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Article ; Online: Prospective observational pilot study on bedside lung ultrasound in patients with severe acute bronchiolitis and pediatric intensive care admission.

Cabrero-Hernández, Marta / García-Salido, Alberto / Leoz-Gordillo, Inés / González-Brabin, Anthony / Iglesias-Bouzas, María Isabel / Unzueta-Roch, José Luis / De Lama Caro-Patón, Gema / Nieto-Moro, Montserrat

Pediatric pulmonology

2024

Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Letter
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.27026
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Article ; Online: PIMS-TS immunophenotype: description and comparison with healthy children, Kawasaki disease and severe viral and bacterial infections.

García-Salido, Alberto / Leoz-Gordillo, Inés / González Brabin, Anthony / García-Teresa, María Ángeles / Martínez-de-Azagra-Garde, Amelia / Iglesias-Bouzas, María Isabel / Cabrero-Hernández, Marta / De Lama Caro-Patón, Gema / Unzueta-Roch, José Luis / Castillo-Robleda, Ana / Ramirez-Orellana, Manuel / Nieto-Moro, Montserrat

Infectious diseases (London, England)

2022 Volume 54, Issue 9, Page(s) 687–691

Abstract: Background: A new clinical syndrome named Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) has been described. This new disease is a leading cause of hospital and paediatric intensive care unit (PICU). It has ... ...

Abstract	Background: A new clinical syndrome named Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) has been described. This new disease is a leading cause of hospital and paediatric intensive care unit (PICU). It has been related to immunity dysregulation. Methods: Prospective-retrospective observational study to describe the innate cell signature and immunophenotype of children admitted to PICU because of PIMS-TS (from March 2020 to September 2020). The immunophenotype was done through the expression analysis of these proteins of mononuclear cells: CD64, CD18, CD11a and CD11b. They were compared with previous healthy controls and children admitted to PICU because of bacterial infection, viral infection and Kawasaki disease (KD). Two hundred and forty-seven children were studied: 183 healthy controls, 25 viral infections, 20 bacterial infections, 6 KD and 13 PIMS-TS. Results: PIMT-TS showed the lowest percentage of lymphocytes and monocytes with higher relative numbers of CD4+ ( Conclusion: We observed a differential cell innate signature in PIMS-TS. These findings are consistent with a proinflammatory status (CD64 elevated expression) and lymphocyte trafficking to tissues (CD11a and CD11b). More studies should be carried out to confirm our results.
MeSH term(s)	Bacterial Infections ; COVID-19/complications ; Child ; Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Prospective Studies ; Receptors, IgG ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications ; Virus Diseases
Chemical Substances	Receptors, IgG
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2839775-7
ISSN	2374-4243 ; 2374-4235
ISSN (online)	2374-4243
ISSN	2374-4235
DOI	10.1080/23744235.2022.2059561
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Article ; Online: Retrospective Study in Children With Necrotizing Pneumonia: Nine Years of Intensive Care Experience.

Blanco-Iglesias, Elena / Oñoro, Gonzalo / Almodovar-Martín, José Luis / García-Salido, Alberto / De Lama Caro-Patón, Gema / Martínez de Azagra-Garde, Amelia / Serrano-González, Ana / Casado-Flores, Juan

The Pediatric infectious disease journal

2020 Volume 39, Issue 7, Page(s) 571–575

Abstract: Background: Although necrotizing pneumonia (NN) is one of the most feared complications of community-acquired pneumonia, data in pediatric patients are scarce. The objective of this article is to describe children admitted to pediatric intensive care ... ...

Abstract	Background: Although necrotizing pneumonia (NN) is one of the most feared complications of community-acquired pneumonia, data in pediatric patients are scarce. The objective of this article is to describe children admitted to pediatric intensive care unit (PICU) because of NN. Methods: Retrospective-prospective observational study in children admitted with NN to PICU (from January 1, 2010, to December 31, 2018). The data collected included information on disease epidemiology, PICU management, respiratory assistance and disease evolution. Results: Fifty-one children were included, 42 of 51 had received 7-valent or 13-valent pneumococcal vaccine. Median age was 3.2 years (1.9-4.2), 15 of 51 had signs of sepsis at admission. Forty-nine patients presented pleural effusion with drainage in 46. The most common respiratory support modality was high-flow oxygen nasal cannula (17/51). Computed tomography was the gold standard for diagnosis. Etiologic diagnosis was obtained in 34 of 51, and pneumococcus was isolated in 29 of 34. In all of these cases, initial detection was made by capsular antigen in pleural fluid. Children with pneumococcal NN had fewer days of evolution prior to PICU admission (P = 0.041). Cefotaxime with clindamycin was used in 49 of 51. Surgery was necessary in 3 of 51 patients. After PICU discharge, only 5 of 51 were readmitted. There were deaths. Conclusions: In our study, the NN was mainly observed in children around 3 years old. The main causal agent was pneumococcus. The evolution towards NN appeared to be faster than in case of other etiologies. Surgery management was unusual. All children required prolonged admissions but had a full clinical recovery.
Language	English
Publishing date	2020-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002633
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Article ; Online: SARS-CoV-2 and Streptococcus pneumoniae coinfection as a cause of severe pneumonia in an infant.

