LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils

    Teuchert-Noodt Gertraud / Moll Gunther H / Grund Thorsten / Brummelte Susanne / Dawirs Ralph R

    Journal of Negative Results in Biomedicine, Vol 7, Iss 1, p

    2008  Volume 2

    Abstract: Abstract It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both ... ...

    Abstract Abstract It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and handling have a positive effect on the dopaminergic fiber density in the prefrontal cortex (PFC) of early traumatized gerbils ( Meriones unguiculatus ). The current study was performed to investigate if enriched environment during MP application has an additional influence on the dopaminergic and GABAergic fiber densities in the PFC and amygdala in this animal model. Animals received a single early dose of methamphetamine (MA; 50 mg/kg; i.p.) on postnatal day (PD) 14, which is known to cause multiple changes in the subsequent development of several neurotransmitter systems including the dopaminergic systems, and were then treated with oral daily applications of MP (5 mg/kg) from PD30–60. Animals treated this way were either transferred to an enriched environment after weaning (on PD30) or were kept under impoverished rearing conditions. There was no effect of an enriched environment on the dopaminergic or GABAergic fiber density neither in the PFC nor in the amygdala. With regard to former studies these results underline the particular impact of MP in the treatment of ADHD.
    Keywords Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 630
    Language English
    Publishing date 2008-05-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Generalization of contextual fear depends on associative rather than non-associative memory components.

    Sauerhöfer, Elisabeth / Pamplona, Fabricio A / Bedenk, Benedikt / Moll, Gunther H / Dawirs, Ralph R / von Hörsten, Stephan / Wotjak, Carsten T / Golub, Yulia

    Behavioural brain research

    2012  Volume 233, Issue 2, Page(s) 483–493

    Abstract: Posttraumatic stress disorder (PTSD) is characterized by the presence of three major symptom clusters: persistent fear memories, hyperarousal, and avoidance. With a passage of time after the trauma, PTSD patients show an increase in unspecific fear and ... ...

    Abstract Posttraumatic stress disorder (PTSD) is characterized by the presence of three major symptom clusters: persistent fear memories, hyperarousal, and avoidance. With a passage of time after the trauma, PTSD patients show an increase in unspecific fear and avoidance, a phenomenon termed "fear generalization". It is not clear whether fear generalization arises from the time-dependent growth of hyperarousal or changes in associative fear. The present study investigated behavioral and neuroanatomical correlates of non-associative and associative fear memory one week vs. one month after a trauma in a mouse model of PTSD with immediate vs. delayed foot shock application. The immediate shock procedure led to a lower contextual fear, but did not influence the hyperarousal (i.e. increased acoustic startle responses) assessed within the first week after the trauma. Only delayed shocked mice demonstrated generalization of contextual fear and an increase in generalized avoidance behavior, with no changes in hyperarousal one month after trauma. We observed the same increase in c-Fos expression following delayed and immediate shock presentation within the lateral, basolateral, central amygdala and CA1, CA3 and dentate gyrus of hippocampus, suggesting that all of these structures contribute to the development of hyperarousal. Only basolateral amygdala and dentate gyrus appeared to be additionally involved in encoding of contextual information. In summary, our results demonstrate the independence of associative and non-associative trauma-related fear. They support the hypothesis that generalized fear emerges in consequence of forgetting specific stimulus attributes associated with the shock context.
    MeSH term(s) Acoustic Stimulation/adverse effects ; Analysis of Variance ; Animals ; Association Learning/physiology ; Behavior, Animal ; Brain/metabolism ; Conditioning, Classical/physiology ; Electroshock/adverse effects ; Fear ; Generalization (Psychology) ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-fos/metabolism ; Reflex, Startle/physiology ; Time Factors
    Chemical Substances Proto-Oncogene Proteins c-fos
    Language English
    Publishing date 2012-08-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2012.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils.

    Brummelte, Susanne / Grund, Thorsten / Moll, Gunther H / Teuchert-Noodt, Gertraud / Dawirs, Ralph R

    Journal of negative results in biomedicine

    2008  Volume 7, Page(s) 2

    Abstract: It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) ...

