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  1. Article ; Online: Relationship between adiponectin and muscle mass in patients with metabolic syndrome and obesity.

    de Luis, Daniel / Primo, David / Izaola, Olatz / Gomez, Juan José Lopez

    Journal of diabetes and its complications

    2024  Volume 38, Issue 4, Page(s) 108706

    Abstract: Background: Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role.: Aims: The objective of the current ... ...

    Abstract Background: Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role.
    Aims: The objective of the current work was to study the association between muscle mass, determined via bioelectrical impedance (BIA), and circulating adiponectin levels among obese patients with metabolic syndrome who are older than 60 years of age.
    Methods: We performed a cross-sectional study incorporating 651 patients with obesity and metabolic syndrome. Anthropometric data, BIA data (total fat mass (FM), fat-free mass (FFM), fat-free mass index (FFMi), skeletal muscle mass (SMM) and skeletal muscle mass index (SMMi)), arterial pressure, HOMA-IR (homeostasis model assessment of insulin resistance), and biochemical parameters were recorded.
    Results: The patients were separated into two groups based on their median SMMi (skeletal muscle mass index) levels. The low-SMMi group presented adiponectin levels that were higher than those in the high-SMMi group (delta value: 4.8 + 0.7 ng/dl: p = 0.02). Serum adiponectin values were negatively correlated with fat mass (FM), fat-free mass (FFM), fat-free mass index (FFMi), SMM, and SMMi. Adiponectin presented a negative correlation with HOMA-IR and a positive correlation with HDL-cholesterol. In the final multivariate model using SMMi as a dependent variable, adiponectin levels explained 18 % of the variability (Beta -0.49, CI95% -0.89 to -0.16) after adjusting for age and gender.
    Conclusions: Serum adiponectin levels are negatively associated with low skeletal muscle mass among obese subjects with metabolic syndrome who are older than 60 years of age.
    MeSH term(s) Humans ; Adiponectin/blood ; Body Mass Index ; Cross-Sectional Studies ; Insulin Resistance ; Metabolic Syndrome/blood ; Metabolic Syndrome/metabolism ; Muscle, Skeletal/metabolism ; Obesity/blood ; Obesity/metabolism
    Chemical Substances Adiponectin
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2024.108706
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  2. Article ; Online: Resistin/uric acid index as a marker of metabolic syndrome in females with obesity.

    Primo, David / Izaola, Olatz / de Luis, Daniel

    International journal of obesity (2005)

    2023  Volume 47, Issue 5, Page(s) 393–398

    Abstract: Background: The resistin/uric index has been considered a prognostic factor for identifying young people with obesity. Obesity and Metabolic Syndrome (MS) are an important health problem in females.: Aims: The objective of this work was to evaluate ... ...

