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  1. AU="De Nisco, Carlo"
  2. AU="Robert A. Harrington"
  3. AU="Xu, Yi-Ming"
  4. AU=Kurokawa Tomohiro
  5. AU="Aggarwal, Samarth"
  6. AU="Lee E. Brown"
  7. AU="Breen, G"
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  1. Article ; Online: Robotic versus laparoscopic transabdominal preperitoneal (TAPP) approaches to bilateral hernia repair: a multicenter retrospective study using propensity score matching analysis.

    Peltrini, Roberto / Corcione, Francesco / Pacella, Daniela / Castiglioni, Simone / Lionetti, Ruggero / Andreuccetti, Jacopo / Pignata, Giusto / De Nisco, Carlo / Ferraro, Luca / Salaj, Adelona / Formisano, Giampaolo / Bianchi, Paolo Pietro / Bracale, Umberto

    Surgical endoscopy

    2022  Volume 37, Issue 2, Page(s) 1188–1193

    Abstract: Background: Since the introduction of minimally invasive surgery, new techniques like transabdominal preperitoneal (TAPP) repair have progressively gained acceptance for the treatment of groin hernia. Laparoscopic TAPP (LTAPP) is recommended for ... ...

    Abstract Background: Since the introduction of minimally invasive surgery, new techniques like transabdominal preperitoneal (TAPP) repair have progressively gained acceptance for the treatment of groin hernia. Laparoscopic TAPP (LTAPP) is recommended for bilateral repairs. Likewise, the introduction of robotic platforms has promised additional surgical benefits for robotic TAPP (RTAPP), which are yet to be confirmed. This study compared multicenter data obtained from patients undergoing bilateral inguinal hernia repair with RTAPP, performed during the preliminary learning curve period, versus conventional LTAPP.
    Materials and methods: All consecutive bilateral inguinal hernia patients from four Italian centers between June 2015 and July 2020 were selected. A propensity score model was used to compare patients treated with LTAPP versus RTAPP, considering sex, age, body mass index, current smoking status, overall comorbidity, hernia classification (primary or recurrent), and associated procedures as covariates. After matching, intraoperative details and postoperative outcomes were evaluated.
    Results: In total, 275 LTAPP and 40 RTAPP were performed. After matching, 80 and 40 patients were allocated to the LTAPP and RTAPP cohorts, respectively. No intraoperative complications or conversion to open surgery occurred. However, a longer operative time was recorded in the RTAPP group (79 ± 21 versus 98 ± 29 min; p < 0.001). Postoperative visual analog scale (VAS) pain scores (p = 0.13) did not differ and complication rates were similar. There were no clinical recurrences in either group, with mean follow-up periods of 52 ± 14 (LTAPP) and 35 ± 8 (RTAPP) months. A statistical difference in length of hospital stay was found between the groups (1.05 ± 0.22 vs 1.50 ± 0.74 days; p < 0.001).
    Conclusion: In this patient population, outcomes for bilateral inguinal hernia repair appear comparable for RTAPP and LTAPP, except for a shorter recovery after laparoscopic surgery. A longer operative time for robotic surgery could be attributable to the learning curve period of each center.
    MeSH term(s) Humans ; Hernia, Inguinal/surgery ; Retrospective Studies ; Herniorrhaphy/methods ; Robotic Surgical Procedures/methods ; Propensity Score ; Surgical Mesh ; Laparoscopy/methods ; Treatment Outcome
    Language English
    Publishing date 2022-09-26
    Publishing country Germany
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09614-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A bleeding umbilical mass.

    Guerra, Francesco / Pulighe, Fabio / Sacchetti, Riccardo / Serra, Stefano / De Nisco, Carlo

    Gut

    2016  Volume 65, Issue 6, Page(s) 913

    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2015-310750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An unsuspected cause of abdominal pain and fever: lost gallstone-related perisplenic abscess.

