LIVIVO - Search results -

Search results

Result 1 - 10 of total 26

Search options

Article ; Online: A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema.

Wells, Athol U / Jacob, Joseph / Sverzellati, Nicola / Cross, Gary / Barnett, Joseph / De Lauretis, Angelo / Antoniou, Katerina / Weycker, Derek / Atwood, Mark / Kirchgaessler, Klaus-Uwe / Cottin, Vincent

Respiratory research

2024 Volume 25, Issue 1, Page(s) 33

Abstract: Background: No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the development ... ...

Abstract	Background: No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the development and validation of a formula to predict emphysema extent in patients with IPF and emphysema. Methods: The development cohort included 76 patients with combined IPF and emphysema at the Royal Brompton Hospital, London, United Kingdom. The formula was derived using stepwise regression to generate the weighted combination of pulmonary function data that fitted best with emphysema extent on high-resolution computed tomography. Test cohorts included patients from two clinical trials (n = 455 [n = 174 with emphysema]; NCT00047645, NCT00075998) and a real-world cohort from the Royal Brompton Hospital (n = 191 [n = 110 with emphysema]). The formula is only applicable for patients with IPF and concomitant emphysema and accordingly was not used to detect the presence or absence of emphysema. Results: The formula was: predicted emphysema extent = 12.67 + (0.92 x percent predicted forced vital capacity) - (0.65 x percent predicted forced expiratory volume in 1 second) - (0.52 x percent predicted carbon monoxide diffusing capacity). A significant relationship between the formula and observed emphysema extent was found in both cohorts (R Conclusion: The formula, designed for use in patients with IPF and emphysema, demonstrated enhanced ability to predict emphysema extent versus individual pulmonary function tests. Trial registration: NCT00047645; NCT00075998.
MeSH term(s)	Humans ; Emphysema/complications ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/complications ; Lung/diagnostic imaging ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/complications ; Retrospective Studies ; Vital Capacity ; Clinical Trials as Topic
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article ; Validation Study
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02589-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Molecular biomarkers in interstitial lung diseases.

De Lauretis, Angelo / Renzoni, Elisabetta A

Molecular diagnosis & therapy

2014 Volume 18, Issue 5, Page(s) 505–522

Abstract: Interstitial lung diseases (ILD) are protean conditions with substantial overlap in terms of diagnosis, prognostic evaluation, and management. However, the management of idiopathic pulmonary fibrosis is different from that of more immunologically driven ... ...

Abstract	Interstitial lung diseases (ILD) are protean conditions with substantial overlap in terms of diagnosis, prognostic evaluation, and management. However, the management of idiopathic pulmonary fibrosis is different from that of more immunologically driven ILD patterns, such as ILD associated with connective tissue diseases. It is important to provide accurate diagnosis and patient selection for prognostication and timely treatment, preferably at baseline. Validated non-invasive biomarkers fulfilling these unmet clinical needs are warranted. Although no ILD biomarker has been adopted in clinical practice so far, advancements in this field have been achieved, especially with the implementation of high-throughput techniques and clinical-laboratory multi-parametric panels. This review focuses on selected validated and/or potentially interesting biomarkers investigated in the peripheral blood and lung tissue of patients with ILD. Current issues and future directions in various aspects of ILD biomarkers research and its clinical application are explored.
MeSH term(s)	Biomarkers/blood ; Biomarkers/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lung/metabolism ; Lung/pathology ; Lung Diseases, Interstitial/blood ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/metabolism ; Lung Diseases, Interstitial/pathology
Chemical Substances	Biomarkers
Language	English
Publishing date	2014-06-16
Publishing country	New Zealand
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2232796-4
ISSN	1179-2000 ; 1177-1062
ISSN (online)	1179-2000
ISSN	1177-1062
DOI	10.1007/s40291-014-0109-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5202: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Review series: Aspects of interstitial lung disease: connective tissue disease-associated interstitial lung disease: how does it differ from IPF? How should the clinical approach differ?

de Lauretis, Angelo / Veeraraghavan, Srihari / Renzoni, Elisabetta

Chronic respiratory disease

2011 Volume 8, Issue 1, Page(s) 53–82

Abstract: The lung is frequently involved in connective tissue diseases (CTDs), although the frequency of lung manifestations varies according to the type of CTD. Interstitial lung diseases (ILD) are frequently seen in CTDs, particularly systemic sclerosis (SSc), ... ...