    Abstract Background: The resistin/uric index has been considered a prognostic factor for identifying young people with obesity. Obesity and Metabolic Syndrome (MS) are an important health problem in females.
    Aims: The objective of this work was to evaluate the relationship of resistin/acid uric index with Metabolic Syndrome on Caucasian females with obesity.
    Methods: We conducted a cross sectional study in 571 females with obesity. Measurements of anthropometric parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C reactive protein, uric acid, resistin and prevalence of Metabolic Syndrome were determined. The resistin/uric acid index was calculated.
    Results: In total, 249 subjects had MS (43.6%). We detected higher levels in the following parameters (Delta; p values); waist circumference (3.1 ± 0.5 cm; p = 0.04), systolic blood pressure (5.3 ± 3.6 mmHg; p = 0.01), diastolic blood pressure (2.3 ± 0.4 mmHg; p = 0.02), glucose levels (7.5 ± 0.9 mg/dL; p = 0.01), insulin levels (2.5 ± 0.3 UI/L; p = 0.02), HOMA-IR (0.7 ± 0.2 units; p = 0.03), uric acid levels (0.9 ± 0.2 mg/dl; p = 0.01), resistin levels (4.1 ± 0.4 ng/dl; p = 0.01) and resistin/uric acid index (0.61 ± 0.01 mg/dl; p = 0.02) in subjects of the high resistin/uric acid index group than low index group. Logistic regression analysis reported a high percentage of hyperglycemia (OR = 1.77, 95% CI = 1.10-2.92; p = 0.02), hypertension (OR = 1.91, 95% CI = 1.36-3.01; p = 0.01), central obesity (OR = 1.48, 95% CI = 1.15-1.84; p = 0.03) and metabolic syndrome percentage (OR = 1.71, 95% CI = 1.22-2.69; p = 0.02) in high resistin/uric acid index group.
    Conclusions: Resistin/uric acid index is related with Metabolic syndrome (MS) risk and criteria of it in a population of Caucasian females with obesity and this index is a correlated with glucose levels, insulin levels and insulin resistance (HOMA-IR).
    MeSH term(s) Humans ; Female ; Adolescent ; Metabolic Syndrome ; Insulin Resistance ; Uric Acid ; Resistin ; Cross-Sectional Studies ; Obesity/metabolism ; Insulin ; Glucose ; Body Mass Index
    Chemical Substances Uric Acid (268B43MJ25) ; Resistin ; Insulin ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 752409-2
    ISSN 1476-5497 ; 0307-0565
    ISSN (online) 1476-5497
    ISSN 0307-0565
    DOI 10.1038/s41366-023-01287-4
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  3. Article: Combined Strategy Using High Hydrostatic Pressure, Temperature and Enzymatic Hydrolysis for Development of Fibre-Rich Ingredients from Oat and Wheat By-Products.

    Jiménez-Pulido, Iván Jesús / Rico, Daniel / De Luis, Daniel / Martín-Diana, Ana Belén

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Wheat bran (WB) and oat hull (OH) are two interesting undervalued cereal processing sources rich in total dietary fibre (TDF) and other associated bioactive compounds, such as β-glucans and polyphenols. The aim of this study was to optimise a combination ...

    Abstract Wheat bran (WB) and oat hull (OH) are two interesting undervalued cereal processing sources rich in total dietary fibre (TDF) and other associated bioactive compounds, such as β-glucans and polyphenols. The aim of this study was to optimise a combination chemical (enzymes) and physical (high hydrostatic pressure-temperature) strategies to increase the bioaccessibility of bioactive compounds naturally bound to the bran and hull outer layers. WB and OH were hydrolysed using food-grade enzymes (UltraFloXL and Viscoferm, for WB and OH, respectively) in combination with HPP at different temperatures (40, 50, 60 and 70 °C) and hydrolysis either before or after HPP. Proximal composition, phytic acid, β-glucans, total phenolics (TPs) and total antioxidant activity (TAC) were evaluated to select the processing conditions for optimal nutritional and bioactive properties of the final ingredients. The application of the hydrolysis step after the HPP treatment resulted in lower phytic acid levels in both matrices (WB and OH). On the other hand, the release of β-glucan was more effective at the highest temperature (70 °C) used during pressurisation. After the treatment, the TP content ranged from 756.47 to 1395.27 µmol GAE 100 g
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13030378
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  4. Article ; Online: Role of rs2282679 in 25-hydroxyvitamin D levels and insulin resistance after a sleeve gastrectomy.

    de Luis, Daniel / Izaola, Olatz / Primo, David / López Gómez, Juan José / Pacheco, David

    Nutrition & diabetes

    2024  Volume 14, Issue 1, Page(s) 12

    Abstract: Background & aims: Some studies have reported links between 25-hydroxyvitamin D levels and the presence of obesity and some genetic variants. The aim of our design was to evaluate the effects of rs2282679 genetic variant of CG gene on 25-hydroxyvitamin ... ...

