LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Mucoadhesive Marine Polysaccharides.

    Yermak, Irina M / Davydova, Viktoriya N / Volod'ko, Aleksandra V

    Marine drugs

    2022  Volume 20, Issue 8

    Abstract: Mucoadhesive polymers are of growing interest in the field of drug delivery due to their ability to interact with the body's mucosa and increase the effectiveness of the drug. Excellent mucoadhesive performance is typically observed for polymers ... ...

    Abstract Mucoadhesive polymers are of growing interest in the field of drug delivery due to their ability to interact with the body's mucosa and increase the effectiveness of the drug. Excellent mucoadhesive performance is typically observed for polymers possessing charged groups or non-ionic functional groups capable of forming hydrogen bonds and electrostatic interactions with mucosal surfaces. Among mucoadhesive polymers, marine carbohydrate biopolymers have been attracting attention due to their biocompatibility and biodegradability, sample functional groups, strong water absorption and favorable physiochemical properties. Despite the large number of works devoted to mucoadhesive polymers, there are very few systematic studies on the influence of structural features of marine polysaccharides on mucoadhesive interactions. The purpose of this review is to characterize the mucoadhesive properties of marine carbohydrates with a focus on chitosan, carrageenan, alginate and their use in designing drug delivery systems. A wide variety of methods which have been used to characterize mucoadhesive properties of marine polysaccharides are presented in this review. Mucoadhesive drug delivery systems based on such polysaccharides are characterized by simplicity and ease of use in the form of tablets, gels and films through oral, buccal, transbuccal and local routes of administration.
    MeSH term(s) Carbohydrates ; Chitosan/chemistry ; Drug Delivery Systems/methods ; Polymers/chemistry ; Polysaccharides ; Tablets
    Chemical Substances Carbohydrates ; Polymers ; Polysaccharides ; Tablets ; Chitosan (9012-76-4)
    Language English
    Publishing date 2022-08-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20080522
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Mucoadhesive Marine Polysaccharides

    Yermak, Irina M. / Davydova, Viktoriya N. / Volod’ko, Aleksandra V.

    Marine drugs. 2022 Aug. 15, v. 20, no. 8

    2022  

    Abstract: Mucoadhesive polymers are of growing interest in the field of drug delivery due to their ability to interact with the body’s mucosa and increase the effectiveness of the drug. Excellent mucoadhesive performance is typically observed for polymers ... ...

    Abstract Mucoadhesive polymers are of growing interest in the field of drug delivery due to their ability to interact with the body’s mucosa and increase the effectiveness of the drug. Excellent mucoadhesive performance is typically observed for polymers possessing charged groups or non-ionic functional groups capable of forming hydrogen bonds and electrostatic interactions with mucosal surfaces. Among mucoadhesive polymers, marine carbohydrate biopolymers have been attracting attention due to their biocompatibility and biodegradability, sample functional groups, strong water absorption and favorable physiochemical properties. Despite the large number of works devoted to mucoadhesive polymers, there are very few systematic studies on the influence of structural features of marine polysaccharides on mucoadhesive interactions. The purpose of this review is to characterize the mucoadhesive properties of marine carbohydrates with a focus on chitosan, carrageenan, alginate and their use in designing drug delivery systems. A wide variety of methods which have been used to characterize mucoadhesive properties of marine polysaccharides are presented in this review. Mucoadhesive drug delivery systems based on such polysaccharides are characterized by simplicity and ease of use in the form of tablets, gels and films through oral, buccal, transbuccal and local routes of administration.
    Keywords alginates ; bioadhesives ; biocompatibility ; biodegradability ; carrageenan ; chitosan ; drugs ; hydrogen ; mucosa ; water uptake
    Language English
    Dates of publication 2022-0815
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20080522
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Physicochemical Properties and Antiherpetic Activity of κ-Carrageenan Complex with Chitosan.

    Davydova, Viktoriya N / Krylova, Natalya V / Iunikhina, Olga V / Volod'ko, Aleksandra V / Pimenova, Evgeniya A / Shchelkanov, Mikhail Y / Yermak, Irina M

    Marine drugs

    2023  Volume 21, Issue 4

    Abstract: Nanoparticles formation is one of the ways to modulate the physicochemical properties and enhance the activity of original polysaccharides. For this purpose, based on the polysaccharide of red algae, κ-carrageenan (κ-CRG), it polyelectrolyte complex (PEC) ...

