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  1. Book ; Online ; E-Book: Pain neuroethics and bioethics

    Buchman, Daniel Z. / Davis, Karen D.

    (Developments in neuroethics and bioethics ; volume 1)

    2018  

    Author's details edited by Daniel Buchman, Karen D. Davis
    Series title Developments in neuroethics and bioethics ; volume 1
    Collection
    Language English
    Size 1 Online-Ressource (xviii, 191 Seiten)
    Edition First edition
    Publisher Elsevier AP
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019856866
    ISBN 978-0-12-815798-5 ; 9780128157978 ; 0-12-815798-4 ; 0128157976
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A PAIN supplement commemorating the 50th anniversary of the International Association for the Study of Pain.

    Davis, Karen D / Sessle, Barry J

    Pain

    2023  Volume 164, Issue 11S, Page(s) S2

    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000003076
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  3. Article ; Online: Sex and gender differences in pain.

    Osborne, Natalie R / Davis, Karen D

    International review of neurobiology

    2022  Volume 164, Page(s) 277–307

    Abstract: Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide. Women and girls are disproportionally affected by chronic pain. About half of chronic pain conditions are more common in women, with only 20% having a higher ... ...

    Abstract Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide. Women and girls are disproportionally affected by chronic pain. About half of chronic pain conditions are more common in women, with only 20% having a higher prevalence in men. There are also sex and gender differences in acute pain sensitivity. Pain is a subjective experience made up of sensory, cognitive, and emotional components. Consequently, there are multiple dimensions through which sex and gender can influence the pain experience. Historically, most preclinical pain research was conducted exclusively in male animals. However, recent studies that included females have revealed significant sex differences in the physiological mechanisms underlying pain, including sex specific involvement of different genes and proteins as well as distinct interactions between hormones and the immune system that influence the transmission of pain signals. Human neuroimaging has revealed sex and gender differences in the neural circuitry associated with pain, including sex specific brain alterations in chronic pain conditions. Clinical pain research suggests that gender can affect how an individual contextualizes and copes with pain. Gender may also influence the susceptibility to develop chronic pain. Sex and gender biases can impact how pain is perceived and treated clinically. Furthermore, the efficacy and side effects associated with different pain treatments can vary according to sex and gender. Therefore, preclinical and clinical research must include sex and gender analyses to understand basic mechanisms of pain and its relief, and to develop personalized pain treatment.
    MeSH term(s) Adult ; Animals ; Chronic Disease ; Chronic Pain/epidemiology ; Female ; Hormones ; Humans ; Male ; Pain Management ; Sex Characteristics ; Sex Factors
    Chemical Substances Hormones
    Language English
    Publishing date 2022-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2022.06.013
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  4. Article ; Online: Introduction to a Special Issue on Innovations and Controversies in Brain Imaging of Pain: Methods and Interpretations.

    Davis, Karen D

    Pain reports

    2019  Volume 4, Issue 4, Page(s) e771

    Abstract: This special issue comprised 14 articles from leaders in the field, that provide opinions and reviews of concepts that are central to the next generation of pain imaging studies. Topics include cutting-edge technologies and approaches that are at the ... ...

    Abstract This special issue comprised 14 articles from leaders in the field, that provide opinions and reviews of concepts that are central to the next generation of pain imaging studies. Topics include cutting-edge technologies and approaches that are at the forefront of such studies, as well as developments toward biomarkers of pain and clinical applications that bring us closer to harnessing understanding of pains and its modulation to offer better options to those suffering from pain.
    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Journal Article
    ISSN 2471-2531
    ISSN (online) 2471-2531
    DOI 10.1097/PR9.0000000000000771
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  5. Article ; Online: Imaging vs quantitative sensory testing to predict chronic pain treatment outcomes.

    Davis, Karen D

    Pain

    2019  Volume 160 Suppl 1, Page(s) S59–S65

    Abstract: In this article, I review the concept of personalized pain management and consider how brain imaging and quantitative sensory testing can be used to derive biomarkers of chronic pain treatment outcome. I review how different modalities of brain imaging ... ...

    Abstract In this article, I review the concept of personalized pain management and consider how brain imaging and quantitative sensory testing can be used to derive biomarkers of chronic pain treatment outcome. I review how different modalities of brain imaging can be used to acquire information about brain structure and function and how this information can be linked to individual measures of pain.
    MeSH term(s) Animals ; Chronic Pain/diagnostic imaging ; Chronic Pain/physiopathology ; Chronic Pain/therapy ; Electroencephalography/methods ; Electroencephalography/trends ; Humans ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/trends ; Pain Management/methods ; Pain Management/trends ; Pain Measurement/methods ; Pain Measurement/trends ; Treatment Outcome
    Language English
    Publishing date 2019-04-17
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000001479
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  6. Article ; Online: Magnetoencephalography: physics, techniques, and applications in the basic and clinical neurosciences.

    Kim, Junseok A / Davis, Karen D

    Journal of neurophysiology

    2021  Volume 125, Issue 3, Page(s) 938–956

    Abstract: Magnetoencephalography (MEG) is a technique used to measure the magnetic fields generated from neuronal activity in the brain. MEG has a high temporal resolution on the order of milliseconds and provides a more direct measure of brain activity when ... ...

