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  1. Article ; Online: The Association Between Meningioma and Breast Cancer: A Systematic Review and Meta-analysis.

    Degeneffe, Aurélie / De Maertelaer, Viviane / De Witte, Olivier / Lefranc, Florence

    JAMA network open

    2023  Volume 6, Issue 6, Page(s) e2318620

    Abstract: Importance: A potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic.: Objective: To provide a comprehensive review of the literature on the ... ...

    Abstract Importance: A potential relationship between meningioma and breast cancer was suggested 70 years ago. However, to date, no conclusive evidence is available on this topic.
    Objective: To provide a comprehensive review of the literature on the association of meningioma with breast cancer, supported by a meta-analysis.
    Data sources: A systematic PubMed search was performed up to April 2023 to identify articles on the association of meningioma with breast cancer. The following key words were used strategically: meningioma, breast cancer, breast carcinoma, association, relation.
    Study selection: All studies reporting women diagnosed with meningioma and breast cancer were identified. The search strategy was not limited by study design or publication date but only included articles in English. Additional articles were identified via citation searching. Studies reporting a complete population of meningiomas or breast cancer patients throughout a specific study period and a proportion of patients with a second pathology could be used for the meta-analysis.
    Data extraction and synthesis: Data extraction was performed by 2 authors in accordance with the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. Meta-analyses regarding both populations were performed using a random-effects model. Risk of bias was assessed.
    Main outcomes and measures: The main measures were whether there was an increased prevalence of breast cancer in female patients with meningioma and whether there was an increased prevalence of meningioma in female patients with breast cancer.
    Results: A total of 51 retrospective studies (case reports, case series, and cancer registry reports) describing 2238 patients with both diseases were identified; 18 studies qualified for prevalence analyses and meta-analysis. The random-effects meta-analysis (13 studies) revealed a significantly greater prevalence of breast cancer in female patients with meningioma than in the overall population (odds ratio [OR], 9.87; 95% CI, 7.31-13.32). Meningioma incidence in patients with breast cancer (11 studies) was greater than that in the baseline population; however, the difference according to the random-effects model was not statistically significant (OR, 1.41; 95% CI, 0.99-2.02).
    Conclusions and relevance: This large systematic review and the meta-analysis on the association between meningioma and breast cancer found nearly 10-fold higher odds of breast cancer in female patients with meningioma compared with the general female population. These findings suggest that female patients with meningioma should be screened more intensively for breast cancer. Further research is required to identify the factors causing this association.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/epidemiology ; Breast Neoplasms/diagnosis ; Meningioma/epidemiology ; Retrospective Studies ; Incidence ; Meningeal Neoplasms/epidemiology
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.18620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Worldwide Evolution of Vaccinable and Nonvaccinable Viral Skin Infections: Google Trends Analysis.

    Simonart, Thierry / Lam Hoai, Xuân-Lan / de Maertelaer, Viviane

    JMIR dermatology

    2022  Volume 5, Issue 4, Page(s) e35034

    Abstract: Background: Most common viral skin infections are not reportable conditions. Studying the population dynamics of these viral epidemics using traditional field methods is costly and time-consuming, especially over wide geographical areas.: Objective: ... ...

    Abstract Background: Most common viral skin infections are not reportable conditions. Studying the population dynamics of these viral epidemics using traditional field methods is costly and time-consuming, especially over wide geographical areas.
    Objective: This study aimed to explore the evolution, seasonality, and distribution of vaccinable and nonvaccinable viral skin infections through an analysis of Google Trends.
    Methods: Worldwide search trends from January 2004 through May 2021 for viral skin infections were extracted from Google Trends, quantified, and analyzed.
    Results: Time series decomposition showed that the total search term volume for warts; zoster; roseola; measles; hand, foot, and mouth disease (HFMD); varicella; and rubella increased worldwide over the study period, whereas the interest for Pityriasis rosea and herpes simplex decreased. Internet searches for HFMD, varicella, and measles exhibited the highest seasonal patterns. The interest for measles and rubella was more pronounced in African countries, whereas the interest for HFMD and roseola was more pronounced in East Asia.
    Conclusions: Harnessing data generated by web searches may increase the efficacy of traditional surveillance systems and strengthens the suspicion that the incidence of some vaccinable viral skin infections such as varicella, measles, and rubella may be globally increasing, whereas the incidence of common nonvaccinable skin infections remains stable.
    Language English
    Publishing date 2022-10-04
    Publishing country Canada
    Document type Journal Article
    ISSN 2562-0959
    ISSN (online) 2562-0959
    DOI 10.2196/35034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Chronic spontaneous urticaria: Evidence of systemic microcirculatory changes.

    Mostmans, Yora / Maurer, Marcus / Richert, Bertrand / Smith, Vanessa / Melsens, Karin / De Maertelaer, Viviane / Saidi, Ines / Corazza, Francis / Michel, Olivier

    Clinical and translational allergy

    2024  Volume 14, Issue 1, Page(s) e12335

    Abstract: Background: Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease where activation of endothelial cells (ECs) at sites of skin lesions leads to increased blood flow, leakage of fluid into the skin, cellular infiltration, and ... ...

    Abstract Background: Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease where activation of endothelial cells (ECs) at sites of skin lesions leads to increased blood flow, leakage of fluid into the skin, cellular infiltration, and vascular remodeling. To understand the disease duration and the sometimes vague systemic symptoms accompanying flares, the objective of this study was to examine if CSU comes with systemic vascular changes at the microcirculatory level.
    Methods: We investigated CSU patients (n = 49) and healthy controls (HCs, n = 44) for microcirculatory differences by nailfold videocapillaroscopy (NVC) and for blood levels of the soluble EC biomarkers serum vascular endothelial growth factor (VEGF), soluble E-selectin, and stem cell factor (SCF). Patients were also assessed for clinical characteristics, disease activity, and markers of autoimmune CSU (aiCSU).
    Results: CSU patients had significantly lower capillary density, more capillary malformations, and more irregular capillary dilations than HCs on NVC. Serum levels of VEGF, soluble E selectin and SCF were similar in CSU patients and HCs. CSU patients with higher VEGF levels had significantly more abnormal capillaries. Patients with markers of aiCSU, that is, low IgE levels or increased anti-TPO levels, had significantly more capillaries and less capillary dilations than those without.
    Conclusion: Our results suggest that CSU comes with systemic microcirculatory changes, which may be driven, in part, by VEGF.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2630865-4
    ISSN 2045-7022
    ISSN 2045-7022
    DOI 10.1002/clt2.12335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Which factors influence Demodex proliferation? A retrospective pilot study highlighting a possible role of subtle immune variations and sebaceous gland status.

    Forton, Fabienne M N / De Maertelaer, Viviane

    The Journal of dermatology

    2021  Volume 48, Issue 8, Page(s) 1210–1220

    Abstract: Demodex folliculorum and brevis are commensal mites that live in low densities in human pilosebaceous follicles as part of the normal adult microbiota, but that give rise to demodicosis and, possibly, rosacea, when they proliferate excessively. This ... ...

    Abstract Demodex folliculorum and brevis are commensal mites that live in low densities in human pilosebaceous follicles as part of the normal adult microbiota, but that give rise to demodicosis and, possibly, rosacea, when they proliferate excessively. This proliferation is favored by various factors, including age, marked immunosuppression, sebaceous gland hyperplasia, and hypervascularization-related factors. To study possible factors influencing mite proliferation, we explored the effects of different variables on Demodex densities (Dd) in a retrospective study of two groups of subjects selected on the basis of their clinical diagnosis: Demodex+, consisting of subjects with demodicosis or with centro-facial papulopustules suggesting rosacea (n = 844, mean Dd 263.5 ± 8.9 D/cm
    MeSH term(s) Adult ; Cell Proliferation ; Female ; Humans ; Male ; Mite Infestations/diagnosis ; Pilot Projects ; Retrospective Studies ; Rosacea/diagnosis ; Sebaceous Glands
    Language English
    Publishing date 2021-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effectiveness of benzyl benzoate treatment on clinical symptoms and Demodex density over time in patients with rosacea and demodicosis: a real life retrospective follow-up study comparing low- and high-dose regimens.

    Forton, Fabienne M N / De Maertelaer, Viviane

    The Journal of dermatological treatment

    2020  Volume 33, Issue 1, Page(s) 456–465

    Abstract: Background: Patients with rosacea and demodicosis have high facial skin Demodex densities (Dds), which decrease with benzyl benzoate (BB) treatment.: Objectives: To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical ... ...

    Abstract Background: Patients with rosacea and demodicosis have high facial skin Demodex densities (Dds), which decrease with benzyl benzoate (BB) treatment.
    Objectives: To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms during prolonged follow-up and to compare low (12% once daily) and high (12% twice daily or 20-24% once daily) BB dose regimens.
    Methods: This retrospective study included 344 patients (103 rosacea, 241 demodicosis) observed for 7.1 ± 0.5 months. Dds were measured on two consecutive standardized skin surface biopsies and symptoms evaluated using investigator global assessment. Compliance was considered good if patients correctly followed treatment instructions.
    Results: At final follow-up, in the 248 patients with good compliance, Dd had normalized in 217 (88%) and symptoms cleared in 204 (82%). The high dose was associated with better compliance and faster results than the low-dose. The higher the initial Dd, the longer it took to normalize. In the 96 poorly compliant patients, treatment was less effective and slower.
    Conclusions: These findings indirectly support a key role of the mite in rosacea and suggest that topical treatment with BB (+crotamiton), especially the higher dose, may be a useful alternative treatment for rosacea as well as for demodicosis.[Formula: see text].
    MeSH term(s) Benzoates ; Follow-Up Studies ; Humans ; Mite Infestations/drug therapy ; Retrospective Studies ; Rosacea/drug therapy
    Chemical Substances Benzoates ; benzyl benzoate (N863NB338G)
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2020.1770168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Epidemiologic evolution of common cutaneous infestations and arthropod bites: A Google Trends analysis.

    Simonart, Thierry / Lam Hoai, Xuân-Lan / De Maertelaer, Viviane

    JAAD international

    2021  Volume 5, Page(s) 69–75

    Abstract: Background: Common cutaneous infestations and arthropod bites are not reportable conditions in most countries. Their worldwide epidemiologic evolution and distribution are mostly unknown.: Objective: To explore the evolution and geographic ... ...

    Abstract Background: Common cutaneous infestations and arthropod bites are not reportable conditions in most countries. Their worldwide epidemiologic evolution and distribution are mostly unknown.
    Objective: To explore the evolution and geographic distribution of common cutaneous infestations and arthropod bites through an analysis of Google Trends.
    Methods: Search trends from 2004 through March 2021 for common cutaneous infestations and arthropod bites were extracted from Google Trends, quantified, and analyzed.
    Results: Time series decomposition showed that total search term volume for pubic lice decreased worldwide over the study period, while the interest for ticks, pediculosis, insect bites, scabies, lice, and bed bugs increased (in increasing order). The interest for bed bugs was more pronounced in the former Union of Soviet Socialist Republics countries, interest for lice in Near East and Middle East countries, and interest for pubic lice in South American countries. Internet searches for bed bugs, insect bites, and ticks exhibited the highest seasonal patterns.
    Limitations: Retrospective analysis limits interpretation.
    Conclusion: Surveillance systems based on Google Trends may enhance the timeliness of traditional surveillance systems and suggest that, while most cutaneous infestations increase worldwide, pubic lice may be globally declining.
    Language English
    Publishing date 2021-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2021.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Real-world adherence to topical therapies in patients with moderate acne.

    Lam Hoai, Xuân-Lan / De Maertelaer, Viviane / Simonart, Thierry

    JAAD international

    2021  Volume 2, Page(s) 109–115

    Abstract: Background: Real-life data on topical treatments in daily practice in patients with moderate acne are poorly characterized.: Objective: To investigate the drug survival of topical treatments administered to patients with moderate acne in a daily ... ...

    Abstract Background: Real-life data on topical treatments in daily practice in patients with moderate acne are poorly characterized.
    Objective: To investigate the drug survival of topical treatments administered to patients with moderate acne in a daily practice.
    Methods: Survival analysis was performed on subjects (Belgian university hospital and private practice outpatient dermatology patients) with moderate acne who received topical therapies according to the current published guidelines.
    Results: A total of 1160 treatment series (1029 patients) were included, including benzoyl peroxide (BPO, n = 93), azelaic acid (n = 246), adapalene (n = 254), a fixed combination of adapalene 0.1% and BPO 2.5% (A/BPO, n = 264), and a fixed combination of clindamycin 1.2% and tretinoin 0.025% gel (Clin-RA, n = 303). The calculated overall median treatment duration of all drugs was 2 months. The probability of treatment discontinuation after only 3 months was 50%. Overall, the drugs were discontinued for the following reasons: controlled acne (9%), side effects (9%), ineffectiveness (52%), combination of side effects and ineffectiveness (3%), and other reasons (1%). Overall, 27% patients were lost to follow-up.
    Limitations: The post hoc study design and generalizability limit interpretation of the data.
    Conclusion: Overall, the median treatment duration of topical anti-acne therapies was short (2 months). The main reason for discontinuation was ineffectiveness.
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2020.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of human papillomavirus vaccine in reducing genital warts: A Google Trends analysis.

    Simonart, Thierry / Lam Hoai, Xuân-Lan / De Maertelaer, Viviane

    Journal of the American Academy of Dermatology

    2021  Volume 86, Issue 4, Page(s) 956–958

    MeSH term(s) Condylomata Acuminata/epidemiology ; Condylomata Acuminata/prevention & control ; Humans ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines ; Search Engine
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.03.091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Chronic Spontaneous Urticaria in Belgium: Deciphering the Clinical Profile and Treatment of Patients Visiting an Urban City Immunology Department.

