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  1. Article ; Online: Embolization of the superior rectal artery: another management option for hemorrhoids.

    De Nardi, P / Maggi, G

    Techniques in coloproctology

    2020  Volume 25, Issue 1, Page(s) 1–2

    MeSH term(s) Embolization, Therapeutic ; Hemorrhoids/therapy ; Humans ; Mesenteric Artery, Inferior/diagnostic imaging ; Rectum/surgery
    Language English
    Publishing date 2020-11-06
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-020-02371-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage: A critical analysis.

    Vignali, Andrea / De Nardi, Paola

    World journal of gastroenterology

    2022  Volume 28, Issue 14, Page(s) 1394–1404

    Abstract: Endoluminal vacuum-assisted therapy (EVT) has been introduced recently to treat colorectal anastomotic leaks in clinically stable non-peritonitic patients. Its application has been mainly reserved to low colorectal and colo-anal anastomoses. The main ... ...

    Abstract Endoluminal vacuum-assisted therapy (EVT) has been introduced recently to treat colorectal anastomotic leaks in clinically stable non-peritonitic patients. Its application has been mainly reserved to low colorectal and colo-anal anastomoses. The main advantage of this new procedure is to ensure continuous drainage of the abscess cavity, to promote and to accelerate the formation of granulation tissue resulting in a reduction of the abscess cavity. The reported results are promising allowing a higher preservation of the anastomosis when compared to conventional treatments that include trans-anastomotic tube placement, percutaneous drainage, endoscopic clipping of the anastomotic defect or stent placement. Nevertheless, despite this procedure is gaining acceptance among the surgical community, indications, inclusion criteria and definitions of success are not yet standardized and extremely heterogeneous, making it difficult to reach definitive conclusions and to ascertain which are the real benefits of this new procedure. Moreover, long-term and functional results are poorly reported. The present review is focused on critically analyzing the theoretical benefits and risks of the procedure, short- and long-term functional results and future direction in the application of EVT.
    MeSH term(s) Abscess ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Colorectal Neoplasms/surgery ; Drainage/adverse effects ; Drainage/methods ; Humans ; Negative-Pressure Wound Therapy/methods
    Language English
    Publishing date 2022-05-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v28.i14.1394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Intra-abdominal myositis ossificans - a clinically challenging disease: A case report.

    Carbone, Gabriele / Andreasi, Valentina / De Nardi, Paola

    World journal of orthopedics

    2023  Volume 14, Issue 5, Page(s) 362–368

    Abstract: Background: Myositis ossificans (MO) is an uncommon disorder characterized by heterotopic ossification within soft tissues. Only a few cases of intra-abdominal MO (IMO) have been described in the literature. Histology could be difficult to understand ... ...

    Abstract Background: Myositis ossificans (MO) is an uncommon disorder characterized by heterotopic ossification within soft tissues. Only a few cases of intra-abdominal MO (IMO) have been described in the literature. Histology could be difficult to understand and a wrong diagnosis could lead to an improper cure.
    Case summary: We herein report the case of IMO in a healthy 69-year-old man. The patient presented with an abdominal mass in the left lower quadrant. A computed tomography scan showed an inhomogeneous mass with multiple calcifications. The patient underwent radical excision of the mass. Histopathological findings were compatible with MO. Five months later the patient showed a recurrence causing hemorrhagic shock due to intractable intralesional bleeding. The patients eventually died within three months since recurrence.
    Conclusion: The case described could be classified as post-traumatic MO that developed close to the previously fractured iliac bone. The subsequent surgical procedure was ineffective and the disease rapidly recurred. The misleading intraoperative diagnosis led to improper surgical treatment with a dramatic evolution.
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v14.i5.362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intestinal obstruction following a hemorrhoid laser procedure (HeLP).

    Giamundo, P / De Nardi, P

    Techniques in coloproctology

    2016  Volume 20, Issue 10, Page(s) 727–728

    MeSH term(s) Hemorrhoids ; Humans ; Intestinal Obstruction
    Language English
    Publishing date 2016
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-016-1520-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy.

    De Nardi, Paola / Giani, Alessandro / Maggi, Giulia / Braga, Marco

    World journal of gastrointestinal oncology

    2022  Volume 14, Issue 2, Page(s) 423–433

    Abstract: The prognostic role of body composition indexes, and specifically sarcopenia, has recently been explored in different cancer types. However, conflicting results have been reported. Heterogeneity in cancer type, cancer stage or oncological treatments, as ... ...