    Guerra, Francesco / Balestra, Francesco / Sacchetti, Riccardo / Pulighe, Fabio / De Nisco, Carlo

    Journal of digestive diseases

    2016  Volume 17, Issue 8, Page(s) 554–556

    MeSH term(s) Abdominal Abscess/diagnostic imaging ; Abdominal Abscess/etiology ; Abdominal Abscess/surgery ; Abdominal Pain/etiology ; Abdominal Pain/surgery ; Adult ; Cholecystectomy, Laparoscopic/adverse effects ; Female ; Fever/etiology ; Gallstones/complications ; Gallstones/diagnostic imaging ; Gallstones/surgery ; Humans ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-08
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 2317117-0
    ISSN 1751-2980 ; 1751-2972
    ISSN (online) 1751-2980
    ISSN 1751-2972
    DOI 10.1111/1751-2980.12366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Robotic-assisted approach to Median Arcuate Ligament Syndrome with left gastric artery originating directly from the aorta. Report of a case and review of the current mini-invasive treatment modalities.

    Podda, Mauro / Gusai, Gian Pietro / Balestra, Francesco / Argenio, Giulio / Pulighe, Fabio / Di Saverio, Salomone / De Nisco, Carlo

    The international journal of medical robotics + computer assisted surgery : MRCAS

    2018  Volume 14, Issue 4, Page(s) e1919

    Abstract: Background: Median Arcuate Ligament Syndrome (MALS) is a rare clinical condition.: Methods: Through the analysis of a case report and a review of the international literature, we examined whether robotic and laparoscopic MAL release are safe and ... ...

    Abstract Background: Median Arcuate Ligament Syndrome (MALS) is a rare clinical condition.
    Methods: Through the analysis of a case report and a review of the international literature, we examined whether robotic and laparoscopic MAL release are safe and feasible.
    Results: Of 354 and 19 patients who underwent laparoscopic MAL release (LMALr) and robotic-assisted MAL release (RMALr), respectively, conversion to open surgery occurred in 6.8% of cases following LMALr, whereas no case of conversion was reported following RMALr. Immediate symptomatic improvement was reported in 92.1% of cases following LMALr and in 84.2% of cases following RMALr. In the LMALr group 9% of patients presented with recurrence of symptoms, whereas the percentage in the RMALr group was 5.3%. LMALr was related to a higher overall complication rate when compared with RMALr (7.3% vs 5.3%).
    Conclusions: Both laparoscopic and robotic-assisted MAL lysis with celiac ganglionectomy can be safely performed with minimal patient morbidity.
    MeSH term(s) Aorta/diagnostic imaging ; Celiac Artery/diagnostic imaging ; Celiac Artery/surgery ; Decompression, Surgical/methods ; Female ; Ganglia, Sympathetic/surgery ; Humans ; Imaging, Three-Dimensional ; Laparoscopy/methods ; Median Arcuate Ligament Syndrome/diagnostic imaging ; Median Arcuate Ligament Syndrome/surgery ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Robotic Surgical Procedures/methods ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2018-05-09
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2151860-9
    ISSN 1478-596X ; 1478-5951
    ISSN (online) 1478-596X
    ISSN 1478-5951
    DOI 10.1002/rcs.1919
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Laparoscopic Transarterial Embolization of Type II Endoleak after Branched/Fenestrated Thoracoabdominal Aortic Aneurysm Endovascular Repair.

    Fadda, Gian Franco / Kasemi, Holta / Di Angelo, Costantino Luca / De Nisco, Carlo / Balestra, Francesco / Cruccu, Antonio / Marino, Mario

    Annals of vascular surgery

    2017  Volume 42, Page(s) 304.e11–304.e16

    Abstract: Type II endoleak is the most frequent procedure-related complication during endovascular aneurysm exclusion. Actually, there is little controversy in the management of type I and III endoleak, while type II endoleak still generates conflicting reports ... ...

