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Article ; Online: Non-invasive cumulus cell analysis can be applied for oocyte ranking and is useful for countries with legal restrictions on embryo generation or freezing.

Adriaenssens, Tom / Van Vaerenbergh, Inge / Van Landuyt, Lisbet / Verheyen, Greta / De Brucker, Michaël / Camus, Michel / Platteau, Peter / De Vos, Michel / Reis, Maria / Van Hecke, Elien / Rosenthal, André / Smitz, Johan

PloS one

2024 Volume 19, Issue 1, Page(s) e0297040

Abstract: Research question: Can a strategy for scoring oocyte quality, based on cumulus cell (CC) gene expression, prioritize oocytes with the highest implantation potential, while limiting the number of embryos to be processed in culture and the number of ... ...

Abstract	Research question: Can a strategy for scoring oocyte quality, based on cumulus cell (CC) gene expression, prioritize oocytes with the highest implantation potential, while limiting the number of embryos to be processed in culture and the number of supernumerary embryos to be vitrified? Design: An interventional, blinded, prospective cohort study was retrospectively analyzed. In the original study, patients underwent a fresh Day3 single embryo transfer with embryos ranked based on morphology and CC gene expression (Aurora Test). The additional ranking of the embryos with the Aurora Test resulted in significant higher clinical pregnancy and live birth rates. Now it is investigated if the Aurora Test ranking could be applied to select oocytes. The effect of an Aurora Test based restriction to 2 and 3 2PN or MII oocytes on clinical pregnancy and other outcomes, was analyzed in two subsets of patients with all 2PN (n = 83) or all MII oocytes (n = 45) ranked. Results: Considering only the top three ranked 2PN oocytes, 95% of the patients would have received a fresh SET on Day3 resulting in 65% clinical pregnancies. This was not different from the pregnancy rate obtained in a strategy using all oocytes but significantly reduced the need for vitrification of supernumerary embryos by 3-fold. Considering only top-ranked MII oocytes gave similar results. Conclusions: In countries with legal restrictions on freezing of embryos, gene expression of CC can be used for the selective processing of oocytes and would thus decrease the twin pregnancy rate and workload, especially for embryo morphology scoring and transfers as the handling and processing of lower competence oocytes is prevented, while improving the ART outcome.
MeSH term(s)	Pregnancy ; Female ; Humans ; Freezing ; Retrospective Studies ; Prospective Studies ; Embryo Transfer ; Cumulus Cells/metabolism ; Oocytes/metabolism ; Pregnancy Rate ; Vitrification ; Cryopreservation/methods
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297040
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Article ; Online: Continuous ropivacaine subfascial wound infusion after cesarean delivery in pain management: A prospective randomized controlled double-blind study.

Rosetti, Jérôme / Francotte, Jacques / Noel, Emmanuel / Drakopoulos, Panagiotis / Rabbachin, Nelson / de Brucker, Michael

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2021 Volume 154, Issue 1, Page(s) 79–84

Abstract: Objective: The aim of this study is to analyze post-cesarean morphine consumption using continuous ropivacaine subfascial wound infusion.: Methods: After standardized spinal anesthesia (0.5% hyperbaric bupivacaine 8-10 mg combined with sufentanil 2-2. ...

Abstract	Objective: The aim of this study is to analyze post-cesarean morphine consumption using continuous ropivacaine subfascial wound infusion. Methods: After standardized spinal anesthesia (0.5% hyperbaric bupivacaine 8-10 mg combined with sufentanil 2-2.5 μg), women undergoing cesarean section (n = 69) were randomly allocated to receive either ropivacaine 0.2% (n = 35) or NaCl 0.9% (n = 34) infused through a subfascial wound catheter during 48 h in a multimodal analgesic approach. As primary outcome, opioid use by intravenous patient-controlled analgesia was analyzed. Secondary outcomes were intensity of pain on visual analog scale at rest and at mobilization, postoperative nausea/vomiting, pruritus and time of first ambulation. Independent t test or Mann-Whitney U test, and Pearson's χ Results: Morphine consumption was significantly lower in the ropivacaine group (21.52 ± 21.56 mg) compared with the placebo group (29.57 ± 22.38 mg; 95% confidence interval -18.8 to 2.76; p = 0.047). No significant differences were observed in pain evaluated by visual analog scale, except for pain at mobilization 6 h after surgery (ropivacaine versus placebo: 3.90 ± 2.66 versus 5.36 ± 2.55; p = 0.030). No significant differences were observed in the incidence of postoperative nausea/vomiting, pruritus, and time of first ambulation. Conclusion: Continuous ropivacaine subfascial wound infusion results in less post-cesarean morphine consumption. EudraCT trail registration number: 2017-004797-33. EudraCT link: https://www.clinicaltrialsregister.eu/ctr-search/trial/2017-004797-33/BE#A.
MeSH term(s)	Adult ; Analgesia, Patient-Controlled/methods ; Analgesics, Opioid/administration & dosage ; Anesthesia, Spinal/adverse effects ; Anesthetics, Local/administration & dosage ; Bupivacaine/administration & dosage ; Cesarean Section/adverse effects ; Double-Blind Method ; Female ; Humans ; Morphine/administration & dosage ; Pain Measurement ; Pain, Postoperative/prevention & control ; Pregnancy ; Prospective Studies ; Ropivacaine/administration & dosage ; Young Adult
Chemical Substances	Analgesics, Opioid ; Anesthetics, Local ; Morphine (76I7G6D29C) ; Ropivacaine (7IO5LYA57N) ; Bupivacaine (Y8335394RO)
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.13544
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Undetectable viral RNA in follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women.