    Abstract Nanoparticles formation is one of the ways to modulate the physicochemical properties and enhance the activity of original polysaccharides. For this purpose, based on the polysaccharide of red algae, κ-carrageenan (κ-CRG), it polyelectrolyte complex (PEC), with chitosan, were obtained. The complex formation was confirmed by ultracentrifugation in a Percoll gradient, with dynamic light scattering. According to electron microscopy and DLS, PEC is dense spherical particles with sizes in the range of 150-250 nm. A decrease in the polydispersity of the initial CRG was detected after the PEC formation. Simultaneous exposure of Vero cells with the studied compounds and herpes simplex virus type 1 (HSV-1) showed that the PEC exhibited significant antiviral activity, effectively inhibiting the early stages of virus-cell interaction. A two-fold increase in the antiherpetic activity (selective index) of PEC compared to κ-CRG was shown, which may be due to a change in the physicochemical characteristics of κ-CRG in PEC.
    MeSH term(s) Animals ; Chlorocebus aethiops ; Carrageenan/chemistry ; Chitosan/pharmacology ; Chitosan/chemistry ; Vero Cells ; Polysaccharides ; Polyelectrolytes ; Herpesvirus 1, Human
    Chemical Substances Carrageenan (9000-07-1) ; Chitosan (9012-76-4) ; Polysaccharides ; Polyelectrolytes
    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21040238
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Carrageenan films as promising mucoadhesive ocular drug delivery systems.

    Volod'ko, Aleksandra V / Son, Elvira Yu / Glazunov, Valery P / Davydova, Viktoriya N / Alexander-Sinkler, Elga I / Aleksandrova, Svetlana A / Blinova, Miralda I / Yermak, Irina M

    Colloids and surfaces. B, Biointerfaces

    2024  Volume 237, Page(s) 113854

    Abstract: Polymer mucoadhesive films being developed for use in ophthalmology represent a new tool for drug delivery and are considered an alternative to traditional dosage forms. Due to their mucoadhesive properties, carrageenans (CRGs) are widely used in various ...

    Abstract Polymer mucoadhesive films being developed for use in ophthalmology represent a new tool for drug delivery and are considered an alternative to traditional dosage forms. Due to their mucoadhesive properties, carrageenans (CRGs) are widely used in various forms for drug delivery. In this study, films based on CRGs of various structural types (κ/β, κ, x, and λ) for use in ophthalmology were studied. The films were loaded with the active substance echinochrome (ECH), a sea urchin pigment used in ophthalmology. Spectral data showed that ECH remained stable after its incorporation into the CRG films and did not oxidize for at least six months. Hydrophilic CRG films with a thickness of 10-12 µm were characterized in terms of their swelling and mucoadhesive properties. The rheological properties of solutions formed after film dissolution in artificial tears were also assessed. κ- and κ/β-CRG films with ECH exhibited pseudoplastic behavior after rehydrating films with an artificial tear solution. The CRG-loaded films had different swelling characteristics depending on the structure of the CRG used. The films based on highly sulfated CRGs dissolved in artificial tears, while the films of low-sulfated κ/β-CRG exhibited limited swelling. All studied ECH-loaded films exhibited mucoadhesive properties, which were evaluated by a texture analyzer using mucous tissue of the small intestine of the pig as a model. There was a slight prolongation of ECH release from CRG films in artificial tears. The effect of CRG/ECH on the epithelial cell lines of the outer shell of the human eye was investigated. At low concentrations, ECH in the composition of the CRG/ECH complex had no cytotoxic effect on corneal epithelial and conjunctival human cells. The use of ECH-containing films can prevent the drug from being immediately washed away by tears and help to retain it by increasing viscosity and having mucoadhesive properties.
    MeSH term(s) Humans ; Animals ; Swine ; Carrageenan/chemistry ; Lubricant Eye Drops/metabolism ; Lubricant Eye Drops/pharmacology ; Drug Delivery Systems ; Eye ; Intestine, Small
    Chemical Substances Carrageenan (9000-07-1) ; Lubricant Eye Drops
    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2024.113854
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Comparative Analysis of the Functional Properties of Films Based on Carrageenans, Chitosan, and Their Polyelectrolyte Complexes.

    Volod'ko, Aleksandra V / Davydova, Viktoriya N / Petrova, Valentina A / Romanov, Dmitry P / Pimenova, Evgeniya A / Yermak, Irina M

    Marine drugs

    2021  Volume 19, Issue 12

    Abstract: The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared. The X- ... ...

