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  1. Article: Antibacterial applications of biologically synthesized

    More, Pragati Rajendra / Shinde, Surbhi / Cao, Zhejiang / Zhang, Jian / Pandit, Santosh / De Filippis, Anna / Mijakovic, Ivan / Galdiero, Massimiliano

    Heliyon

    2024  Volume 10, Issue 4, Page(s) e25664

    Abstract: Objectives: This article highlights the biological synthesis of silver nanoparticles (AgNPs) with their characteristic analysis, and it focuses on the application of synthesized NPs against multidrug resistance (MDR) bacteria. A cytotoxicity study was ... ...

    Abstract Objectives: This article highlights the biological synthesis of silver nanoparticles (AgNPs) with their characteristic analysis, and it focuses on the application of synthesized NPs against multidrug resistance (MDR) bacteria. A cytotoxicity study was performed to assess the biocompatibility.
    Methods: Silver nanoparticle (AgNPs) formation was confirmed by different characterization methods such as UV-Vis spectrophotometer, Dynamic light scattering (DLS)- Zeta, Fourier transform infrared (FTIR), and Transmission electron microscope (TEM). The antimicrobial activity of the AgNPs was checked against various bacterial strains of
    Results: The primary analysis of the formation of nanoparticles (NPs) was made by UV-Vis spectrophotometric analysis at 400 nm. At the same time, the efficient capping checked by FTIR shows the presence of a functional group at different wavelengths 3284, 1641,1573,1388,1288, and 1068 cm
    Conclusion: Our findings indicate the remarkable antimicrobial activity of the biologically synthesized AgNPs, which can be an antimicrobial agent against multi-drug-resistant bacteria.
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e25664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effects of ultra-weak fractal electromagnetic signals on the aqueous phase in living systems: a test-case analysis of molecular rejuvenation markers in fibroblasts.

    Madl, Pierre / De Filippis, Anna / Tedeschi, Alberto

    Electromagnetic biology and medicine

    2020  Volume 39, Issue 3, Page(s) 227–238

    Abstract: Skin aging is primarily associated with the alterations in dermal extracellular matrix, in particular a decrease in collagen type-1 content. Recent studies have shown that collagen-degrading matrix metalloproteinase (MMP-1) is produced by fibroblasts in ... ...

    Abstract Skin aging is primarily associated with the alterations in dermal extracellular matrix, in particular a decrease in collagen type-1 content. Recent studies have shown that collagen-degrading matrix metalloproteinase (MMP-1) is produced by fibroblasts in response to chronoaging, which in human dermal fibroblasts leads to the release of proinflammatory cytokines. Past studies showed that anti-inflammatory capabilities could be induced via non-chemical means. One of these methods makes use of ultra-weak fractal electromagnetic (uwf-EM) signals. Such ultra-/very-low frequency (U/VLF) signals (few nT in intensity and within 0.5-30 kHz) interact with aqueous solutions in living systems. The fractal nature of such EM-signals relates to the self-similar property by which a "cut-out" and magnified piece of this signal reveals again the original. Thus, the aim of this study is twofold, to i) investigate the extent of this modulating effect using Human Dermal Fibroblasts (HDF)-cells, and ii) analyse molecular rejuvenation markers therein. We could demonstrate that a 10 min uwf-EM exposure (prior to incubation) increases type-1 collagen and modulates elastin in human fibroblasts cultured up to 96 h, while at the same time reduces IL-6, TNF-α and MMP-1 (the later three being statistically significant). Such up- respectively down-regulation of corresponding genes are strong indicators of an EM-induced hormetic effect that influences the epigenomic landscape of HDFs. In the Appendix, we present, in the framework of Quantum Field Theory (QFT), water as a biphasic liquid and how its coherent fraction can be affected by uwf-EM signals while at the same time resolving the "kT paradox".
    MeSH term(s) Biomarkers/metabolism ; Cell Survival/radiation effects ; Collagen Type I/genetics ; Cytokines/metabolism ; Dermis/metabolism ; Dermis/radiation effects ; Elastin/genetics ; Electromagnetic Fields/adverse effects ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/radiation effects ; Fractals ; Gene Expression Regulation, Enzymologic/radiation effects ; Humans ; Matrix Metalloproteinase 1/genetics
    Chemical Substances Biomarkers ; Collagen Type I ; Cytokines ; Elastin (9007-58-3) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
    Language English
    Publishing date 2020-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2588120-6
    ISSN 1536-8386 ; 1536-8378
    ISSN (online) 1536-8386
    ISSN 1536-8378
    DOI 10.1080/15368378.2020.1762634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Antiherpetic Activity of Taurisolo

    Zannella, Carla / Chianese, Annalisa / Annunziata, Giuseppe / Ambrosino, Annalisa / De Filippis, Anna / Tenore, Gian Carlo / Novellino, Ettore / Stornaiuolo, Mariano / Galdiero, Massimiliano

    Microorganisms

    2023  Volume 11, Issue 5

    Abstract: Herpes simplex virus (HSV) is widespread in the population, causing oral or genital ulcers and, rarely, severe complications such as encephalitis, keratitis, and neonatal herpes. Current available anti-HSV drugs are acyclovir and its derivatives, ... ...

    Abstract Herpes simplex virus (HSV) is widespread in the population, causing oral or genital ulcers and, rarely, severe complications such as encephalitis, keratitis, and neonatal herpes. Current available anti-HSV drugs are acyclovir and its derivatives, although long-term therapy with these agents can lead to drug resistance. Thus, the discovery of novel antiherpetic compounds merits additional studies. In recent decades, much scientific effort has been invested in the discovery of new synthetic or natural compounds with promising antiviral properties. In our study, we tested the antiviral potential of a novel polyphenol-based nutraceutical formulation (named Taurisolo
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11051346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hylin-a1: A Host Defense Peptide with Antibacterial Potential against

    Chianese, Annalisa / Zannella, Carla / Foglia, Francesco / Nastri, Bianca Maria / Monti, Alessandra / Doti, Nunzianna / Franci, Gianluigi / De Filippis, Anna / Galdiero, Massimiliano

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 4

    Abstract: In recent years, the resistance of pathogenic microorganisms to common antimicrobial agents has raised to a severe public health problem. The moderate and wise use of antimicrobials and the prevention of infections are the most effective strategies for ... ...

    Abstract In recent years, the resistance of pathogenic microorganisms to common antimicrobial agents has raised to a severe public health problem. The moderate and wise use of antimicrobials and the prevention of infections are the most effective strategies for decreasing the spread and development of resistance. Therefore, the World Health Organization (WHO) has intensified the search for new drugs to fight emerging pathogens. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), play a crucial role in innate immunity, representing one of the first line of defense against microbial attacks. In this study, we evaluated the antibacterial activity of the AMP named Hylin-a1 (derived from the skin of the frog
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16040509
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  5. Article: Melittin-Related Peptides Interfere with Sandfly Fever Naples Virus Infection by Interacting with Heparan Sulphate.

    Chianese, Annalisa / Zannella, Carla / Palma, Francesca / Di Clemente, Laura / Monti, Alessandra / Doti, Nunzianna / De Filippis, Anna / Galdiero, Massimiliano

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Emerging viruses pose an important global public health challenge, and early action is needed to control their spread. ... ...

    Abstract Emerging viruses pose an important global public health challenge, and early action is needed to control their spread. The
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102446
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  6. Article ; Online: Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses.

    Chianese, Annalisa / Zannella, Carla / Monti, Alessandra / Doti, Nunzianna / Sanna, Giuseppina / Manzin, Aldo / De Filippis, Anna / Galdiero, Massimiliano

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and ... ...

    Abstract Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and antiviral drugs against respiratory viral infections and the emergence and re-emergence of new viruses, novel broad-spectrum antiviral drugs are needed for the prevention and treatment of these infections. Antimicrobial peptides with an antiviral effect, also known as AVPs, have already been reported as potent inhibitors of viral infections by affecting different stages of the virus lifecycle. In the present study, we analyzed the activity of the AVP Hylin-a1, secreted by the frog
    MeSH term(s) Humans ; Animals ; Influenza A Virus, H1N1 Subtype ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Anura ; Coronavirus 229E, Human
    Chemical Substances hylin ; Antiviral Agents
    Language English
    Publishing date 2023-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813888
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  7. Article ; Online: Cistus incanus

    De Filippis, Anna / D'Amelia, Vincenzo / Folliero, Veronica / Zannella, Carla / Franci, Gianluigi / Galdiero, Massimiliano / Di Loria, Antonio / Laezza, Carmen / Monti, Simona Maria / Piccinelli, Anna Lisa / Celano, Rita / Rigano, Maria Manuela

    Natural product research

    2024  , Page(s) 1–14

    Abstract: The discovery of natural molecules with antimicrobial properties has become an urgent need for the global treatment of bacterium and virus infections. ...

    Abstract The discovery of natural molecules with antimicrobial properties has become an urgent need for the global treatment of bacterium and virus infections.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2335353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A case of

    Foglia, Francesco / Greco, Giuseppe / Zannella, Carla / Chianese, Annalisa / Ambrosino, Annalisa / Conzo, Alessandra / Conzo, Giovanni / De Filippis, Anna / Finamore, Emiliana / Docimo, Ludovico / Galdiero, Massimiliano

    IDCases

    2024  Volume 36, Page(s) e01959

    Abstract: Magnusiomyces capitatus (M. capitatus) ...

    Abstract Magnusiomyces capitatus (M. capitatus)
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2024.e01959
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  9. Article: Ligand-Free Silver Nanoparticles: An Innovative Strategy against Viruses and Bacteria.

    Morone, Maria Vittoria / Chianese, Annalisa / Dell'Annunziata, Federica / Folliero, Veronica / Lamparelli, Erwin Pavel / Della Porta, Giovanna / Zannella, Carla / De Filippis, Anna / Franci, Gianluigi / Galdiero, Massimiliano / Morone, Antonio

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: The spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. ... ...

    Abstract The spread of antibiotic-resistant bacteria and the rise of emerging and re-emerging viruses in recent years constitute significant public health problems. Therefore, it is necessary to develop new antimicrobial strategies to overcome these challenges. Herein, we describe an innovative method to synthesize ligand-free silver nanoparticles by Pulsed Laser Ablation in Liquid (PLAL-AgNPs). Thus produced, nanoparticles were characterized by total X-ray fluorescence, zeta potential analysis, transmission electron microscopy (TEM), and nanoparticle tracking analysis (NTA). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to evaluate the nanoparticles' cytotoxicity. Their potential was evaluated against the enveloped herpes simplex virus type 1 (HSV-1) and the naked poliovirus type 1 (PV-1) by plaque reduction assays and confirmed by real-time PCR and fluorescence microscopy, showing that nanoparticles interfered with the early stage of infection. Their action was also examined against different bacteria. We observed that the PLAL-AgNPs exerted a strong effect against both methicillin-resistant
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040820
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  10. Article ; Online: Oreoch-1: A broad-spectrum virus and host-targeting peptide against animal infections.

    Nastri, Bianca M / Chianese, Annalisa / Giugliano, Rosa / Di Clemente, Laura / Capasso, Carla / Monti, Alessandra / Doti, Nunzianna / Iovane, Valentina / Montagnaro, Serena / Pagnini, Ugo / Iovane, Giuseppe / Zannella, Carla / De Filippis, Anna / Galdiero, Massimiliano

    Journal of peptide science : an official publication of the European Peptide Society

    2024  , Page(s) e3593

    Abstract: In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral ... ...

    Abstract In recent decades, the global rise of viral emerging infectious diseases has posed a substantial threat to both human and animal health worldwide. The rapid spread and accumulation of mutations into viruses, and the limited availability of antiviral drugs and vaccines, stress the urgent need for alternative therapeutic strategies. Antimicrobial peptides (AMPs) derived from natural sources present a promising avenue due to their specificity and effectiveness against a broad spectrum of pathogens. The present study focuses on investigating the antiviral potential of oreochromicin-1 (oreoch-1), a fish-derived AMP obtained from Nile tilapia, against a wide panel of animal viruses including canine distemper virus (CDV), Schmallenberg virus (SBV), caprine herpesvirus 1 (CpHV-1), and bovine herpesvirus 1 (BoHV-1). Oreoch-1 exhibited a strong antiviral effect, demonstrating an inhibition of infection at concentrations in the micromolar range. The mechanism of action involves the interference with viral entry into host cells and a direct interaction between oreoch-1 and the viral envelope. In addition, we observed that the peptide could also interact with the cell during the CDV infection. These findings not only highlight the efficacy of oreoch-1 in inhibiting viral infection but also emphasize the potential of fish-derived peptides, specifically oreoch-1, as effective antiviral agents against viral infections affecting animals, whose potential to spill into humans is high. This research contributes valuable insights to the ongoing quest for novel antiviral drugs with the potential to mitigate the impact of infectious diseases on a global scale.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1234416-3
    ISSN 1099-1387 ; 1075-2617
    ISSN (online) 1099-1387
    ISSN 1075-2617
    DOI 10.1002/psc.3593
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