Article ; Online: Clinical Impact of Supplementation with Pasteurized Donor Human Milk by High-Temperature Short-Time Method versus Holder Method in Extremely Low Birth Weight Infants: A Multicentre Randomized Controlled Trial.
2024 Volume 16, Issue 7
Abstract: Nosocomial infections are a frequent and serious problem in extremely low birth weight (ELBW) infants. Donor human milk (DHM) is the best alternative for feeding these babies when mother's own milk (MOM) is not available. Recently, a patented prototype ... ...
| Abstract | Nosocomial infections are a frequent and serious problem in extremely low birth weight (ELBW) infants. Donor human milk (DHM) is the best alternative for feeding these babies when mother's own milk (MOM) is not available. Recently, a patented prototype of a High-Temperature Short-Time (HTST) pasteurizer adapted to a human milk bank setting showed a lesser impact on immunologic components. We designed a multicentre randomized controlled trial that investigates whether, in ELBW infants with an insufficient MOM supply, the administration of HTST pasteurized DHM reduces the incidence of confirmed catheter-associated sepsis compared to DHM pasteurized with the Holder method. From birth until 34 weeks postmenstrual age, patients included in the study received DHM, as a supplement, pasteurized by the Holder or HTST method. A total of 213 patients were randomized; 79 (HTST group) and 81 (Holder group) were included in the analysis. We found no difference in the frequency of nosocomial sepsis between the patients of the two methods-41.8% (33/79) of HTST group patients versus 45.7% (37/81) of Holder group patients, relative risk 0.91 (0.64-1.3), |
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| MeSH term(s) | Infant ; Infant, Newborn ; Humans ; Infant, Extremely Low Birth Weight ; Milk, Human ; Temperature ; Dietary Supplements ; Sepsis/epidemiology ; Sepsis/prevention & control |
| Language | English |
| Publishing date | 2024-04-08 |
| Publishing country | Switzerland |
| Document type | Randomized Controlled Trial ; Multicenter Study ; Journal Article |
| ZDB-ID | 2518386-2 |
| ISSN | 2072-6643 ; 2072-6643 |
| ISSN (online) | 2072-6643 |
| ISSN | 2072-6643 |
| DOI | 10.3390/nu16071090 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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