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  1. Article ; Online: Expanding Role of Contrast-Enhanced Ultrasound in Guidance and Monitoring of Percutaneous Thermal Ablation.

    De Angelis, Chiara / Mauri, Giovanni

    Ultrasound in medicine & biology

    2016  Volume 42, Issue 12, Page(s) 3051–3052

    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Letter
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2015.10.026
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    Zs.A 963: Show issues Location:
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  2. Article: Laser thermal ablation to treat a recurrent soft-tissue sarcoma of the leg: a case report.

    De Angelis, Chiara / Vigna, Paolo Della / Varano, Gianluca Maria / Mauri, Giovanni

    Ecancermedicalscience

    2019  Volume 13, Page(s) 908

    Abstract: We present the case of a 52-year-old male patient with recurrence of a soft-tissue sarcoma of the left leg treated with percutaneous laser ablation. The patient received the diagnosis of sarcoma for the first time in 2011; further local recurrences and a ...

    Abstract We present the case of a 52-year-old male patient with recurrence of a soft-tissue sarcoma of the left leg treated with percutaneous laser ablation. The patient received the diagnosis of sarcoma for the first time in 2011; further local recurrences and a pulmonary metastatic spread occurred during follow-up, so the patient has been treated several times with chemotherapy, limb-sparing surgery and radiotherapy. In September 2017, a new local recurrence of sarcoma occurred, for which limb amputation was proposed but refused by the patient. Laser ablation with ultrasound guidance was performed, with complete ablation at 6 months and limb salvage.
    Language English
    Publishing date 2019-03-05
    Publishing country England
    Document type Case Reports
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2019.908
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  3. Article ; Online: Nutritional approach to preterm infants on noninvasive ventilation: An update.

    Bozzetti, Valentina / De Angelis, Chiara / Tagliabue, Paolo E

    Nutrition (Burbank, Los Angeles County, Calif.)

    2017  Volume 37, Page(s) 14–17

    Abstract: Nutrition and pulmonary function in very-low-birth-weight infants (VLBWIs) are strictly related. Preterm infants on noninvasive ventilation may have respiratory instability that can interfere with feeding tolerance. Moreover, feeding may impair pulmonary ...

    Abstract Nutrition and pulmonary function in very-low-birth-weight infants (VLBWIs) are strictly related. Preterm infants on noninvasive ventilation may have respiratory instability that can interfere with feeding tolerance. Moreover, feeding may impair pulmonary function. These infants have nutritional requirements different from nonventilated infants. The main challenge of the nutritional support in such patients is to guarantee adequate caloric intake while avoiding episodes of feeding intolerance. The aim of this study was to review the issues and strategies of enteral feeding of preterm infants on noninvasive ventilation.
    MeSH term(s) Databases, Factual ; Enteral Nutrition ; Gastric Emptying/physiology ; Humans ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Infant, Premature ; Infant, Very Low Birth Weight ; Meta-Analysis as Topic ; Noninvasive Ventilation ; Nutritional Requirements ; Nutritional Support ; Splanchnic Circulation/physiology
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2016.12.010
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  4. Article ; Online: Efficacy of Preoperative Administration of Paracetamol-Codeine on Pain following Impacted Mandibular Third Molar Surgery: A Randomized, Split-Mouth, Placebo-Controlled, Double-Blind Clinical Trial.

    Cristalli, Maria Paola / La Monaca, Gerardo / De Angelis, Chiara / Pranno, Nicola / Annibali, Susanna

    Pain research & management

    2017  Volume 2017, Page(s) 9246352

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041085-2
    ISSN 1918-1523 ; 1203-6765
    ISSN (online) 1918-1523
    ISSN 1203-6765
    DOI 10.1155/2017/9246352
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    Zs.A 5498: Show issues Location:
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  5. Article ; Online: Urgent need to apply a common language in image-guided thermal ablations.

    Mauri, Giovanni / Pisani Mainini, Anna / Monaco, Cristian / Pescatori, Lorenzo Carlo / De Angelis, Chiara / Sconfienza, Luca Maria

    Journal of ultrasound

    2018  Volume 21, Issue 1, Page(s) 77–78

    MeSH term(s) Humans ; Language ; Magnetic Resonance Imaging ; Thyroid Nodule
    Language English
    Publishing date 2018-01-08
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-017-0278-x
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  6. Article ; Online: A computer-aided diagnosis system for the assessment and characterization of low-to-high suspicion thyroid nodules on ultrasound.

