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Article ; Online: Oncostatin M, Serpins, and Oxidative Stress in Extracellular Matrix Remodeling and Arteriovenous Fistula Maturation.

DeMarco, Nathaniel / Rai, Vikrant / Wilson, Daniel R / Agrawal, Devendra K

Cardiology and cardiovascular medicine

2023 Volume 7, Issue 2, Page(s) 129–140

Abstract: End-stage renal disease is a crippling diagnosis that generally requires dialysis to prolong life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous fistula (AVF) is commonly performed. Maturation of the AVF ... ...

Abstract	End-stage renal disease is a crippling diagnosis that generally requires dialysis to prolong life. To facilitate filtration of patient's blood in dialysis, surgical formation of an arteriovenous fistula (AVF) is commonly performed. Maturation of the AVF is required to allow for successful dialysis. However, AVFs commonly fail to mature, leading to the fistula closure, the necessity for another fistula site, and markedly increased morbidity and mortality. The current literature concerning molecular mechanisms associated with AVF maturation failure supports the role of inflammatory mediators involving immune cells and inflammatory cytokines. However, the role of oncostatin M (OSM), an inflammatory cytokine, and its downstream targets are not well investigated. Through inflammation, oxidative stress, and hypoxic conditions, the vascular tissue surrounding the AVF undergoes fibrosis, stenosis, and wall thickening, leading to complete occlusion and nonfunctional. In this report, first we critically review the existing literature on the role of OSM in the most common causes of early AVF failure - vascular inflammation, thrombosis, and stenosis. We next consider the potential of using OSM as a therapeutic target, and finally discuss therapeutic agents targeting inflammatory mediators involved in OSM signaling to potentiate successful maturation of the AVF.
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article
ISSN	2572-9292
ISSN (online)	2572-9292
DOI	10.26502/fccm.92920318
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Article ; Online: Post-Secondary Food Service Manager Perspectives on Fruit and Vegetable Nudging Strategies: Qualitative Study.

Bains, Kiran / DeMarco, Natalie / Brauer, Paula / Yi, Sunghwan

Current developments in nutrition

2021 Volume 5, Issue 9, Page(s) nzab109

Abstract: Background: Changing the choice architecture in post-secondary food service contexts to "nudge" customers to choose more fruits and vegetables (FV) shows promise in intervention studies to date. If such approaches are to become more widely adopted, they ...

Abstract	Background: Changing the choice architecture in post-secondary food service contexts to "nudge" customers to choose more fruits and vegetables (FV) shows promise in intervention studies to date. If such approaches are to become more widely adopted, they must be feasible and acceptable to food service managers. Among possible early adopters, managers of food services in post-secondary education institutions may have unique insights on implementation of such approaches, as they have dual mandates to support student health and maintain profitability. Objective: The goal of this exploratory study was to examine current knowledge, practice, facilitators, and barriers to uptake of nudge strategies promoting FV in a sample of post-secondary food service managers. Methods: A qualitative telephone interview study was undertaken with food service managers across Canada ( Results: Managers from 9 universities and 1 technical college participated. Local context, governance, and resources varied widely. Eight of 10 institutions used some form of FV nudging as part of their marketing and health promotion, most commonly to reduce the effort associated with choosing FV. Nudging strategies aimed at increasing the range and composition of FV offerings, providing a social reference (opinion leaders) for choosing FV, and changing consequences with loyalty cards were also common. Other nudging strategies were used infrequently. Cost, operational ease of implementation, and students' privacy and choices were critical issues in adoption. Conclusions: The results can inform development and testing of locally adapted nudge interventions. It is critical that managers be involved from the outset of any planned academic implementation study.
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article
ISSN	2475-2991
ISSN (online)	2475-2991
DOI	10.1093/cdn/nzab109
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Article: Adverse Hematological Effects of COVID-19 Vaccination and Pathomechanisms of Low Acquired Immunity in Patients with Hematological Malignancies.

Yazdani, Armand N / DeMarco, Nathaniel / Patel, Parth / Abdi, Arian / Velpuri, Prathosh / Agrawal, Devendra K / Rai, Vikrant

Vaccines

2023 Volume 11, Issue 3

Abstract: The SARS-CoV-2 virus and the COVID-19 pandemic have spread across the world and severely impacted patients living with hematological conditions. Immunocompromised patients experience rapidly progressing symptoms following COVID-19 infection and are at ... ...

Abstract	The SARS-CoV-2 virus and the COVID-19 pandemic have spread across the world and severely impacted patients living with hematological conditions. Immunocompromised patients experience rapidly progressing symptoms following COVID-19 infection and are at high risk of death. In efforts to protect the vulnerable population, vaccination efforts have increased exponentially in the past 2 years. Although COVID-19 vaccination is safe and effective, mild to moderate side effects such as headache, fatigue, and soreness at the injection site have been reported. In addition, there are reports of rare side effects, including anaphylaxis, thrombosis with thrombocytopenia syndrome, Guillain-Barré Syndrome, myocarditis, and pericarditis after vaccination. Further, hematological abnormalities and a very low and transient response in patients with hematological conditions after vaccination raise concerns. The objective of this review is to first briefly discuss the hematological adverse effects associated with COVID-19 infection in general populations followed by critically analyzing the side effects and pathomechanisms of COVID-19 vaccination in immunocompromised patients with hematological and solid malignancies. We reviewed the published literature, with a focus on hematological abnormalities associated with COVID-19 infection followed by the hematological side effects of COVID-19 vaccination, and the mechanisms by which complications can occur. We extend this discussion to include the viability of vaccination efforts within immune-compromised patients. The primary aim is to provide clinicians with critical hematologic information on COVID-19 vaccination so that they can make informed decisions on how to protect their at-risk patients. The secondary goal is to clarify the adverse hematological effects associated with infection and vaccination within the general population to support continued vaccination within this group. There is a clear need to protect patients with hematological conditions from infection and modulate vaccine programs and procedures for these patients.
Language	English
Publishing date	2023-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11030662
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Article: A Review of Hematological Complications and Treatment in COVID-19.

Yazdani, Armand N / Abdi, Arian / Velpuri, Prathosh / Patel, Parth / DeMarco, Nathaniel / Agrawal, Devendra K / Rai, Vikrant

Hematology reports

2023 Volume 15, Issue 4, Page(s) 562–577

Abstract: COVID-19, caused by SARS-CoV-2, and its variants have spread rapidly across the globe in the past few years, resulting in millions of deaths worldwide. Hematological diseases and complications associated with COVID-19 severely impact the mortality and ... ...

Abstract	COVID-19, caused by SARS-CoV-2, and its variants have spread rapidly across the globe in the past few years, resulting in millions of deaths worldwide. Hematological diseases and complications associated with COVID-19 severely impact the mortality and morbidity rates of patients; therefore, there is a need for oversight on what pharmaceutical therapies are prescribed to hematologically at-risk patients. Thrombocytopenia, hemoglobinemia, leukopenia, and leukocytosis are all seen at increased rates in patients infected with COVID-19 and become more prominent in patients with severe COVID-19. Further, COVID-19 therapeutics may be associated with hematological complications, and this became more important in immunocompromised patients with hematological conditions as they are at higher risk of hematological complications after treatment. Thus, it is important to understand and treat COVID-19 patients with underlying hematological conditions with caution. Hematological changes during COVID-19 infection and treatment are important because they may serve as biomarkers as well as to evaluate the treatment response, which will help in changing treatment strategies. In this literature review, we discuss the hematological complications associated with COVID-19, the mechanisms, treatment groups, and adverse effects of commonly used COVID-19 therapies, followed by the hematological adverse events that could arise due to therapeutic agents used in COVID-19.
Language	English
Publishing date	2023-10-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.3390/hematolrep15040059
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Article ; Online: Exploring Bacterial Cellulose and a Biosurfactant as Eco-Friendly Strategies for Addressing Pharmaceutical Contaminants.

Castanho, Nathália Roberta Cardoso Mendes / de Marco, Nathane / Caetano, Érika Leão Ajala / Alves, Patrícia Lius Melo / Pickler, Thaisa Borim / Ibanez, Natasha Lien de Almeida / Jozala, Angela Faustino / Grotto, Denise

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 2

Abstract: Aquatic environments face contamination by pharmaceuticals, prompting concerns due to their toxicity even at low concentrations. To combat this, we developed an ecologically sustainable biosurfactant derived from a microorganism and integrated it into ... ...

Abstract	Aquatic environments face contamination by pharmaceuticals, prompting concerns due to their toxicity even at low concentrations. To combat this, we developed an ecologically sustainable biosurfactant derived from a microorganism and integrated it into bacterial cellulose (BC). This study aimed to evaluate BC's efficacy, with and without the biosurfactant, as a sorbent for paracetamol and 17α-ethinylestradiol (EE2) in water. We cultivated BC membranes using
MeSH term(s)	Acetaminophen ; Adsorption ; Cellulose ; Water ; Pharmaceutical Preparations
Chemical Substances	Acetaminophen (362O9ITL9D) ; Cellulose (9004-34-6) ; Water (059QF0KO0R) ; Pharmaceutical Preparations
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020448
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Article ; Online: Prevalence of Low Birth Weight, Premature Birth, and Stillbirth Among Pregnant Adolescents in Canada: A Systematic Review and Meta-analysis.

DeMarco, Natalie / Twynstra, Jasna / Ospina, Maria B / Darrington, Marissa / Whippey, Caroline / Seabrook, Jamie A

Journal of pediatric and adolescent gynecology

2021 Volume 34, Issue 4, Page(s) 530–537

Abstract: Although most studies show that adolescent pregnant women are at a higher risk for adverse birth outcomes, there has been limited research examining this relationship in Canada. This systematic review and meta-analysis investigated the prevalence of low ... ...

Abstract	Although most studies show that adolescent pregnant women are at a higher risk for adverse birth outcomes, there has been limited research examining this relationship in Canada. This systematic review and meta-analysis investigated the prevalence of low birthweight (LBW), preterm birth (PTB), and stillbirth in Canadian adolescent women compared to adult women. Studies were included if they were primary research and included a sample of adolescent mothers (≤19 years) and adult mothers (≥20 years) who gave birth to singleton infants in Canada. Birth outcomes must have been measured consistently in at least 3 studies for inclusion. Comprehensive electronic literature searches were conducted from database inception until August 2020 in 5 databases. Random effects meta-analysis models were used to estimate pooled odds ratios (pOR) for LBW, PTB, and stillbirth between adolescent and adult pregnant women. Outcomes reported included PTB (8 studies), LBW (6 studies), and stillbirth (3 studies). Compared to adult mothers, adolescent mothers had a 56% increase in the prevalence of LBW (pOR 1.56, 95% confidence interval [CI] 1.24, 1.97), a 23% increase in PTB (pOR 1.23, 95% CI 1.06, 1.42), a 20% increase in stillbirth (pOR 1.20, 95% CI 1.05, 1.37). Heterogeneity, as assessed by I
MeSH term(s)	Adolescent ; Adult ; Canada/epidemiology ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Pregnancy ; Pregnancy in Adolescence/statistics & numerical data ; Premature Birth/epidemiology ; Prevalence ; Stillbirth/epidemiology
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1325079-6
ISSN	1873-4332 ; 1083-3188
ISSN (online)	1873-4332
ISSN	1083-3188
DOI	10.1016/j.jpag.2021.03.003
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Zs.A 2337: Show issues

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Article ; Online: Evaluation of Bacillus subtilis as a Tool for Biodegrading Diesel Oil and Gasoline in Experimentally Contaminated Water and Soil.

Salmazo, Paulo / De Marco, Nathane / Soeiro, Victória Soares / Castanho, Nathália Roberta Cardoso Mendes / Leite, Fernanda Gomes / Chaud, Marco Vinicius / Grotto, Denise / Jozala, Angela F

Current microbiology

2023 Volume 80, Issue 3, Page(s) 94

Abstract: Benzene, toluene, ethylbenzene and xylene (BTEX) are toxic petroleum hydrocarbons pollutants that can affect the central nervous system and even cause cancer. For that reason, studies regarding BTEX degradation are extremely important. Our study aimed ... ...

Abstract	Benzene, toluene, ethylbenzene and xylene (BTEX) are toxic petroleum hydrocarbons pollutants that can affect the central nervous system and even cause cancer. For that reason, studies regarding BTEX degradation are extremely important. Our study aimed evaluate the microorganism Bacillus subtilis as a tool for degrading petroleum hydrocarbons pollutants. Assays were run utilizing water or soil distinctly contaminated with gasoline and diesel oil, with and without B. subtilis. The ability of B. subtilis to degrade hydrophobic compounds was analyzed by Fourier-Transform Infrared Spectroscopy (FTIR) and gas chromatography. The FTIR results indicated, for water assays, that B. subtilis utilized the gasoline and diesel oil to produce the biosurfactant, and, as a consequence, performed a biodegradation process. In the same way, for soil assay, B. subtilis biodegraded the diesel oil. The gas chromatography results indicated, for gasoline in soil assay, the B. subtilis removed BTEX. So, B. subtilis was capable of degrading BTEX, producing biosurfactant and it can also be used for other industrial applications. Bioremediation can be an efficient, economical, and versatile alternative for BTEX contamination.
MeSH term(s)	Gasoline ; Bacillus subtilis/metabolism ; Soil/chemistry ; Hydrocarbons/metabolism ; Benzene/chemistry ; Benzene/metabolism ; Toluene/metabolism ; Petroleum/metabolism ; Xylenes/metabolism ; Biodegradation, Environmental ; Soil Pollutants/metabolism ; Environmental Pollutants/metabolism ; Soil Microbiology
Chemical Substances	Gasoline ; Soil ; ethylbenzene (L5I45M5G0O) ; Hydrocarbons ; Benzene (J64922108F) ; Toluene (3FPU23BG52) ; Petroleum ; Xylenes ; Soil Pollutants ; Environmental Pollutants
Language	English
Publishing date	2023-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-022-03175-y
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Zs.A 1446: Show issues

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Article: Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development

De Marco, N / C. Campanella / M. Tussellino / R. Carotenuto / R. Ronca / S. Biffo / S. Rizzolio

Developmental biology. 2017 July 01, v. 427

2017

Abstract: The eukaryotic initiation translation factor eIF6 is a highly conserved, essential protein implicated in translation. eIF6 is regulated in vivo by extracellular signals, such as IGF signaling (for a review see Miluzio et al., 2009). In Xenopus, eif6 over- ...

Abstract	The eukaryotic initiation translation factor eIF6 is a highly conserved, essential protein implicated in translation. eIF6 is regulated in vivo by extracellular signals, such as IGF signaling (for a review see Miluzio et al., 2009). In Xenopus, eif6 over-expression causes a delay in eye development (De Marco et al., 2011). In this study we showed that eif6 co-immunoprecipitates with the insulin-like growth factor receptor (igfr) and may function downstream of igf in eye formation. The relationship between eif6 and gipc2, a protein partner of a variety of molecules including membrane proteins, was investigated. gipc2 is required for maintaining igf-induced akt activation on eye development (Wu et al., 2006). Significantly eif6 and gipc2 have opposite effects in eye development. While eif6 is required for eye formation below threshold levels, gipc2 knockdown impairs eye development (De Marco et al., 2011; Wu et al., 2006). In this study, it was shown that in eif6 over-expressors, the delay in eye morphogenesis is reversed by gipc2 injection, while the injection of eif6 down-regulates gipc2 expression. Real-time-PCR indicates that eif6 regulates gipc2 expression in a dose-dependent manner. In contrast, gipc2 knockdown has no significant effect on eif6 mRNA levels. These results suggest that eif6 regulation of gipc2 enables correct morphogenesis of Xenopus eye and stimulate questions on the molecular network implicated in this process.
Keywords	dose response ; eyes ; membrane proteins ; messenger RNA ; morphogenesis ; somatomedins ; Xenopus
Language	English
Dates of publication	2017-0701
Size	p. 148-154.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2017.04.017
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: In X. laevis embryos high levels of the anti-apoptotic factor p27BBP/eIF6 are stage-dependently found in BrdU and TUNEL-reactive territories.

De Marco, N / Campanella, C / Carotenuto, R

Zygote (Cambridge, England)

2011 Volume 19, Issue 2, Page(s) 157–163

Abstract: p27BBP/eIF6 (β4 binding protein/eukaryotic initiation factor 6) is a highly conserved protein necessary for cell life. In adult eIF6 mice, a 50% decrease in the protein levels in all tissues is accompanied by a reduction in cell proliferation only in the ...

Abstract	p27BBP/eIF6 (β4 binding protein/eukaryotic initiation factor 6) is a highly conserved protein necessary for cell life. In adult eIF6 mice, a 50% decrease in the protein levels in all tissues is accompanied by a reduction in cell proliferation only in the liver, fat cells and cultured fibroblasts. During X. laevis embryogenesis expression of p27BBP/eIF6 is abundant in high proliferative territories. However, in Xenopus cell proliferation appears unaffected following p27BBP/eIF6 over-expression or down-regulation. Indeed, p27BBP/eIF6 is an anti-apoptotic factor acting upstream of Bcl2 that reduces endogenous apoptosis. We studied p27BBP/eIF6 protein localization in wild type embryos and compared it to proliferation and apoptosis. At the beginning of embryogenesis, high levels of p27BBP/eIF6, proliferation and apoptosis overlap. In later development stages high proliferation levels are present in the same regions where higher p27BBP/eIF6 expression is observed, while apoptosis does not appear specifically concentrated in the same sites. The higher presence of p27BBP/eIF6 would appear related to an increased need of apoptosis control in the regions where cell death is essential for normal development.
MeSH term(s)	Animals ; Apoptosis ; Bromodeoxyuridine/metabolism ; Carrier Proteins/analysis ; Carrier Proteins/metabolism ; Cell Death ; Cell Proliferation ; Embryo, Nonmammalian/cytology ; Embryo, Nonmammalian/metabolism ; Embryonic Development ; Fluorescent Antibody Technique ; In Situ Nick-End Labeling ; Intermediate Filament Proteins/analysis ; Intermediate Filament Proteins/metabolism ; Peptide Initiation Factors/analysis ; Peptide Initiation Factors/metabolism ; Xenopus Proteins/analysis ; Xenopus Proteins/metabolism ; Xenopus laevis
Chemical Substances	Carrier Proteins ; Intermediate Filament Proteins ; Peptide Initiation Factors ; Xenopus Proteins ; eIF-6 ; eIF6 protein, Xenopus ; Bromodeoxyuridine (G34N38R2N1)
Language	English
Publishing date	2011-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166294-3
ISSN	1469-8730 ; 0967-1994
ISSN (online)	1469-8730
ISSN	0967-1994
DOI	10.1017/S0967199410000213
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Zs.A 3816: Show issues

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Article ; Online: Production of polyhydroxybutyrate by the cyanobacterium cf. Anabaena sp.

Simonazzi, Mara / Pezzolesi, Laura / Galletti, Paola / Gualandi, Chiara / Pistocchi, Rossella / De Marco, Nicole / Paganelli, Zoe / Samorì, Chiara

International journal of biological macromolecules

2021 Volume 191, Page(s) 92–99

Abstract: Polyhydroxybutyrate (PHB) production by the cyanobacterium cf. Anabaena sp. was here studied by varying the medium composition and the carbon source used to induce mixotrophic growth conditions. The highest PHB productivity (0.06 ... ...

Abstract	Polyhydroxybutyrate (PHB) production by the cyanobacterium cf. Anabaena sp. was here studied by varying the medium composition and the carbon source used to induce mixotrophic growth conditions. The highest PHB productivity (0.06 g
MeSH term(s)	Anabaena/growth & development ; Anabaena/metabolism ; Biomass ; Hydroxybutyrates/metabolism ; Industrial Microbiology/methods ; Phosphorus/metabolism ; Polyesters/metabolism
Chemical Substances	Hydroxybutyrates ; Polyesters ; poly-beta-hydroxybutyrate (26063-00-3) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2021-09-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2021.09.054
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