaxel, can improve overall survival in metastatic HSPC. Clear opportunities exist to improve survival outcomes for men with metastatic HSPC but need to be balanced against cost, accessibility, toxicity, and patient-specific factors.
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359221086827
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  4. Article ; Online: Triplet therapy for prostate cancer.

    Davis, Ian D

    Lancet (London, England)

    2022  Volume 399, Issue 10336, Page(s) 1670–1671

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols ; Humans ; Male ; Prostatic Neoplasms/drug therapy
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00427-5
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  5. Article ; Online: Small Steps and Giant Leaps or Just Getting on With It?

    Davis, Ian D

    JNCI cancer spectrum

    2021  Volume 5, Issue 6

    Language English
    Publishing date 2021-10-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkab083
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  6. Article ; Online: Opening a Scan of Worms.

    Davis, Ian D

    European urology oncology

    2020  Volume 3, Issue 6, Page(s) 725–727

    MeSH term(s) Hormones ; Humans ; Male ; Prostatic Neoplasms
    Chemical Substances Hormones
    Language English
    Publishing date 2020-10-31
    Publishing country Netherlands
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2020.10.009
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  7. Article ; Online: Answering Questions and Questioning Answers: More Evidence To Guide Decision-making About Chemohormonal Therapy in Metastatic Prostate Cancer.

    Davis, Ian D

    European urology

    2018  Volume 73, Issue 6, Page(s) 856–858

    MeSH term(s) Decision Making ; Humans ; Male ; Prostatic Neoplasms
    Language English
    Publishing date 2018-03-07
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.02.020
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    Zs.A 1247: Show issues Location:
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  8. Article ; Online: A phase 2 pilot study of water irrigation after transurethral resection of bladder tumor (WATIP) demonstrating safety, feasibility and activity.

    Li, Mo / Nandurkar, Ruchira / Toniolo, Jason / Davis, Ian D / Sengupta, Shomik

    World journal of urology

    2024  Volume 42, Issue 1, Page(s) 115

    Abstract: Purpose: Non-muscle-invasive bladder cancer (NMIBC) can recur, partly due to seeding of free tumour cells after transurethral resection of bladder tumour (TURBT). Intravesical chemotherapy post-TURBT can reduce the risk but is used infrequently and ... ...

    Abstract Purpose: Non-muscle-invasive bladder cancer (NMIBC) can recur, partly due to seeding of free tumour cells after transurethral resection of bladder tumour (TURBT). Intravesical chemotherapy post-TURBT can reduce the risk but is used infrequently and inconsistently due to cost, complexity and side effects. The objective of this study was to prospectively assess continuous bladder irrigation using water, which may be a safer and easier alternative with comparable effectiveness.
    Methods: WATIP was a prospective, single-arm phase 2 study of water irrigation during and for at least 3 h after TURBT for bladder tumours noted on imaging or flexible cystoscopy. Participants were assessed clinically for adverse effects and with blood tests within 24 h for sodium, haemoglobin and lactate dehydrogenase. The primary endpoints were safety (defined as < 10% adverse events of CTCAE grade ≥ 3), and feasibility (defined as the intervention being delivered as planned in > 90% of cases) and secondary endpoint was recurrence-free rates (RFR).
    Results: Water irrigation was delivered as planned in 29 (97%) of 30 participants (median age 67 years, 25 (83%) males). The only adverse event (grade 2) was clot retention in one (3.3%) participant. Water irrigation significantly reduced urothelial cell counts in catheter effluent over time, unlike saline irrigation which did not. RFR was 56.2% (9/16 participants with low-risk NMIBC) at first cystoscopy (median interval 108 days) and 62.5% (5/8 evaluable low-risk NMIBC) at 12 months.
    Conclusion: Water irrigation during and after TURBT is feasible and safe. Prospective assessment of its effect on NMIBC recurrence compared to post-TURBT intravesical chemotherapy is needed before recommending its use in routine clinical practice. Trial registration ANZCTR registration ID ACTRN12619000517178 on 1 April 2019.
    MeSH term(s) Male ; Humans ; Aged ; Female ; Pilot Projects ; Feasibility Studies ; Non-Muscle Invasive Bladder Neoplasms ; Prospective Studies ; Transurethral Resection of Bladder ; Urinary Bladder Neoplasms/surgery ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-024-04800-0
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  9. Article ; Online: Quality of transurethral resection of bladder tumour documentation: implications for non-muscle-invasive bladder cancer risk stratification and management.

    Botros, Abram / Rival, Paul M / Page, Fiona / Davis, Ian D / Sengupta, Shomik

    BJU international

    2024  Volume 133 Suppl 4, Page(s) 7–10

    MeSH term(s) Humans ; Non-Muscle Invasive Bladder Neoplasms ; Transurethral Resection of Bladder ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Urologic Surgical Procedures ; Risk Assessment ; Neoplasm Invasiveness ; Cystectomy ; Neoplasm Recurrence, Local/surgery
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.16273
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    Ui VI Zs.107: Show issues Location:
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  10. Article ; Online: The impact of multidisciplinary cancer meetings in guiding treatment intent in patients with upper tract urothelial carcinoma.

    Kealey, Joshua / Ip, Christopher / Davis, Ian D / Sengupta, Shomik

    Asia-Pacific journal of clinical oncology

    2023  Volume 20, Issue 1, Page(s) 41–45

    Abstract: Introduction: Patient presentation at multidisciplinary cancer meetings (MDMs) is a key quality indicator in cancer care and may have particular utility in rare malignancies, such as upper tract urothelial carcinoma (UTUC). This study aims to ... ...

    Abstract Introduction: Patient presentation at multidisciplinary cancer meetings (MDMs) is a key quality indicator in cancer care and may have particular utility in rare malignancies, such as upper tract urothelial carcinoma (UTUC). This study aims to investigate what proportion of patients diagnosed with UTUC had treatment intent changed at MDM, the nature of these changes, and what patient factors may correlate with a suggested change.
    Methods: This study analyzed patients diagnosed with UTUC between 2015 and 2020 at an Australian tertiary referral center. MDM discussion rate and suggested treatment intent changes were analyzed. Patient factors that may prompt change, including age, estimated glomerular filtration rate (eGFR), Charlson Comorbidity Index (CCI), and Eastern Cooperation Oncology Group performance status (ECOG PS), were assessed.
    Results: Seventy-five patients were diagnosed with UTUC of whom 71 (94.6%) were discussed at an MDM upon diagnosis. Change to palliative intent was suggested in 8/71 (11%) patients. Patients for whom change to palliative treatment was suggested had a higher age (median 85 vs. 78 years, p<.01), CCI (median 7 vs. 4, p<.005), ECOG PS (median 2 vs. 0, p<.002), and lower eGFR (mean 31 vs. 66 mL/min/1.73 m
    Conclusion: MDM discussion resulted in clinically important changes of treatment intent in a substantial proportion of patients with UTUC, potentially sparing futile treatments. Several patient factors were associated with suggested changes, highlighting the requirement for accurate, in-depth patient information at MDM discussion.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/surgery ; Australia/epidemiology ; Glomerular Filtration Rate ; Tertiary Care Centers ; Retrospective Studies
    Language English
    Publishing date 2023-03-31
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13952
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