Boudry, Liese / Essahib, Wafaa / Mateizel, Ileana / Van de Velde, Hilde / De Geyter, Deborah / Piérard, Denis / Waelput, Wim / Uvin, Valerie / Tournaye, Herman / De Vos, Michel / De Brucker, Michael

Fertility and sterility

2022 Volume 117, Issue 4, Page(s) 771–780

Abstract: Objective: To study the presence of viral RNA in the follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women undergoing assisted reproductive technology (ART).: Design: Prospective, single-center, observational ... ...

Abstract	Objective: To study the presence of viral RNA in the follicular fluid, cumulus cells, and endometrial tissue samples in SARS-CoV-2-positive women undergoing assisted reproductive technology (ART). Design: Prospective, single-center, observational study. Setting: Tertiary hospital. Patient(s): A total of 16 patients undergoing transvaginal oocyte retrieval who had a positive SARS-CoV-2 RNA test <48 hours before the procedure. All patients underwent the retrieval between September 2020 and June 2021 and used in vitro fertilization or intracytoplasmic sperm injection. All embryos were vitrified to avoid conception during SARS-CoV-2 infection. Intervention(s): Follicular fluid aspirated during oocyte retrieval, cumulus cells, and endometrial samples were analyzed for SARS-CoV-2 RNA using the RealStar SARS-CoV-2 RT-PCR-Kit1.0. Main outcome measure(s): The primary outcome parameter was the detection of viral RNA in the follicular fluid, cumulus cells, and endometrial cells. Fertilization rate, embryo developmental potential, and clinical outcome after frozen embryo transfer were secondary outcome parameters. Result(s): Samples from 16 patients were analyzed. Cycle threshold values of <40 were considered positive. All samples were negative for SARS-CoV-2 viral RNA. No inflammatory lesions of the endometrium were identified histologically. Fertilization rate, embryo development, and clinical outcomes after embryo transfer were reassuring. Conclusion(s): In women infected with SARS-CoV-2 who underwent ART, viral RNA was undetectable in the follicular fluid, cumulus cells, and endometrium. Caution is warranted in view of the small sample size, and the risk of SARS-CoV-2 affecting the embryo via ART cannot be ruled out. Adequate counseling of women and couples undergoing ART is crucial in parallel with further research on the effect of exposure of the early human embryo to SARS-CoV-2. Clinical trial registration number: NCT04425317.
MeSH term(s)	COVID-19/diagnosis ; Cumulus Cells ; Female ; Fertilization in Vitro/adverse effects ; Follicular Fluid ; Humans ; Prospective Studies ; RNA, Viral/genetics ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-01-01
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2021.12.032
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Article ; Online: Improved clinical outcomes after non-invasive oocyte selection and Day 3 eSET in ICSI patients.

Van Vaerenbergh, Inge / Adriaenssens, Tom / Coucke, Wim / Van Landuyt, Lisbet / Verheyen, Greta / De Brucker, Michaël / Camus, Michel / Platteau, Peter / De Vos, Michel / Van Hecke, Elien / Rosenthal, André / Smitz, Johan

Reproductive biology and endocrinology : RB&E

2021 Volume 19, Issue 1, Page(s) 26

Abstract: Background: Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elective single embryo transfer) ICSI ...

