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  1. Article ; Online: Ion transport: Tipping a cell's ionic balance.

    Davis, Jeffery T

    Nature chemistry

    2014  Volume 6, Issue 10, Page(s) 852–853

    MeSH term(s) Animals ; Anion Transport Proteins/metabolism ; Apoptosis/drug effects ; Chlorides/pharmacology ; Humans ; Small Molecule Libraries/metabolism
    Chemical Substances Anion Transport Proteins ; Chlorides ; Small Molecule Libraries
    Language English
    Publishing date 2014-09-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.2072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Advances in anion transport and supramolecular medicinal chemistry

    Davis, Jeffery T / Gale, Philip A / Quesada, Roberto

    Chemical Society reviews. 2020 Aug. 17, v. 49, no. 16

    2020  

    Abstract: Advances in anion transport by synthetic supramolecular systems are discussed in this article. Developments in the design of discrete molecular carriers for anions and supramolecular anion channels are reviewed followed by an overview of the use of these ...

    Abstract Advances in anion transport by synthetic supramolecular systems are discussed in this article. Developments in the design of discrete molecular carriers for anions and supramolecular anion channels are reviewed followed by an overview of the use of these systems in biological systems as putative treatments for diseases such as cystic fibrosis and cancer.
    Keywords anions ; chemistry ; cystic fibrosis ; design ; society
    Language English
    Dates of publication 2020-0817
    Size p. 6056-6086.
    Publishing place The Royal Society of Chemistry
    Document type Article
    Note NAL-light
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c9cs00662a
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: A G

    Xiao, Songjun / Davis, Jeffery T

    Chemical communications (Cambridge, England)

    2018  Volume 54, Issue 80, Page(s) 11300–11303

    Abstract: A G4·K+ hydrogel made from 5'-hydrazinoguanosine and KCl reacts with α,β-unsaturated carbonyls of different electrophilicities (acrolein, methyl vinyl ketone and methyl acrylate) in water and the gas phase to form cyclic adducts. This aza-Michael ... ...

    Abstract A G4·K+ hydrogel made from 5'-hydrazinoguanosine and KCl reacts with α,β-unsaturated carbonyls of different electrophilicities (acrolein, methyl vinyl ketone and methyl acrylate) in water and the gas phase to form cyclic adducts. This aza-Michael addition/cyclization domino reaction by the 5'-hydrazino G4·K+ hydrogel has promise for environmental remediation of toxic α,β-unsaturated carbonyls from water and the atmosphere.
    Language English
    Publishing date 2018-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c8cc07228k
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  4. Article ; Online: A self-assembled peroxidase from 5'-GMP and heme.

    Harraz, Deiaa M / Davis, Jeffery T

    Chemical communications (Cambridge, England)

    2018  Volume 54, Issue 13, Page(s) 1587–1590

    Abstract: Guanosine 5'-monophosphate (5'-GMP) and Fe(iii)-heme form a supramolecular catalyst with peroxidase activity. Catalysis, which depends on self-assembly of 5'-GMP into a G-quadruplex that binds hemin, can be modulated by nucleotide concentration, ... ...

    Abstract Guanosine 5'-monophosphate (5'-GMP) and Fe(iii)-heme form a supramolecular catalyst with peroxidase activity. Catalysis, which depends on self-assembly of 5'-GMP into a G-quadruplex that binds hemin, can be modulated by nucleotide concentration, temperature and the identity of the nucleotide's sugar.
    MeSH term(s) Benzothiazoles/chemistry ; Catalysis ; Deoxyguanine Nucleotides/chemistry ; G-Quadruplexes ; Guanosine Monophosphate/chemistry ; Guanosine Monophosphate/genetics ; Hemin/chemistry ; Hydrogen Bonding ; Hydrogen Peroxide/chemistry ; Macromolecular Substances/chemistry ; Oxidation-Reduction ; Sulfonic Acids/chemistry ; Temperature
    Chemical Substances Benzothiazoles ; Deoxyguanine Nucleotides ; Macromolecular Substances ; Sulfonic Acids ; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Hemin (743LRP9S7N) ; 2'-deoxyguanosine 5'-phosphate (7EAM4TG712) ; Guanosine Monophosphate (85-32-5) ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2018-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c7cc09900b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: G

    Xiao, Songjun / Davis, Jeffery T

    Faraday discussions

    2018  Volume 209, Page(s) 97–112

    Abstract: The creation of supramolecular hydrogels from relatively simple building blocks demonstrates the power of molecular self-assembly to make functional materials. G4-quartet hydrogels are appealing for a number of applications, including the environmental ... ...

    Abstract The creation of supramolecular hydrogels from relatively simple building blocks demonstrates the power of molecular self-assembly to make functional materials. G4-quartet hydrogels are appealing for a number of applications, including the environmental remediation of pollutants in water. We find that the guanosine analog, 5'-deoxy-5'-hydrazinoguanosine (HG 2) self-assembles into a self-standing hydrogel in the presence of stoichiometric amounts (0.25 equiv.) of KCl. The higher water solubility of HG 2 (14.5 mM), compared to that of the parent compound G 1 (2.1 mM), likely contributes to its enhanced gelation. The structural basis for this HG 2·KCl hydrogel, confirmed by PXRD, IR and CD, is the G4·K+ quartet, which forms extended 1D ion-channel assemblies that entangle to give a stable and long-lived hydrogel. We also find that adding KCl to a saturated solution of HG 2 triggers the generation of colloidal G4·K+ assemblies in situ that selectively and efficiently binds the anionic dye naphthol blue black (NBB) over a cationic dye. In addition to this non-covalent electrostatic binding of anions, the nucleophilic 5'-hydrazino group in the HG 2·KCl hydrogel HG 2 enables the efficient absorption of propionaldehyde from both the gas phase and from water solution via the formation of covalent hydrazone linkages with the gel matrix.
    Language English
    Publishing date 2018-05-17
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1364-5498
    ISSN (online) 1364-5498
    DOI 10.1039/c8fd00038g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advances in anion transport and supramolecular medicinal chemistry.