    Abstract Background & aims: Some studies have reported links between 25-hydroxyvitamin D levels and the presence of obesity and some genetic variants. The aim of our design was to evaluate the effects of rs2282679 genetic variant of CG gene on 25-hydroxyvitamin D levels, weight loss and metabolic parameters after a robotic sleeve gastrectomy in premenopausal females with obesity.
    Methods: 76 participants were enrolled. 25-hydroxyvitamin D levels, biochemical evaluation and anthropometric parameters were registered before surgery and after 3, 6 and 12 months follow up. Genotype of rs2282679 CG gene was evaluated.
    Results: The improvements in anthropometric parameters, blood pressure and lipid profile were similar in both genotypes (TT vs TG + GG). Basal insulin levels and HOMA-IR were greater in G allele carriers than non-carriers (Delta: 6.7 ± 1.2 mUI/L; p = 0.01) and (Delta: 1.3 ± 0.1 units; p = 0.02). 25-hydroxyvitamin D levels were lower in G allele carriers than non-carriers (Delta: 8.1 ± 1.1 ng/dl; p = 0.03). The levels of insulin and HOMA-IR remained greater in G allele carriers than non-carriers throughout all the visits. The levels of 25-hydroxyvitamin D remained lower in G allele carriers than non-G allele. The average level of 25-hydroxyvitamin D at 12 months in non-G allele carriers were above 30 ng/dl (36.0 ± 3.1 ng/dl) and the level in G allele carriers were below (24.9 ± 4.9 ng/dl).
    Conclusions: rs 2282679 (GC) was related with low 25 hydroxyvitamin D levels and insulin resistance. In addition, the presence of G allele produced a decrease in the improvement of 25-hydroxyvitamin D levels and insulin resistance after weight loss during 12 months.
    MeSH term(s) Female ; Humans ; Insulin Resistance ; Polymorphism, Single Nucleotide ; Obesity/metabolism ; Insulin ; Weight Loss ; Vitamin D/analogs & derivatives
    Chemical Substances 25-hydroxyvitamin D (A288AR3C9H) ; Insulin ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2609314-5
    ISSN 2044-4052 ; 2044-4052
    ISSN (online) 2044-4052
    ISSN 2044-4052
    DOI 10.1038/s41387-024-00272-8
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  5. Article ; Online: Role of resistin (rs7139228) gene polymorphism with metabolic response after a hypocaloric mediterranean diet.

    de Luis, Daniel Antonio / Primo, David / Izaola, Olatz / Aller, Rocío

    Endocrinologia, diabetes y nutricion

    2023  Volume 70, Issue 2, Page(s) 88–97

    Abstract: Background: The SNP (rs7139228) of the RETN gene is a polymorphism that has been associated with metabolic disorder in subjects with obesity, and its effect on metabolic response after dietary intervention has not been evaluated.: Objective: Our ... ...

    Abstract Background: The SNP (rs7139228) of the RETN gene is a polymorphism that has been associated with metabolic disorder in subjects with obesity, and its effect on metabolic response after dietary intervention has not been evaluated.
    Objective: Our objective was to analyse the effects of the polymorphism of the RETN gene rs7139228 on metabolic changes secondary to weight loss with a hypocaloric Mediterranean diet.
    Design: 1000 obese Caucasian patients were evaluated. An anthropometric evaluation and a biochemical analysis were performed before and after 12 weeks of a hypocaloric Mediterranean diet. The statistical analysis was performed as a dominant model (GG vs GA+AA).
    Results: Improvements in anthropometric parameters, leptin levels and systolic blood pressure were similar in both genotype groups. In non- A allele carriers, levels of resistin, insulin, HOMA-IR, triglycerides and C-reactive protein decreased. The improvements were statistically significant in this group; resistin (-1.3+0.1ng/dL: p=0.02), triglycerides (-22.9+4.9mg/dl: p=0.02), CRP (-2.7+0 0.4mg/dl: p=0.02), insulin -6.5+1.8 mIU/L: p=0.02) and HOMA-IR (-2.2+0.8: p=0, 03). In addition, insulin, HOMA-IR and resistin levels were higher in A allele carriers than in non-carriers. Finally, the prevalence of metabolic syndrome and hyperglycaemia were higher in A allele carriers, and these percentages only decreased after intervention in non-A allele carriers.
    Conclusion: The A rs7139228 allele is associated with a worse metabolic response (insulin, HOMA-IR, triglycerides and CRP) after weight loss with a hypocaloric Mediterranean diet. A non-significant decrease in the prevalence of metabolic syndrome and hyperglycaemia were detected in A allele carriers.
    MeSH term(s) Humans ; Resistin/genetics ; Diet, Reducing ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics ; Diet, Mediterranean ; Insulin Resistance/genetics ; Polymorphism, Single Nucleotide ; Obesity/epidemiology ; Obesity/genetics ; Insulin ; Weight Loss/genetics ; Triglycerides ; Hyperglycemia
    Chemical Substances Resistin ; Insulin ; Triglycerides
    Language English
    Publishing date 2023-02-23
    Publishing country Spain
    Document type Journal Article
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2022.10.004
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  6. Article ; Online: Role of irisin and myostatin on sarcopenia in malnourished patients diagnosed with GLIM criteria.

