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Article ; Online: 'Like a fish on dry land': an explorative qualitative study into severe asthma and the impact of biologicals on patients' everyday life.

de Graaff, M B / Bendien, S A / van de Bovenkamp, H M

The Journal of asthma : official journal of the Association for the Care of Asthma

2021 Volume 59, Issue 5, Page(s) 980–988

Abstract: Results: Findings show how our respondents experience a high burden of disease (breathlessness, fatigue, exacerbations, loss of family, friends and employment) and treatment (oral corticosteroids' side-effects, dependency, life-style changes). Treatment ...

Abstract	Results: Findings show how our respondents experience a high burden of disease (breathlessness, fatigue, exacerbations, loss of family, friends and employment) and treatment (oral corticosteroids' side-effects, dependency, life-style changes). Treatment with biologicals is relatively new for respondents. They mention to be cautious in their embrace of biologicals and in expressing hope for the future. Respondents who react to treatment with biologicals experience relief of both the burden of disease and treatment. They aim to regain their social life and societal participation, a contrast to those for whom biologicals prove ineffective. Biologicals' burden of treatment is experienced as low and minor side-effects are mentioned by three respondents. Respondents appear relatively unconcerned about the lack of knowledge concerning the long-term effects of biologicals.
MeSH term(s)	Adrenal Cortex Hormones ; Asthma/therapy ; Biological Products/adverse effects ; Employment ; Humans ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones ; Biological Products
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2021.1888976
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Article ; Online: Transforming clients into experts-by-experience: A pilot in client participation in Dutch long-term elderly care homes inspectorate supervision.

de Graaff, M B / Stoopendaal, A / Leistikow, I

Health policy (Amsterdam, Netherlands)

2018 Volume 123, Issue 3, Page(s) 275–280

Abstract: As experts-by-experience, clients are thought to give specific input for and legitimacy to regulatory work. In this paper we track a 2017 pilot by the Dutch Health and Youth Care Inspectorate that aimed to use experiential knowledge in risk regulation ... ...

Abstract	As experts-by-experience, clients are thought to give specific input for and legitimacy to regulatory work. In this paper we track a 2017 pilot by the Dutch Health and Youth Care Inspectorate that aimed to use experiential knowledge in risk regulation through engaging with clients of long-term elderly care homes. Through an ethnographic inquiry we evaluate the design of this pilot. We find how the pilot transforms selected clients into experts-by-experience through training and site visits. In this transformation, clients attempt, and fail, to bring to the fore their definitions of quality and safety, negating their potentially specific contributions. Paradoxically, in their attempts to expose valid new knowledge on the quality of care, the pilot constructs the experts-by-experience in such a way that this knowledge is unlikely to be opened up. Concurrently, we find that in their attempts to have their input seen as valid, experts-by-experience downplay the value of their experiential knowledge. Thus, we show how dominating, legitimated interpretations of (knowledge about) quality of care resonate in experimental regulatory practices that explicitly try to move beyond them, emphasizing the need for a pragmatic and reflexive engagement with clients in the supervision of long-term elderly care.
MeSH term(s)	Aged ; Female ; Homes for the Aged/standards ; Humans ; Long-Term Care/standards ; Male ; Netherlands ; Patient Participation/methods ; Patient Participation/psychology ; Pilot Projects ; Quality of Health Care/standards
Language	English
Publishing date	2018-11-17
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2018.11.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: A meta-analysis of soil biodiversity impacts on the carbon cycle

de Graaff, M.-A. / Adkins, J. / Kardol, P. / Throop, H. L.

eISSN: 2199-398X

2018

Abstract: Loss of biodiversity impacts ecosystem functions, such as carbon (C) cycling. Soils are the largest terrestrial C reservoir, containing more C globally than the biotic and atmospheric pools together. As such, soil C cycling, and the processes controlling ...