Abstract	The lung is frequently involved in connective tissue diseases (CTDs), although the frequency of lung manifestations varies according to the type of CTD. Interstitial lung diseases (ILD) are frequently seen in CTDs, particularly systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM) and rheumatoid arthritis (RA), accounting for a significant proportion of deaths. A large percentage of patients with CTD-associated ILD has limited and stable disease, not requiring treatment. However, a significant minority has severe and/or progressive disease, necessitating prompt initiation of treatment. CTD-ILD histological patterns include non-specific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP), organizing pneumonia (OP), diffuse alveolar damage (DAD) and lymphocytic interstitial pneumonia (LIP). NSIP is the most common pattern in all CTDs, except for RA, characterized by a higher frequency of UIP. ILD can present acutely or chronically, with acute presentations being more common in systemic lupus erythematosus and PM/DM. Idiopathic pulmonary fibrosis (IPF) is a progressively worsening ILD characterized by inflammation and fibrosis. The characteristic histological pattern of IPF is UIP. Interestingly, a UIP pattern is associated with a significantly better survival in CTD-related disease compared to the idiopathic variety. Prognosis in IPF is dismal, with a median survival since diagnosis of 2-3 years. No treatment regimen has been shown to improve survival in IPF. By contrast, although there have been only two randomized placebo-controlled trials investigating the effect of immunosuppressive treatment in SSc-associated ILD, clinical experience suggests that immunosuppressive drugs in CTD-related ILDs are capable of benefiting a significant proportion of patients, particularly those with certain histological patterns of disease. This review will essentially focus on CTD-associated ILD and will compare aspects of clinical presentation and management to those of IPF.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Connective Tissue Diseases/complications ; Connective Tissue Diseases/drug therapy ; Connective Tissue Diseases/pathology ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/mortality ; Idiopathic Pulmonary Fibrosis/pathology ; Immunosuppressive Agents/therapeutic use ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/mortality ; Lung Diseases, Interstitial/pathology ; Prognosis
Chemical Substances	Adrenal Cortex Hormones ; Immunosuppressive Agents
Language	English
Publishing date	2011
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2211488-9
ISSN	1479-9731 ; 1479-9723
ISSN (online)	1479-9731
ISSN	1479-9723
DOI	10.1177/1479972310393758
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6215: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical characteristics and outcome of COVID-19 pneumonia in elderly subjects.

Bongiovanni, Marco / De Lauretis, Angelo / Manes, Giampiero / Marra, Alessandro Maria / Bodini, Bruno Dino / Pellegrini, Lucienne / Berra, Sergio Antonio / Picascia, Desiree / Schettino, Mario / Bini, Francesco

The Journal of infection

2020 Volume 82, Issue 2, Page(s) e33–e34

MeSH term(s)	Aged ; COVID-19 ; Follow-Up Studies ; Hospitalization ; Humans ; Prognosis ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.08.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 48: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Demyelinating Guillain-Barré syndrome recurs more frequently than axonal subtypes.

Notturno, Francesca / Kokubun, Norito / Sekiguki, Yukari / Nagashima, Takahide / De Lauretis, Angelo / Yuki, Nobuhiro / Kuwabara, Satoshi / Uncini, Antonino

Journal of the neurological sciences

2016 Volume 365, Page(s) 132–136

Abstract: Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors ... ...