    Abstract Type II endoleak is the most frequent procedure-related complication during endovascular aneurysm exclusion. Actually, there is little controversy in the management of type I and III endoleak, while type II endoleak still generates conflicting reports about their timing and type of treatment. Currently, the intervention is needed only in case of sac enlargement but not in case of persistent endoleak alone. We report the case of a 77-year-old man treated with a custom-made branched/fenestrated endograft for a type III thoracoabdominal aortic aneurysm. A low-flow type II endoleak was detected at the end of the intervention, and a conservative approach was adopted. The sixth month follow-up computed tomography scan demonstrated a 6-mm aneurysm sac growth that required the type II endoleak management. The endoleak nidus, situated between the inferior mesenteric artery (IMA) and left renal artery stent graft, was embolized through the IMA punctured laparoscopically. IMA origin laparoscopic clipping completed the intervention. To our knowledge, this is a unique case in the literature. Type II endoleak management should be reserved to selected patients. The combination of different techniques may offer safe and feasible treatment options in complex aneurysms treated with advanced endovascular materials.
    Language English
    Publishing date 2017-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2016.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinical outcomes and quality of life associated with the use of a biosynthetic mesh for complex ventral hernia repair: analysis of the "Italian Hernia Club" registry.

    Rognoni, Carla / Cuccurullo, Diego / Borsoi, Ludovica / Bonavina, Luigi / Asti, Emanuele / Crovella, Feliciano / Bassi, Uberto Andrea / Carbone, Gabriele / Guerini, Francesca / De Paolis, Paolo / Pessione, Silvia / Greco, Vincenzo Maria / Baccarini, Elisabetta / Soliani, Giorgio / Sagnelli, Carlo / Crovella, Clotilde / Trapani, Vincenzo / De Nisco, Carlo / Eugeni, Emilio /
    Zanzi, Federico / De Nicola, Enrico / Marioni, Antonio / Rosignoli, Alessandro / Silvestro, Roberto / Tarricone, Rosanna / Piccoli, Micaela

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 10706

    Abstract: With the development of newer meshes and approaches to hernia repair, it is currently difficult to evaluate their performances while considering the patients' perspective. The aim of the study was to assess the clinical outcomes and quality of life ... ...

    Abstract With the development of newer meshes and approaches to hernia repair, it is currently difficult to evaluate their performances while considering the patients' perspective. The aim of the study was to assess the clinical outcomes and quality of life consequences of abdominal hernia repairs performed in Italy using Phasix and Phasix ST meshes through the analysis of real-world data to support the choice of new generation biosynthetic meshes. An observational, prospective, multicentre study was conducted in 10 Italian clinical centres from May 2015 to February 2018 and in 15 Italian clinical centres from March 2018 to May 2019. The evaluation focused on patients with VHWG grade II-III who underwent primary ventral hernia repair or incisional hernia intervention with a follow-up of at least 18 months. Primary endpoints included complications' rates, and secondary outcomes focused on patient quality of life as measured by the EuroQol questionnaire. Seventy-five patients were analysed. The main complications were: 1.3% infected mesh removal, 4.0% superficial infection requiring procedural intervention, 0% deep/organ infection, 8.0% recurrence, 5.3% reintervention, and 6.7% drained seroma. The mean quality of life utility values ranged from 0.768 (baseline) to 0.967 (36 months). To date, Phasix meshes have proven to be suitable prostheses in preventing recurrence, with promising outcomes in terms of early and late complications and in improving patient quality of life.
    MeSH term(s) Abdominal Wall/pathology ; Adult ; Aged ; Aged, 80 and over ; Biocompatible Materials/therapeutic use ; Electronic Health Records/statistics & numerical data ; Female ; Hernia, Inguinal/surgery ; Hernia, Ventral/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Humans ; Italy ; Male ; Middle Aged ; Prospective Studies ; Quality of Life/psychology ; Recurrence ; Secondary Prevention ; Surgical Mesh ; Surveys and Questionnaires ; Treatment Outcome
    Chemical Substances Biocompatible Materials
    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-67821-w
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  7. Article ; Online: Correction to: Appendectomy versus conservative treatment with antibiotics for patients with uncomplicated acute appendicitis: a propensity score-matched analysis of patient-centered outcomes (the ACTUAA prospective multicenter trial).

