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Article ; Online: Notes from the Field: Chikungunya Outbreak - Paraguay, 2022-2023.

Torales, Martha / Beeson, Amy / Grau, Lorena / Galeano, Miguel / Ojeda, Andrea / Martinez, Bettiana / León, Nancy / Cabello, Agueda / Rojas, Fátima / de Egea, Viviana / Galeano, Rosa / Ocampos, Sandra / Vazquez, Cynthia / Montoya, Romeo / Hills, Susan / Sequera, Guillermo

MMWR. Morbidity and mortality weekly report

2023 Volume 72, Issue 23, Page(s) 636–638

MeSH term(s)	Humans ; Chikungunya Fever/epidemiology ; Paraguay/epidemiology ; Disease Outbreaks
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7223a5
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Article ; Online: Colonization of the nasal airways by Staphylococcus aureus on admission to a major heart surgery operating room: A real-world experience.

Bouza, Emilio / Burillo, Almudena / de Egea, Viviana / Hortal, Javier / Barrio, José M / Vicente, Teresa / Muñoz, Patricia / Pérez-Granda, María Jesús

Enfermedades infecciosas y microbiologia clinica (English ed.)

2019 Volume 38, Issue 10, Page(s) 466–470

Abstract: Introduction: Nasal swab culture is used to identify Staphylococcus aureus colonization, as this is a major risk factor for surgical site infection (SSI) in patients who are going to undergo major heart surgery (MHS). We determined nasal carriage of S. ... ...

Abstract	Introduction: Nasal swab culture is used to identify Staphylococcus aureus colonization, as this is a major risk factor for surgical site infection (SSI) in patients who are going to undergo major heart surgery (MHS). We determined nasal carriage of S. aureus in patients undergoing MHS by comparing the yield of a conventional culture with that of a rapid molecular test (Xpert® SA Nasal Complete, Cepheid). Methods: From July 2015 to April 2017, all patients who were to undergo MHS were invited to participate in the study. We obtained two nasal cultures from each patient just before entering the operating room, independently of a previous test for the determination of nasal colonization by this microorganism performed before surgery. One swab was used for conventional culture in the microbiology laboratory, and the other was used for the rapid molecular test. We defined nasal colonization as the presence of a positive culture for S. aureus using either of the two techniques. All patients were followed up until hospital discharge or death. Results: Overall, 57 out of 200 patients (28.5%) were colonized by S. aureus at the time of surgery. Thirty-three patients had both conventional culture- and PCR-positive results. Twenty-four patients had a negative culture and a positive PCR test. Only twenty-one percent (12/57) of colonized patients had undergone an attempt to decolonise before the surgical intervention. Conclusion: A significant proportion of patients undergoing MHS are colonized by S. aureus in the nostrils on entering the operating room. New strategies to prevent SSI by this microorganism are needed. Rapid molecular tests immediately before MHS, followed by immediate decolonisation, must be evaluated. Trial Registration Clinical Trials.gov NCT02640001.
MeSH term(s)	Cardiac Surgical Procedures ; Humans ; Nose/microbiology ; Operating Rooms ; Staphylococcal Infections ; Staphylococcus aureus/isolation & purification
Language	Spanish
Publishing date	2019-10-23
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2019.07.013
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Article ; Online: Gradient diffusion antibiogram used directly on bronchial aspirates for a rapid diagnosis of ventilator-associated pneumonia.

Burillo, Almudena / de Egea, Viviana / Onori, Raffaella / Martín-Rabadán, Pablo / Cercenado, Emilia / Jiménez-Navarro, Laura / Muñoz, Patricia / Bouza, Emilio

Antimicrobial resistance and infection control

2019 Volume 8, Page(s) 176

Abstract: Background: In patients with suspected ventilator-associated pneumonia, a rapid etiological diagnosis is crucial as incorrect or delayed treatment in the first few hours leads to a worse prognosis and a higher mortality rate. This study examines the ... ...

