Article ; Online: Tumor Tissue Oxidative Stress Changes and Na, K-ATPase Evaluation in Head and Neck Squamous Cell Carcinoma.
The Journal of membrane biology
2021 Volume 254, Issue 5-6, Page(s) 475–486
Abstract: Changes in metabolism are mechanisms that are largely implicated in the development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC) and also in resistance to different anticancer therapies. Identification of biomarkers for ... ...
| Abstract | Changes in metabolism are mechanisms that are largely implicated in the development, progression, and metastasis of head and neck squamous cell carcinoma (HNSCC) and also in resistance to different anticancer therapies. Identification of biomarkers for differentiation between cancerous and normal epithelium, treatment design and prognosis remain a vital issue in the field of head and neck cancer. The present study analyzed the main biochemical changes that occur in HNSCC tumors by through mechanisms involving oxidative stress. The release of substances reactive to thiobarbituric acid was significantly lower in HNSCC tumor tissue as compared to healthy tissue. The assays related to the lipid profile assays showed changes in membrane biophysics of tumor cells due to an increase in total phospholipids and total cholesterol, as well as an increased activity and expression of the α1 subunit of Na, K-ATPase, which is fundamental in the process of carcinogenesis. The modulation of the antioxidant system was also affected, with a decrease in the catalytic activity of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), as well as a reduction of glutathione (GSH) content and an increase in H |
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| MeSH term(s) | Adenosine Triphosphatases ; Head and Neck Neoplasms ; Humans ; Hydrogen Peroxide ; Oxidative Stress ; Squamous Cell Carcinoma of Head and Neck | |||||
| Chemical Substances | Hydrogen Peroxide (BBX060AN9V) ; Adenosine Triphosphatases (EC 3.6.1.-) | |||||
| Language | English | |||||
| Publishing date | 2021-06-08 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 3082-x | |||||
| ISSN | 1432-1424 ; 0022-2631 | |||||
| ISSN (online) | 1432-1424 | |||||
| ISSN | 0022-2631 | |||||
| DOI | 10.1007/s00232-021-00185-y | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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