    Gitto, Salvatore / Grassi, Giorgia / De Angelis, Chiara / Monaco, Cristian Giuseppe / Sdao, Silvana / Sardanelli, Francesco / Sconfienza, Luca Maria / Mauri, Giovanni

    La Radiologia medica

    2018  Volume 124, Issue 2, Page(s) 118–125

    Abstract: Aim of the study: To compare the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system for thyroid ultrasound (US) with that of a non-computer-aided radiologist in the characterization of low-to-high suspicion thyroid ... ...

    Abstract Aim of the study: To compare the diagnostic performance of a commercially available computer-aided diagnosis (CAD) system for thyroid ultrasound (US) with that of a non-computer-aided radiologist in the characterization of low-to-high suspicion thyroid nodules.
    Methods: This retrospective study included a consecutive series of adult patients referred for US-guided fine-needle aspiration biopsy (FNAB) of a thyroid nodule. All patients were eligible for thyroid nodule FNAB according to the current international guidelines. An interventional radiologist experienced in thyroid imaging acquired the US images subsequently used for post-processing, performed FNAB and provided the US features of each nodule. A radiology resident and an endocrinology resident in consensus performed post-processing using the CAD system to assess the same nodule characteristics. The diagnostic performance and agreement of US features between the CAD system and the radiologist were compared.
    Results: Sixty-two patients (50 F; age 60 ± 12 years) were enrolled: 77.4% (48/62) of thyroid nodules were benign, 22.6% (14/62) were undetermined to malignant and required follow-up or surgery. Interobserver agreement between the CAD system and the radiologist was substantial for orientation (K = 0.69), fair for composition (K = 0.36), echogenicity (K = 0.36), K-TIRADS (K = 0.29), and slight for margins (K = 0.03). The radiologist demonstrated a significantly higher sensitivity than the CAD system (78.6% vs. 21.4%; P = 0.008), while there was no statistical difference in specificity (66.7% vs. 81.3%; P = 0.065).
    Conclusion: This CAD system is less sensitive than an experienced radiologist and showed slight-to-substantial agreement with the radiologist for the characterization of thyroid nodules. Although it is an innovative tool with good potential, additional efforts are needed to improve its diagnostic performance.
    MeSH term(s) Diagnosis, Computer-Assisted ; Diagnosis, Differential ; Female ; Humans ; Image-Guided Biopsy ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology ; Ultrasonography/methods
    Language English
    Publishing date 2018-09-22
    Publishing country Italy
    Document type Comparative Study ; Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-018-0942-z
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  7. Article ; Online: Carbon dioxide (CO

    De Angelis, Chiara / Sardanelli, Francesco / Perego, Matteo / Alì, Marco / Casilli, Francesco / Inglese, Luigi / Mauri, Giovanni

    The international journal of cardiovascular imaging

    2017  Volume 33, Issue 11, Page(s) 1655–1662

    Abstract: To assess feasibility, efficacy and safety of carbon dioxide ( ... ...

    Abstract To assess feasibility, efficacy and safety of carbon dioxide (CO
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2055311-0
    ISSN 1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
    ISSN (online) 1875-8312 ; 1573-0743
    ISSN 1569-5794 ; 0167-9899
    DOI 10.1007/s10554-017-1175-2
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    Zs.A 2104: Show issues Location:
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  8. Article ; Online: Image-guided thermal ablation of benign thyroid nodules.

    Mainini, Anna Pisani / Monaco, Cristian / Pescatori, Lorenzo Carlo / De Angelis, Chiara / Sardanelli, Francesco / Sconfienza, Luca Maria / Mauri, Giovanni

    Journal of ultrasound

    2016  Volume 20, Issue 1, Page(s) 11–22

    Abstract: Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become ... ...

    Abstract Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become symptomatic, surgical excision is still considered standard treatment. In the last few years, several experiences in the treatment of benign thyroid nodules through image-guided percutaneous thermal ablation have been reported with encouraging results, so that currently, these treatments are often proposed as first-choice options for patients with symptomatic benign thyroid nodules. In this paper, we discuss the present literature on the topic, focusing on different techniques available for image-guided percutaneous ablation, particularly radiofrequency (RFA), laser (LA), microwave (MWA), and high-intensity-focus ultrasound (HIFU). Little evidence about the efficacy of MWA and HIFU is now available. According to the literature, good results have been obtained with RFA and LA. Regarding RFA, volume reduction after ablative treatment has been found to range from 47 to 84 % at 3-6 months, and from 62 to 93 % at 1 year; LA also seems to be effective in achieving shrinkage of thyroid nodules, with volume reduction from 37 to 81 % at 3-6 months, and from 13 to 82 % at 1-year follow-up. Moreover, applications of advanced image-guidance modality, such as contrast-enhanced ultrasound and virtual navigation with fusion imaging, are discussed.
    MeSH term(s) Ablation Techniques/adverse effects ; Ablation Techniques/instrumentation ; Ablation Techniques/methods ; Humans ; Surgery, Computer-Assisted/adverse effects ; Surgery, Computer-Assisted/instrumentation ; Surgery, Computer-Assisted/methods ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/surgery
    Language English
    Publishing date 2016-10-21
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-016-0221-6
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  9. Article ; Online: Proteome profile and biological activity of caprine, bovine and human milk fat globules.