Abstract	Background: Non-invasive oocyte quality scoring, based on cumulus gene expression analysis, in combination with morphology scoring, can increase the clinical pregnancy (CPR) and live birth rates (LBR) in Day 3 eSET (elective single embryo transfer) ICSI patients. This was first investigated in a pilot study and is now confirmed in a large patient cohort of 633 patients. It was investigated whether CPR, LBR and time-to-pregnancy could be improved by analyzing the gene expression profile of three predictive genes in the cumulus cells, compared to patients with morphology-based embryo selection only. Methods: A large interventional, non-randomized, assessor-blinded cohort study with 633 ICSI patients was conducted in a tertiary fertility center. Non-PCOS patients, 22-39 years old, with good ovarian reserve, were stimulated with HP-hMG using a GnRH antagonist protocol and planned for fresh Day 3 eSET. The cumulus cells from individually denuded oocytes were ranked by a lab-developed cumulus cell test: qRT-PCR for three predictive genes (CAMK1D, EFNB2 and SASH1) and two control genes (UBC, B2M). The embryo selected for transfer was highest ranked from the pool of morphologically transferable Day 3 embryos. Patients in the control (n = 520) and experimental arm (n = 113) were compared for clinical pregnancy and live birth, using a weighted generalized linear model, and time-to-pregnancy using Kaplan-Meier curves. Results: The CPR was 61% in the experimental arm (n = 113) vs 29% in the control arm (n = 520, p < 0.0001). The LBR in the experimental arm (50%) was significantly higher than in the control arm (27%,p < 0.0001). Time-to-pregnancy was significantly shortened by 3 transfer cycles independent of the number of embryos available on Day 3 (Kaplan-Meier, p < 0.0001). Cumulus cell tested patients < 35 years (n = 65) or ≥ 35 years (n = 48) had a CPR of 62 and 60% respectively (ns). For cumulus cell tested patients with 2, 3-4, or > 4 transferable embryos, the CPR was 66, 52, and 67% (ns) respectively, and thus independent of the number of transferable embryos on Day 3. Conclusions: This study provides further evidence of the clinical usefulness of the non-invasive cumulus cell test over time in a larger patient cohort. Trial registration: Clinicaltrials.gov, NCT03659786 / NCT02962466 (Registered 6Sep2018/11Nov2016, retrospectively registered.
MeSH term(s)	Adult ; Belgium ; Birth Rate ; Cohort Studies ; Embryo Transfer/methods ; Female ; Humans ; Infertility/diagnosis ; Infertility/therapy ; Live Birth ; Models, Theoretical ; Oocyte Retrieval/methods ; Oocytes/cytology ; Pregnancy ; Pregnancy Rate ; Single Embryo Transfer/methods ; Single-Blind Method ; Sperm Injections, Intracytoplasmic/methods ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Validation Study
ISSN	1477-7827
ISSN (online)	1477-7827
DOI	10.1186/s12958-021-00704-5
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Article ; Online: Impact of thyroid autoimmunity on cumulative delivery rates in in vitro fertilization/intracytoplasmic sperm injection patients.

Unuane, David / Velkeniers, Brigitte / Deridder, Sander / Bravenboer, Bert / Tournaye, Herman / De Brucker, Michael

Fertility and sterility

2016 Volume 106, Issue 1, Page(s) 144–150

Abstract: Objective: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI.: Design: Retrospective cohort ... ...

