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Article ; Online: Decapeptide Modified Doxorubicin Loaded Solid Lipid Nanoparticles as Targeted Drug Delivery System against Prostate Cancer.

De, Kakali

Langmuir : the ACS journal of surfaces and colloids

2021 Volume 37, Issue 45, Page(s) 13194–13207

Abstract: Growing instances of prostate cancer with poor prognosis have become a challenging task in cancer therapy. Luteinizing-hormone-releasing-hormone (LHRH) receptors are overexpressed in prostate cancer cells. Polyethylene glycol (PEG) conjugated lipids ... ...

Abstract	Growing instances of prostate cancer with poor prognosis have become a challenging task in cancer therapy. Luteinizing-hormone-releasing-hormone (LHRH) receptors are overexpressed in prostate cancer cells. Polyethylene glycol (PEG) conjugated lipids exhibit superiority in terms of retention/circulation in biological systems. PEGylated dipalmitoylphosphatedylethanolamine (DPPE-PEG), covalently linked with 6-hydrazinopyridine-3-carboxylic-acid, was conjugated with new LHRH-receptor positive peptide analog (DPPE-PEG-HYNIC-d-Glu-His-Trp-Ser-Tyr-d-Asn-Leu-d-Gln-Pro-Gly-NH
MeSH term(s)	Cell Line, Tumor ; Doxorubicin/therapeutic use ; Drug Carriers ; Drug Delivery Systems ; Humans ; Liposomes ; Male ; Nanoparticles ; Polyethylene Glycols ; Prostatic Neoplasms/drug therapy
Chemical Substances	Drug Carriers ; Lipid Nanoparticles ; Liposomes ; Polyethylene Glycols (3WJQ0SDW1A) ; Doxorubicin (80168379AG)
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.1c01370
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Article ; Online: Aggregation-Induced Fluorescence Upconversion of Pyrene under Low Fluence: In Solutions and Polymeric Nanoparticles.

Banerjee, Anwesha / De, Kheyali / Bhattacharjee, Ujjal

The journal of physical chemistry. B

2024 Volume 128, Issue 3, Page(s) 849–856

Abstract: In this study, aggregation-induced photon upconversion (iPUC) is demonstrated in the small polyaromatic molecule, pyrene. In binary-solvent mixtures, water, which induces the aggregation of polyaromatic molecules, assisted in triplet-triplet annihilation- ...

Abstract	In this study, aggregation-induced photon upconversion (iPUC) is demonstrated in the small polyaromatic molecule, pyrene. In binary-solvent mixtures, water, which induces the aggregation of polyaromatic molecules, assisted in triplet-triplet annihilation-based upconversion. No upconverted emission was observed in a dry solvent. Although upconverted emission in the absence of a triplet sensitizer was assigned to pyrene-aggregate-induced sensitization, the presence of a triplet sensitizer enhanced the upconversion efficiency. This experimental finding was further simulated to explore the possibility of iPUC in the condensed-phase polymer matrix. We studied 2-aminoethyl methacrylate hydrochloride-polystyrene copolymer nanoparticles embedded with the molecular upconversion system. The nanoparticle iPUC agreed with the proposition that water domains were present in polymer nanoparticles and helped aggregate pyrene in the host polymer. Despite the low systemic upconversion efficiency, this study provides a method for achieving fluorescence upconversion in relatively simple systems.
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c06349
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Article: Characterizations of generalized Robertson-Walker spacetimes concerning gradient solitons.

De, Krishnendu / Khan, Mohammad Nazrul Islam / De, Uday Chand

Heliyon

2024 Volume 10, Issue 4, Page(s) e25702

Abstract: In this article, we examine gradient type Ricci solitons ... ...

Abstract	In this article, we examine gradient type Ricci solitons and
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25702
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Article: Decapeptide Modified Doxorubicin Loaded Solid Lipid Nanoparticles as Targeted Drug Delivery System against Prostate Cancer

