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  1. Article: Ototopical therapies for post tympanostomy tube otorrhoea in children.

    Mather, Michael W / Talks, Benjamin / Dawe, Nicholas / Powell, Jason

    Translational pediatrics

    2022  Volume 11, Issue 10, Page(s) 1739–1742

    Language English
    Publishing date 2022-11-04
    Publishing country China
    Document type Editorial
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-22-387
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  2. Article: School nurses: undervalued, underfunded and overstretched.

    Dawe, Natasha / Sealey, Katrina

    British journal of nursing (Mark Allen Publishing)

    2019  Volume 28, Issue 2, Page(s) 129–131

    MeSH term(s) Child ; Humans ; Nurse's Role ; School Health Services ; School Nursing/economics ; School Nursing/organization & administration ; United Kingdom
    Language English
    Publishing date 2019-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1119191-0
    ISSN 0966-0461
    ISSN 0966-0461
    DOI 10.12968/bjon.2019.28.2.129
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    Zs.A 3449: Show issues Location:
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  3. Article ; Online: Functional swallowing outcomes following treatment for oropharyngeal carcinoma: a systematic review of the evidence comparing trans-oral surgery versus non-surgical management.

    Dawe, N / Patterson, J / O'Hara, J

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2016  Volume 41, Issue 4, Page(s) 371–385

    Abstract: Background: Trans-oral surgical and non-surgical management options for oropharyngeal squamous cell carcinoma (OPSCC) appear to offer similar survival outcomes. Functional outcomes, in particular swallowing, have become of increasing interest in the ... ...

    Abstract Background: Trans-oral surgical and non-surgical management options for oropharyngeal squamous cell carcinoma (OPSCC) appear to offer similar survival outcomes. Functional outcomes, in particular swallowing, have become of increasing interest in the debate regarding treatment options. Contemporary reviews on function following treatment frequently include surrogate markers and limit the value of comparative analysis.
    Objectives of review: A systematic review was performed to establish whether direct comparisons of swallowing outcomes could be made between trans-oral surgical approaches (trans-oral laser microsurgery (TLM)/trans-oral robotic surgery (TORS)) and (chemo)radiotherapy ((C)RT).
    Type of review: Systematic review.
    Search strategy: MEDLINE, Embase and Cochrane databases were interrogated using the following MeSH terms: antineoplastic protocols, chemotherapy, radiotherapy, deglutition disorders, swallowing, lasers, and trans-oral surgery.
    Evaluation method: Two authors performed independent systematic reviews and consensus was sought if opinions differed. The WHO ICF classification was applied to generate analysis based around body functions and structure, activity limitations and participation restriction.
    Results: Thirty-seven citations were included in the analysis. Twenty-six papers reported the outcomes for OPSCC treatment following primary (C)RT in 1377 patients, and 15 papers following contemporary trans-oral approaches in 768 patients. Meta-analysis was not feasible due to varying methodology and heterogeneity of outcome measures. Instrumental swallowing assessments were presented in 13/26 (C)RT versus 2/15 TLM/TORS papers. However, reporting methods of these studies were not standardised. This variety of outcome measures and the wide-ranging intentions of authors applying the measures in individual studies limit any practical direct comparisons of the effects of treatment on swallowing outcomes between interventions.
    Conclusions: From the current evidence, no direct comparisons could be made of swallowing outcomes between the surgical and non-surgical modalities. Swallowing is a multidimensional construct, and the range of assessments utilised by authors reflects the variety of available reporting methods. The MD Anderson Dysphagia Inventory is a subjective measure that allows limited comparison between the currently available heterogeneous data, and is explored in detail. The findings highlight that further research may identify the most appropriate tools for measuring swallowing in patients with OPSCC. Consensus should allow their standardised integration into future studies and randomised control trials.
    MeSH term(s) Chemoradiotherapy ; Deglutition Disorders/physiopathology ; Humans ; Laser Therapy/methods ; Microsurgery/methods ; Oral Surgical Procedures ; Oropharyngeal Neoplasms/physiopathology ; Oropharyngeal Neoplasms/therapy ; Postoperative Complications/physiopathology ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2016-02-08
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.12526
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    Zs.A 1309: Show issues Location:
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  4. Article ; Online: Swallowing after transoral surgery for oropharyngeal cancer: comparison with primary chemoradiotherapy outcomes.