    de Luis, Daniel / Primo, David / Izaola, Olatz / Gómez, Juan José López

    Nutrition (Burbank, Los Angeles County, Calif.)

    2023  Volume 120, Page(s) 112348

    Abstract: Objectives: Sarcopenia is characterized by the loss of muscle mass. Skeletal muscle can produce and secrete different molecules called myokines. Irisin and myostatin are antagonistic myokines, and to our knowledge, no studies of both myokines have been ... ...

    Abstract Objectives: Sarcopenia is characterized by the loss of muscle mass. Skeletal muscle can produce and secrete different molecules called myokines. Irisin and myostatin are antagonistic myokines, and to our knowledge, no studies of both myokines have been conducted in patients with disease-related malnutrition (DRM). This study aimed to investigate the role of circulating irisin and myostatin in sarcopenia in patients with DRM.
    Methods: The study included 108 outpatients with DRM according to the Global Leadership Initiative on Malnutrition criteria. Participants had a mean age of 67.4 ± 3.4 y. Anthropometric data, muscle mass by ultrasound at the rectus femoris quadriceps (RFQ) level, impedancemetry (skeletal muscle mass [SMM], appendicular SMM [aSMM], and aSMM index [aSMMI]), dynamometry, biochemical parameters, dietary intake, circulating irisin and myostatin levels were determined in all patients. Confirmed sarcopenia was diagnosed as criteria of probable sarcopenia (low muscle strength) plus abnormal aSMMI.
    Results: Of the 108 patients, 44 presented sarcopenia (41%); 64 did not present with the disorder (59%). The following parameters were worse in patients with sarcopenia: Patients without sarcopenia were stronger than those with the disorder (7.9 ±1.3 kg; P = 0.01). Circulating irisin levels were higher in patients without sarcopenia than those with sarcopenia (651.3 ± 221.3 pg/mL; P =0.01). Myostatin levels were similar in both groups. Finally, logistic regression analysis reported a low risk for sarcopenia (odds ratio, 0.39; 95% confidence interval, 0.19-0.92; P = 0.03) in high irisin median levels as a dichotomic parameter after adjusting for body mass index, sex, energy intake, and age.
    Conclusion: The present study reported that low levels of serum irisin were closely associated with sarcopenia in patients with DRM.
    MeSH term(s) Aged ; Humans ; Middle Aged ; Fibronectins ; Malnutrition/complications ; Malnutrition/diagnosis ; Muscle, Skeletal/pathology ; Myostatin ; Sarcopenia/complications ; Sarcopenia/diagnosis
    Chemical Substances Fibronectins ; Myostatin ; MSTN protein, human ; FNDC5 protein, human
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2023.112348
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  7. Article ; Online: Dietary Intervention during 9 Months with a Hypocaloric Diet, Interaction of the Genetic Variant of Adiponectin Gene rs822393 with Metabolic Parameters.

    Izaola, Olatz / Primo, David / de Luis, Daniel

    Disease markers

    2022  Volume 2022, Page(s) 7058389

    Abstract: Background and aims: rs822393 (-4522C/T) genetic variant is associated with hypoadiponectinemia and other metabolic parameters. The aim of our investigation was to analyze the effects of a hypocaloric diet with Mediterranean dietary pattern during 9 ... ...

    Abstract Background and aims: rs822393 (-4522C/T) genetic variant is associated with hypoadiponectinemia and other metabolic parameters. The aim of our investigation was to analyze the effects of a hypocaloric diet with Mediterranean dietary pattern during 9 months according to genetic variant rs822393 of
    Methods and results: A sample of 269 obese patients was enrolled. Anthropometric and serum parameters (lipid profile, insulin, homeostasis model assessment (HOMA-IR), glucose, C reactive protein, and adipokines) were determined, at basal time and after 3 and 9 months. All patients were genotyped in the rs822393. The genotype distribution was as follow; 176 patients (65.4%) CC, 83 patients CT (30.9%), and 10 patients TT (3.7%). After dietary intervention, the following parameters improved in non-T allele carriers; BMI, weight, fat mass, waist circumference, systolic blood pressure, insulin levels, HOMA-IR, leptin, total cholesterol, and LDL-cholesterol improved significantly. HDL-cholesterol (delta: 5.7 ± 1.1 mg/dl vs. 1.0 ± 0.8 mg/dl;
    Conclusion: T allele carriers showed lower levels of HDL-cholesterol, adiponectin, and adiponectin/leptin ratio than non-T allele carriers. A medium-term hypocaloric diet with a Mediterranean partner increased adiponectin levels, ratio adiponectin/leptin, and HDL-cholesterol in non-T allele carriers.
    MeSH term(s) Adiponectin/genetics ; Adult ; Caloric Restriction ; Diet, Mediterranean ; Female ; Humans ; Male ; Middle Aged ; Obesity/blood ; Obesity/diet therapy ; Obesity/genetics ; Outcome Assessment, Health Care ; Young Adult
    Chemical Substances Adiponectin
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/7058389
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  8. Article ; Online: Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects.

    Primo, David / Izaola, Olatz / de Luis, Daniel A

    Annals of nutrition & metabolism

    2022  Volume 79, Issue 2, Page(s) 238–245

    Abstract: Background: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects.!# ...

    Abstract Background: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects.
    Aims: The objective of this work was to detect the cutoff point of the TyG index for the diagnosis of MS according to ATPIII criteria on obese subjects and to compare with HOMA-IR.
    Methods: We conducted a cross-sectional study in 1,494 obese subjects. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C-reactive protein, adipokines, and the prevalence of MS were determined. The TyG index was calculated from the next equation: Ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL))/2.
    Results: A total of 1,494 subjects were recruited, 421 males (28.1%) and 1,073 females (71.8%), with an average age of 45.8 ± 15.3 years (range: 29-62). A total of 677 subjects had MS (45.5%) and 817 did not show MS (54.6%). The averages of HOMA-IR and TyG index values increased as the components of MS were aggregated, and both indexes were higher in subjects with MS. The area under the curve (AUC) of the TyG index according to ATPIII criteria showed values of 0.746 (0.721-0.771; p = 0.001). The cutoff point according to the Youden index was 4.72, with sensitivity and specificity of 87% and 88.2%, respectively. For the HOMA-IR, AUC showed values of 0.682 (0.654-0.710; p = 0.01). The cutoff point was 3.23, with sensitivity and specificity of 78% and 70.1%, respectively.
    Conclusions: The TyG index is more powerful for predicting MS than HOMA-IR in Caucasian obese subjects.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Glucose ; Metabolic Syndrome ; Insulin Resistance ; Blood Glucose/metabolism ; Triglycerides ; Cross-Sectional Studies ; Prevalence ; Obesity ; Biomarkers
    Chemical Substances Glucose (IY9XDZ35W2) ; Blood Glucose ; Triglycerides ; Biomarkers
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 392341-1
    ISSN 1421-9697 ; 0250-6807 ; 1018-9688
    ISSN (online) 1421-9697
    ISSN 0250-6807 ; 1018-9688
    DOI 10.1159/000526988
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  9. Article ; Online: Clinical, glycometric features and treatment in a family with monogenic diabetes due to a new mutation in the insulin gene.