Abstract	Background: In patients with suspected ventilator-associated pneumonia, a rapid etiological diagnosis is crucial as incorrect or delayed treatment in the first few hours leads to a worse prognosis and a higher mortality rate. This study examines the efficacy of a rapid antibiogram on bronchial aspirates in patients with suspected ventilator-associated pneumonia (VAP). Methods: The direct gradient diffusion susceptibility testing method (GDM) on respiratory samples was compared with a standard broth microdilution method (BMD) after quantitative cultures in patients with suspicion of VAP. Samples were preselected by Gram staining (for good quality microbiological samples with a predominant single bacterial morphotype). The antibiotics tested were ceftazidime, ceftobiprole, ceftolozane-tazobactam, meropenem, doripenem, and tedizolid. Results: Over a 16-month study period, 445 bronchial aspirate samples were selected from 1376 samples received at our laboratory from 672 adult patients. By direct plating on Mueller-Hinton agar, we recovered 504 (95.5%) of the 528 microorganisms identified by the standard semiquantitative method. Antimicrobial susceptibility testing by GDM was compared with the BMD method in 472 strains (216 Conclusions: The six GDM strips directly placed on plated bronchial aspirates obtained from patients with a suspicion of VAP provided accurate and reliable susceptibility results within 24 h.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bodily Secretions/microbiology ; Bronchi ; Humans ; Liquid Biopsy/methods ; Microbial Sensitivity Tests/methods ; Pneumonia, Ventilator-Associated/diagnosis ; Pneumonia, Ventilator-Associated/drug therapy ; Pneumonia, Ventilator-Associated/etiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-11-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2666706-X
ISSN	2047-2994 ; 2047-2994
ISSN (online)	2047-2994
ISSN	2047-2994
DOI	10.1186/s13756-019-0640-1
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Article ; Online: Reply to "Absence of pleocytosis alone is insufficient to exclude encephalitis caused by herpes simplex virus in children".

López Roa, Paula / Alonso, Roberto / de Egea, Viviana / Muñoz, Patricia / Bouza, Emilio

Journal of clinical microbiology

2014 Volume 52, Issue 3, Page(s) 1023

MeSH term(s)	Cerebrospinal Fluid/virology ; Encephalitis, Herpes Simplex/diagnosis ; Female ; Herpesvirus 1, Human/isolation & purification ; Herpesvirus 2, Human/isolation & purification ; Humans ; Male ; Molecular Diagnostic Techniques/methods ; Polymerase Chain Reaction/methods ; Virology/methods
Language	English
Publishing date	2014-02-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.03321-13
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Article ; Online: PCR for detection of herpes simplex virus in cerebrospinal fluid: alternative acceptance criteria for diagnostic workup.

López Roa, Paula / Alonso, Roberto / de Egea, Viviana / Usubillaga, Rafael / Muñoz, Patricia / Bouza, Emilio

Journal of clinical microbiology

2013 Volume 51, Issue 9, Page(s) 2880–2883

Abstract: The determination of herpes simplex virus (HSV) infection using a PCR assay is one of the most commonly requested tests for analysis of cerebrospinal fluid (CSF), although only a very low proportion of results are positive. A previously reported study ... ...