    Abstract It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and handling have a positive effect on the dopaminergic fiber density in the prefrontal cortex (PFC) of early traumatized gerbils (Meriones unguiculatus). The current study was performed to investigate if enriched environment during MP application has an additional influence on the dopaminergic and GABAergic fiber densities in the PFC and amygdala in this animal model. Animals received a single early dose of methamphetamine (MA; 50 mg/kg; i.p.) on postnatal day (PD) 14, which is known to cause multiple changes in the subsequent development of several neurotransmitter systems including the dopaminergic systems, and were then treated with oral daily applications of MP (5 mg/kg) from PD30-60. Animals treated this way were either transferred to an enriched environment after weaning (on PD30) or were kept under impoverished rearing conditions. There was no effect of an enriched environment on the dopaminergic or GABAergic fiber density neither in the PFC nor in the amygdala. With regard to former studies these results underline the particular impact of MP in the treatment of ADHD.
    MeSH term(s) Amygdala/drug effects ; Animals ; Dopamine/metabolism ; Dopamine Uptake Inhibitors/pharmacology ; Environment ; Gerbillinae ; Methylphenidate/pharmacology ; Models, Biological ; Nerve Fibers/drug effects ; Neurons/drug effects ; Prefrontal Cortex/drug effects ; Time Factors ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Dopamine Uptake Inhibitors ; Methylphenidate (207ZZ9QZ49) ; gamma-Aminobutyric Acid (56-12-2) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2008-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091480-5
    ISSN 1477-5751 ; 1477-5751
    ISSN (online) 1477-5751
    ISSN 1477-5751
    DOI 10.1186/1477-5751-7-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Thesis ; Online: Laboruntersuchungen zur larvalen Entwicklung von Carcinus maenas L. (Decapoda, Portunidae) und Pagurus Bernhardus L. (Decapoda, Paguridae)

    Dawirs, Ralph R.

    1982  

    Language German
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.

    Neddens, Jörg / Dawirs, Ralph R / Bagorda, Francesco / Busche, Andrea / Horstmann, Sven / Teuchert-Noodt, Gertraud

    Brain research

    2004  Volume 1021, Issue 2, Page(s) 200–208

    Abstract: Long-term effects of postnatal differential rearing conditions and/or early methamphetamine (MA) application on serotonin (5-HT) fibre density were investigated in several cortical areas of both hemispheres of gerbils. The aim of this study was twofold: ( ...

    Abstract Long-term effects of postnatal differential rearing conditions and/or early methamphetamine (MA) application on serotonin (5-HT) fibre density were investigated in several cortical areas of both hemispheres of gerbils. The aim of this study was twofold: (1) Is the 5-HT fibre innervation of the cerebral cortex lateralised, and (2) if so, do postnatal environmental conditions and/or an early drug challenge interfere with development of 5-HT cerebral asymmetries? For that purpose, male gerbils were reared either under semi-natural or restricted environmental and social conditions, under both conditions once (on postnatal day 14) being treated with either a single dose of MA (50 mg/kg, i.p.) or saline. On postnatal day 110, 5-HT fibres were immunohistochemically stained and innervation densities quantified in prefrontal cortex, insular cortex, frontal cortex, parietal cortex, and entorhinal cortex. It was found that (1) 5-HT innervation in the cerebral cortex was clearly lateralised; (2) direction and extent of this asymmetry were not uniformly distributed over the different areas investigated; (3) both early methamphetamine challenge and rearing condition differentially interfered with adult 5-HT cerebral asymmetry; (4) combining MA challenge with subsequent restricted rearing tended to reverse the effects of MA on 5-HT cerebral asymmetry in some of the cortical areas investigated; and (5) significant responses in 5-HT cerebral asymmetry only occurred in prefrontal and entorhinal association cortices. The present findings suggest that the ontogenesis of cortical laterality is influenced by epigenetic factors and that disturbances of the postnatal maturation of lateralised functions may be associated with certain psychopathological behaviours.
    MeSH term(s) Adrenergic Agents/pharmacology ; Animals ; Cell Count ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Epigenesis, Genetic ; Functional Laterality/drug effects ; Gerbillinae ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Male ; Methamphetamine/pharmacology ; Nerve Fibers/drug effects ; Nerve Fibers/physiology ; Serotonin/metabolism ; Social Isolation
    Chemical Substances Adrenergic Agents ; Serotonin (333DO1RDJY) ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2004-09-24
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2004.06.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Thesis ; Online: Aufzuchtbedingungen oekosystemrelevanter Decapoden der Nordsee (Pagurus Bernhardus und Carcinus maenas)

    Dawirs, Ralph R.

    1979  

    Language German
    Publishing country de
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils.

