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Article ; Online: Step-by-step illustrated guide to central neck dissection.

Chu, F / De Berardinis, R / Pietrobon, G / Tagliabue, M / Giugliano, G / Ansarin, M

2021 , Page(s) 1–6

Abstract: Background: The incidence of thyroid carcinoma has been increasing worldwide and surgery is the primary treatment. Central compartment dissection of the neck is a very delicate procedure given the risks of recurrent laryngeal nerve injury and ... ...

Abstract	Background: The incidence of thyroid carcinoma has been increasing worldwide and surgery is the primary treatment. Central compartment dissection of the neck is a very delicate procedure given the risks of recurrent laryngeal nerve injury and hypoparathyroidism. Methods: This paper gives a detailed description of this surgical technique in a patient affected by papillary carcinoma of the thyroid gland, supported by highly representative iconographic materials from a tertiary department. Results: A stepwise description is provided, along with high-quality pictures and specific tips and tricks. Although neck dissection is a well-codified procedure, the fine details of this surgical technique are not currently available and are still the prerogative of the expert surgeon. Conclusion: The central neck compartment contains several vulnerable structures; damage to these structures would affect patients' lives, possibly permanently. Anatomical knowledge and standardisation are needed for all surgeons, particularly new surgeons (such as residents) who cannot rely simply on experience.
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S002221512100270X
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Article ; Online: FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.

Dai, Wenting / Wang, Zhichao / Wang, Guan / Wang, Qiong A / DeBerardinis, Ralph / Jiang, Lei

Cell reports

2023 Volume 42, Issue 8, Page(s) 112971

Abstract: Fatty acid synthase (FASN) maintains de novo lipogenesis (DNL) to support rapid growth in most proliferating cancer cells. Lipogenic acetyl-coenzyme A (CoA) is primarily produced from carbohydrates but can arise from glutamine-dependent reductive ... ...

Abstract	Fatty acid synthase (FASN) maintains de novo lipogenesis (DNL) to support rapid growth in most proliferating cancer cells. Lipogenic acetyl-coenzyme A (CoA) is primarily produced from carbohydrates but can arise from glutamine-dependent reductive carboxylation. Here, we show that reductive carboxylation also occurs in the absence of DNL. In FASN-deficient cells, reductive carboxylation is mainly catalyzed by isocitrate dehydrogenase-1 (IDH1), but IDH1-generated cytosolic citrate is not utilized for supplying DNL. Metabolic flux analysis (MFA) shows that FASN deficiency induces a net cytosol-to-mitochondria citrate flux through mitochondrial citrate transport protein (CTP). Previously, a similar pathway has been shown to mitigate detachment-induced oxidative stress in anchorage-independent tumor spheroids. We further report that tumor spheroids show reduced FASN activity and that FASN-deficient cells acquire resistance to oxidative stress in a CTP- and IDH1-dependent manner. Collectively, these data indicate that by inducing a cytosol-to-mitochondria citrate flux, anchorage-independent malignant cells can gain redox capacity by trading off FASN-supported rapid growth.
MeSH term(s)	Citric Acid/metabolism ; Cytosol/metabolism ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Cell Line, Tumor ; Citrates/metabolism ; Oxidative Stress ; Nitric Oxide Synthase/metabolism ; Fatty Acid Synthases/metabolism ; Mitochondria/metabolism ; Lipogenesis
Chemical Substances	Citric Acid (2968PHW8QP) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; Citrates ; Nitric Oxide Synthase (EC 1.14.13.39) ; Fatty Acid Synthases (EC 2.3.1.85)
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112971
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Article: FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.

Dai, Wenting / Wang, Zhichao / Wang, Guan / Wang, Qiong A / DeBerardinis, Ralph / Jiang, Lei

bioRxiv : the preprint server for biology

2023

Abstract: Fatty acid synthase (FASN) ... ...

Abstract	Fatty acid synthase (FASN) maintains
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.14.532533
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Article ; Online: Unlocking tracheoesophageal speech from pharyngoesophageal spasm: preliminary results of a videofluoroscopic-guided botulinum toxin A injection technique.

Bandi, Francesco / Chu, Francesco / Zurlo, Valeria / Di Natale, Valentina / Zorzi, Stefano / Pietrobon, Giacomo / De Berardinis, Rita / Tagliabue, Marta / Ansarin, Mohssen

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2024 Volume 281, Issue 4, Page(s) 1885–1893

Abstract: Purpose: The tracheoesophageal puncture for the voice prosthesis (VP) placement is the recognized gold standard in post-laryngectomy voice rehabilitation. Despite the development of specific intraoperative techniques, a subset of patients will suffer ... ...

Abstract	Purpose: The tracheoesophageal puncture for the voice prosthesis (VP) placement is the recognized gold standard in post-laryngectomy voice rehabilitation. Despite the development of specific intraoperative techniques, a subset of patients will suffer from poor functional outcomes due to pharyngoesophageal spasms (PES). This paper evaluates the functional outcomes after transcutaneous botulinum toxin type A (BTX-A) infiltration for PES with a videofluoroscopy-guided technique. Methods: Since 2022, eight consecutive patients with VP and affected by PES were treated with BTX-A injection by a standard videofluoroscopic guided technique at the European Institute of Oncology, IRCCS (IEO) in Milan. A lidocaine test was performed pre-operatively to evaluate the potential effect of chemical neurectomy. All patients with positive lidocaine tests were injected with 50 IU of BTX-A (Allergan, Irvine, CA) according to the sites marked during the videofluoroscopy. Reported symptoms (VHI, SECEL), perceptual (INFVo), aerodynamic (MPT) and manometric parameters were collected before and after treatment. Results: In all cases, BTX-A was performed as an outpatient procedure without complications. For seven patients, only one BTX-A injection was needed, while one patient required a re-injection. Subjective and perceptive improvement after BTX-A was significant for VHI, SECEL and INFVo. MPT showed significant improvement after a chemical neurectomy. After a mean follow-up of 6 months, all patients maintained a good TES quality. Conclusion: The videofluoroscopic guided BTX-A injection of the pharyngoesophageal tract showed to be a feasible and reproducible technique in all cases. The pharyngoesophageal videofluoroscopy allows defining of patients' anatomical landmarks that help the surgeon to perform a homogeneous injection, empowered by post-injection massage.
MeSH term(s)	Humans ; Botulinum Toxins, Type A ; Speech ; Laryngectomy/adverse effects ; Speech, Esophageal ; Spasm/etiology ; Lidocaine ; Treatment Outcome
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69) ; Lidocaine (98PI200987)
Language	English
Publishing date	2024-01-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-024-08448-9
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Article: A Lung Cancer Mouse Model Database.

Cai, Ling / Gao, Ying / DeBerardinis, Ralph / Chen, Ting / Winslow, Monte / Xiao, Guanghua / Rudin, Charles / Oliver, Trudy / Minna, John / Xie, Yang

bioRxiv : the preprint server for biology

2024

Abstract: Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to ... ...

Abstract	Lung cancer, the leading cause of cancer mortality, exhibits diverse histological subtypes and genetic complexities. Numerous preclinical models have been developed to study lung cancer, but data from these models are disparate, siloed, and difficult to compare in a centralized fashion. Here we established the Lung Cancer Mouse Model Database (LCMMDB), an extensive repository of 1,354 samples from 77 transcriptomic datasets. Meticulous curation and collaboration with data depositors have produced a robust and comprehensive database, enhancing the fidelity of the genetic landscape it depicts. The LCMMDB aligns 859 tumors from genetically engineered mouse models (GEMMs) with human lung cancer mutations, enabling comparative analysis and revealing a pressing need to broaden the diversity of genetic aberrations modeled in GEMMs. Accompanying this resource, we developed a web application that offers researchers intuitive tools for in-depth gene expression analysis and fostering potential collaborations. With standardized reprocessing of gene expression data, the LCMMDB serves as a powerful platform for cross-study comparison and lays the groundwork for future research, aiming to bridge the gap between mouse models and human lung cancer for improved translational relevance.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.28.582577
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Article ; Online: Nose sinus manometry in evaluating functional outcomes of anterior and posterior endoscopic dacryocystorhinostomy.

Bruno, Ernesto / Roselli, Lucrezia / Porozaj, Dea / De Berardinis, Rita / Gamerra, Mario

Acta otorrinolaringologica espanola

2021 Volume 72, Issue 4, Page(s) 212–217

Abstract: Objective: The aim of this study is to evaluate the effectiveness of anterior and posterior dacryorhinocystostomy (En-Dcr) by assessing the surgical outcome with a new objective technique, nose sinus manometry.: Materials and methods: Thirty adult ... ...

Abstract	Objective: The aim of this study is to evaluate the effectiveness of anterior and posterior dacryorhinocystostomy (En-Dcr) by assessing the surgical outcome with a new objective technique, nose sinus manometry. Materials and methods: Thirty adult patients presenting nasolacrimal duct obstruction were enrolled in this study and randomly divided in two groups. In group A patients underwent anterior endonasal dacryorhinocystostomy, group B underwent the posterior approach. All patients were evaluated through Nose Sinus Manometry, endoscopic dye disappearance functional test (EDFT) and subjective assessment three months post-op. Pearson test and T-student Test were used for evaluations. Results: The mean differences in the pressure values were significantly different in the two groups of treatment, therefore, the patients of group B had strong improvement in pressure values compared with patients of group A. Conclusion: This study confirms a relevant physical distinction between posterior En-Dcr outcomes compared to anterior En-Dcr and reveals a significant success rate difference between the two groups of patients. The posterior surgical technique shows better results than the anterior one, by providing an almost physiological post- operative endonasal outcome. These results also showed the effectiveness of Nose Sinus Manometry in assessing the post- operative outcomes after En-Dcr.
MeSH term(s)	Adult ; Dacryocystorhinostomy ; Endoscopy ; Humans ; Lacrimal Duct Obstruction ; Manometry ; Nasolacrimal Duct
Language	English
Publishing date	2021-07-22
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5735
ISSN (online)	2173-5735
DOI	10.1016/j.otoeng.2021.06.001
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Article ; Online: COVID-19 and head and neck cancer management. Experience of an oncological hub comprehensive cancer centre and literature review.

Chu, Francesco / Zocchi, Jacopo / De Berardinis, Rita / Bandi, Francesco / Pietrobon, Giacomo / Scaglione, Donatella / Radice, Davide / Tagliabue, Marta / Ansarin, Mohssen

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2022 Volume 42, Issue Suppl. 1, Page(s) S79–S86

MeSH term(s)	COVID-19 ; Head and Neck Neoplasms/therapy ; Humans
Language	English
Publishing date	2022-06-28
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-suppl.1-42-2022-09
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Article ; Online: The hump columellar strut: a reliable technique for correction of nasal tip underprojection.

Giacomini, P G / Mocella, S / Di Girolamo, S / De Berardinis, R / Boccieri, A

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2017 Volume 38, Issue 1, Page(s) 45–50

Abstract: Nasal tip under projection is often found in rhinoplasty cases both for congenital or post-traumatic deformity. Nasal trauma may result in alteration of the external and internal nasal structures with following aesthetic impairment and difficulties in ... ...

Abstract	Nasal tip under projection is often found in rhinoplasty cases both for congenital or post-traumatic deformity. Nasal trauma may result in alteration of the external and internal nasal structures with following aesthetic impairment and difficulties in breathing. Post-traumatic surgery is frequent, but restoration of pre-traumatic form and function remains a challenge. The present paper describes a new method to increase tip projection by a columellar strut harvested from the autologous nasal bone and cartilage of the resected hump. A total of 15 cases (11 women/4 men, mean age 32.6 ± 12.3 years) of major tip projection/misalignment abnormalities to be corrected by increased nasal tip projection were drawn, and all underwent closed or open rhinoplasty with the placement of a bony columellar strut harvested from the resected hump of the patient. Short and long-term advantages of this procedure are to be underlined. Harvesting is routinely performed during dorsal resection and preparation of the graft is easy. Differently from bone of the vomer or the inferior turbinate, this is cortical bone straight in shape and rigid in framework, and therefore ideal to gain reliable tip support overtime. No additional harvesting areas are needed. Placement of this bony strut is carried out in the standard fashion without additional dissection or further procedures. Long-term follow-up shows maintained projection over time. This graft can be combined with various grafting or suturing techniques usually applied according to each surgeon's experience and the needs of each patient.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Nasal Bone/transplantation ; Nasal Cartilages/transplantation ; Nose/abnormalities ; Nose/surgery ; Nose Deformities, Acquired/surgery ; Retrospective Studies ; Rhinoplasty/methods
Language	English
Publishing date	2017-05-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-1182
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Article ; Online: Benzene-Exposed Army Soldiers: Nasal Cytology as a Screening Tool.

Bruno, Ernesto / De Berardinis, Rita / di Folco, Francesco / Russo, Carmelo / Tatangelo, Pietro

Journal of occupational and environmental medicine

2020 Volume 63, Issue 2, Page(s) e92–e97

Abstract: Objective: Assessment of the nasal cytology in revealing early nasal mucosa alteration of workers exposed to benzene.: Methods: Nasal cytology was compared among non-exposed and exposed workers to benzene. A comparison of the two groups was performed ...

Abstract	Objective: Assessment of the nasal cytology in revealing early nasal mucosa alteration of workers exposed to benzene. Methods: Nasal cytology was compared among non-exposed and exposed workers to benzene. A comparison of the two groups was performed considering rhino-cytological features. Results: In the exposed group neutrophils count range was 14 to 70, compared to 2 to 5 in control group. Ciliated cells ratio range was respectively 0.28 to 2.8 and 0.25 to 0.31. In subjects exposed to benzene >10 years, nasal mucosa showed an inflammatory status and an ongoing mucipar metaplasia, defined by an alteration of mucipar/ciliated cells ratio. Conclusions: Nasal cytology may be a useful research tool for the health surveillance of workers exposed to benzene and may be applied to study the effects of other upper airways chemicals irritants.
MeSH term(s)	Benzene/toxicity ; Humans ; Mass Screening ; Military Personnel ; Nasal Mucosa ; Neutrophils
Chemical Substances	Benzene (J64922108F)
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000002106
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Article ; Online: COVID alias challenge to onco-rehabilitation and to viable indications and decisions: Cues from an Italian COVID+ oral cancer patient.

Pietrobon, Giacomo / Tagliabue, Marta / Chu, Francesco / De Berardinis, Rita / Ansarin, Mohssen

Oral oncology

2020 Volume 105, Page(s) 104745

MeSH term(s)	Betacoronavirus ; COVID-19 ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/virology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Humans ; Italy ; Male ; Middle Aged ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/virology ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-24
Publishing country	England
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2020.104745
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