Nieto-Moro, Montserrat / Ecclesia, Francesco Giuseppe / Tomé-Masa, Irene / De Lama Caro-Patón, Gema / Leoz-Gordillo, Inés / Cabrero-Hernández, Marta / García-Salido, Alberto

Pediatric pulmonology

2020 Volume 55, Issue 9, Page(s) 2198–2200

MeSH term(s)	Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coinfection/epidemiology ; Coronavirus Infections ; Humans ; Infant ; Italy ; Pandemics ; Pneumonia, Viral/epidemiology ; Preliminary Data ; SARS-CoV-2 ; Streptococcus pneumoniae
Keywords	covid19
Language	English
Publishing date	2020-06-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24916
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Article ; Online: Erratum to Ulcerative Colitis and Atypical Hemolytic-Uremic Syndrome: An Unusual But Potentially Life-threatening Complication.

Viada Bris, Javier Francisco / Velasco Rodríguez-Belvís, Marta / de Lucas Collantes, Carmen / Aparicio López, Cristina / Martínez de Azagra, Amelia / de Lama Caro-Patón, Gema / de Prada Vicente, Inmaculada / Muñoz Codoceo, Rosa Ana

Inflammatory bowel diseases

2019 Volume 25, Issue 11, Page(s) e151

Language	English
Publishing date	2019-01-08
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izy343
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Article ; Online: Severe SARS-CoV-2 Infection in Children With Suspected Acute Abdomen: A Case Series From a Tertiary Hospital in Spain.

Cabrero-Hernández, Marta / García-Salido, Alberto / Leoz-Gordillo, Inés / Alonso-Cadenas, Jose Antonio / Gochi-Valdovinos, Ainhoa / González Brabin, Anthony / De Lama Caro-Patón, Gema / Nieto-Moro, Montserrat / de-Azagra-Garde, Amelia Martínez- / Serrano-González, Ana

The Pediatric infectious disease journal

2020 Volume 39, Issue 8, Page(s) e195–e198

Abstract: We describe 5 children with severe SARS-CoV-2 infection, hemodynamic instability and suspected acute abdomen. This form of the disease has not been previously documented. Four of the cases were confirmed SARS-CoV-2 infection and 1 probable. All of them ... ...

Abstract	We describe 5 children with severe SARS-CoV-2 infection, hemodynamic instability and suspected acute abdomen. This form of the disease has not been previously documented. Four of the cases were confirmed SARS-CoV-2 infection and 1 probable. All of them were previously healthy and needed a pediatric critical care unit admission. The respiratory symptoms were not dominant or were absent. Also, fever was observed. Laboratory testing revealed lymphopenia and high levels of C-reactive protein and procalcitonin with D-dimer, ferritin and interleukin-6 usually elevated. Respiratory support and inotropic support were almost always necessary. In all of them, deterioration occurred on the day of admission.
MeSH term(s)	Abdomen, Acute/complications ; Abdomen, Acute/diagnostic imaging ; Abdomen, Acute/physiopathology ; Abdomen, Acute/therapy ; Adolescent ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Cough ; Fever ; Hospitalization ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Skin/pathology ; Spain ; Tertiary Care Centers ; Thorax/diagnostic imaging
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000002777
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Article: Children in Critical Care Due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Experience in a Spanish Hospital.

García-Salido, Alberto / Leoz-Gordillo, Inés / Martínez de Azagra-Garde, Amelia / Nieto-Moro, Montserrat / Iglesias-Bouzas, María Isabel / García-Teresa, María Ángeles / Cabrero-Hernández, Marta / De Lama Caro-Patón, Gema / Gochi Valdovinos, Ainhoa / González-Brabin, Anthony / Serrano-González, Ana

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2020 Volume 21, Issue 8, Page(s) e576–e580

Abstract: Objectives: Spain has been one of the countries most severely affected by the coronavirus disease 2019. This study aims to describe a series of children admitted to a PICU due to coronavirus disease 2019 infection.: Design: Prospective observational ... ...