    Grund, Thorsten / Teuchert-Noodt, Gertraud / Busche, Andrea / Neddens, Jörg / Brummelte, Susanne / Moll, Gunther H / Dawirs, Ralph R

    Brain research

    2007  Volume 1176, Page(s) 124–132

    Abstract: The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil ... ...

    Abstract The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the development of DA fiber innervation in control animals sensitive to a clinically relevant subchronic treatment with MP? (2) Is the development of DA fiber innervation in the forebrain altered by a single early MA challenge? (3) If so, might the subsequent institution of a therapeutically relevant MP application scheme interfere with such early induced alternative developmental trajectories for DA fiber innervation? For this purpose, gerbils pretreated both with saline and MA (50 mg/kg, i.p.) on day 14 received either H(2)O or MP (5 mg/kg) orally on days 30 to 60. On day 90, DA fibers were immunohistochemically detected and quantified. As a result, MP on its own did not have any significant influence on the postnatal development of the DA fiber systems, whereas it prevented a previously MA triggered suppressive development of DA fiber innervation in the prefrontal cortex and amygdala complex (30% less fiber innervation in both areas). Thus, MP prevented previously initiated miswiring of DA fibers from actually being implemented in the gerbil forebrain. During earlier studies, rather complex miswiring has been documented in response to an early preweaning MA challenge. This miswiring was associated with functional deficits resembling some of the symptoms of patients with ADHD. Therefore, morphogenetic properties of MP need further attention.
    MeSH term(s) Administration, Oral ; Aging/drug effects ; Aging/physiology ; Amygdala/drug effects ; Amygdala/growth & development ; Amygdala/metabolism ; Animals ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/pharmacology ; Gerbillinae ; Growth Cones/drug effects ; Growth Cones/metabolism ; Growth Cones/ultrastructure ; Male ; Methylphenidate/pharmacology ; Neural Pathways/drug effects ; Neural Pathways/growth & development ; Neural Pathways/metabolism ; Neurogenesis/drug effects ; Neurogenesis/physiology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/growth & development ; Prefrontal Cortex/metabolism ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/growth & development ; Ventral Tegmental Area/metabolism
    Chemical Substances Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49)
    Language English
    Publishing date 2007-10-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2007.06.107
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Early preweaning methamphetamine and postweaning rearing conditions interfere with the development of peripheral stress parameters and neural growth factors in gerbils.

    Lehmann, Konrad / Rodriguez, Enrique Garea / Kratz, Oliver / Moll, Gunther H / Dawirs, Ralph R / Teuchert-Noodt, Gertraud

    The International journal of neuroscience

    2007  Volume 117, Issue 11, Page(s) 1621–1638

    Abstract: Adrenal steroid hormones and neuronal growth factors are two interacting systemic factors that mediate the environment's influence on the brain's structure and function. In order to further elucidate their role and relationship in the effects of early ... ...

    Abstract Adrenal steroid hormones and neuronal growth factors are two interacting systemic factors that mediate the environment's influence on the brain's structure and function. In order to further elucidate their role and relationship in the effects of early stressful experience and isolated rearing (IR), this study measured blood corticosterone titres and relative adrenal weights and assessed nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) concentrations in brain regions of both hemispheres of young adult Mongolian gerbils injected on postnatal day 14 with a single high dose of methamphetamine (MA) or saline and raised after weaning either in an enriched or an impoverished environment. Irrespective of MA challenge, IR decreased corticosterone titres to about half, but increased relative adrenal weights. BDNF concentrations were decreased by IR in saline-injected animals in the left prefrontal and parietal cortices and right entorhinal and hippocampal cortices, and in the subcortical regions of both hemispheres. NGF concentrations were unaltered by IR in saline-injected animals, but increased in MA challenged animals in the entorhinal/hippocampal cortices and subcortical areas of both hemispheres. MA application induced shifts of the lateral asymmetry in NGF contents in prefrontal and entorhinal cortices. The results suggest that an early pharmacological traumatization can set a switch for further brain development, and that growth factor concentrations might possibly be influenced by peripheral stress hormones.
    MeSH term(s) Adrenal Glands/pathology ; Animals ; Brain/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Central Nervous System Stimulants/administration & dosage ; Central Nervous System Stimulants/pharmacology ; Corticosterone/blood ; Dominance, Cerebral ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Environment ; Gerbillinae ; Male ; Methamphetamine/administration & dosage ; Methamphetamine/pharmacology ; Nerve Growth Factors/metabolism ; Organ Size ; Social Isolation ; Stress, Physiological/etiology ; Stress, Physiological/pathology ; Stress, Physiological/physiopathology ; Weaning
    Chemical Substances Brain-Derived Neurotrophic Factor ; Central Nervous System Stimulants ; Nerve Growth Factors ; Methamphetamine (44RAL3456C) ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2007-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1543-5245 ; 0020-7454
    ISSN (online) 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207450600934937
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 657: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: αCaMKII autophosphorylation controls the establishment of alcohol drinking behavior.