    Davis, Jeffery T / Gale, Philip A / Quesada, Roberto

    Chemical Society reviews

    2020  

    Abstract: Advances in anion transport by synthetic supramolecular systems are discussed in this article. Developments in the design of discrete molecular carriers for anions and supramolecular anion channels are reviewed followed by an overview of the use of these ...

    Abstract Advances in anion transport by synthetic supramolecular systems are discussed in this article. Developments in the design of discrete molecular carriers for anions and supramolecular anion channels are reviewed followed by an overview of the use of these systems in biological systems as putative treatments for diseases such as cystic fibrosis and cancer.
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c9cs00662a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Supramolecular gels made from nucleobase, nucleoside and nucleotide analogs.

    Peters, Gretchen Marie / Davis, Jeffery T

    Chemical Society reviews

    2016  Volume 45, Issue 11, Page(s) 3188–3206

    Abstract: Supramolecular or molecular gels are attractive for various applications, including diagnostics, tissue scaffolding and targeted drug release. Gelators derived from natural products are of particular interest for biomedical purposes, as they are ... ...

    Abstract Supramolecular or molecular gels are attractive for various applications, including diagnostics, tissue scaffolding and targeted drug release. Gelators derived from natural products are of particular interest for biomedical purposes, as they are generally biocompatible and stimuli-responsive. The building blocks of nucleic acids (i.e. nucleobases, nucleosides, and nucleotides) are desirable candidates for supramolecular gelation as they readily engage in reversible, noncovalent interactions. In this review, we describe a number of organo- and hydrogels formed through the assembly of nucleosides, nucleotides, and their derivatives. While natural nucleosides and nucleotides generally require derivatization to induce gelation, guanosine and its corresponding nucleotides are well known gelators. This unique gelating ability is due to propensity of the guanine nucleobase to self-associate into stable higher-order assemblies, such as G-ribbons, G4-quartets, and G-quadruplexes.
    MeSH term(s) Animals ; Drug Stability ; Humans ; Hydrogels/chemistry ; Nucleotides/chemistry ; Purine Nucleosides/chemistry ; Pyrimidine Nucleosides/chemistry
    Chemical Substances Hydrogels ; Nucleotides ; Purine Nucleosides ; Pyrimidine Nucleosides
    Language English
    Publishing date 2016--07
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/c6cs00183a
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  8. Article ; Online: A G4·K(+) hydrogel that self-destructs.

    Plank, Taylor N / Davis, Jeffery T

    Chemical communications (Cambridge, England)

    2016  Volume 52, Issue 28, Page(s) 5037–5040

    Abstract: A G4-quartet based hydrogel formed by self-assembly of borate esters of 5'-deoxy-5'-iodoguanosine (5'-IG 2) undergoes in situ cyclization to give 5'-deoxy-N3,5'-cycloguanosine (5'-cG 3). Formation of 5'-cG 3 causes self-destruction of the gel. This ... ...

    Abstract A G4-quartet based hydrogel formed by self-assembly of borate esters of 5'-deoxy-5'-iodoguanosine (5'-IG 2) undergoes in situ cyclization to give 5'-deoxy-N3,5'-cycloguanosine (5'-cG 3). Formation of 5'-cG 3 causes self-destruction of the gel. This intramolecular cyclization can be used to release nucleoside analogs that have been pre-incorporated into the gel network.
    MeSH term(s) Cyclization ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemical synthesis ; Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry ; Molecular Conformation
    Chemical Substances Hydrogel, Polyethylene Glycol Dimethacrylate (25852-47-5)
    Language English
    Publishing date 2016-04-11
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c6cc01494a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cation-Templated Self-Assembly of a Lipophilic Deoxyguanosine:  Solution Structure of a K

    Marlow, Allison L / Mezzina, Elisabetta / Spada, Gian Piero / Masiero, Stefano / Davis, Jeffery T / Gottarelli, Giovanni

    The Journal of organic chemistry

    2021  Volume 64, Issue 14, Page(s) 5116–5123

    Abstract: The lipophilic nucleoside 3',5'-didecanoyl-2'-deoxyguanosine, ... ...

    Abstract The lipophilic nucleoside 3',5'-didecanoyl-2'-deoxyguanosine, dG
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo9901440
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  10. Article ; Online: Supramolecular chemistry: anion transport as easy as pi.

    Davis, Jeffery T

    Nature chemistry

    2010  Volume 2, Issue 7, Page(s) 516–517

    MeSH term(s) Anions/chemistry ; Chlorides/chemistry ; Imides/chemistry ; Ion Transport ; Lipid Bilayers/metabolism ; Naphthalenes/chemistry
    Chemical Substances Anions ; Chlorides ; Imides ; Lipid Bilayers ; Naphthalenes ; naphthalenediimide (22291-04-9)
    Language English
    Publishing date 2010-06-22
    Publishing country England
    Document type News
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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