De, Kakali

Langmuir. 2021 Nov. 01, v. 37, no. 45

2021

Abstract	Growing instances of prostate cancer with poor prognosis have become a challenging task in cancer therapy. Luteinizing-hormone-releasing-hormone (LHRH) receptors are overexpressed in prostate cancer cells. Polyethylene glycol (PEG) conjugated lipids exhibit superiority in terms of retention/circulation in biological systems. PEGylated dipalmitoylphosphatedylethanolamine (DPPE-PEG), covalently linked with 6-hydrazinopyridine-3-carboxylic-acid, was conjugated with new LHRH-receptor positive peptide analog (DPPE-PEG-HYNIC-d-Glu-His-Trp-Ser-Tyr-d-Asn-Leu-d-Gln-Pro-Gly-NH₂). Surface modified doxorubicin (DOX) loaded solid lipid nanoparticle (SLN) was prepared using soylecithin, stearic acid and Poloxamer-188 by solvent emulsification/evaporation method for targeted delivery of DOX into prostate cancer cells. SLN, DOX loaded SLN (DSLN) and surface modified DSLN (M-DSLN) were characterized by means of their size, zeta potential, morphology, storage time, drug payload, and subsequent release kinetics studies. Homogeneity of surface morphology, upon modification of SLN, was revealed from the dynamic light scattering, atomic force microscopy, and scanning electron microscopic studies. Homogeneous adsolubilization of DOX throughout the hydrophobic moiety of SLN was established by the differential scanning calorimetric studies. Release of DOX were sustained in DSLN and M-DSLN. Cellular uptake and in vitro activities of formulations against LHRH positive PC3/SKBR3 cancer cell lines revealed higher cellular internalization, cytotoxicity that followed the sequence DOX < DSLN < M-DSLN. Dye staining and flow cytometry studies revealed higher apoptosis in cancer cells. Such receptor specific drug delivery systems are considered to have substantial potential in prostate cancer therapy.
Keywords	apoptosis ; atomic force microscopy ; cancer therapy ; chemical bonding ; cytotoxicity ; doxorubicin ; drug delivery systems ; dyes ; emulsifying ; evaporation ; flow cytometry ; hydrophobicity ; moieties ; neoplasm cells ; polyethylene glycol ; prognosis ; prostatic neoplasms ; solvents ; stearic acid ; storage time ; zeta potential
Language	English
Dates of publication	2021-1101
Size	p. 13194-13207.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.1c01370
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Article ; Online: Bridging gaps in the Indian freshwater biodiversity conservation through science-based and policy-backed recommendations

De, Kritish / Dwivedi, Arvind Kumar

European Regional Centre for Ecohydrology of the Polish Academy of Sciences Ecohydrology & Hydrobiology. 2023 July 19,

2023

Abstract: India's freshwater biological resources are threatened by multiple stressors and ongoing conservation efforts are insufficient to tackle these challenges. We therefore propose 14 recommendations to halt India's freshwater biodiversity loss. i) Set up a ... ...

Abstract	India's freshwater biological resources are threatened by multiple stressors and ongoing conservation efforts are insufficient to tackle these challenges. We therefore propose 14 recommendations to halt India's freshwater biodiversity loss. i) Set up a separate ministry on biodiversity to develop and monitor policies. ii) Collection of comprehensive ecological data and sharing with the global scientific community for better assessment. iii) Assessment of data reliability and relevance towards conservation and sustainable management. iv) Integrating terrestrial-freshwater ecosystem management to effectively conserve freshwater biota. v) Implementation of environmental flow regulations for maintaining hydrological connectivity. vi) Augmentation of Protected Areas to protect freshwater biota. vii) Implementation of regulatory frameworks for trade in exotic species to reduce invasiveness. viii) Avoiding fish seed ranching programs in rivers to evade contamination of natural stocks and disease outbreaks from aquaculture. ix) Increasing collaboration between neighboring states and countries on shared freshwater ecosystem for global and regional sustainability. x) Inclusion of compulsory curriculum on biodiversity at different educational stages for developing responsibility towards protecting biodiversity. xi) Building trust among all stakeholders for better management plans through their active participation. xii) Providing alternative livelihood options to improve the socio-economic status of local people to reduce their direct dependency on freshwater ecosystems. xiii) Promotion of citizen science approach on remuneration basis in conserving freshwater biodiversity. xiv) Enabling better use of digital technologies for freshwater biodiversity monitoring. Inclusion of these timely science-based and policy-backed aquatic ecosystems protection guidelines will therefore help to achieve freshwater biodiversity conservation goals successfully in India.
Keywords	aquaculture ; biodiversity ; biodiversity conservation ; citizen science ; curriculum ; ecosystem management ; fish ; freshwater ; freshwater ecosystems ; hydrobiology ; introduced species ; livelihood ; socioeconomic status ; stakeholders ; trade ; wages and remuneration ; India ; Aquatic ecosystems ; Biological resources ; Threats ; Protection guidelines ; Socio-economic developments
Language	English
Dates of publication	2023-0719
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2504067-4
ISSN	2080-3397 ; 1642-3593
ISSN (online)	2080-3397
ISSN	1642-3593
DOI	10.1016/j.ecohyd.2023.06.013
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Article ; Online: Unveiling of climate change-driven decline of suitable habitat for Himalayan bumblebees.

Singh, Amar Paul / De, Kritish / Uniyal, Virendra Prasad / Sathyakumar, Sambandam

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4983

Abstract: Insect pollinators, especially bumblebees are rapidly declining from their natural habitat in the mountain and temperate regions of the world due to climate change and other anthropogenic activities. We still lack reliable information about the current ... ...