Abstract	Loss of biodiversity impacts ecosystem functions, such as carbon (C) cycling. Soils are the largest terrestrial C reservoir, containing more C globally than the biotic and atmospheric pools together. As such, soil C cycling, and the processes controlling it, has the potential to affect atmospheric CO 2 concentrations and subsequent climate change. Despite the growing evidence of links between plant diversity and soil C cycling, there is a dearth of information on whether similar relationships exist between soil biodiversity and C cycling. This knowledge gap occurs even though there has been increased recognition that soil communities display high levels of both taxonomic and functional diversity and are key drivers of fluxes of C between the atmosphere and terrestrial ecosystems. Here, we used meta-analysis and regression analysis to quantitatively assess how soil biodiversity affects soil C cycling pools and processes (i.e., soil C respiration, litter decomposition, and plant biomass). We compared the response of process variables to changes in diversity both within and across groups of soil organisms that differed in body size, a grouping that typically correlates with ecological function. When studies that manipulated both within- and across-body size group diversity were included in the meta-analysis, loss of diversity significantly reduced soil C respiration (−27.5%) and plant tissue decomposition (−18%) but did not affect above- or belowground plant biomass. The loss of within-group diversity significantly reduced soil C respiration, while loss of across-group diversity did not. Decomposition was negatively affected both by loss of within-group and across-group diversity. Furthermore, loss of microbial diversity strongly reduced soil C respiration (−41%). In contrast, plant tissue decomposition was negatively affected by loss of soil faunal diversity but was unaffected by loss of microbial diversity. Taken together, our findings show that loss of soil biodiversity strongly impacts on soil C cycling processes, and highlight the importance of diversity across groups of organisms (e.g., primary consumers and secondary decomposers) for maintaining full functionality of C cycle processes. However, our understanding of the complex relationships between soil biodiversity and C cycling processes is currently limited by the sheer number of methodological concerns associated with these studies, which can greatly overestimate or underestimate the impact of soil biodiversity on soil C cycling, challenging extrapolation to natural field settings. Future studies should attempt to further elucidate the relative importance of taxonomic diversity (species numbers) versus functional diversity.
Subject code	910
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Partners in Healing: Redesign and expansion of family involvement in inpatient nursing care.

Van De Graaff, Michelle / Hopkins, Ramona O / Gee, Julie / Beesley, Sarah J / Butler, Jorie / Richards, Tammy / Crowley, Annette / Lappe, Donald / Brown, Samuel M

Nursing

2021 Volume 51, Issue 11, Page(s) 64–68

MeSH term(s)	Hospitalization ; Humans ; Inpatients ; Nursing Care
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	197895-0
ISSN	1538-8689 ; 0360-4039
ISSN (online)	1538-8689
ISSN	0360-4039
DOI	10.1097/01.NURSE.0000795328.29869.94
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Thesis ; Online: Resource recovery from black water

de Graaff, M.S.

2010

Abstract: New sanitation systems based on separation at source offer a large potential for resource recovery from wastewater, e.g. energy and nutrients from black water and irrigation water from grey water. This review focuses on the components in source separated ...

Abstract	New sanitation systems based on separation at source offer a large potential for resource recovery from wastewater, e.g. energy and nutrients from black water and irrigation water from grey water. This review focuses on the components in source separated black water. The treatment options for the key components are reviewed, focusing on recovery of organic compounds, nitrogen and phosphorus and removal of hormones, pharmaceutical residues and pathogens. A feasible treatment system for black water (faeces and urine), collected with vacuum toilets, would consist of anaerobic treatment followed by struvite precipitation for phosphorus recovery and autotrophic nitrogen removal. By applying these techniques, it is possible to produce 56 MJ/p/y of electricity, representing 40% of the energy that now is required for conventional WWTPs. Furthermore, the production of global artificial phosphorus fertilizer can be reduced by maximum 21%. As an alternative a higher degree of separation could be applied by separating the urine from the faeces, but this only would be feasible if the urine can be directly reused as a fertilizer. The issue of hormones, pharmaceuticals and pathogens in wastewater and their entry into the environment requires more research to determine to which extent additional treatment is necessary. Finally, the scope of this thesis is explained and the research questions which were addressed are presented. Zelfs toiletwater is geen afval, maar het is een waardevolle stroom met grondstoffen. Ongeveer de helft van het organisch materiaal, 80% van het stikstof en 70% van het fosfaat van de totale huishoudelijke afvalwaterstroom zit in het toiletwater. Door het gebruik van vacuüm toiletten wordt maar 1 liter drinkwater gebruikt en hierdoor bespaar je maar liefst 25% op je drinkwater rekening. Er ontstaat dan een stroom die ongeveer 25 keer geconcentreerder is dan ‘normaal’ afvalwater. Door deze hoge concentraties, kun je relatief gemakkelijk het organisch materiaal omzetten in methaan, wat genoeg is om ...
Keywords	anaerobic digestion ; bioenergy ; collection ; new sanitation ; nitrification ; sewage effluent ; sewerage ; urine ; anaërobe afbraak ; bio-energie ; nieuwe sanitatie ; nitrificatie ; riolering ; rioolafvalwater ; verzamelen
Subject code	660
Language	Dutch
Publishing country	nl
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Soil organic carbon is not just for soil scientists: measurement recommendations for diverse practitioners.

Billings, S A / Lajtha, K / Malhotra, A / Berhe, A A / de Graaff, M-A / Earl, S / Fraterrigo, J / Georgiou, K / Grandy, S / Hobbie, S E / Moore, J A M / Nadelhoffer, K / Pierson, D / Rasmussen, C / Silver, W L / Sulman, B N / Weintraub, S / Wieder, W

Ecological applications : a publication of the Ecological Society of America

2021 Volume 31, Issue 3, Page(s) e02290

Abstract: Soil organic carbon (SOC) regulates terrestrial ecosystem functioning, provides diverse energy sources for soil microorganisms, governs soil structure, and regulates the availability of organically bound nutrients. Investigators in increasingly diverse ... ...