    Podda, Mauro / Poillucci, Gaetano / Pacella, Daniela / Mortola, Lorenzo / Canfora, Alfonso / Aresu, Simona / Pisano, Marcello / Erdas, Enrico / Pisanu, Adolfo / Cillara, Nicola / Serventi, Fernando / Marini, Stefano / Sirigu, Danilo / Piga, Michela / Coppola, Massimiliano / Balestra, Francesco / De Nisco, Carlo / Pazzona, Marco / Anania, Marco /
    Pulighe, Fabio / Lai, Antonio / Ottonello, Roberto / De Angelis, Renato / Piro, Silverio / Calò, Pietro Giorgio / Podda, Francesco / Saba, Luca / Bottino, Vincenzo / Dalla Caneva, Patrizia / Canu, Luisa / Piras, Emanuele / Deserra, Antonello / Virdis, Francesco / Gerardi, Chiara / Gordini, Luca / Sanna, Silvia

    International journal of colorectal disease

    2021  Volume 36, Issue 3, Page(s) 599

    Language English
    Publishing date 2021-02-22
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-021-03862-5
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  8. Article ; Online: Correction to: Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR).

    Monsellato, Igor / Alongi, Filippo / Bertocchi, Elisa / Gori, Stefania / Ruffo, Giacomo / Cassinotti, Elisa / Baldari, Ludovica / Boni, Luigi / Pernazza, Graziano / Pulighe, Fabio / De Nisco, Carlo / Perinotti, Roberto / Morpurgo, Emilio / Contardo, Tania / Mammano, Enzo / Elmore, Ugo / Delpini, Roberto / Rosati, Riccardo / Perna, Federico /
    Coratti, Andrea / Menegatti, Benedetta / Gentilli, Sergio / Baroffio, Paolo / Buccianti, Piero / Balestri, Riccardo / Ceccarelli, Cristina / Torri, Valter / Cavaliere, Davide / Solaini, Leonardo / Ercolani, Giorgio / Traverso, Elena / Fusco, Vittorio / Rossi, Maura / Priora, Fabio / Numico, G / Franzone, Paola / Orecchia, Sara

    BMC cancer

    2020  Volume 20, Issue 1, Page(s) 128

    Abstract: Following publication of the original article [1], the authors reported that the family name of the author, Ludovica Baldari, was misspelled. ...

    Abstract Following publication of the original article [1], the authors reported that the family name of the author, Ludovica Baldari, was misspelled.
    Language English
    Publishing date 2020-02-17
    Publishing country England
    Document type Journal Article ; Published Erratum
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-020-6632-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Expression levels of circulating miRNAs as biomarkers during multimodal treatment of rectal cancer - TiMiSNAR-mirna: a substudy of the TiMiSNAR Trial (NCT03962088).

    Monsellato, Igor / Garibaldi, Elisabetta / Cassinotti, Elisa / Baldari, Ludovica / Boni, Luigi / Elmore, Ugo / Delpini, Roberto / Rosati, Riccardo / Perinotti, Roberto / Alongi, Filippo / Bertocchi, Elisa / Gori, Stefania / Ruffo, Giacomo / Pernazza, Graziano / Pulighe, Fabio / De Nisco, Carlo / Morpurgo, Emilio / Contardo, Tania / Mammano, Enzo /
    Perna, Federico / Menegatti, Benedetta / Coratti, Andrea / Buccianti, Piero / Balestri, Riccardo / Ceccarelli, Cristina / Cavaliere, Davide / Solaini, Leonardo / Ercolani, Giorgio / Traverso, Elena / Fusco, Vittorio / Torri, Valter / Orecchia, Sara

    Trials

    2020  Volume 21, Issue 1, Page(s) 678

    Abstract: Background: Neoadjuvant chemoradiotherapy followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage (downstaging). Extensive ... ...

