Article ; Online: Bilateral Corneal Perforation in a Patient Under Anti-PD1 Therapy.
2020 Volume 40, Issue 2, Page(s) 245–247
Abstract: Abstract: Immune checkpoint inhibition has improved the clinical outcomes for numerous patients with cancer. However, the downside is a whole new spectrum of immune-related adverse events. We report a 68-year-old man with a history of nonsmall cell lung ...
Abstract | Abstract: Immune checkpoint inhibition has improved the clinical outcomes for numerous patients with cancer. However, the downside is a whole new spectrum of immune-related adverse events. We report a 68-year-old man with a history of nonsmall cell lung cancer presenting with a spontaneous corneal perforation in the right eye after 22 cycles of pembrolizumab. In addition, a chronic central nonhealing epithelial defect developed after performing a penetrating keratoplasty. Treatment with autologous serum drops resulted in complete healing of the corneal ulcer, where other conventional therapies had no effect. One month after reinitiating pembrolizumab therapy, our patient presented again with a corneal perforation in the fellow eye. This case describes relapsing sterile ulcerations associated with pembrolizumab use and presents an unexpected cure. |
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MeSH term(s) | Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Bandages ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Contact Lenses ; Corneal Perforation/etiology ; Corneal Perforation/therapy ; Corneal Ulcer/chemically induced ; Corneal Ulcer/therapy ; Humans ; Keratoplasty, Penetrating ; Lung Neoplasms/drug therapy ; Male ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Serum/physiology ; Tissue Adhesives |
Chemical Substances | Antibodies, Monoclonal, Humanized ; Programmed Cell Death 1 Receptor ; Tissue Adhesives ; pembrolizumab (DPT0O3T46P) |
Language | English |
Publishing date | 2020-12-21 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 604826-2 |
ISSN | 1536-4798 ; 0277-3740 |
ISSN (online) | 1536-4798 |
ISSN | 0277-3740 |
DOI | 10.1097/ICO.0000000000002490 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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