Abstract	Objective: To predict the impact of thyroid autoimmunity (TAI) on the probability of delivery after a defined number of treatment cycles, using analysis of cumulative delivery rates in patients with and without TAI. Design: Retrospective cohort study performed at the Center for Reproductive Medicine and Department of Endocrinology, University Hospital of Brussels, approved by the institutional review board of the hospital. Setting: University hospital. Patient(s): All patients who started their first IVF/intracytoplasmic sperm injection cycle at our fertility center between January 1, 2010 and December 31, 2011 were included. Main outcome measure(s): Live birth delivery after 25 weeks' gestation was taken as the primary endpoint of our study Cumulative delivery rates were calculated for both groups until six treatment cycles. Intervention(s): All patients (in both groups) received the usual IVF treatment protocols (i.e., antagonist or agonist protocol). Result(s): In total 2,406 women who consulted our center were included. We included 333 patients with TAI and 2019 patients without TAI. In the TAI group the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 65%. In our control the crude cumulative delivery rate after six cycles was 47%, whereas the expected cumulative delivery rate was 76%. Conclusion(s): Our study did not confirm an influence of TAI status in patients undergoing fertility treatment on cumulative delivery rates after six IVF/intracytoplasmic sperm injection cycles.
MeSH term(s)	Adult ; Autoantibodies/blood ; Autoantigens/immunology ; Autoimmune Diseases/blood ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Autoimmunity ; Belgium ; Biomarkers/blood ; Embryo Implantation ; Embryo Transfer ; Female ; Fertility ; Fertilization in Vitro/adverse effects ; Hospitals, University ; Humans ; Infertility/complications ; Infertility/diagnosis ; Infertility/physiopathology ; Infertility/therapy ; Iodide Peroxidase/immunology ; Iron-Binding Proteins/immunology ; Live Birth ; Male ; Middle Aged ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Risk Factors ; Sperm Injections, Intracytoplasmic/adverse effects ; Thyroid Diseases/blood ; Thyroid Diseases/complications ; Thyroid Diseases/diagnosis ; Thyroid Diseases/immunology ; Thyroid Gland/immunology ; Thyroid Hormones/blood ; Treatment Outcome ; Young Adult
Chemical Substances	Autoantibodies ; Autoantigens ; Biomarkers ; Iron-Binding Proteins ; Thyroid Hormones ; TPO protein, human (EC 1.11.1.7) ; Iodide Peroxidase (EC 1.11.1.8)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2016.03.011
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Article ; Online: The effect of cigarette smoking on the semen parameters of infertile men.

De Brucker, Simon / Drakopoulos, Panagiotis / Dhooghe, Edouard / De Geeter, Jeroen / Uvin, Valerie / Santos-Ribeiro, Samuel / Michielsen, Dirk / Tournaye, Herman / De Brucker, Michaël

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2020 Volume 36, Issue 12, Page(s) 1127–1130

Abstract: Introduction: 36.9% of men worldwide use tobacco. Previous studies suggest a negative effect of cigarette smoking on semen quality, but the results are contradictory. We have studied the effects of smoking on the semen characteristics such as sperm ... ...

Abstract	Introduction: 36.9% of men worldwide use tobacco. Previous studies suggest a negative effect of cigarette smoking on semen quality, but the results are contradictory. We have studied the effects of smoking on the semen characteristics such as sperm concentration, semen volume, sperm motility, sperm vitality and sperm morphology in a large group of infertile men. Methods: This retrospective study was conducted on a total of 5146 infertile men with at least one year of idiopathic infertility, who admitted to the Centre for Reproductive medicine (CRG) at the Brussels University Hospital, Belgium between 2010 and 2017. The smokers were classified as mild (1-10 cigarettes/d), moderate (11-20 cigarettes/d) or heavy smokers (> 20 cigarettes/d). Semen analysis was performed for all patients. Statistical analysis was performed using the R software package and t-test or Mann-Whitney U tests were used, group comparisons were performed using ANOVA, ANCOVA or Kruskal-Wallis tests as appropriate. A p-value <0.05 was considered as statistically significant. Results: Comparing the semen parameters in the two global groups showed that smoking had a significant decrease in semen volume ( Conclusion: We concluded that smoking had a significant and independent effect on the sperm concentration in a semen analysis. Other parameters, like semen volume, sperm motility, sperm vitality and sperm morphology were not influenced by smoking.
MeSH term(s)	Adult ; Cigarette Smoking/blood ; Cigarette Smoking/physiopathology ; Follicle Stimulating Hormone/blood ; Humans ; Infertility, Male/blood ; Infertility, Male/physiopathology ; Luteinizing Hormone/blood ; Male ; Retrospective Studies ; Semen Analysis ; Sperm Count ; Sperm Motility ; Spermatozoa/pathology ; Testosterone/blood ; Tobacco Products
Chemical Substances	Testosterone (3XMK78S47O) ; Luteinizing Hormone (9002-67-9) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2020-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2020.1775195
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Zs.A 2284: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 608: Show issues

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Article ; Online: IVF in women aged 43 years and older: a 20-year experience.

Fernandez, Alice Machado / Drakopoulos, Panagiotis / Rosetti, Jerome / Uvin, Valerie / Mackens, Shari / Bardhi, Erlisa / De Vos, Michel / Camus, Michel / Tournaye, Herman / De Brucker, Michael

Reproductive biomedicine online

2020 Volume 42, Issue 4, Page(s) 768–773

Abstract: Research question: What are the reproductive outcomes of women aged 43 years and older undergoing IVF and intracytoplasmic sperm injection (ICSI) treatment using their own eggs.: Design: Retrospective study of 833 woman aged 43 years or older ... ...