Abstract	Soil organic carbon (SOC) regulates terrestrial ecosystem functioning, provides diverse energy sources for soil microorganisms, governs soil structure, and regulates the availability of organically bound nutrients. Investigators in increasingly diverse disciplines recognize how quantifying SOC attributes can provide insight about ecological states and processes. Today, multiple research networks collect and provide SOC data, and robust, new technologies are available for managing, sharing, and analyzing large data sets. We advocate that the scientific community capitalize on these developments to augment SOC data sets via standardized protocols. We describe why such efforts are important and the breadth of disciplines for which it will be helpful, and outline a tiered approach for standardized sampling of SOC and ancillary variables that ranges from simple to more complex. We target scientists ranging from those with little to no background in soil science to those with more soil-related expertise, and offer examples of the ways in which the resulting data can be organized, shared, and discoverable.
MeSH term(s)	Carbon ; Carbon Sequestration ; Ecosystem ; Nutrients ; Soil
Chemical Substances	Soil ; Carbon (7440-44-0)
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2290
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Thesis ; Online: Interactions between plants and soil nutrient cycling under elevated CO2

de Graaff, M.A.

2007

Abstract: The atmospheric concentration of the greenhouse gas CO2 is rising and may stimulate plant production and soil C input. If soil C input rates exceed soil C respiration rates under elevated CO2, global warming may be mitigated by long-term soil C ... ...

Abstract	The atmospheric concentration of the greenhouse gas CO2 is rising and may stimulate plant production and soil C input. If soil C input rates exceed soil C respiration rates under elevated CO2, global warming may be mitigated by long-term soil C sequestration. However, whether soils will serve as CO2 sinks is still debated, since it is uncertain how elevated CO2 will affect the interactions between plant growth and soil nutrient cycling. In the first part of this dissertation, I explored how long-term elevated CO2 affects soil C inputs versus SOM decomposition, and how these changes ultimately feedback to soil C sequestration. This research was carried out in a Free Air Carbon dioxide Experiment (FACE) in Switzerland that had been exposed to elevated CO2 and N fertilization treatments for 10 years. The isotopic label of the applied CO2 and N allowed for tracing new C and N dynamics in the system. In addition, I summarized available data related to plant growth and soil nutrient cycling from long-term CO2-enrichment experiments using the statistical tool Meta analysis. By incubating litter and soil derived from Swiss FACE, I concluded that the impact of elevated CO2 on litter quality and litter decomposition rates was minor. Therefore, elevated CO2 is not expected to affect soil C contents through its impact on litter quality and decomposition. The Meta analysis showed that the main driver of soil C sequestration is not SOC decomposition, but soil C input through plant growth, which is strongly controlled by nutrient availability. If soil nutrient availability was high, soil C input outweighed C decomposition leading to net C sequestration. However, if soil nutrient availability was low, soil C input rates lagged behind soil C decomposition rates due to CO2-induced nutrient immobilization, which had reduced plant growth. Thus, for soil C sequestration under elevated CO2 ample soil nutrient availability is required. In the Swiss FACE experiment however, soil C sequestration did not increase under elevated CO2, ...
Keywords	carbon ; carbon dioxide ; carbon sequestration ; cycling ; greenhouse gases ; nutrients ; plants ; soil ; soil carbon sequestration ; soil plant relationships ; bodem ; bodem-plant relaties ; broeikasgassen ; kooldioxide ; koolstof ; koolstofsekwestratie ; koolstofvastlegging in de bodem ; kringlopen ; planten ; voedingsstoffen
Subject code	580
Language	English
Publishing country	nl
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Lymphangiogenesis and Lymphatic Absorption Are Related and Increased in Chronic Kidney Failure, Independent of Exposure to Dialysis Solutions.

Vlahu, Carmen A / de Graaff, Marijke / Aten, Jan / Struijk, Dirk G / Krediet, Raymond T

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

2015 Volume 31, Page(s) 21–25

Abstract: Increased lymphatic absorption might contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphangiogenesis develops during PD, but little is known about the relationship between its morphologic and functional parameters. The relationships ... ...