Abstract	Insect pollinators, especially bumblebees are rapidly declining from their natural habitat in the mountain and temperate regions of the world due to climate change and other anthropogenic activities. We still lack reliable information about the current and future habitat conditions of bumblebees in the Himalaya. In this study, we used the maximum entropy algorithm for SDM to look at current and future (in 2050 and 2070) suitable habitats for bumblebees in the Himalaya. We found that the habitat conditions in the Himalayan mountain range do not have a very promising future as suitable habitat for most species will decrease over the next 50 years. By 2050, less than 10% of the Himalayan area will remain a suitable habitat for about 72% of species, and by 2070 this number will be raised to 75%. During this time period, the existing suitable habitat of bumblebees will be declined but some species will find new suitable habitat which clearly indicates possibility of habitat range shift by Himalayan bumblebees. Overall, about 15% of the Himalayan region is currently highly suitable for bumblebees, which should be considered as priority areas for the conservation of these pollinators. Since suitable habitats for bumblebees lie between several countries, nations that share international borders in the Himalayan region should have international agreements for comprehensive pollinator diversity conservation to protect these indispensable ecosystem service providers.
MeSH term(s)	Animals ; Bees ; Ecosystem ; Climate Change ; Forecasting ; Himalayas
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52340-9
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Article ; Online: Reef on the edge: resilience failure of marginal patch coral reefs in Eastern Arabian Sea under recurrent coral bleaching, coral diseases, and local stressors

De, Kalyan / Nanajkar, Mandar / Mote, Sambhaji / Ingole, Baban

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 3 p.7288-7302

2023

Abstract: Marked by strong El Niño-Southern Oscillation (ENSO) effects during 2014-2016, global coral reefs underwent mass bleaching. Here, we conducted a comprehensive (2014-2019) study, coinciding with the 2014-16 ENSO, to investigate the response and resilience ...

Abstract	Marked by strong El Niño-Southern Oscillation (ENSO) effects during 2014-2016, global coral reefs underwent mass bleaching. Here, we conducted a comprehensive (2014-2019) study, coinciding with the 2014-16 ENSO, to investigate the response and resilience potential of marginal coral communities to the combined impact of recurrent thermal anomalies and multiple anthropogenic stressors before, during, and after the mass bleaching episodes. Our result unveiled that thermal-stress-driven back-to-back annual coral bleaching episodes caused coral mortality and significantly decimated coral cover, primarily in 2015 and 2016. Subsequent benthic regime shifts toward macroalgal and algal turf colonization, followed by an increase in coral disease prevalence and recruitment failure was observed after the recurrent bleaching episodes. Algal cover increased from 21% in 2014 to 52.90% in 2019, and a subsequent increase in coral disease occurrence was observed from 16% in 2015 to 29% in 2019. The cascading negative effect of multiple stressors magnified coral loss and decreased the coral cover significantly from 45% in 2014 to 20% in 2019. The corals in the intensive recreational diving activity sites showed higher disease prevalence, concurring with high mechanical coral damage. The present study demonstrates that consecutive thermal bleaching episodes combined with local stressors can cause declines in coral cover and promote an undesirable regime shift to algal dominance in marginal coral reef habitats within a short duration. These results are of particular interest given that marginal reefs were traditionally perceived as resilient reef habitats due to their higher survival threshold to environmental changes. The present study indicates that mitigation of local stressors by effective management strategies, in conjunction with globally coordinated efforts to ameliorate climate change, can protect these unique coral reefs.
Keywords	anthropogenic stressors ; climate change ; coral reefs ; corals ; disease occurrence ; disease prevalence ; macroalgae ; mortality ; turf algae ; Arabian Sea
Language	English
Dates of publication	2023-01
Size	p. 7288-7302.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22651-3
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Article ; Online: Cleavable Amphiphilic Biocides with Ester-Bearing Moieties: Aggregation Properties and Antibacterial Activity.

De, Kathakali / Dey, Rajib / Acharya, Yash / Aswal, Vinod Kumar / Haldar, Jayanta

Langmuir : the ACS journal of surfaces and colloids

2024

Abstract: The rise of multidrug-resistant bacterial infections and the dwindling supply of newly approved antibiotics have emerged as a grave threat to public health. Toward the ever-growing necessity of the development of novel antimicrobial agents, herein, we ... ...