    Spertino, Stefano / Cipriani, Valentina / De Angelis, Chiara / Giuffrida, Maria Gabriella / Marsano, Francesco / Cavaletto, Maria

    Molecular bioSystems

    2012  Volume 8, Issue 4, Page(s) 967–974

    Abstract: Upon combining bidimensional electrophoresis with monodimensional separation, a more comprehensive analysis of the milk fat globule membrane has been obtained. The proteomic profile of caprine milk fat globules revealed the presence of butyrophilin, ... ...

    Abstract Upon combining bidimensional electrophoresis with monodimensional separation, a more comprehensive analysis of the milk fat globule membrane has been obtained. The proteomic profile of caprine milk fat globules revealed the presence of butyrophilin, lactadherin and perilipin as the major proteins, they were also associated to bovine and human milk fat globule membranes. Xanthine dehydrogenase/oxidase has been detected only in monodimensional gels. Biological activity of milk fat globules has been evaluated in Caco2-cells, as a representative model of the intestinal barrier. The increase of cell viability was indicative of a potential nutraceutical role for the whole milk fat globule, suggesting a possible employment in milk formula preparation.
    MeSH term(s) Animals ; Butyrophilins ; Caco-2 Cells ; Cattle ; Cell Survival ; Dietary Supplements ; Glycolipids/chemistry ; Glycoproteins/chemistry ; Goats ; Humans ; Membrane Glycoproteins/analysis ; Membrane Proteins/analysis ; Milk/chemistry ; Milk Proteins/analysis ; Milk, Human/chemistry ; Proteome/chemistry ; Proteomics/methods ; Xanthine Dehydrogenase/analysis ; Xanthine Oxidase/analysis
    Chemical Substances Butyrophilins ; Glycolipids ; Glycoproteins ; Membrane Glycoproteins ; Membrane Proteins ; Milk Proteins ; Proteome ; milk fat globule ; Xanthine Dehydrogenase (EC 1.17.1.4) ; Xanthine Oxidase (EC 1.17.3.2)
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2188635-0
    ISSN 1742-2051 ; 1742-206X
    ISSN (online) 1742-2051
    ISSN 1742-206X
    DOI 10.1039/c2mb05400k
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  10. Article ; Online: Predictive factors of relapse and survival in childhood acute myeloid leukemia: role of minimal residual disease.

    Rizzari, Carmelo / Cazzaniga, Giovanni / Coliva, Tiziana / De Angelis, Chiara / Conter, Valentino

    Expert review of anticancer therapy

    2011  Volume 11, Issue 9, Page(s) 1391–1401

    Abstract: Minimal residual disease (MRD) in acute myeloid leukemia (AML) can be measured either by flow cytometry to detect leukemic immunophenotypes or by PCR amplification of fusion transcripts, gene mutations and overexpressed genes. Flow cytometry MRD is ... ...

    Abstract Minimal residual disease (MRD) in acute myeloid leukemia (AML) can be measured either by flow cytometry to detect leukemic immunophenotypes or by PCR amplification of fusion transcripts, gene mutations and overexpressed genes. Flow cytometry MRD is widely applicable but has an intermediate sensitivity; PCR MRD is highly sensitive but has a restricted applicability. MRD, measured at different time points throughout AML treatment, has proven to powerfully predict the risk of relapse. Acute promyelocytic leukemia, a subtype of AML, represents an excellent example of systematic evaluation and established clinical application of MRD performed by PCR. However, a standardization of MRD techniques, threshold levels, time-points and clinical interventions based on its results is still needed in this field. This article is focused on the current available information on MRD as a prognostic marker in childhood AML.
    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Neoplasm, Residual/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Prognosis ; Recurrence
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1586/era.11.37
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