    Easton, Alanna C / Lucchesi, Walter / Lourdusamy, Anbarasu / Lenz, Bernd / Solati, Jalal / Golub, Yulia / Lewczuk, Piotr / Fernandes, Cathy / Desrivieres, Sylvane / Dawirs, Ralph R / Moll, Gunther H / Kornhuber, Johannes / Frank, Josef / Hoffmann, Per / Soyka, Michael / Kiefer, Falk / Schumann, Gunter / Peter Giese, K / Müller, Christian P /
    Treutlein, Jens / Cichon, Sven / Ridinger, Monika / Mattheisen, Peter / Herms, Stefan / Wodarz, Norbert / Zill, Peter / Maier, Wolfgang / Mössner, Rainald / Gaebel, Wolfgang / Dahmen, Norbert / Scherbaum, Norbert / Schmäl, Christine / Steffens, Michael / Lucae, Susanne / Ising, Marcus / Müller-Myhsok, Bertram / Nöthen, Markus M / Mann, Karl / Rietschel, Marcella

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2013  Volume 38, Issue 9, Page(s) 1636–1647

    Abstract: The α-Ca(2+)/calmodulin-dependent protein kinase II (αCaMKII) is a crucial enzyme controlling plasticity in the brain. The autophosphorylation of αCaMKII works as a 'molecular memory' for a transient calcium activation, thereby accelerating learning. We ... ...

    Abstract The α-Ca(2+)/calmodulin-dependent protein kinase II (αCaMKII) is a crucial enzyme controlling plasticity in the brain. The autophosphorylation of αCaMKII works as a 'molecular memory' for a transient calcium activation, thereby accelerating learning. We investigated the role of αCaMKII autophosphorylation in the establishment of alcohol drinking as an addiction-related behavior in mice. We found that alcohol drinking was initially diminished in αCaMKII autophosphorylation-deficient αCaMKII(T286A) mice, but could be established at wild-type level after repeated withdrawals. The locomotor activating effects of a low-dose alcohol (2 g/kg) were absent in αCaMKII(T286A) mice, whereas the sedating effects of high-dose (3.5 g/kg) were preserved after acute and subchronic administration. The in vivo microdialysis revealed that αCaMKII(T286A) mice showed no dopamine (DA) response in the nucleus accumbens to acute or subchronic alcohol administration, but enhanced serotonin (5-HT) responses in the prefrontal cortex. The attenuated DA response in αCaMKII(T286A) mice was in line with altered c-Fos activation in the ventral tegmental area after acute and subchronic alcohol administration. In order to compare findings in mice with the human condition, we tested 23 single-nucleotide polymorphisms (SNPs) in the CAMK2A gene for their association with alcohol dependence in a population of 1333 male patients with severe alcohol dependence and 939 controls. We found seven significant associations between CAMK2A SNPs and alcohol dependence, one of which in an autophosphorylation-related area of the gene. Together, our data suggest αCaMKII autophosphorylation as a facilitating mechanism in the establishment of alcohol drinking behavior with changing the DA-5-HT balance as a putative mechanism.
    MeSH term(s) Alcohol Drinking/metabolism ; Alcoholism/genetics ; Animals ; Behavior, Addictive/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Case-Control Studies ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Ethanol/pharmacology ; Female ; Genetic Predisposition to Disease/genetics ; Humans ; Hypnotics and Sedatives/pharmacology ; Male ; Mice ; Motor Activity/drug effects ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Phosphorylation ; Polymorphism, Single Nucleotide/genetics ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/metabolism ; Serotonin/metabolism ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/physiology
    Chemical Substances Hypnotics and Sedatives ; Serotonin (333DO1RDJY) ; Ethanol (3K9958V90M) ; CAMK2A protein, human (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Camk2a protein, mouse (EC 2.7.11.17) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2013-03-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/npp.2013.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2379: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top