    Mostmans, Yora / Richert, Bertrand / De Maertelaer, Viviane / Saidi, Ines / Benslimane, Asma / Thi Thanh, Thao Tran / Corazza, Francis / Michel, Olivier

    Dermatology (Basel, Switzerland)

    2023  Volume 239, Issue 6, Page(s) 926–936

    Abstract: Background: Chronic urticaria (CSU) is a chronic inflammatory mast cell-driven disorder of which reliable clinical data in Belgium are lacking. This study focusses on clinical characteristics of CSU patients presenting at an urban Immunology-Allergology ...

    Abstract Background: Chronic urticaria (CSU) is a chronic inflammatory mast cell-driven disorder of which reliable clinical data in Belgium are lacking. This study focusses on clinical characteristics of CSU patients presenting at an urban Immunology-Allergology department.
    Methods: Outpatients with CSU were included from 2018 to 2021. Clinical characteristics, Dermatology Life Quality Index (DLQI) and Urticaria activity score (UAS7) were collected by thorough anamnesis and questionnaires. Furthermore, patients underwent provocational testing, an autologous serum skin test (ASST) and a blood analysis.
    Results: The study included 49 CSU patients and 20 non-CSU subjects. CSU was distributed differently with age and sex, showing higher numbers in female patients below the age of 46 years. 67% of CSU patients had accompanying angioedema of which 9% were reported genital. CSU patients scored a mean 8/30 on their DLQI questionnaire. There was no significant difference in immunoglobulin E (IgE), C-reactive protein, and tryptase levels between CSU patients and controls. Oral glucocorticosteroids were prescribed in 23% of CSU patients during their disease course though only half of these patients had a severity grade 4 CSU. In 82% of the included CSU patients, Urticaria Control Test (UCT) scores were below 12. When we hypothetically considered low IgE levels and high IgG anti-thyroid peroxidase levels as differentiation marker for autoimmune (ai)CSU and non-aiCSU, we found that 4% of all included CSU patients could be considered aiCSU.
    Conclusion: Generally, the inner-city population displayed the same clinical characteristics, as previous cohorts from Northern Europe. The relatively high rate of CSU patients receiving oral glucocorticosteroid treatment for their disease though not always classified as severe, underlines the need to train doctors of various specialties in the treatment algorithms of CSU. Furthermore, by looking at potential autoimmune characteristics, our findings open perspectives on the identification of new routinely used clinical parameters for the detection of aiCSU, a relatively small immunological subtype of CSU.
    MeSH term(s) Humans ; Female ; Middle Aged ; Belgium ; Chronic Urticaria/drug therapy ; Urticaria/drug therapy ; Disease Progression ; Immunoglobulin E ; Chronic Disease
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2023-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000533394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prevalence of scratching during examination among patients with scabies and among patients with other pruritic dermatoses.

    Lam Hoai, Xuân-Lan / De Maertelaer, Viviane / Simonart, Thierry

    International journal of dermatology

    2020  Volume 60, Issue 1, Page(s) 70–72

    Abstract: Background: Scabies is a parasitic skin disease. Its clinical diagnosis may be challenging.: Methods: In a prospective observational study, we enrolled all consecutive patients ≥16 years of age with a presumptive diagnosis of scabies and all patients ...

    Abstract Background: Scabies is a parasitic skin disease. Its clinical diagnosis may be challenging.
    Methods: In a prospective observational study, we enrolled all consecutive patients ≥16 years of age with a presumptive diagnosis of scabies and all patients ≥16 years of age with a diffuse itchy dermatosis lasting for more than 1 week. We investigated whether patients with scabies were more prone to scratch themselves during the consultation than patients with other pruritic dermatoses.
    Results: We observed that a significant proportion of patients (25/62, 40%) with scabies had to scratch while talking or being examined. This clinical sign was less frequently noticed in patients with pruritic dermatoses of other origins (26/196, 13%) (P < 0.001).
    Conclusions: The observation of a patient scratching himself during the consultation should prompt serious consideration of scabies. This easily observable clinical sign may be especially useful in low-resource settings, where scabies is known to be very prevalent.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Dermatitis, Photoallergic/complications ; Drug Eruptions/complications ; Eczema/complications ; Female ; Granuloma Annulare/complications ; Humans ; Lymphoma/complications ; Male ; Middle Aged ; Pemphigoid, Bullous/complications ; Physical Examination ; Prospective Studies ; Pruritus/etiology ; Psoriasis/complications ; Scabies/complications ; Scabies/diagnosis ; Symptom Assessment ; Urticaria/complications ; Young Adult
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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