Abstract	Guillain-Barré syndrome (GBS) is considered a monophasic disorder yet recurrences occur in up to 6% of patients. We retrospectively studied an Italian-Japanese population of 236 GBS and 73 Miller Fisher syndrome (MFS) patients and searched for factors which may be associated with recurrence. A recurrent patient was defined as having at least two episodes that fulfilled the diagnostic criteria for GBS and MFS with an identifiable recovery after each episode and a minimum of 2months between episodes. Preceding Campylobacter jejuni (C. jejuni) infection and antiganglioside antibodies were also assessed. Seven (3%) recurrent GBS and one (1.4%) recurrent MFS patients were identified. In the individual patient the clinical features during episodes were usually similar varying in severity whereas the preceding infection differed. None of the patients had GBS in one episode and MFS in the recurrence or vice versa. Recurrent GBS patients, compared with monophasic GBS, did not have preceding diarrhea at the first episode and considering the electrophysiological subtypes, acute inflammatory demyelinating polyneuropathies recurred more frequently than axonal GBS (6.5% vs 0.9%, p=0.04). In conclusion in a GBS population with a balanced number of demyelinating and axonal subtypes less frequent diarrhea and demyelination at electrophysiology were associated with recurrence.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antibodies/metabolism ; Campylobacter Infections/epidemiology ; Campylobacter Infections/immunology ; Child ; Electric Stimulation ; Female ; Gangliosides/immunology ; Guillain-Barre Syndrome/epidemiology ; Guillain-Barre Syndrome/physiopathology ; Humans ; Italy/epidemiology ; Japan/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Miller Fisher Syndrome/epidemiology ; Miller Fisher Syndrome/physiopathology ; Neural Conduction/physiology ; Recurrence ; Retrospective Studies ; Statistics, Nonparametric ; Young Adult
Chemical Substances	Antibodies ; Gangliosides
Language	English
Publishing date	2016-06-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2016.02.053
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 308: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis.

Jacob, Joseph / Odink, Arlette / Brun, Anne Laure / Macaluso, Claudio / de Lauretis, Angelo / Kokosi, Maria / Devaraj, Anand / Desai, Sujal / Renzoni, Elisabetta / Wells, Athol U

Respiratory medicine

2018 Volume 138, Page(s) 95–101

Abstract: Background: Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers ... ...

Abstract	Background: Pleuroparenchymal fibroelastosis (PPFE) has been described in hypersensitivity pneumonitis (HP) yet its functional implications are unclear. Combined pulmonary fibrosis and emphysema (CPFE) has occasionally been described in never-smokers with HP, but epidemiological data regarding its prevalence is sparse. CTs in a large HP cohort were therefore examined to identify the prevalence and effects of PPFE and emphysema. Methods: 233 HP patients had CT extents of interstitial lung disease (ILD) and emphysema quantified to the nearest 5%. Lobar percentage pleural involvement of PPFE was quantified on a 4-point categorical scale: 0 = absent, 1 = affecting <10%, 2 = affecting 10-33%, 3 = affecting >33%. Marked PPFE reflected a total lung score of ≥3/18. Results were evaluated against FVC, DLco and mortality. Results: Marked PPFE prevalence was 23% whilst 23% of never-smokers had emphysema. Following adjustment for patient age, gender, smoking status, and ILD and emphysema extents, marked PPFE independently linked to reduced baseline FVC (p = 0.0002) and DLco (p = 0.002) and when examined alongside the same covariates, independently linked to worsened survival (p = 0.01). CPFE in HP demonstrated a characteristic functional profile of artificial lung volume preservation and disproportionate DLco reduction. CPFE did not demonstrate a worsened outcome when compared to HP patients without emphysema beyond that explained by CT extents of ILD and emphysema. Conclusions: PPFE is not uncommon in HP, and is independently associated with impaired lung function and increased mortality. Emphysema was identified in 23% of HP never-smokers. CPFE appears not to link to a malignant microvascular phenotype as outcome is explained by ILD and emphysema extents.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alveolitis, Extrinsic Allergic/diagnostic imaging ; Alveolitis, Extrinsic Allergic/epidemiology ; Alveolitis, Extrinsic Allergic/physiopathology ; Elastic Tissue/pathology ; Female ; Fibrosis/diagnostic imaging ; Fibrosis/epidemiology ; Fibrosis/physiopathology ; Forced Expiratory Volume/physiology ; Humans ; London/epidemiology ; Male ; Middle Aged ; Pleura/diagnostic imaging ; Pleura/pathology ; Prevalence ; Prognosis ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/epidemiology ; Pulmonary Emphysema/physiopathology ; Respiratory Function Tests ; Smoking/epidemiology ; Tomography, X-Ray Computed ; Vital Capacity/physiology
Language	English
Publishing date	2018-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2018.03.031
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui III Zs.19: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Clinical characteristics and outcome of COVID-19 pneumonia in elderly subjects