    Abstract The prognostic role of body composition indexes, and specifically sarcopenia, has recently been explored in different cancer types. However, conflicting results have been reported. Heterogeneity in cancer type, cancer stage or oncological treatments, as well as different methodology and definition of sarcopenia, could be accounted for different conclusions retrieved from literature. When focusing on colorectal cancer, it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and treatments. Particularly, patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical surgery. This review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and prognosis. Literature was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy (NCRT) followed by radical surgery, in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were measured. Eight full-text articles were selected and included in the present review. The main findings of our review were: (1) The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance; (2) There was a great deal of heterogeneity in the definition and measures of sarcopenia, in the definition of cut-off values, and in the method to measure change in muscle mass; (3) There was not full agreement on the association between sarcopenia at baseline and/or after chemo-radiotherapy and prognosis, and only few studies found a significance in the multivariate analysis; and (4) It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free survival. In conclusion, analysis of muscle mass might provide prognostic information on patients with rectal cancer, however more robust evidence is needed to define the role of muscle depletion and/or muscle change during neoadjuvant treatments, related to this specific group of patients. If a prognostic role would be confirmed by future studies, the role of preoperative intervention aimed at modifying muscle mass could be explored in order to improve outcomes.
    Language English
    Publishing date 2022-03-24
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v14.i2.423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emergency surgical treatment of colonic acute diverticulitis: a multicenter observational study on behalf of the Italian society of colorectal surgery (SICCR) Lombardy committee.

    Ferrara, Francesco / Guerci, Claudio / Bondurri, Andrea / Spinelli, Antonino / De Nardi, Paola

    Updates in surgery

    2023  Volume 75, Issue 4, Page(s) 863–870

    Abstract: Colonic diverticulitis can be treated conservatively, but some cases require surgery. Patients can undergo Hartmann's procedure (H) or resection with primary anastomosis (RA), with or without diverting stoma. This multicenter observational retrospective ... ...

    Abstract Colonic diverticulitis can be treated conservatively, but some cases require surgery. Patients can undergo Hartmann's procedure (H) or resection with primary anastomosis (RA), with or without diverting stoma. This multicenter observational retrospective study aims to evaluate the adherence to current guidelines by assessing the rate of RA and H in Lombardy, Italy, and to analyze differences in patients' features. This study included data collected from nine surgical units performing emergency surgery in Lombardy, in 2019 and 2021. Data for each year were retrospectively collected through a survey among Italian Society of Colorectal Surgery (SICCR) Lombardy members. Additional data were about: Hinchey's classification, laparoscopic (VLS) or converted procedures, procedures with more than two operators, procedures in which the first operator was older than 40 years, night or weekend procedures, older-than-80 patients, COVID-19 positivity (just 2021). The total number of operations performed was 254, 115 RA and 130 H (45.3% and 51.2%, diff. 12%, p = 0.73), and 9 (3.5%) other procedures. RAs were more frequent for Hinchey 1 and 2 patients, whereas Hs were more frequent for Hinchey 3 and 4. RAs without ileostomy were significantly less than Hs (66 vs. 130, p = 0.04). Laparoscopy was more used for RA compared to H (57 vs. 21, p = 0.03), whereas no difference was found between RA and H with respect to conversion rate, the presence of more than two operators in the team, the presence of a first operator older than 40 years, night or weekend operations, and for older-than-80 patients. This study confirms the adherence to current guidelines for the treatment of acute colonic diverticulitis in Lombardy, Italy. It can be considered as a preliminary survey with interesting results that may open the way to a further prospective observational study to clarify some aspects in the management of this disease.
    MeSH term(s) Humans ; Diverticulitis, Colonic/surgery ; Retrospective Studies ; Colorectal Surgery ; COVID-19 ; Diverticulitis/surgery ; Colostomy ; Anastomosis, Surgical/methods ; Laparoscopy/methods ; Intestinal Perforation/surgery ; Treatment Outcome ; Peritonitis/surgery
    Language English
    Publishing date 2023-03-19
    Publishing country Italy
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01487-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hemorrhoid laser dearterialization: systematic review and meta-analysis.

    De Nardi, Paola / Maggi, Giulia / Pagnanelli, Michele / Vlasakov, Iliyan / Corbetta, Davide

    Lasers in medical science

    2023  Volume 38, Issue 1, Page(s) 54

    Abstract: Hemorrhoidal disease is a common and troublesome condition. Excisional hemorrhoidectomy can assure the best chance of cure but it is hampered by postoperative pain and potential long-term morbidity therefore minimally invasive techniques have been ... ...