Abstract	The determination of herpes simplex virus (HSV) infection using a PCR assay is one of the most commonly requested tests for analysis of cerebrospinal fluid (CSF), although only a very low proportion of results are positive. A previously reported study showed that selecting only those CSF samples with >5 leukocytes/mm(3) or a protein level of >50 mg/dl was adequate for the diagnostic workup. The aim of the present study was to assess the reliability of alternative acceptance criteria based on elevated CSF white blood cell counts (>10 cells/mm(3)). We analyzed all requests for HSV PCR received between January 2008 and December 2011. CSF samples were accepted for analysis if they had >10 cells/mm(3) or if the sample was from an immunocompromised patient or a child aged <2 years. In order to evaluate our selection criteria, we identified those CSF samples with a leukocyte count of 5 to 10 cells/mm(3) or protein levels of >50 mg/dl in order to test them for HSV type 1 and 2 (HSV-1 and HSV-2) DNA. During the study period, 466 CSF samples were submitted to the microbiology laboratory for HSV PCR. Of these, 268 (57.5%) were rejected, and 198 (42.5%) were tested according to our routine criteria. Of the tested samples, 11 (5.5%) were positive for HSV DNA (7 for HSV-1 and 4 for HSV-2). Of the 268 rejected specimens, 74 met the criteria of >5 cells/mm(3) and/or protein levels of >50 mg/dl. Of these, 70 (94.6%) were available for analysis. None of the samples yielded a positive HSV PCR result. Acceptance criteria based on CSF leukocyte counts, host immune status, and age can help to streamline the application of HSV PCR without reducing sensitivity.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cerebrospinal Fluid/cytology ; Cerebrospinal Fluid/virology ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Encephalitis, Herpes Simplex/diagnosis ; Female ; Herpesvirus 1, Human/genetics ; Herpesvirus 1, Human/isolation & purification ; Herpesvirus 2, Human/genetics ; Herpesvirus 2, Human/isolation & purification ; Humans ; Infant ; Infant, Newborn ; Leukocyte Count ; Male ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Virology/methods ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2013-06-26
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00950-13
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Article ; Online: Differences between a probable and proven BCG infection following intravesical instillations: 16 years experience in a tertiary care hospital.

González-Del Vecchio, Marcela / Ruíz-Serrano, María Jesús / Gijón, Paloma / Sánchez-Somolinos, Mar / de Egea, Viviana / García de Viedma, Darío / Sánchez Fresneda, María Norberta / Bouza, Emilio

Diagnostic microbiology and infectious disease

2016 Volume 85, Issue 3, Page(s) 338–343

Abstract: Background: Intravesical instillation of Bacillus Calmette-Guérin (BCG) is an efficient immunotherapy for superficial bladder cancer. BCG infection represents a major yet uncommon adverse event that occurs in 5-10% of the patients treated with BCG ... ...

Abstract	Background: Intravesical instillation of Bacillus Calmette-Guérin (BCG) is an efficient immunotherapy for superficial bladder cancer. BCG infection represents a major yet uncommon adverse event that occurs in 5-10% of the patients treated with BCG instillations, though the pathogenesis of this entity is not clear. Methods: We report two cases of patients presented at our institution with BCG infection after instillation: one with microbiological BCG isolate and another without, and review all the medical records of patients instilled with BCG in our institution from 1996 until 2012, comparing patients with probable and proven BCG infection. Results: During the study period, a total of 786 patients received BCG intravesical instillations. Of them, 31 (4%) patients had to suspend treatment because of adverse events and, specifically, 11 (1.3%) patients had to interrupt treatment because of suspected BCG infection. The incidence of BCG infection during our study period was 0.87 episodes per 1,000 instilled patients/year and 140 cases per 10,000 instilled patients. Of the 11 patients with suspected BCG infection, 7 (64%) had a probable BCG infection, while 4 (36%) patients had a proven BCG infection. All patients with a proven infection had a previous underlying condition, compared to a high proportion of patients with probable infection (57%) that did not present with underlying diseases. Common findings between both groups of patients were abnormal imaging studies and laboratory tests. Regarding treatment, 8 (73%) of the 11 patients with BCG infection received at least two first line drugs active against M. bovis (isoniazid, rifampicin or ethambutol), four patients (36%) received steroids as part of the treatment and curation was obtained in 10 (91%) patients, while 1 patient with a proven infection had a death related to BCG infection. Conclusions: We can conclude that BCG infection after intravesical instillations has a low incidence in our institution. Patients with previous underlying conditions seem to have more proven infections. A high proportion of patients do not yield positive microbiological tests; in those cases the diagnosis relies in clinical, radiological and laboratory findings. Treatment for BCG infection should include at least two active drugs against M. bovis and coadjuvant steroid treatment for systemic BCG infections.
MeSH term(s)	Administration, Intravesical ; Aged ; Antitubercular Agents/therapeutic use ; Biological Therapy/adverse effects ; Biological Therapy/methods ; Humans ; Incidence ; Male ; Middle Aged ; Mycobacterium bovis/isolation & purification ; Tertiary Care Centers ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Tuberculosis/microbiology ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2016-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2016.04.006
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Article ; Online: Characteristics and Outcome of Streptococcus pneumoniae Endocarditis in the XXI Century: A Systematic Review of 111 Cases (2000-2013).