Abstract	Research question: What are the reproductive outcomes of women aged 43 years and older undergoing IVF and intracytoplasmic sperm injection (ICSI) treatment using their own eggs. Design: Retrospective study of 833 woman aged 43 years or older undergoing their first IVF and ICSI cycle using autologous oocytes at a tertiary referral hospital between January 1995 and December 2019. Live birth rate (LBR) after 24 weeks' gestation was the primary outcome. Results: Ninety-five out of 833 (11.4%) had a positive HCG, whereas 59 (62.1% per positive HCG) had a miscarriage before 12 weeks' gestation and 36 (4.3%) live births were achieved. Analysis by age showed that the number of cumulus-oocyte complexes retrieved was significantly different between the four age groups: 43 years (5 [3-9]); 44 years (5 [2-7]); 45 years (3 [2-8)]); ≥45 years (2.5 [2-6]); P < 0.01; the number of metaphase II oocytes, however, was similar. Positive HCG rates remained low: 43 years (78/580 [13.4%]); 44 years (14/192 [7.3%]); 45 years (1/39 [2.6%]; and ≥46 years (2/22 [9.1%]); P = 0.03, as did LBR: 43 years (28 [4.8%]); 44 (7 [3.6%]); 45 years (0 [0%]); and ≥46 years (1 [4.5%]); P = 0.5. Multivariate regression analysis revealed that only number of metaphase II was significantly associated with LBR, when age was considered as a continuous (OR 1.08, 96% CI 1.004 to 1.16) or categorical variable (OR 1.08, 95% CI 1.005 to 1.16). Conclusion: The chances of achieving a live birth in patients aged 43 years and older undergoing IVF/ICSI with their own gametes are low, even in cases of patients with a relatively 'normal' ovarian reserve for their age.
MeSH term(s)	Adult ; Birth Rate ; Female ; Fertilization in Vitro/statistics & numerical data ; Humans ; Maternal Age ; Middle Aged ; Oocyte Retrieval/statistics & numerical data ; Ovulation Induction ; Pregnancy ; Retrospective Studies
Language	English
Publishing date	2020-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2020.12.002
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Zs.A 5792: Show issues

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Article ; Online: Cumulative delivery rates after ICSI with donor spermatozoa in different age groups.

De Brucker, Michaël / Camus, Michel / Haentjens, Patrick / Francotte, Jacques / Verheyen, Greta / Tournaye, Herman

Reproductive biomedicine online

2014 Volume 28, Issue 5, Page(s) 599–605

Abstract: This retrospective cohort study followed a total of 364 women from their first fresh, donor intracytoplasmic sperm injection (ICSI) cycle through to up to six ICSI cycles. All patients started their treatment between January 2003 and December 2007. Live ... ...

Abstract	This retrospective cohort study followed a total of 364 women from their first fresh, donor intracytoplasmic sperm injection (ICSI) cycle through to up to six ICSI cycles. All patients started their treatment between January 2003 and December 2007. Live delivery after 25 weeks of gestation was the main outcome measure. The overall crude cumulative delivery rate (CDR) after six cycles was 66% while the overall expected CDR was 90%. In women aged 38-39 years, the crude and expected CDR after six cycles were 54% and 82%, respectively. In women aged 30-37 years, the crude and expected CDR after six cycles were 66% and 91%, respectively. In women aged 20-29 years the crude and expected CDR after six cycles were 81% and 93%, respectively. No significant difference was found between the CDR of patients who had a primary ICSI treatment (no previous intrauterine insemination) and patients who had previous intrauterine insemination. This study corroborates the impact of age on ICSI with donor spermatozoa.
MeSH term(s)	Adult ; Age Factors ; Delivery, Obstetric/statistics & numerical data ; Female ; Humans ; Infertility, Male/epidemiology ; Infertility, Male/therapy ; Insemination, Artificial, Heterologous/methods ; Insemination, Artificial, Heterologous/statistics & numerical data ; Male ; Maternal Age ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Sperm Injections, Intracytoplasmic/methods ; Sperm Injections, Intracytoplasmic/statistics & numerical data ; Tissue Donors ; Young Adult
Language	English
Publishing date	2014-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2014.01.010
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Article ; Online: Is ovarian response associated with adverse perinatal outcomes in GnRH antagonist IVF/ICSI cycles?

