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  1. Article: A population-based serological survey of

    Clutter, Christy H / Klarman, Molly B / Cajusma, Youseline / Cato, Emilie T / Sayeed, Abu / Brinkley, Lindsey / Jensen, Owen / Baril, Chantale / De Rochars, V Madsen Beau / Azman, Andrew S / Long, Maureen T / Cummings, Derek / Leung, Daniel T / Nelson, Eric J

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: After three years with no confirmed cholera cases in Haiti, an outbreak ... ...

    Abstract After three years with no confirmed cholera cases in Haiti, an outbreak of
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.06.23285537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Population-Based Serologic Survey of Vibrio cholerae Antibody Titers before Cholera Outbreak, Haiti, 2022.

    Clutter, Christy H / Klarman, Molly B / Cajusma, Youseline / Cato, Emilee T / Abu Sayeed, Md / Brinkley, Lindsey / Jensen, Owen / Baril, Chantale / De Rochars, V Madsen Beau / Azman, Andrew S / Long, Maureen T / Cummings, Derek / Leung, Daniel T / Nelson, Eric J

    Emerging infectious diseases

    2023  Volume 29, Issue 9, Page(s) 1864–1867

    Abstract: A Vibrio cholerae O1 outbreak emerged in Haiti in October 2022 after years of cholera absence. In samples from a 2021 serosurvey, we found lower circulating antibodies against V. cholerae lipopolysaccharide in children <5 years of age and no vibriocidal ... ...

    Abstract A Vibrio cholerae O1 outbreak emerged in Haiti in October 2022 after years of cholera absence. In samples from a 2021 serosurvey, we found lower circulating antibodies against V. cholerae lipopolysaccharide in children <5 years of age and no vibriocidal antibodies, suggesting high susceptibility to cholera, especially among young children.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Cholera/epidemiology ; Haiti/epidemiology ; Antibodies, Bacterial ; Vibrio cholerae O1/genetics ; Disease Outbreaks
    Chemical Substances Antibodies, Bacterial
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2909.230174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti.

    Mavian, Carla N / Tagliamonte, Massimiliano S / Alam, Meer T / Sakib, S Nazmus / Cash, Melanie N / Moir, Monika / Jimenez, Juan Perez / Riva, Alberto / Nelson, Eric J / Cato, Emilie T / Ajayakumar, Jayakrishnan / Louis, Rigan / Curtis, Andrew / De Rochars, V Madsen Beau / Rouzier, Vanessa / Pape, Jean William / de Oliveira, Tulio / Morris, J Glenn / Salemi, Marco /
    Ali, Afsar

    Emerging infectious diseases

    2023  Volume 29, Issue 10, Page(s) 2072–2082

    Abstract: The 2010 cholera epidemic in Haiti was thought to have ended in 2019, and the Prime Minister of Haiti declared the country cholera-free in February 2022. On September 25, 2022, cholera cases were again identified in Port-au-Prince. We compared genomic ... ...

    Abstract The 2010 cholera epidemic in Haiti was thought to have ended in 2019, and the Prime Minister of Haiti declared the country cholera-free in February 2022. On September 25, 2022, cholera cases were again identified in Port-au-Prince. We compared genomic data from 42 clinical Vibrio cholerae strains from 2022 with data from 327 other strains from Haiti and 1,824 strains collected worldwide. The 2022 isolates were homogeneous and closely related to clinical and environmental strains circulating in Haiti during 2012-2019. Bayesian hypothesis testing indicated that the 2022 clinical isolates shared their most recent common ancestor with an environmental lineage circulating in Haiti in July 2018. Our findings strongly suggest that toxigenic V. cholerae O1 can persist for years in aquatic environmental reservoirs and ignite new outbreaks. These results highlight the urgent need for improved public health infrastructure and possible periodic vaccination campaigns to maintain population immunity against V. cholerae.
    MeSH term(s) Humans ; Vibrio cholerae/genetics ; Haiti/epidemiology ; Bayes Theorem ; Cholera/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2910.230554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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