Abstract	The rise of multidrug-resistant bacterial infections and the dwindling supply of newly approved antibiotics have emerged as a grave threat to public health. Toward the ever-growing necessity of the development of novel antimicrobial agents, herein, we synthesized a series of cationic amphiphilic biocides featuring two cationic headgroups separated by different hydrophobic spacers, accompanied by the inclusion of two lipophilic tails through cleavable ester functionality. The detailed aggregation properties offered by these biocides were investigated by small-angle neutron scattering (SANS) and conductivity. The critical micellar concentration of the biocides and the size and shape of the micellar aggregates differed with variation of pendant and spacer hydrophobicity. Furthermore, the aggregation number and size of the micelles were found to vary with changing concentration and temperature. These easily synthesized biocides exhibited potent antibacterial properties against various multidrug-resistant bacteria. The optimized biocides with minimum hematotoxicity and potent antibacterial activity against methicillin-resistant
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.3c02771
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Article ; Online: Reef on the edge: resilience failure of marginal patch coral reefs in Eastern Arabian Sea under recurrent coral bleaching, coral diseases, and local stressors.

De, Kalyan / Nanajkar, Mandar / Mote, Sambhaji / Ingole, Baban

Environmental science and pollution research international

2022 Volume 30, Issue 3, Page(s) 7288–7302

Abstract	Marked by strong El Niño-Southern Oscillation (ENSO) effects during 2014-2016, global coral reefs underwent mass bleaching. Here, we conducted a comprehensive (2014-2019) study, coinciding with the 2014-16 ENSO, to investigate the response and resilience potential of marginal coral communities to the combined impact of recurrent thermal anomalies and multiple anthropogenic stressors before, during, and after the mass bleaching episodes. Our result unveiled that thermal-stress-driven back-to-back annual coral bleaching episodes caused coral mortality and significantly decimated coral cover, primarily in 2015 and 2016. Subsequent benthic regime shifts toward macroalgal and algal turf colonization, followed by an increase in coral disease prevalence and recruitment failure was observed after the recurrent bleaching episodes. Algal cover increased from 21% in 2014 to 52.90% in 2019, and a subsequent increase in coral disease occurrence was observed from 16% in 2015 to 29% in 2019. The cascading negative effect of multiple stressors magnified coral loss and decreased the coral cover significantly from 45% in 2014 to 20% in 2019. The corals in the intensive recreational diving activity sites showed higher disease prevalence, concurring with high mechanical coral damage. The present study demonstrates that consecutive thermal bleaching episodes combined with local stressors can cause declines in coral cover and promote an undesirable regime shift to algal dominance in marginal coral reef habitats within a short duration. These results are of particular interest given that marginal reefs were traditionally perceived as resilient reef habitats due to their higher survival threshold to environmental changes. The present study indicates that mitigation of local stressors by effective management strategies, in conjunction with globally coordinated efforts to ameliorate climate change, can protect these unique coral reefs.
MeSH term(s)	Animals ; Coral Reefs ; Anthozoa/physiology ; Coral Bleaching ; Ecosystem ; Climate Change
Language	English
Publishing date	2022-08-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22651-3
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Article: The Impact of Senior Mobility Funding on Hearing Aid Acquisition and Compliance to Hearing Aid Use in a Singapore Hospital.

Chua Wei De, Kenneth

Journal of audiology & otology

2020 Volume 25, Issue 1, Page(s) 8–13

Abstract: Background and objectives: In 2013, the Singapore government reviewed and expanded the Senior Mobility Fund (SMF) to provide subsidy for assistive devices, including hearing aids (HA). While SMF has improved accessibility to HA, its impact on HA ... ...

Abstract	Background and objectives: In 2013, the Singapore government reviewed and expanded the Senior Mobility Fund (SMF) to provide subsidy for assistive devices, including hearing aids (HA). While SMF has improved accessibility to HA, its impact on HA acquisition has not been determined. The study aims to elucidate the influence of SMF on HA acquisition and the relationship between financial funding and compliance to HA use. Subjects and methods: Retrospective review of 643 patients seen between January 2017 to January 2018 at the earnose and throat specialist outpatient clinic, who were referred for a hearing aid evaluation. Of the 643 patients, 109 patients with baseline hearing handicap (HH) scores recorded, and no formal diagnosis of cognitive impairment were included. The patients were grouped according to SMF eligibility and clinical data were obtained. Results: The odds ratio for acquiring HA was significantly higher with SMF, regardless of HH scores. When looking at actual degree of hearing loss (DHL), HA uptake was significantly higher in the least severe of DHL categories. There is no relationship between SMF and compliance to HA use. However, HH score is positively correlated with data log in regression analyses. Conclusions: SMF appears to influence HA acquisition. Especially in financially funded patients with low self-perceived HH, the benefits of HA may be underappreciated given the few hours of HA use. Further studies are warranted to investigate the impact of financial funding on outcomes of HA users to help policy planners and clinicians be prudent in the utilization of SMF.
Language	English
Publishing date	2020-11-16
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3018961-5
ISSN	2384-1710 ; 2384-1621
ISSN (online)	2384-1710
ISSN	2384-1621
DOI	10.7874/jao.2020.00213
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