    Dawe, Nicholas / O'Hara, James

    Current opinion in otolaryngology & head and neck surgery

    2017  Volume 25, Issue 2, Page(s) 101–107

    Abstract: Purpose of review: Survival equipoise is recognized between the contemporary surgical and oncological approaches to oropharyngeal squamous cell carcinoma treatment. Primary transoral surgery (TOS) options have emerged that utilize either laser or ... ...

    Abstract Purpose of review: Survival equipoise is recognized between the contemporary surgical and oncological approaches to oropharyngeal squamous cell carcinoma treatment. Primary transoral surgery (TOS) options have emerged that utilize either laser or robotic techniques. Our review presents an overview of the evidence available for swallowing outcomes following TOS approaches and compares these with outcomes following primary oncological management.
    Recent findings: Meta-analysis of swallow outcomes following TOS or (chemo)radiotherapy is not possible given the heterogeneity of the available data. There are suggestions of less swallowing impairment following primary TOS, but the favourable selection of patients to these case series must be considered.
    Summary: Minimizing swallowing impairment following oropharyngeal squamous cell carcinoma treatment, while ensuring oncological efficacy, should be a priority for head and neck healthcare providers. Primary TOS may offer an advantage to patients, but only through a team approach that considers how adjuvant oncological therapy could be tailored to individuals. High-quality clinical trials are in progress that will inform future practice.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000340
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    Zs.A 4814: Show issues Location:
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  5. Article ; Online: Eosinophilic oesophagitis: a systematic review for otolaryngologists.

    Bahgat, M / Dawe, N / Flood, L

    The Journal of laryngology and otology

    2015  Volume 129, Issue 12, Page(s) 1156–1166

    Abstract: Background: Eosinophilic oesophagitis is a chronic, immune/antigen-mediated oesophageal disease, only recently, but increasingly, recognised in the world literature. It is diagnosed and managed primarily by medical gastroenterologists and allergy ... ...

    Abstract Background: Eosinophilic oesophagitis is a chronic, immune/antigen-mediated oesophageal disease, only recently, but increasingly, recognised in the world literature. It is diagnosed and managed primarily by medical gastroenterologists and allergy specialists, and is a distinct disease entity, affecting both children and adults. Few studies have been published in otolaryngology journals, although otolaryngologists will encounter patients with undiagnosed eosinophilic oesophagitis. Patients may present with dysphagia, bolus obstruction or with other ENT disorders, such as atopic rhinitis, reflecting the underlying systemic allergic disorder.
    Objective: This paper systematically reviews the evidence base published on the epidemiology, clinical presentation, diagnosis, treatment and prognosis of eosinophilic oesophagitis, particularly as it relates to otolaryngology practice.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Adult ; Biological Products/therapeutic use ; Biopsy, Needle ; Child ; Deglutition Disorders/etiology ; Deglutition Disorders/physiopathology ; Diet ; Eosinophilic Esophagitis/diagnosis ; Eosinophilic Esophagitis/therapy ; Esophagoscopy/methods ; Evidence-Based Medicine ; Female ; Humans ; Immunohistochemistry ; Male ; Otolaryngology/education ; Prognosis ; Randomized Controlled Trials as Topic ; Risk Assessment ; Treatment Outcome ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Biological Products
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215115002777
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  6. Article ; Online: The application and value of the 'T-14 tool' as a patient-reported outcome measure for paediatric tonsillectomy: a report on 45 cases.

    Dawe, N / Erskine, S / Moor, J W

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2015  Volume 40, Issue 1, Page(s) 41–44

    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Male ; Parents ; Patient Outcome Assessment ; Predictive Value of Tests ; Quality of Life ; Surveys and Questionnaires ; Tonsillectomy ; Tonsillitis/surgery
    Language English
    Publishing date 2015-02
    Publishing country England
    Document type Letter
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.12311
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    Zs.A 1309: Show issues Location:
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  7. Article ; Online: Targeted use of endoscopic CO2 laser cricopharyngeal myotomy for improving swallowing function following head and neck cancer treatment.

    Dawe, N / Patterson, J / Hamilton, D / Hartley, C

    The Journal of laryngology and otology

    2014  Volume 128, Issue 12, Page(s) 1105–1110

    Abstract: Background: Cricopharyngeal dysfunction following head and neck cancer treatment may lead to a significant reduction in oral intake. Carbon dioxide laser is an established procedure for the treatment of non-malignant cricopharyngeal disorders. We report ...