    Abstract The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared. The X-ray diffractograms of carrageenan films reflected its amorphous structure, whereas chitosan and three-layer films were characterized by strong reflection in the regions of 20° and 15° angles, respectively. The SEM of the cross-sectional morphology showed dense packing of the chitosan film, as well as the layer-by-layer structure of different densities for the PEC. Among the tested samples, κ/β-carrageenan and chitosan films showed the highest tensile strength and maximum elongation. Films containing the drug substance echinochrome were obtained. Mucoadhesive properties were assessed as the ability of the films to swell on the mucous tissue and their erosion after contact with the mucosa. All studied films exhibited mucoadhesive properties. All studied films exhibited mucoadhesive properties which depended on the carrageenans structure. Multilayer films are stronger than single-layer carrageenan films due to PEC formation. The resulting puncture strength of the obtained films was comparable to that of commercial samples described in the literature.
    MeSH term(s) Animals ; Aquatic Organisms ; Biofilms ; Carrageenan/chemistry ; Chitosan/chemistry ; Polyelectrolytes/chemistry ; Tensile Strength
    Chemical Substances Polyelectrolytes ; Carrageenan (9000-07-1) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2021-12-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19120704
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Comparative Analysis of the Functional Properties of Films Based on Carrageenans, Chitosan, and Their Polyelectrolyte Complexes

    Volod’ko, Aleksandra V. / Davydova, Viktoriya N. / Petrova, Valentina A. / Romanov, Dmitry P. / Pimenova, Evgeniya A. / Yermak, Irina M.

    Marine drugs. 2021 Dec. 12, v. 19, no. 12

    2021  

    Abstract: The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared. The X- ... ...

    Abstract The influence of the structural features of carrageenan on the functional properties of the films was studied. The carrageenans and chitosan films, as well as three-layer films containing a polyelectrolyte complex (PEC) of the two, were prepared. The X-ray diffractograms of carrageenan films reflected its amorphous structure, whereas chitosan and three-layer films were characterized by strong reflection in the regions of 20° and 15° angles, respectively. The SEM of the cross-sectional morphology showed dense packing of the chitosan film, as well as the layer-by-layer structure of different densities for the PEC. Among the tested samples, κ/β-carrageenan and chitosan films showed the highest tensile strength and maximum elongation. Films containing the drug substance echinochrome were obtained. Mucoadhesive properties were assessed as the ability of the films to swell on the mucous tissue and their erosion after contact with the mucosa. All studied films exhibited mucoadhesive properties. All studied films exhibited mucoadhesive properties which depended on the carrageenans structure. Multilayer films are stronger than single-layer carrageenan films due to PEC formation. The resulting puncture strength of the obtained films was comparable to that of commercial samples described in the literature.
    Keywords X-ray diffraction ; bioadhesives ; carrageenan ; chitosan ; drugs ; electrolytes ; mucosa ; tensile strength
    Language English
    Dates of publication 2021-1212
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md19120704
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The Comparative Immunotropic Activity of Carrageenan, Chitosan and Their Complexes.

    Davydova, Viktoriya N / Sorokina, Irina V / Volod'ko, Aleksandra V / Sokolova, Ekaterina V / Borisova, Marina S / Yermak, Irina M

    Marine drugs

    2020  Volume 18, Issue 9

    Abstract: The immunotropic activity of polyelectrolyte complexes (PEC) of κ-carrageenan (κ-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an ... ...

    Abstract The immunotropic activity of polyelectrolyte complexes (PEC) of κ-carrageenan (κ-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an excess of CH (CH:CGN mass ratios of 10:1) and with an excess of CGN (CH: CGN mass ratios of 1:10) were prepared. The ability of PEC to scavenge NO depended on the content of the κ-CGN in the PEC. The ability of the PEC to induce the synthesis of pro-inflammatory (tumor necrosis factor-α (TNF-α)) and anti-inflammatory (interleukine-10 (IL-10)) cytokines in peripheral blood mononuclear cell was determined by the activity of the initial κ-CGN, regardless of their composition. The anti-inflammatory activity of PEC and the initial compounds was studied using test of histamine-, concanavalin A-, and sheep erythrocyte immunization-induced inflammation in mice. The highest activity of PEC, as well as the initial polysaccharides κ-CGN and CH, was observed in a histamine-induced exudative inflammation, directly related to the activation of phagocytic cells, i.e., macrophages and neutrophils.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/pharmacology ; Carrageenan/pharmacology ; Chitosan/analogs & derivatives ; Chitosan/pharmacology ; Cytokines/metabolism ; Disease Models, Animal ; Edema/immunology ; Edema/metabolism ; Edema/prevention & control ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/prevention & control ; Lymphocytes/drug effects ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice, Inbred C57BL ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Phagocytosis/drug effects ; Polyelectrolytes/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Cytokines ; Polyelectrolytes ; Carrageenan (9000-07-1) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18090458
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: The Comparative Immunotropic Activity of Carrageenan, Chitosan and Their Complexes

    Davydova, Viktoriya N / Sorokina, Irina V / Volod’ko, Aleksandra V / Sokolova, Ekaterina V / Borisova, Marina S / Yermak, Irina M

    Marine drugs. 2020 Sept. 04, v. 18, no. 9

    2020  

    Abstract: The immunotropic activity of polyelectrolyte complexes (PEC) of κ-carrageenan (κ-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an ... ...

    Abstract The immunotropic activity of polyelectrolyte complexes (PEC) of κ-carrageenan (κ-CGN) and chitosan (CH) of various compositions was assessed in comparison with the initial polysaccharides in comparable doses. For this, two soluble forms of PEC, with an excess of CH (CH:CGN mass ratios of 10:1) and with an excess of CGN (CH: CGN mass ratios of 1:10) were prepared. The ability of PEC to scavenge NO depended on the content of the κ-CGN in the PEC. The ability of the PEC to induce the synthesis of pro-inflammatory (tumor necrosis factor-α (TNF-α)) and anti-inflammatory (interleukine-10 (IL-10)) cytokines in peripheral blood mononuclear cell was determined by the activity of the initial κ-CGN, regardless of their composition. The anti-inflammatory activity of PEC and the initial compounds was studied using test of histamine-, concanavalin A-, and sheep erythrocyte immunization-induced inflammation in mice. The highest activity of PEC, as well as the initial polysaccharides κ-CGN and CH, was observed in a histamine-induced exudative inflammation, directly related to the activation of phagocytic cells, i.e., macrophages and neutrophils.
    Keywords anti-inflammatory activity ; carrageenan ; chitosan ; drugs ; electrolytes ; erythrocytes ; inflammation ; interleukin-10 ; macrophages ; mass ; mice ; mononuclear leukocytes ; necrosis ; neoplasms ; neutrophils ; sheep ; synthesis
    Language English
    Dates of publication 2020-0904
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18090458
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Inhibitory Effects of Carrageenans on Endotoxin-Induced Inflammation.

    Yermak, Irina M / Volod'ko, Aleksandra V / Khasina, Eleonora I / Davydova, Viktoriya N / Chusovitin, Evgeniy A / Goroshko, Dmitry L / Kravchenko, Anna O / Solov'eva, Tamara F / Maleev, Victor V

    Marine drugs

    2020  Volume 18, Issue 5

    Abstract: The inhibitory effects of carrageenans (CRGs) on lipopolysaccharide (LPS) induced inflammation in a mouse model of endotoxemia and in complex therapy of patients with enteric infections of Salmonella etiology were studied. The atomic force microscopy ( ... ...

    Abstract The inhibitory effects of carrageenans (CRGs) on lipopolysaccharide (LPS) induced inflammation in a mouse model of endotoxemia and in complex therapy of patients with enteric infections of Salmonella etiology were studied. The atomic force microscopy (AFM) examination of LPS and its mixture with CRGs showed that the LPS morphology is significantly changed under the action of κ- and κ/β-CRGs. CRGs were able to increase the synthesis of anti-inflammatory interleukin 10 (IL-10) in vitro, and, at low concentrations, their activity in the mixture with LPS was higher. The protective effect of CRGs against
    MeSH term(s) Animals ; Carrageenan/administration & dosage ; Carrageenan/isolation & purification ; Dietary Supplements ; Disease Models, Animal ; Endotoxemia/diet therapy ; Endotoxemia/immunology ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/immunology ; Humans ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/immunology ; Lipopolysaccharides/toxicity ; Male ; Mice ; Rhodophyta/chemistry ; Salmonella/isolation & purification ; Salmonella Food Poisoning/blood ; Salmonella Food Poisoning/diet therapy ; Salmonella Food Poisoning/immunology ; Salmonella Food Poisoning/microbiology
    Chemical Substances Lipopolysaccharides ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2020-05-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md18050248
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top