Abstract	Objectives: Spain has been one of the countries most severely affected by the coronavirus disease 2019. This study aims to describe a series of children admitted to a PICU due to coronavirus disease 2019 infection. Design: Prospective observational study. Setting: Tertiary hospital in Madrid, Spain. Patients: Children admitted to the PICU with severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2) infection, from March 1, 2020, to April 15, 2020. Interventions: Observational study. Measurements and main results: Epidemiologic data, previous clinical characteristics, support therapy needed, imaging tests, laboratory observations on admission, and pharmacologic therapy. Eleven children were admitted to the PICU, with suspected coronavirus disease 2019; the polymerase chain reaction test was positive in seven. The median age was 100.7 months (range, 0.5-162). Five were admitted from the emergency department and two from the ward. The Pediatric Sequential Organ Failure Assessment score was 3 (range, 0-9), and Pediatric Risk of Mortality II score was 4 (range, 0-16). All children were previously healthy except one (allogeneic hematopoietic stem cell transplantation). Respiratory symptoms and fever were prevalent. A chest radiograph led to a pneumonia diagnosis. Not all patients presented with lymphopenia on admission. D-Dimer and ferritin were elevated. All patients needed oxygen therapy through a nasal cannula; five patients received high-flow nasal cannula therapy, which was later substituted with noninvasive ventilation in four. Mechanical ventilation was necessary in two patients on the first day of PICU admission. Two children required mechanical ventilation and inotropic support. Tocilizumab was applied in two intubated children. Also, four children received heparin. No patients died. Conclusions: On the whole, the children were previously healthy and are more than 1 year old. Respiratory symptoms were the leading cause of PICU admission, making respiratory support the principal therapy. Patients requiring mechanical ventilation showed deterioration on the first day of admission. These children seemed to require close monitoring, and multicenter studies are necessary.
MeSH term(s)	Adolescent ; Adrenal Cortex Hormones/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Critical Care ; Female ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric ; Male ; Oxygen Inhalation Therapy ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; Prospective Studies ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/physiopathology ; Severe Acute Respiratory Syndrome/therapy ; Severe Acute Respiratory Syndrome/virology ; Severity of Illness Index ; Spain ; Tertiary Care Centers
Chemical Substances	Adrenal Cortex Hormones ; Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002475
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Article ; Online: Ulcerative Colitis and Atypical Hemolytic-Uremic Syndrome: An Unusual But Potentially Life-threatening Complication.

Inflammatory bowel diseases

2018 Volume 25, Issue 4, Page(s) e27–e28

Abstract: Hemolytic-uremic syndrome (HUS) is defined as the triad of nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure, in which the underlying lesions are mediated by systemic thrombotic microangiopathy (TMA). The atypical HUS (aHUS) can be ... ...

Abstract	Hemolytic-uremic syndrome (HUS) is defined as the triad of nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure, in which the underlying lesions are mediated by systemic thrombotic microangiopathy (TMA). The atypical HUS (aHUS) can be considered a subtype of HUS that is rare in childhood and has a worse prognosis. Recent findings have established that the TMA in aHUS are consequences of the disregulation of the complement activation, leading to endotelial damage mediated by the complement terminal pathway.1, 2 Likewise, previous research suggests an important role for the deregulation of the alternative complement cascade in the pathogenesis of inflammatory bowel disease (IBD).3, 4 We report the case of a patient with ulcerative colitis (UC) who developed aHUS during a flare-up of her chronic disease. This association is extremely infrequent and had been previously reported in only 1 patient.5.
MeSH term(s)	Adolescent ; Atypical Hemolytic Uremic Syndrome/etiology ; Atypical Hemolytic Uremic Syndrome/pathology ; Atypical Hemolytic Uremic Syndrome/therapy ; Colitis, Ulcerative/complications ; Female ; Humans ; Prognosis
Language	English
Publishing date	2018-06-21
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izy226
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Article: SARS-CoV-2 and Streptococcus pneumoniae coinfection as a cause of severe pneumonia in an infant

Nieto-Moro, Montserrat / Ecclesia, Francesco Giuseppe / Tomé-Masa, Irene / De Lama Caro-Patón, Gema / Leoz-Gordillo, Inés / Cabrero-Hernández, Marta / García-Salido, Alberto

Pediatr. pulmonol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #620342
Database	COVID19

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Article ; Online: SARS‐CoV‐2 and Streptococcus pneumoniae coinfection as a cause of severe pneumonia in an infant

Nieto‐Moro, Montserrat / Ecclesia, Francesco Giuseppe / Tomé‐Masa, Irene / De Lama Caro‐Patón, Gema / Leoz‐Gordillo, Inés / Cabrero‐Hernández, Marta / García‐Salido, Alberto

Pediatric Pulmonology

2020 Volume 55, Issue 9, Page(s) 2198–2200

Keywords	Pediatrics, Perinatology, and Child Health ; Pulmonary and Respiratory Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24916
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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