J. infect

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #739917
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Natural history of COVID-19 infection in healthcare workers in Northern Italy

Bongiovanni, Marco / Marra, Alessandro Maria / De Lauretis, Angelo / Bini, Francesco / Di Carlo, Daniela / Manes, Giampiero / Bodini, Bruno Dino / Pellegrini, Lucienne / Schettino, Mario / Picascia, Desiree / Bellini, Aldo

J. hosp. infect

Abstract: Currently, 14 days after clinical recovery is considered the adequate time-frame for quarantined individuals infected by COVID-19, but no data have been reported in healthcare workers. In our population of 142 healthcare workers infected by COVID-19, the ...

Abstract	Currently, 14 days after clinical recovery is considered the adequate time-frame for quarantined individuals infected by COVID-19, but no data have been reported in healthcare workers. In our population of 142 healthcare workers infected by COVID-19, the mean time for viral clearance was 31.8 days. Asymptomatic subjects cleared the virus earlier than symptomatic (22 vs 34,2 days, p<0.0001); the presence of fever at the time of diagnosis was associated with a longer time to viral clearance (RR 11.45, 95% CI 8.66-14.25, p<0.0001). These findings may have a significant impact on healthcare strategies for the future management of the COVID-19 pandemic.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #791575
Database	COVID19

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Clinical characteristics and outcome of COVID-19 pneumonia in elderly subjects

Journal of Infection ; ISSN 0163-4453

2020

Keywords	Microbiology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.jinf.2020.08.023
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Serum markers of pulmonary epithelial damage in systemic sclerosis-associated interstitial lung disease and disease progression.

Respirology (Carlton, Vic.)

2020 Volume 26, Issue 5, Page(s) 461–468

Abstract: Background and objective: The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable, and accurate prognostic markers are needed. KL-6 is a mucin-like glycoprotein (MUC1) expressed by type II pneumocytes, while ... ...

Abstract	Background and objective: The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) is highly variable, and accurate prognostic markers are needed. KL-6 is a mucin-like glycoprotein (MUC1) expressed by type II pneumocytes, while CYFRA 21-1 is expressed by alveolar and bronchiolar epithelial cells. Both are released into the blood from cell injury. Methods: Serum KL-6 and CYFRA 21-1 levels were measured in a retrospective (n = 189) and a prospective (n = 118) cohort of SSc patients. Genotyping of MUC1 rs4072037 was performed. Linear mixed-effect models were used to evaluate the relationship with change in lung function parameters over time, while association with survival was evaluated with Cox proportional hazard analysis. Results: In both cohorts, KL-6 and CYFRA 21-1 were highest in patients with lung involvement, and in patients with extensive rather than limited ILD. KL-6 was higher in patients carrying the MUC1 rs4072037 G allele in both cohorts. In patients with SSc-ILD, serum KL-6, but not CYFRA 21-1, was significantly associated with DL Conclusion: Our results suggest serum KL-6 predicts decline in lung function in SSc, suggesting its clinical utility in risk stratification for progressive SSc-ILD.
MeSH term(s)	Antigens, Neoplasm/immunology ; Antigens, Neoplasm/physiology ; Biomarkers ; Disease Progression ; Humans ; Keratin-19/immunology ; Keratin-19/physiology ; Lung/physiology ; Lung Diseases, Interstitial/etiology ; Prospective Studies ; Retrospective Studies ; Scleroderma, Systemic/complications
Chemical Substances	Antigens, Neoplasm ; Biomarkers ; Keratin-19 ; antigen CYFRA21.1
Language	English
Publishing date	2020-12-17
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.13988
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 4957: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

Inter-library loan at ZB MED

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito