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  1. Article ; Online: Foreword: Advances in Hemoglobinopathies.

    De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2021  Volume 92, Issue 4, Page(s) e2021410

    Abstract: Starting from 2021, Acta Biomedica Parmensis will dedicate an annual update to the "Advances in Hemoglobinopathies". The section editor of this new editorial initiative is prof. Ashraf T Soliman, Pediatrician and Endocrinologist at Hamad Medical Center ( ... ...

    Abstract Starting from 2021, Acta Biomedica Parmensis will dedicate an annual update to the "Advances in Hemoglobinopathies". The section editor of this new editorial initiative is prof. Ashraf T Soliman, Pediatrician and Endocrinologist at Hamad Medical Center (HMC) of Doha. Prof Soliman is a pionier in the study of endocrine complications in hemoglobinopathies and effects of blood transfusions on spermatogenesis. He collaborates strictly with prof. Mohamed Yassin, Hematologist-Oncologist at MCH and the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A). This issue of Acta Biomedica contains three articles on: The different patterns of insulin response during Oral Glucose Tolerance Test (OGTT) in transfused young patients with β- Thalassemia; Immigration and screening programs for hemoglobinopathies in Italy, Spain and Turkey and The effects of treatment with blood transfusion, iron chelation and hydroxyurea on puberty, growth and spermatogenesis in sickle cell disease,.
    MeSH term(s) Anemia, Sickle Cell ; Emigration and Immigration ; Hemoglobinopathies/therapy ; Humans ; Male ; Thalassemia ; beta-Thalassemia/therapy
    Language English
    Publishing date 2021-09-02
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92i4.11927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence, Clinical Manifestations, and Biochemical Data of Hypertensive versus Normotensive Symptomatic Patients with COVID-19: A Comparative Study.

    De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 4, Page(s) e2020164

    Abstract: Background: There is a scarcity of data regarding the effect of hypertension on the clinical presentation and outcome of symptomatic patients with COVID-19 infection in comparison with non-hypertensive patients.: Aim of the study: To describe the ... ...

    Abstract Background: There is a scarcity of data regarding the effect of hypertension on the clinical presentation and outcome of symptomatic patients with COVID-19 infection in comparison with non-hypertensive patients.
    Aim of the study: To describe the clinical presentation, radiological and hematological data of a cohort of symptomatic COVID-19 positive hypertensive patients (n=50) in comparison with another cohort of normotensive symptomatic COVID-19 positive patients (n=250) diagnosed at the same time and managed in the same health facilities (from Jan 2020 to May 2020). Associated comorbidities were assessed, and the Charlson Comorbidity Index was calculated. The outcomes, including duration of hospitalization, length of ICU stay, duration of mechanical ventilation, and duration of O2 supplementation, were also assessed.
    Results: The prevalence of hypertension in symptomatic COVID-19 positive patients was 50/300 (16%; the prevalence of hypertension in Qatari adults is ~30%). Hypertensive patients had a higher prevalence of DM, CKD, and cardiac dysfunction compared to normotensive patients (p<0.01).They had a higher Charlson Co-morbidity score (2.3±1.8) compared to the normotensive patients (0.4±0.9) (p<0.01). Clinically and radiologically, hypertensive patients had significantly higher percentage of pneumonia, severe pneumonia, and ARDS versus normotensive patients (p<0.01). CBC and differential WBC did not differ between hypertensive and normotensive patients. Hypertensive patients had significantly higher CRP(58.5±84), compared to normotensive patients (28±59) (p<0.01). Furthermore, a longer duration of hospitalization, intensive care unit (ICU) stay, mechanical ventilation and oxygen therapy versus normotensive patients was also observed. CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r=0.56 and 0.61, respectively; p<0.01).
    Conclusions: Hypertensive patients with COVID-19 had a higher inflammatory response (higher CRP levels), a significant increase of comorbidities, and a more aggressive course of the disease necessitating a higher rate of ICU admission, longer requirement for hospitalization and oxygen use compared to normotensive patients.
    MeSH term(s) Adult ; Aged ; COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Humans ; Hypertension/complications ; Middle Aged ; Prevalence ; Retrospective Studies
    Language English
    Publishing date 2020-11-10
    Publishing country Italy
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i4.10540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Can we Predict Incipient Diabetes Mellitus in Patients with Transfusion Dependent β-Thalassemia (β-TDT) Referred with a History of Prediabetes?

    De Sanctis, Vincenzo / Soliman, Ashraf T / Daar, Shahina / Tzoulis, Ploutarchos / Kattamis, Christos

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024005

    Abstract: Background: Prediabetes and diabetes mellitus (DM) are complications in adult patients with transfusion-dependent β-thalassemia (β-TDT), with their incidence increasing with age.: Objective: This retrospective observational study describes the ... ...

    Abstract Background: Prediabetes and diabetes mellitus (DM) are complications in adult patients with transfusion-dependent β-thalassemia (β-TDT), with their incidence increasing with age.
    Objective: This retrospective observational study describes the glycemic trajectories and evaluates predictive indices of β-cell function and insulin sensitivity/resistance in β-TDT patients with prediabetes, both in a steady state and during 3-h oral glucose tolerance test (OGTT), in order to identify patients at high risk for incipient diabetes.
    Setting: The study was mainly conducted at the Pediatric and Adolescent Outpatient Clinic, Quisisana Hospital, Ferrara (Italy), in collaboration with thalassemia referring centers across Italy.
    Patients: The study included 11 β-TDT (aged 15.11-31.10 years) with prediabetes.
    Results: The duration of progression from prediabetes to DM, expressed in years, showed a positive direct correlation with corrected insulin response (CIR-30 = r: 0.7606, P: 0.0065), insulinogenic index (IGI 0-120 = r: 0.6121, P:0.045), oral disposition index (oDI = r: 0.7119, P:0.013), insulin growth factor-1 (IGF-1= r: 0.6246, P: 0.039) and an inverse linear correlation with serum ferritin (SF = r: -0.7197, P: 0.012). The number of patients with 1-hour post-load PG value ≥ 155 mg/dL ( ≥ 8.6 mmol/L) was at -4 years: 4/9 (44.4%); -3 years: 8/9 (88.8%); - 2 years: 7/10 (70 %) and at -1 year: 11/11 (100%) (PG range:162-217 mg/dL).
    Conclusions: A progressive increase in 1-hour PG in response to OGTT is associated with progressive β-cell failure, peripheral resistance to insulin action, and reduced oDI and may be considered a relevant marker for incipient DM in β-TDT patients with prediabetes.
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Foreword.

    De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2019  Volume 90, Issue 8-S, Page(s) 5

    Abstract: It is a great honor for me to introduce this supplement of Acta Biomedica on " Growth and Nutritional Changes in Qatari Children after Medical and Nutritional Interventions". [ ... ]. ...

    Abstract It is a great honor for me to introduce this supplement of Acta Biomedica on " Growth and Nutritional Changes in Qatari Children after Medical and Nutritional Interventions". [...].
    MeSH term(s) Child ; Child Nutrition Disorders/diagnosis ; Child Nutrition Disorders/therapy ; Developing Countries ; Humans ; Nutrition Assessment ; Nutritional Requirements ; Periodicals as Topic ; Qatar
    Language English
    Publishing date 2019-09-23
    Publishing country Italy
    Document type Introductory Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v90i8-S.8531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Prevalence and Significance of Leukopenia Induced by Intravenous Iron Therapy in a Large Cohort of Females with Iron Deficiency Anemia (IDA).

    De Sanctis, Vincenzo / Soliman, Ashraf T / Yassin, Mohamed A

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 2, Page(s) e2022183

    Abstract: Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases.: Objective: To assess the ... ...

    Abstract Introduction: Iron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases.
    Objective: To assess the prevalence of leukopenia, neutropenia and/or lymphocytopenia and its possible clinical impact if any, after intravenous iron therapy in adult patients with IDA.
    Patients and methods: This is a retrospective study conducted in Hamad Medical Corporation, Doha (Qatar). The clinical and biochemical data of 1.567 females (mean age: 29.5 years) with IDA who attended the Hematology Clinic and were treated with intravenous (i.v.) iron therapy were collected and analysed. Complete and differential blood counts and iron profile were studied before and after i.v. iron therapy. In addition, cases who developed infections during the time of leukopenia were noted and checked for possible complications.
    Results: 30 cases (1.91%) developed leukopenia,15 cases (0.95%) developed neutropenia and 12 cases (0.76%) developed lymphocytopenia. All had normal white blood cell counts before treatment. Two patients (6.66%) had infection. One had upper respiratory tract infection and the other had urinary tract infection, the latter was treated with antibiotics. There was no reported other infection during or after i.v. iron therapy.
    Conclusions: Leukopenia in form of neutropenia or lymphocytopenia may occur as a side effect of i.v. iron therapy, however, its clinical significance appears to be limited.
    MeSH term(s) Adult ; Anemia ; Anemia, Iron-Deficiency/drug therapy ; Anemia, Iron-Deficiency/epidemiology ; Female ; Humans ; Iron/adverse effects ; Iron Deficiencies ; Lymphopenia ; Neutropenia ; Prevalence ; Retrospective Studies
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2022-05-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i2.11978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the "high clinical risk" category?

    Karimi, Mehran / De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 50–56

    Abstract: We're all flying blind regarding coronavirus, but it's fair to think if thalassemic patients are particularly vulnerable to SARS-COV-2  infection or are at potential higher risk of complications from COVID-19 than normal population, specially when they ... ...

    Abstract We're all flying blind regarding coronavirus, but it's fair to think if thalassemic patients are particularly vulnerable to SARS-COV-2  infection or are at potential higher risk of complications from COVID-19 than normal population, specially when they become older. The frustrating thing is that, right now,  this virus is still new. It only came to the attention of the World Health Organization at the end of December. Very few cases in thalassemia have so far been reported; is this due to lack of testing or a true lack of infection/susceptibility? However, we believe that more data should be collected to better characterise the impact of SARS-CoV-2 infection in patients with thalassemias. Therefore, a multicenter registry and the collection of comprehensive data from both positive COVID-19 thalassemia major and non-transfusion dependent thalassemia are necessary to clarify debated issues. In the meantime an early and vigilant monitoring along with high quality supportive care are needed in thalassemic patients at high risk for SARS-CoV-2 infection.
    MeSH term(s) Betacoronavirus ; Blood Transfusion ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Risk Factors ; SARS-CoV-2 ; Splenectomy ; Thalassemia/complications
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The medical concerns of patients with thalassemias at the time of COVID-19 outbreak: The personal experience and the international recommendations.

    Canatan, Duran / De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 218–221

    Abstract: ...

    Abstract .
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hemoglobinopathies ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thalassemia ; Turkey
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses.

    Canatan, Duran / De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 195–198

    Abstract: Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is ... ...

    Abstract Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is arranged as 5p-replicase (orf1/ab)-structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] -3. Viruses are obligate intracellular infectious agents that use the host cellular machinery to ensure their own fitness and survival. MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. This review focuses to the genomic structure of coronaviruses, the functions of genomic proteins, the effects of micro RNA (miRNA) on virus replication and its pathogenesis.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; Coronavirus/genetics ; Genome, Viral ; Genotype ; Humans ; MicroRNAs/genetics ; SARS-CoV-2 ; Virus Replication
    Chemical Substances MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multidisciplinary care of haemoglobinopathies in Qatar.

    De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2018  Volume 89, Issue 2-S, Page(s) 7081

    Abstract: Not available. ...

    Abstract Not available.
    MeSH term(s) Hemoglobinopathies/therapy ; Humans
    Language English
    Publishing date 2018-02-16
    Publishing country Italy
    Document type Introductory Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v89i2-S.7081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Haematological malignancies in Qatar: from childhood to adulthood.

    De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2018  Volume 89, Issue 3-S, Page(s) 5–6

    Abstract: Not available. ...

    Abstract Not available.
    MeSH term(s) Adult ; Child ; Hematologic Neoplasms/epidemiology ; Humans ; Qatar/epidemiology
    Language English
    Publishing date 2018-04-03
    Publishing country Italy
    Document type Introductory Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v89i3-S.7211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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