    Abstract Background: Neoadjuvant chemoradiotherapy followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage (downstaging). Extensive histopathological work-up of the tumor specimen after surgery including tumor regression grading and lymph node status helped to visualize individual tumor sensitivity to chemoradiotherapy, retrospectively. As the response to neoadjuvant chemoradiotherapy is heterogeneous, however, valid biomarkers are needed to monitor tumor response. A relevant number of studies aimed to identify molecular markers retrieved from tumor tissue while the relevance of blood-based biomarkers is less stringent assessed. MicroRNAs are currently under investigation to serve as blood-based biomarkers. To date, no screening approach to identify relevant miRNAs as biomarkers in blood of patients with rectal cancer was undertaken. The aim of the study is to investigate the role of circulating miRNAs as biomarkers in those patients included in the TiMiSNAR Trial (NCT03465982). This is a biomolecular substudy of TiMiSNAR Trial (NCT03962088).
    Methods: All included patients in the TiMiSNAR Trial are supposed to undergo blood collection at the time of diagnosis, after neoadjuvant treatment, after 1 month from surgery, and after adjuvant chemotherapy whenever indicated.
    Discussion: TiMiSNAR-MIRNA will evaluate the association of variation between preneoadjuvant and postneoadjuvant expression levels of miRNA with pathological complete response. Moreover, the study will evaluate the role of liquid biopsies in the monitoring of treatment, correlate changes in expression levels of miRNA following complete surgical resection with disease-free survival, and evaluate the relation between changes in miRNA during surveillance and tumor relapse.
    Trial registration: Clinicaltrials.gov NCT03962088 . Registered on 23 May 2019.
    MeSH term(s) Biomarkers/blood ; Chemoradiotherapy ; Combined Modality Therapy ; Disease-Free Survival ; Humans ; MicroRNAs/blood ; Neoadjuvant Therapy ; Neoplasm Staging ; Observational Studies as Topic ; Randomized Controlled Trials as Topic ; Rectal Neoplasms/blood ; Rectal Neoplasms/therapy ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Biomarkers ; MicroRNAs
    Language English
    Publishing date 2020-07-25
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-020-04568-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR).

    Monsellato, Igor / Alongi, Filippo / Bertocchi, Elisa / Gori, Stefania / Ruffo, Giacomo / Cassinotti, Elisa / Baldari, Ludovica / Boni, Luigi / Pernazza, Graziano / Pulighe, Fabio / De Nisco, Carlo / Perinotti, Roberto / Morpurgo, Emilio / Contardo, Tania / Mammano, Enzo / Elmore, Ugo / Delpini, Roberto / Rosati, Riccardo / Perna, Federico /
    Coratti, Andrea / Menegatti, Benedetta / Gentilli, Sergio / Baroffio, Paolo / Buccianti, Piero / Balestri, Riccardo / Ceccarelli, Cristina / Torri, Valter / Cavaliere, Davide / Solaini, Leonardo / Ercolani, Giorgio / Traverso, Elena / Fusco, Vittorio / Rossi, Maura / Priora, Fabio / Numico, G / Franzone, Paola / Orecchia, Sara

    BMC cancer

    2019  Volume 19, Issue 1, Page(s) 1215

    Abstract: Background: The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not complete until after several months. ... ...

    Abstract Background: The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not complete until after several months. More recently, increasing pathologic Complete Response rates have been demonstrated to be correlated with longer time interval. The purpose of the trial is to demonstrate if delayed timing of surgery after neoadjuvant chemoradiotherapy actually affects pathologic Complete Response and reflects on disease-free survival and overall survival rather than standard timing.
    Methods: The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer. Three-hundred and forty patients will be randomized on an equal basis to either robotic-assisted/standard laparoscopic rectal cancer surgery after 8 weeks or robotic-assisted/standard laparoscopic rectal cancer surgery after 12 weeks.
    Discussion: To date, it is well-know that pathologic Complete Response is associated with excellent prognosis and an overall survival of 90%. In the Lyon trial the rate of pCR or near pathologic Complete Response increased from 10.3 to 26% and in retrospective studies the increase rate was about 23-30%. These results may be explained on the relationship between radiation therapy and tumor regression: DNA damage occurs during irradiation, but cellular lysis occurs within the next weeks. Study results, whether confirmed that performing surgery after 12 weeks from neoadjuvant treatment is advantageous from a technical and oncological point of view, may change the current pathway of the treatment in those patient suffering from rectal cancer.
    Trial registration: ClinicalTrials.gov NCT3465982.
    MeSH term(s) Adult ; Aged ; Humans ; Middle Aged ; Young Adult ; Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Chemoradiotherapy ; Disease-Free Survival ; Laparoscopy ; Minimally Invasive Surgical Procedures ; Neoadjuvant Therapy ; Prognosis ; Prospective Studies ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/surgery ; Time Factors ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-019-6271-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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