Abstract	Increased lymphatic absorption might contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphangiogenesis develops during PD, but little is known about the relationship between its morphologic and functional parameters. The relationships between lymph vessel density, the effective lymphatic absorption rate (ELAR), and fibrosis were investigated in a rat model of chronic kidney failure (CKD) with exposure to dialysis solutions. Wistar rats (n = 44) were allocated to these groups: NKF (normal kidney function), CKD (70% nephrectomy), CKDD [CKD, with daily intraperitoneal (i.p.) Dianeal 3.86% (Baxter Healthcare BV, Utrecht, Netherlands)], CKDP [CKD, with daily i.p. Physioneal 3.86% (Baxter Healthcare BV)]. After 16 weeks, a peritoneal function test was performed, and the ELAR was calculated from the disappearance rate of i.p. dextran 70. The lymph vessel profile density (LVPD) was assessed using STEPanizer image analysis (Java application from Tschanz SA, Bern, Germany) of omental sections after anti-podoplanin immunostaining. Fibrosis was quantified by picro-sirius red staining. The LVPD was significantly increased in CKD rats compared with NKF rats, and no additional effect of dialysis solutions was present. The ELAR was increased in uremic rats compared with NKF rats. For all rats together, the LVPD correlated positively with the ELAR and with the amount of fibrosis. Chronic kidney disease itself induces lymphangiogenesis and fibrosis and increases the ELAR, independent of exposure to dialysis fluids. The ELAR is related to the LVPD in peritoneal tissue.
MeSH term(s)	Animals ; Dextrans/metabolism ; Dialysis Solutions/metabolism ; Disease Models, Animal ; Fibrosis ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/pathology ; Kidney Failure, Chronic/therapy ; Lymphangiogenesis/physiology ; Male ; Peritoneal Dialysis ; Peritoneum/metabolism ; Peritoneum/pathology ; Plasma Substitutes/metabolism ; Rats ; Rats, Wistar
Chemical Substances	Dextrans ; Dialysis Solutions ; Plasma Substitutes
Language	English
Publishing date	2015
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1197-8554
ISSN	1197-8554
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Article ; Online: Investigating the influence of the pressure distribution in a membrane module on the cascaded membrane system for post-combustion capture

Brinkmann, T. / Pohlmann, J. / Bram, M. / Zhao, L. / Tota, A. / Escalona, N.J. / de Graaff, M. / Stolten, D.

International Journal of Greenhouse Gas Control ; 1750-5836

2015

Abstract: Polyactive® membranes show promising properties for CO2 separation from flue gas. An investigation of different module types using Polyactive® membranes was carried out for this paper. A test rig was built to explore, amongst other process parameters, ... ...

Abstract	Polyactive® membranes show promising properties for CO2 separation from flue gas. An investigation of different module types using Polyactive® membranes was carried out for this paper. A test rig was built to explore, amongst other process parameters, the pressure drop in envelope-type membrane modules. The experimental data and simulation results were compared with quite good consistency. This validation enabled further simulations for different modules in a virtual pilot plant configuration. Applying the data from the pilot plant simulation to a reference power plant, the scaled-up cascaded membrane system was analyzed using different membrane modules. Considering the required membrane area, energy consumption and pressure drop in different modules, a counter-current membrane module configuration exhibited the best performance and had a marginal advantage in comparison with the chemical absorption process.
Keywords	Advanced Engineering Materials ; 620.11
Subject code	660
Publisher	GKSS Forschungszentrum Geesthacht GmbH
Publishing country	de
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Soil organic carbon is not just for soil scientists: measurement recommendations for diverse practitioners

Billings, S. A / Lajtha, K / Malhotra, A / Berhe, A. A / de Graaff, M.‐A / Earl, S / Fraterrigo, J / Georgiou, K / Grandy, S / Hobbie, S. E / Moore, J. A. M / Nadelhoffer, K / Pierson, D / Rasmussen, C / Silver, W. L / Sulman, B. N / Weintraub, S / Wieder, W

Ecological applications. 2021 Apr., v. 31, no. 3

2021

Abstract	Soil organic carbon (SOC) regulates terrestrial ecosystem functioning, provides diverse energy sources for soil microorganisms, governs soil structure, and regulates the availability of organically bound nutrients. Investigators in increasingly diverse disciplines recognize how quantifying SOC attributes can provide insight about ecological states and processes. Today, multiple research networks collect and provide SOC data, and robust, new technologies are available for managing, sharing, and analyzing large data sets. We advocate that the scientific community capitalize on these developments to augment SOC data sets via standardized protocols. We describe why such efforts are important and the breadth of disciplines for which it will be helpful, and outline a tiered approach for standardized sampling of SOC and ancillary variables that ranges from simple to more complex. We target scientists ranging from those with little to no background in soil science to those with more soil‐related expertise, and offer examples of the ways in which the resulting data can be organized, shared, and discoverable.
Keywords	energy ; soil organic carbon ; soil structure ; terrestrial ecosystems
Language	English
Dates of publication	2021-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2290
Database	NAL-Catalogue (AGRICOLA)

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