de Egea, Viviana / Muñoz, Patricia / Valerio, Maricela / de Alarcón, Arístides / Lepe, José Antonio / Miró, José M / Gálvez-Acebal, Juan / García-Pavía, Pablo / Navas, Enrique / Goenaga, Miguel Angel / Fariñas, María Carmen / Vázquez, Elisa García / Marín, Mercedes / Bouza, Emilio

Medicine

2015 Volume 94, Issue 39, Page(s) e1562

Abstract: Streptococcus pneumoniae is an infrequent cause of severe infectious endocarditis (IE). The aim of our study was to describe the epidemiology, clinical and microbiological characteristics, and outcome of a series of cases of S. pneumoniae IE diagnosed in ...

Abstract	Streptococcus pneumoniae is an infrequent cause of severe infectious endocarditis (IE). The aim of our study was to describe the epidemiology, clinical and microbiological characteristics, and outcome of a series of cases of S. pneumoniae IE diagnosed in Spain and in a series of cases published since 2000 in the medical literature. We prospectively collected all cases of IE diagnosed in a multicenter cohort of patients from 27 Spanish hospitals (n = 2539). We also performed a systematic review of the literature since 2000 and retrieved all cases with complete clinical data using a pre-established protocol. Predictors of mortality were identified using a logistic regression model. We collected 111 cases of pneumococcal IE: 24 patients from the Spanish cohort and 87 cases from the literature review. Median age was 51 years, and 23 patients (20.7%) were under 15 years. Men accounted for 64% of patients, and infection was community-acquired in 96.4% of cases. The most important underlying conditions were liver disease (27.9%) and immunosuppression (10.8%). A predisposing heart condition was present in only 18 patients (16.2%). Pneumococcal IE affected a native valve in 93.7% of patients. Left-sided endocarditis predominated (aortic valve 53.2% and mitral valve 40.5%). The microbiological diagnosis was obtained from blood cultures in 84.7% of cases. In the Spanish cohort, nonsusceptibility to penicillin was detected in 4.2%. The most common clinical manifestations included fever (71.2%), a new heart murmur (55%), pneumonia (45.9%), meningitis (40.5%), and Austrian syndrome (26.1%). Cardiac surgery was performed in 47.7% of patients. The in-hospital mortality rate was 20.7%. The multivariate analysis revealed the independent risk factors for mortality to be meningitis (OR, 4.3; 95% CI, 1.4-12.9; P < 0.01). Valve surgery was protective (OR, 0.1; 95% CI, 0.04-0.4; P < 0.01). Streptococcus pneumoniae IE is a community-acquired disease that mainly affects native aortic valves. Half of the cases in the present study had concomitant pneumonia, and a considerable number developed meningitis. Mortality was high, mainly in patients with central nervous system (CNS) involvement. Surgery was protective.
MeSH term(s)	Adolescent ; Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Cardiac Surgical Procedures ; Comorbidity ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/physiopathology ; Endocarditis, Bacterial/therapy ; Female ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Opportunistic Infections/physiopathology ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/physiopathology ; Spain ; Young Adult
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2015-09-30
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000001562
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Article ; Online: A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality.

Bassetti, Matteo / Righi, Elda / Ansaldi, Filippo / Merelli, Maria / Scarparo, Claudio / Antonelli, Massimo / Garnacho-Montero, Jose / Diaz-Martin, Ana / Palacios-Garcia, Inmaculada / Luzzati, Roberto / Rosin, Chiara / Lagunes, Leonel / Rello, Jordi / Almirante, Benito / Scotton, Pier Giorgio / Baldin, Gianmaria / Dimopoulos, George / Nucci, Marcio / Munoz, Patricia /

Vena, Antonio / Bouza, Emilio / de Egea, Viviana / Colombo, Arnaldo Lopes / Tascini, Carlo / Menichetti, Francesco / Tagliaferri, Enrico / Brugnaro, Pierluigi / Sanguinetti, Maurizio / Mesini, Alessio / Sganga, Gabriele / Viscoli, Claudio / Tumbarello, Mario

Intensive care medicine

2015 Volume 41, Issue 9, Page(s) 1601–1610

Abstract: Purpose: Clinical data on patients with intra-abdominal candidiasis (IAC) is still scarce.: Methods: We collected data from 13 hospitals in Italy, Spain, Brazil, and Greece over a 3-year period (2011-2013) including patients from ICU, medical, and ... ...

Abstract	Purpose: Clinical data on patients with intra-abdominal candidiasis (IAC) is still scarce. Methods: We collected data from 13 hospitals in Italy, Spain, Brazil, and Greece over a 3-year period (2011-2013) including patients from ICU, medical, and surgical wards. Results: A total of 481 patients were included in the study. Of these, 27% were hospitalized in ICU. Mean age was 63 years and 57% of patients were male. IAC mainly consisted of secondary peritonitis (41%) and abdominal abscesses (30%); 68 (14%) cases were also candidemic and 331 (69%) had concomitant bacterial infections. The most commonly isolated Candida species were C. albicans (n = 308 isolates, 64%) and C. glabrata (n = 76, 16%). Antifungal treatment included echinocandins (64%), azoles (32%), and amphotericin B (4%). Septic shock was documented in 40.5% of patients. Overall 30-day hospital mortality was 27% with 38.9% mortality in ICU. Multivariate logistic regression showed that age (OR 1.05, 95% CI 1.03-1.07, P < 0.001), increments in 1-point APACHE II scores (OR 1.05, 95% CI 1.01-1.08, P = 0.028), secondary peritonitis (OR 1.72, 95% CI 1.02-2.89, P = 0.019), septic shock (OR 3.29, 95% CI 1.88-5.86, P < 0.001), and absence of adequate abdominal source control (OR 3.35, 95% CI 2.01-5.63, P < 0.001) were associated with mortality. In patients with septic shock, absence of source control correlated with mortality rates above 60% irrespective of administration of an adequate antifungal therapy. Conclusions: Low percentages of concomitant candidemia and high mortality rates are documented in IAC. In patients presenting with septic shock, source control is fundamental.
MeSH term(s)	Abdomen ; Brazil ; Candidiasis/complications ; Candidiasis/drug therapy ; Candidiasis/epidemiology ; Candidiasis/mortality ; Cohort Studies ; Female ; Greece ; Humans ; Italy ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Shock, Septic/microbiology ; Spain
Language	English
Publishing date	2015-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-015-3866-2
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Article ; Online: Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort.

Casco, Nicolas / Jorge, Alberto Levi / Palmero, Domingo Juan / Alffenaar, Jan-Willem / Fox, Greg J / Ezz, Wafaa / Cho, Jin-Gun / Denholm, Justin / Skrahina, Alena / Solodovnikova, Varvara / Arbex, Marcos Abdo / Alves, Tatiana / Rabahi, Marcelo Fouad / Pereira, Giovana Rodrigues / Sales, Roberta / Silva, Denise Rossato / Saffie, Muntasir M / Salinas, Nadia Escobar / Miranda, Ruth Caamaño /

