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  1. Article ; Online: Oxford hip and knee scores deteriorate in patients awaiting lower limb arthroplasty during the COVID-19 pandemic and predict a health state 'worse than death'.

    Clark, Jack O / Razii, Nima / Lee, S W Justin / Grant, Stephen J / Davison, Martin J / Bailey, Oliver

    Bone & joint open

    2023  Volume 4, Issue 3, Page(s) 138–145

    Abstract: The COVID-19 pandemic has caused unprecedented disruption to elective orthopaedic services. The primary objective of this study was to examine changes in functional scores in patients awaiting total hip arthroplasty (THA), total knee arthroplasty (TKA), ... ...

    Abstract The COVID-19 pandemic has caused unprecedented disruption to elective orthopaedic services. The primary objective of this study was to examine changes in functional scores in patients awaiting total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty (UKA). Secondary objectives were to investigate differences between these groups and identify those in a health state 'worse than death' (WTD). In this prospective cohort study, preoperative Oxford hip and knee scores (OHS/OKS) were recorded for patients added to a waiting list for THA, TKA, or UKA, during the initial eight months of the COVID-19 pandemic, and repeated at 14 months into the pandemic (mean interval nine months (SD 2.84)). EuroQoL five-dimension five-level health questionnaire (EQ-5D-5L) index scores were also calculated at this point in time, with a negative score representing a state WTD. OHS/OKS were analyzed over time and in relation to the EQ-5D-5L. A total of 174 patients (58 THA, 74 TKA, 42 UKA) were eligible, after 27 were excluded (one died, seven underwent surgery, 19 non-responders). The overall mean OHS/OKS deteriorated from 15.43 (SD 6.92), when patients were added to the waiting list, to 11.77 (SD 6.45) during the pandemic (p < 0.001). There were significantly worse EQ-5D-5L index scores in the THA group (p = 0.005), with 22 of these patients (38%) in a health state WTD, than either the TKA group (20 patients; 27% WTD), or the UKA group (nine patients; 21% WTD). A strong positive correlation between the EQ-5D-5L index score and OHS/OKS was observed (
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article
    ISSN 2633-1462
    ISSN (online) 2633-1462
    DOI 10.1302/2633-1462.43.BJO-2022-0136.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Careful assessment the key to diagnosing adolescent heel pain.

    Davison, Martin J / David-West, S Kenneth / Duncan, Roderick

    The Practitioner

    2016  Volume 260, Issue 1793, Page(s) 30–2, 3

    Abstract: The most common cause of adolescent heel pain is calcaneal apophysitis also known as Sever's disease. The condition may occur in adolescent athletes, particularly those involved in running or jumping activities, during the pubertal growth spurt. The mean ...

    Abstract The most common cause of adolescent heel pain is calcaneal apophysitis also known as Sever's disease. The condition may occur in adolescent athletes, particularly those involved in running or jumping activities, during the pubertal growth spurt. The mean age of presentation in Sever's disease is ten, (range 7-15). It presents with posterior heel pain that is worse with activity and relieved by rest in most cases. Sever's disease, Osgood Schlatter's disease (tibial tuberosity) and Sinding-Larsen Johansson syndrome (distal patella) are all overuse syndromes brought about by repetitive submaximal loading and microtrauma. They are, however, entirely self-limiting and resolve at skeletal maturity or earlier. Careful assessment is required to differentiate them from other rare pathologies. Achilles tendinitis is rare under the age of 14. As in Sever's disease, it may occur in jumping athletes, those who suddenly increase their sporting activities and in individuals with relative gastrosoleus tightness. It may also occur in those with inflammatory arthropathies and merit rheumatological investigation if there are other suggestive signs or symptoms. Benign and malignant tumours of the adolescent calcaneus are extremely rare In a unilateral case, atypical features such as night pain or absence of a precipitating activity should raise the index of suspicion. There may be localised swelling and bony expansion.
    MeSH term(s) Adolescent ; Athletic Injuries/complications ; Bursitis/complications ; Bursitis/physiopathology ; Calcaneus/pathology ; Calcaneus/physiopathology ; Child ; Cumulative Trauma Disorders/diagnosis ; Cumulative Trauma Disorders/etiology ; Cumulative Trauma Disorders/physiopathology ; Diagnosis, Differential ; Heel/pathology ; Heel/physiopathology ; Humans ; Pain/diagnosis ; Pain/etiology ; Pain Measurement/methods ; Tendinopathy/complications ; Tendinopathy/physiopathology
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 124095-x
    ISSN 0032-6518
    ISSN 0032-6518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nanopit-induced osteoprogenitor cell differentiation: The effect of nanopit depth.

    Davison, Martin J / McMurray, Rebecca J / Smith, Carol-Anne / Dalby, Matthew J / Meek, Rm Dominic

    Journal of tissue engineering

    2016  Volume 7, Page(s) 2041731416652778

    Abstract: We aimed to assess osteogenesis in osteoprogenitor cells by nanopits and to assess optimal feature depth. Topographies of depth 80, 220 and 333 nm were embossed onto polycaprolactone discs. Bone marrow-derived mesenchymal stromal cells were seeded onto ... ...

    Abstract We aimed to assess osteogenesis in osteoprogenitor cells by nanopits and to assess optimal feature depth. Topographies of depth 80, 220 and 333 nm were embossed onto polycaprolactone discs. Bone marrow-derived mesenchymal stromal cells were seeded onto polycaprolactone discs, suspended in media and incubated. Samples were fixed after 3 and 28 days. Cells were stained for the adhesion molecule vinculin and the osteogenic transcription factor RUNX2 after 3 days. Adhesion was lowest on planar controls and it was the shallowest, and 80-nm-deep pits supported optimal adhesion formation. Deep pits (80 and 220 nm) induced most RUNX2 accumulation. After 28 days, osteocalcin and osteopontin expression were used as markers of osteoblastic differentiation. Deep pits (220 nm) produced cells with the highest concentrations of osteopontin and osteocalcin. All topographies induced higher expression levels than controls. We demonstrated stimulation of osteogenesis in a heterogeneous population of mesenchymal stromal cells. All nanopit depths gave promising results with an optimum depth of 220 nm after 28 days. Nanoscale modification of implant surfaces could optimise fracture union or osteointegration.
    Language English
    Publishing date 2016-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2573915-3
    ISSN 2041-7314
    ISSN 2041-7314
    DOI 10.1177/2041731416652778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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