    Abstract Magnetoencephalography (MEG) is a technique used to measure the magnetic fields generated from neuronal activity in the brain. MEG has a high temporal resolution on the order of milliseconds and provides a more direct measure of brain activity when compared with hemodynamic-based neuroimaging methods such as magnetic resonance imaging and positron emission tomography. The current review focuses on basic features of MEG such as the instrumentation and the physics that are integral to the signals that can be measured, and the principles of source localization techniques, particularly the physics of beamforming and the techniques that are used to localize the signal of interest. In addition, we review several metrics that can be used to assess functional coupling in MEG and describe the advantages and disadvantages of each approach. Lastly, we discuss the current and future applications of MEG.
    MeSH term(s) Action Potentials/physiology ; Animals ; Biophysical Phenomena/physiology ; Brain/physiology ; Humans ; Magnetoencephalography/methods ; Magnetoencephalography/trends ; Neurosciences/methods ; Neurosciences/trends ; Physics/methods ; Physics/trends
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00530.2020
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  7. Article ; Online: Neural Oscillations: Understanding a Neural Code of Pain.

    Kim, Junseok A / Davis, Karen D

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    2020  Volume 27, Issue 5, Page(s) 544–570

    Abstract: Neural oscillations play an important role in the integration and segregation of brain regions that are important for brain functions, including pain. Disturbances in oscillatory activity are associated with several disease states, including chronic pain. ...

    Abstract Neural oscillations play an important role in the integration and segregation of brain regions that are important for brain functions, including pain. Disturbances in oscillatory activity are associated with several disease states, including chronic pain. Studies of neural oscillations related to pain have identified several functional bands, especially alpha, beta, and gamma bands, implicated in nociceptive processing. In this review, we introduce several properties of neural oscillations that are important to understand the role of brain oscillations in nociceptive processing. We also discuss the role of neural oscillations in the maintenance of efficient communication in the brain. Finally, we discuss the role of neural oscillations in healthy and chronic pain nociceptive processing. These data and concepts illustrate the key role of regional and interregional neural oscillations in nociceptive processing underlying acute and chronic pains.
    MeSH term(s) Brain ; Chronic Pain ; Humans ; Magnetoencephalography
    Language English
    Publishing date 2020-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1233753-5
    ISSN 1089-4098 ; 1073-8584
    ISSN (online) 1089-4098
    ISSN 1073-8584
    DOI 10.1177/1073858420958629
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  8. Article: Legal and ethical issues of using brain imaging to diagnose pain.

    Davis, Karen D

    Pain reports

    2016  Volume 1, Issue 4, Page(s) e577

    Abstract: Pain, by definition, is a subjective experience, and as such its presence has usually been based on a self-report. However, limitations of self-reports for pain diagnostics, particularly for legal and insurance purposes, has led some to consider a brain- ... ...

    Abstract Pain, by definition, is a subjective experience, and as such its presence has usually been based on a self-report. However, limitations of self-reports for pain diagnostics, particularly for legal and insurance purposes, has led some to consider a brain-imaging-based objective measure of pain. This review will provide an overview of (1) differences between pain and nociception, (2) intersubject variability in pain perception and the associated brain structures and functional circuits, and (3) capabilities and limitations of current brain-imaging technologies. I then discuss how these factors impact objective proxies of pain. Finally, the ethical, privacy, and legal implications of a brain-imaging-based objective measure of pain are considered as potential future technological developments necessary to create a so-called "painometer test."
    Language English
    Publishing date 2016-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2471-2531
    ISSN 2471-2531
    DOI 10.1097/PR9.0000000000000577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differentiating trait pain from state pain: a window into brain mechanisms underlying how we experience and cope with pain.

    Davis, Karen D / Cheng, Joshua C

    Pain reports

    2019  Volume 4, Issue 4, Page(s) e735

    Abstract: Across various biological and psychological attributes, individuals have a set point around which they can fluctuate transiently into various states. However, if one remains in a different state other than their set point for a considerable period (eg, ... ...

    Abstract Across various biological and psychological attributes, individuals have a set point around which they can fluctuate transiently into various states. However, if one remains in a different state other than their set point for a considerable period (eg, induced by a disease), this different state can be considered to be a new set point that also has associated surrounding states. This concept is instructive for understanding chronic pain, where an individual's set point may maladaptively shift such that they become stuck at a new set point of pain (trait pain), from which pain can fluctuate on different timescales (ie, pain states). Here, we discuss the importance of considering trait and state pains in neuroimaging studies of brain structure and function to gain an understanding of not only an individual's current pain state but also more broadly to their trait pain, which may be more reflective of their general condition.
    Language English
    Publishing date 2019-08-07
    Publishing country United States
    Document type Journal Article
    ISSN 2471-2531
    ISSN (online) 2471-2531
    DOI 10.1097/PR9.0000000000000735
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  10. Article ; Online: International Association for the Study of Pain publications over the 50-year span.

    Davis, Karen D / Basbaum, Allan I / Bushnell, M Catherine / Yarnitsky, David / Fields, Howard L

    Pain

    2023  Volume 164, Issue 11S, Page(s) S27–S30

    Abstract: Abstract: The International Association for the Study of Pain (IASP) has a 50-year history of publishing educational and research materials, ranging from traditional print format books, journals, and other informational formats to online and electronic ... ...

    Abstract Abstract: The International Association for the Study of Pain (IASP) has a 50-year history of publishing educational and research materials, ranging from traditional print format books, journals, and other informational formats to online and electronic formats. Here we provide a historical overview of IASP publications and reflections from the perspective of 5 former or current Editors-in-Chief.
    MeSH term(s) Educational Status ; Publishing
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000003059
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