    Abstract Background: Cricopharyngeal dysfunction following head and neck cancer treatment may lead to a significant reduction in oral intake. Carbon dioxide laser is an established procedure for the treatment of non-malignant cricopharyngeal disorders. We report our experience of laser cricopharyngeal myotomy with objective swallowing outcome measures, before and after treatment.
    Methods: We identified 11 patients who had undergone carbon dioxide laser cricopharyngeal myotomy for dysphagia following radiotherapy, with or without chemotheraphy between January 2006 and July 2011. We analysed the swallowing outcomes following carbon dioxide laser cricopharyngeal myotomy by retrospective grading of pre- and post-procedure videofluoroscopic swallowing study of liquids, using the validated Modified Barium Swallow Impairment Profile.
    Results: The median Modified Barium Swallow Impairment Profile score was 13 pre-myotomy and 10 post-myotomy. This difference between scores was non-significant (p = 0.41). The median, cricopharyngeal-specific Modified Barium Swallow Impairment Profile variables (14 and 17) improved from 3 to 2, but were similarly non-significant (p = 0.16). We observed the improved Modified Barium Swallow Impairment Profile scores post-procedure in the majority of patients.
    Conclusion: Endoscopic carbon dioxide laser cricopharyngeal myotomy remains a viable option in treatment-related cricopharyngeal dysfunction; its targeted role requires further prospective study. Objective analysis of the technique can be reported using the validated Modified Barium Swallow Impairment Profile.
    MeSH term(s) Aged ; Aged, 80 and over ; Cricoid Cartilage/pathology ; Cricoid Cartilage/surgery ; Deglutition Disorders/etiology ; Deglutition Disorders/pathology ; Deglutition Disorders/physiopathology ; Deglutition Disorders/surgery ; Endoscopy/methods ; Female ; Fibrosis ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/radiotherapy ; Humans ; Lasers, Gas/therapeutic use ; Male ; Middle Aged ; Pharyngeal Muscles/pathology ; Pharyngeal Muscles/surgery ; Radiation Injuries/etiology ; Radiation Injuries/physiopathology ; Radiation Injuries/surgery ; Retrospective Studies
    Language English
    Publishing date 2014-11-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215114002692
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  8. Article ; Online: The Role of Succinate in the Regulation of Intestinal Inflammation.

    Connors, Jessica / Dawe, Nick / Van Limbergen, Johan

    Nutrients

    2018  Volume 11, Issue 1

    Abstract: Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported ... ...

    Abstract Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate⁻SUCNR1 signaling in gut immune functions.
    MeSH term(s) Animals ; Bacteria/metabolism ; Dysbiosis ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/physiology ; Inflammatory Bowel Diseases ; Intestinal Mucosa/drug effects ; Intestinal Mucosa/immunology ; Intestines/immunology ; Intestines/microbiology ; Receptors, G-Protein-Coupled/physiology ; Signal Transduction/physiology ; Succinic Acid/metabolism ; Succinic Acid/pharmacology
    Chemical Substances Receptors, G-Protein-Coupled ; Succinic Acid (AB6MNQ6J6L)
    Language English
    Publishing date 2018-12-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11010025
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  9. Article ; Online: Inconsistent availability of hearing aids during acute admission.

    Mather, Michael W / Dawe, Nicholas / Wilson, Janet

    BMJ (Clinical research ed.)

    2018  Volume 361, Page(s) k1944

    MeSH term(s) Acute Disease ; Audiology/organization & administration ; Deafness ; Health Services Accessibility/organization & administration ; Hearing Aids/supply & distribution ; Hospitalization ; Humans ; Patients' Rooms
    Language English
    Publishing date 2018-05-10
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k1944
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  10. Article ; Online: Is anticoagulation beneficial in acute mastoiditis complicated by sigmoid sinus thrombosis?

    Mather, Michael / Musgrave, Kate / Dawe, Nicholas

    The Laryngoscope

    2018  Volume 128, Issue 11, Page(s) 2435–2436

    MeSH term(s) Anticoagulants/therapeutic use ; Humans ; Mastoiditis/complications ; Mastoiditis/drug therapy ; Sinus Thrombosis, Intracranial/drug therapy ; Sinus Thrombosis, Intracranial/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.27151
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