Cisterna, Catalina / Concha, Clorinda / Fernandez, Israel / Villalón, Claudia / Vera, Carolina Guajardo / Tapia, Patricia Gallegos / Cancino, Viviana / Carbonell, Monica / Cruz, Arturo / Muñoz, Eduardo / Muñoz, Camila / Navarro, Indira / Pizarro, Rolando / Cristina Sánchez, Gloria Pereira / Vergara Riquelme, Maria Soledad / Vilca, Evelyn / Soto, Aline / Flores, Ximena / Garavagno, Ana / Bahamondes, Martina Hartwig / Merino, Luis Moyano / Pradenas, Ana María / Revillot, Macarena Espinoza / Rodriguez, Patricia / Salinas, Angeles Serrano / Taiba, Carolina / Valdés, Joaquín Farías / Subiabre, Jorge Navarro / Ortega, Carlos / Palma, Sofia / Castillo, Patricia Perez / Pinto, Mónica / Bidegain, Francisco Rivas / Venegas, Margarita / Yucra, Edith / Li, Yang / Cruz, Andres / Guelvez, Beatriz / Victoria Plaza, Regina / Tello Hoyos, Kelly Yoana / Cardoso-Landivar, José / Van Den Boom, Martin / Andréjak, Claire / Blanc, François-Xavier / Dourmane, Samir / Froissart, Antoine / Izadifar, Armine / Rivière, Frédéric / Schlemmer, Frédéric / Manika, Katerina / Diallo, Boubacar Djelo / Hassane-Harouna, Souleymane / Artiles, Norma / Mejia, Licenciada Andrea / Gupta, Nitesh / Ish, Pranav / Mishra, Gyanshankar / Patel, Jigneshkumar M / Singla, Rupak / Udwadia, Zarir F / Alladio, Francesca / Angeli, Fabio / Calcagno, Andrea / Centis, Rosella / Codecasa, Luigi Ruffo / De Lauretis, Angelo / Esposito, Susanna M R / Formenti, Beatrice / Gaviraghi, Alberto / Giacomet, Vania / Goletti, Delia / Gualano, Gina / Matteelli, Alberto / Migliori, Giovanni Battista / Motta, Ilaria / Palmieri, Fabrizio / Pontali, Emanuele / Prestileo, Tullio / Riccardi, Niccolò / Saderi, Laura / Saporiti, Matteo / Sotgiu, Giovanni / Spanevello, Antonio / Stochino, Claudia / Tadolini, Marina / Torre, Alessandro / Villa, Simone / Visca, Dina / Kurhasani, Xhevat / Furjani, Mohammed / Rasheed, Najia / Danila, Edvardas / Diktanas, Saulius / Ridaura, Ruy López / Luna López, Fátima Leticia / Torrico, Marcela Muñoz / Rendon, Adrian / Akkerman, Onno W / Chizaram, Onyeaghala / Al-Abri, Seif / Alyaquobi, Fatma / Althohli, Khalsa / Aguirre, Sarita / Teixeira, Rosarito Coronel / De Egea, Viviana / Irala, Sandra / Medina, Angélica / Sequera, Guillermo / Sosa, Natalia / Vázquez, Fátima / Llanos-Tejada, Félix K / Manga, Selene / Villanueva-Villegas, Renzo / Araujo, David / Sales Marques, Raquel DuarteTânia / Socaci, Adriana / Barkanova, Olga / Bogorodskaya, Maria / Borisov, Sergey / Mariandyshev, Andrei / Kaluzhenina, Anna / Vukicevic, Tatjana Adzic / Stosic, Maja / Beh, Darius / Ng, Deborah / Ong, Catherine W M / Solovic, Ivan / Dheda, Keertan / Gina, Phindile / Caminero, José A / De Souza Galvão, Maria Luiza / Dominguez-Castellano, Angel / García-García, José-María / Pinargote, Israel Molina / Fernandez, Sarai Quirós / Sánchez-Montalvá, Adrián / Huguet, Eva Tabernero / Murguiondo, Miguel Zabaleta / Bart, Pierre-Alexandre / Mazza-Stalder, Jesica / D'Ambrosio, Lia / Kamolwat, Phalin / Bakko, Freya / Barnacle, James / Bird, Sophie / Brown, Annabel / Chandran, Shruthi / Killington, Kieran / Man, Kathy / Papineni, Padmasayee / Ritchie, Flora / Tiberi, Simon / Utjesanovic, Natasa / Zenner, Dominik / Hearn, Jasie L / Heysell, Scott / Young, Laura

The European respiratory journal

2023 Volume 62, Issue 5

Abstract: Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.: Methods: We collected data from ...

Abstract	Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.
MeSH term(s)	Humans ; Male ; COVID-19/complications ; HIV Infections/complications ; Coinfection ; Risk Factors ; Tuberculosis, Miliary ; Retrospective Studies
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.00925-2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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