    Abstract Hemorrhoidal disease is a common and troublesome condition. Excisional hemorrhoidectomy can assure the best chance of cure but it is hampered by postoperative pain and potential long-term morbidity therefore minimally invasive techniques have been developed. Since 2009 a doppler-guided hemorrhoidal dearterialization with laser (the hemorrhoidal laser procedure; HeLP) has been proposed to control symptoms without significant sequelae. The aim of this systematic review is to analyze the benefits and disadvantages of HeLP for symptomatic hemorrhoids. The Medline/PubMed, Embase, and Cochrane library databases were searched from January 2010 to March 2022, language was restricted to English and documents to the full text. Randomized and non-randomized, prospective and retrospective cohort studies were included. Risk of bias assessment was performed using the Risk of bias for non-randomized studies (ROBINS-I) and the RoB2 Tool for randomized clinical trial. Primary outcome was to assess the efficacy of HeLP on symptoms' resolution. Secondary objectives were postoperative pain and complications, comparison with other interventional techniques, and evaluation of long-term recurrence. Whenever possible, a meta-analysis was conducted. The GRADE approach was employed to assess the certainty of evidence. We included six non-randomized and one randomized study. HeLP improved or resolved preoperative symptoms in 83.6 to 100% of patients during follow-up. In the randomized study symptoms resolved in 90% of patients after HeLP and 53.3% after rubber band ligation as comparator. Published data indicate that HeLP is effective, relatively safe, with limited recurrence rate, after a short to medium follow-up. The quality of evidence was however low. There is a paucity of studies assessing the benefits or harms of laser dearterialization for the treatment of hemorrhoids and randomized trials are furthermore rare, therefore trials with adequate power and proper design, assessing the advantages and disadvantages of HeLP versus other minimally invasive techniques, are needed. Furthermore, studies evaluating long-term follow-up are wanted.
    MeSH term(s) Humans ; Hemorrhoids/complications ; Lasers ; Ligation/adverse effects ; Neoplasm Recurrence, Local ; Pain, Postoperative/etiology ; Prospective Studies ; Retrospective Studies ; Treatment Outcome ; Clinical Trials as Topic
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-022-03703-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does inferior mesenteric artery ligation affect outcome in elective colonic resection for diverticular disease?

    De Nardi, Paola / Gazzetta, Paolo

    ANZ journal of surgery

    2018  Volume 88, Issue 11, Page(s) E778–E781

    Abstract: Background: The aim of our study was to analyse the role of inferior mesenteric artery (IMA) ligation during elective colonic resection for diverticular disease (DD) with respect to surgical outcome.: Methods: All patients who underwent elective ... ...

    Abstract Background: The aim of our study was to analyse the role of inferior mesenteric artery (IMA) ligation during elective colonic resection for diverticular disease (DD) with respect to surgical outcome.
    Methods: All patients who underwent elective laparoscopic or open colonic resection for DD from January 2006 to December 2012 were studied. The patients were divided into two groups based on IMA ligation or preservation. The primary end point was to compare anastomotic leakage in the two groups. The secondary end points were operative time, stoma formation, overall post-operative complications, restoration of bowel function and length of post-operative hospital stay.
    Results: During the study period, 219 elective colonic resections with primary anastomosis for DD were performed. A laparoscopic technique was employed in 132 (60.3%) cases. IMA ligation was performed in 66 patients (30.1%). Overall anastomotic leakage rate was 4.1%, 4.5% in IMA ligation and 3.9% in IMA preservation group, respectively (P = ns). Mean operative time was 225 ± 43.4 and 191 ± 41.7 min in IMA ligation and preservation group, respectively (P = 0.002). No differences were observed in the rate of overall complications, stoma formation, restoration of bowel function and post-operative length of hospital stay.
    Conclusions: No differences were observed in surgical outcome in IMA ligation and preservation groups, particularly preservation or ligation of the IMA did not affect leakage rate.
    MeSH term(s) Adult ; Aged ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Colectomy/methods ; Diverticulitis, Colonic/surgery ; Elective Surgical Procedures/methods ; Female ; Humans ; Laparoscopy ; Ligation ; Male ; Mesenteric Artery, Inferior/surgery ; Middle Aged ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2018-07-30
    Publishing country Australia
    Document type Comparative Study ; Journal Article
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.14724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The American Society of Colon and Rectal Surgeons 2013 annual meeting.

    De Nardi, P / Vignali, A

    Techniques in coloproctology

    2013  Volume 17, Issue 4, Page(s) 465–466

    MeSH term(s) Colorectal Surgery/standards ; Colorectal Surgery/trends ; Congresses as Topic ; Forecasting ; Humans ; Patient Safety ; Quality Improvement ; Societies, Medical ; United States
    Language English
    Publishing date 2013-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-013-1034-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online ; Conference proceedings: New trends in management of colorectal cancer.

    De Nardi, P / Gazzetta, P

    Techniques in coloproctology

    2013  Volume 17, Issue 1, Page(s) 129–130

    MeSH term(s) Anal Canal ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/therapy ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Neoplasm Staging ; Organ Sparing Treatments
    Language English
    Publishing date 2013-02
    Publishing country Italy
    Document type Congresses
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-012-0944-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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