Artikel ; Online: Noncoding RNAs as circulating biomarkers in osteosarcoma patients.
Journal of cellular physiology
2019 Band 234, Heft 11, Seite(n) 19249–19255
Abstract: Noncoding RNAs (ncRNAs) identify a large family of RNAs that do not encode proteins and represent an important group of tumor biomarkers, directly involved in the process of tumor pathogenesis and progression. Many of them have also been identified in ... ...
| Abstract | Noncoding RNAs (ncRNAs) identify a large family of RNAs that do not encode proteins and represent an important group of tumor biomarkers, directly involved in the process of tumor pathogenesis and progression. Many of them have also been identified in biological fluids of patients with cancer, especially blood, suggesting their role as an emerging class of circulating biomarkers. Many ncRNAs, both miRNAs and lncRNAs, are deregulated in sarcoma tissues, with the most consistent data in osteosarcomas. In patients with osteosarcoma, the role of ncRNAs as circulating biomarkers is taking enormous value, above all for their ability to vary expression levels during disease progression and in response to therapy. In this mini-review, we summarize the main studies supporting the role of circulating ncRNAs in monitoring disease status in patients with osteosarcoma. |
|---|---|
| Mesh-Begriff(e) | Biomarkers, Tumor/blood ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MicroRNAs/blood ; MicroRNAs/genetics ; Osteosarcoma/blood ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; RNA, Long Noncoding/blood ; RNA, Long Noncoding/genetics ; RNA, Untranslated/blood ; RNA, Untranslated/genetics |
| Chemische Substanzen | Biomarkers, Tumor ; MicroRNAs ; RNA, Long Noncoding ; RNA, Untranslated |
| Sprache | Englisch |
| Erscheinungsdatum | 2019-04-29 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 3116-1 |
| ISSN | 1097-4652 ; 0021-9541 |
| ISSN (online) | 1097-4652 |
| ISSN | 0021-9541 |
| DOI | 10.1002/jcp.28744 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Uc I Zs.212: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.