    Pérez López, Paloma / Bahillo Curieses, Pilar / Fernández, Pablo / Martínez, Rosa / Delgado, Esther / Ortolá, Ana / de Luis, Daniel / Díaz-Soto, Gonzalo

    Endocrinologia, diabetes y nutricion

    2024  Volume 71, Issue 2, Page(s) 77–82

    Abstract: Monogenic diabetes caused by changes in the gene that encodes insulin (INS) is a very rare form of monogenic diabetes (<1%). The aim of this work is to describe the clinical and glycaemic control characteristics over time from four members of a family ... ...

    Abstract Monogenic diabetes caused by changes in the gene that encodes insulin (INS) is a very rare form of monogenic diabetes (<1%). The aim of this work is to describe the clinical and glycaemic control characteristics over time from four members of a family diagnosed with monogenic diabetes with the novel mutation: c.206del,p.(Gly69Aalfs*62) located in exon 3 of the gene INS. 75% are females, with debut in adolescence and negative autoimmunity. In all cases, C-peptide is detectable decades after diagnosis (>0.6ng/ml). Currently, patients are being treated either with insulin in a bolus-basal regimen, oral antidiabetics or hybrid closed loop system. Monogenic diabetes due to mutation in the INS is an entity with heterogeneous presentation, whose diagnosis requires high suspicion and presents an important clinical impact. Given the lack of standards in this regard, therapy must be individualized, although insulin therapy could help preserve beta cell functionality in these subjects.
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Autoimmunity ; Diabetes Mellitus/diagnosis ; Hypoglycemic Agents/therapeutic use ; Insulin/genetics ; Mutation
    Chemical Substances Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2024-03-29
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2530-0180
    ISSN (online) 2530-0180
    DOI 10.1016/j.endien.2024.03.006
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  10. Article ; Online: Correlation of the Phase Angle with Muscle Ultrasound and Quality of Life in Obese Females.

    Primo, David / Izaola, Olatz / Gómez, J J López / de Luis, Daniel

    Disease markers

    2022  Volume 2022, Page(s) 7165126

    Abstract: Introduction: Phase angle (PhA) has been suggested to be an indicator of body cell mass and nutritional status. Clinically, the phase angle supposedly reflects body cell mass and cell membrane function, and the higher the phase angle, the better is the ... ...

    Abstract Introduction: Phase angle (PhA) has been suggested to be an indicator of body cell mass and nutritional status. Clinically, the phase angle supposedly reflects body cell mass and cell membrane function, and the higher the phase angle, the better is the cell function. Muscle ultrasound (US) is an emerging nutritional assessment technique.
    Objective: The aim of this study was to investigate the usefulness and correlation of PhA with muscle US of quadriceps rectus femoris (QRF) in obese female subjects and the relationship with quality of life and physical performance.
    Results: In total, 50 female obese patients were included with a mean age of 45.9 ± 2.4 years. The mean body mass index was 32.1 ± 1.6 kg/m
    Conclusion: PhA was correlated with muscle area, muscle circumference, muscle echo intensity, serum protein, quality of life SF-36, and strength physical performance.
    MeSH term(s) Adult ; Body Composition/physiology ; Electric Impedance ; Female ; Humans ; Middle Aged ; Muscles ; Obesity/diagnostic imaging ; Quality of Life
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2022/7165126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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