Bardhi, Erlisa / Blockeel, Christophe / Cools, Wilfried / Santos-Ribeiro, Samuel / Racca, Annalisa / Mackens, Shari / De Vos, Michel / Polyzos, Nikolaos P / Popovic-Todorovic, Biljana / De Brucker, Michael / Muzii, Ludovico / Panici, Pierluigi Benedetti / Tournaye, Herman / Drakopoulos, Panagiotis

Reproductive biomedicine online

2020 Volume 41, Issue 2, Page(s) 263–270

Abstract: Research question: Is there an association between ovarian response and perinatal outcomes?: Design: A retrospective, single-centre cohort study including all women undergoing their first ovarian stimulation cycle in a gonadotrophin releasing hormone ...

Abstract	Research question: Is there an association between ovarian response and perinatal outcomes? Design: A retrospective, single-centre cohort study including all women undergoing their first ovarian stimulation cycle in a gonadotrophin releasing hormone antagonist protocol, with a fresh embryo transfer that resulted in a singleton live birth from January 2009 to December 2015. Patients were categorized into four groups according to the number of oocytes retrieved: one to three (category 1), four to nine (category 2), 10-15 (category 3), or over 15 oocytes (category 4). Results: The overall number of patients analysed was 964. No relevant statistical difference was found among neonatal outcomes across the four ovarian response categories. Neonatal weight (in grams) was comparable between all groups (3222 ± 607 versus 3254 ± 537 versus 3235 ± 575 versus 3200 ± 622; P = 0.85, in categories 1, 2, 3 and 4, respectively). No statistically significant differences were found among the ovarian response categories for birth weight z-scores (taking into account neonatal sex and delivery term). The incidence of pre-term birth and low birth weight was comparable across the different ovarian response groups (P = 0.127 and P = 0.19, respectively). Finally, the occurrence of adverse obstetric outcomes did not differ among the ovarian response categories. Multivariate regression analysis revealed that the number of oocytes was not associated with neonatal birth weight. Conclusions: No association was found between ovarian response and adverse perinatal outcomes in antagonist IVF and intracytoplasmic sperm injection cycles. Future, larger scale and prospectively designed investigations are needed to validate these results.
MeSH term(s)	Adult ; Birth Rate ; Birth Weight ; Female ; Fertilization in Vitro/methods ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Hormone Antagonists/administration & dosage ; Humans ; Infant, Newborn ; Oocyte Retrieval ; Ovary/drug effects ; Ovulation Induction/methods ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Sperm Injections, Intracytoplasmic/methods
Chemical Substances	Hormone Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2020-04-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2020.03.010
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Article ; Online: Assisted reproduction using donor spermatozoa in women aged 40 and above: the high road or the low road?

De Brucker, Michaël / Camus, Michel / Haentjens, Patrick / Verheyen, Greta / Collins, John / Tournaye, Herman

Reproductive biomedicine online

2013 Volume 26, Issue 6, Page(s) 577–585

Abstract: The effect of age on outcome is one of the most intriguing areas in the assisted reproduction field. In older patients using donor spermatozoa to reproduce, it remains undefined as to which is the treatment of choice: intrauterine insemination (IUI) or ... ...

Abstract	The effect of age on outcome is one of the most intriguing areas in the assisted reproduction field. In older patients using donor spermatozoa to reproduce, it remains undefined as to which is the treatment of choice: intrauterine insemination (IUI) or IVF/intracytoplasmic sperm injection (ICSI). Since life-table analysis provides data that are easy to use for patient counselling, this study analysed cumulative delivery rates (CDR) in patients using donor spermatozoa undergoing either primarily IUI or IVF/ICSI and patients who eventually switched from IUI to IVF/ICSI. Crude and expected CDR after six IUI cycles and three primary ICSI cycles (no previous IUI) were similar in both groups (24% versus 26% and 29% versus 35%, respectively). Since time-to pregnancy is an important factor in these older patients, ICSI treatment is advised to be started immediately, since a single cycle of ICSI will achieve the same success rate as a much longer period with at least six IUI cycles. If patients switch to ICSI after failed IUI, this only adds marginal benefit in CDR. Nearly all deliveries in the primary ICSI group were achieved in the first cycle.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Pregnancy ; Reproductive Techniques, Assisted ; Retrospective Studies ; Spermatozoa
Language	English
Publishing date	2013-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2113823-0
ISSN	1472-6491 ; 1472-6483
ISSN (online)	1472-6491
ISSN	1472-6483
DOI	10.1016/j.rbmo.2013.02.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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