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  1. Book: Harnblasenkarzinom

    Stenzl, Arnulf / De Santis, Maria

    muskelinvasiv, lokal fortgeschritten, metastasiert ; ein Leitfaden für die Praxis ; 23 Tabellen

    2012  

    Author's details hrsg. von Arnulf Stenzl. Unter Mitarb. von Maria De Santis
    Keywords Blasenkrebs
    Subject Blasencarcinom ; Harnblasenkrebs ; Blasenkarzinom ; Harnblasenkarzinom
    Language German
    Size X, 56 S. : Ill., graph. Darst., 170 mm x 240 mm
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017459765
    ISBN 978-3-13-170451-1 ; 3-13-170451-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5705 order for loan Magazin

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  2. Article ; Online: Front-line Platinum Continues To Have a Role in Advanced Bladder Cancer.

    Vogl, Ursula M / Testi, Irene / De Santis, Maria

    European urology focus

    2024  

    Abstract: Cisplatin remains a valid option in muscle-invasive or metastatic urothelial carcinoma, and is even more efficient when nivolumab is added. The well-known side-effect profile and the limited number of treatment cycles represent great advantages over ... ...

    Abstract Cisplatin remains a valid option in muscle-invasive or metastatic urothelial carcinoma, and is even more efficient when nivolumab is added. The well-known side-effect profile and the limited number of treatment cycles represent great advantages over modern drug combinations such as enfortumab-vedotin plus pembrolizumab.
    Language English
    Publishing date 2024-04-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploiting pancreatic cancer metabolism: challenges and opportunities.

    De Santis, Maria Chiara / Bockorny, B / Hirsch, E / Cappello, P / Martini, M

    Trends in molecular medicine

    2024  

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell functions and tumor growth. We also discuss ongoing clinical trials that explore metabolic modulation for PDAC, targeting mitochondrial metabolism, asparagine and glutamine addiction, and autophagy inhibition. Overcoming challenges in understanding nutrient effects on immune-stromal-tumor interactions holds promise for innovative therapeutic strategies.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2024.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Update Systemtherapie des Urothelkarzinoms – Therapie im Wandel.

    Tauber, Robert / von Amsberg, Gunhild / De Santis, Maria

    Aktuelle Urologie

    2022  Volume 53, Issue 2, Page(s) 167–179

    Abstract: The systemic treatment of locally advanced and metastatic urothelial carcinoma has been changing at a breathtaking pace for a few years. However, platinum-based chemotherapy continues to be the central component of perioperative therapies and first-line ... ...

    Title translation Update on systemic treatment of urothelial cancer: therapy in transition.
    Abstract The systemic treatment of locally advanced and metastatic urothelial carcinoma has been changing at a breathtaking pace for a few years. However, platinum-based chemotherapy continues to be the central component of perioperative therapies and first-line treatment in the metastatic stage. Immunotherapies with immune checkpoint inhibitors are now an integral part of therapy algorithms. New targeted forms of chemotherapy are about to be approved. Advances in understanding the molecular genetic analysis of tumour tissue will soon enable personalised therapy options. This article is intended to provide an overview of current systemic therapy options and the underlying database. New developments are identified by presenting ongoing phase III trials. After reading this article, the reader should feel informed about the current status of systemic therapy for urothelial carcinoma.
    MeSH term(s) Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/genetics ; Clinical Trials, Phase III as Topic ; Humans ; Immunotherapy ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/genetics
    Language German
    Publishing date 2022-03-28
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1779-8764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 146: Show issues
    Zs.A 676/X: Show issues Location:
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  5. Article ; Online: Postmastectomy radiation therapy in women with T1-T2 tumors and 1 to 3 positive lymph nodes: analysis of the breast international group 02-98 trial.

    Gregucci, Fabiana / De Santis, Maria Carmen / Lozza, Laura / Fiorentino, Alba

    Translational cancer research

    2022  Volume 8, Issue Suppl 2, Page(s) S84–S86

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2018.08.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The earlier the better? Apalutamide for non-metastatic castration resistant prostate cancer.

    De Santis, Maria / Steuber, Thomas

    ESMO open

    2019  Volume 4, Issue 2, Page(s) e000484

    Language English
    Publishing date 2019-04-12
    Publishing country England
    Document type Editorial
    ISSN 2059-7029
    ISSN 2059-7029
    DOI 10.1136/esmoopen-2018-000484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 5 reasons to encourage anti-SARS-CoV-2 vaccination in patients with rheumatic diseases.

    Motta, Francesca / Selmi, Carlo / De Santis, Maria

    Expert review of clinical immunology

    2021  Volume 17, Issue 12, Page(s) 1241–1244

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Health Promotion ; Humans ; Rheumatic Diseases ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2021.1978289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6661: Show issues Location:
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  8. Article ; Online: [No title information]

    Rexer, Heidrun / De Santis, Maria / Doehn, Christian

    Aktuelle Urologie

    2021  Volume 52, Issue 4, Page(s) 318–319

    Title translation Eine offene, randomisierte Phase-III-Studie mit MK-6482 versus Everolimus bei Teilnehmern mit fortgeschrittenem Nierenzellkarzinom, das nach vorherigen, auf PD-1/L1- und VEGF-gezielten Therapien eine Tumorprogression aufweist (HIF-005) – AUO-Nr. AN 51/19.
    MeSH term(s) Carcinoma, Renal Cell ; Everolimus ; Humans ; Kidney Neoplasms ; Programmed Cell Death 1 Receptor ; Vascular Endothelial Growth Factor A
    Chemical Substances Programmed Cell Death 1 Receptor ; Vascular Endothelial Growth Factor A ; Everolimus (9HW64Q8G6G)
    Language German
    Publishing date 2021-07-27
    Publishing country Germany
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 124847-9
    ISSN 1438-8820 ; 0001-7868
    ISSN (online) 1438-8820
    ISSN 0001-7868
    DOI 10.1055/a-1525-7885
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 146: Show issues
    Zs.A 676/X: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Assessing HER2 status in breast cancer through next-generation sequencing of circulating tumor cells.

    Di Cosimo, Serena / Silvestri, Marco / De Marco, Cinzia / Reduzzi, Carolina / Folli, Secondo / De Santis, Maria Carmen / Cappelletti, Vera

    The International journal of biological markers

    2024  , Page(s) 3936155241246542

    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 645113-5
    ISSN 1724-6008 ; 0393-6155
    ISSN (online) 1724-6008
    ISSN 0393-6155
    DOI 10.1177/03936155241246542
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2491: Show issues Location:
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  10. Article: Interstitial lung disease associated with inflammatory myositis: Autoantibodies, clinical phenotypes, and progressive fibrosis.

    Ceribelli, Angela / Tonutti, Antonio / Isailovic, Natasa / De Santis, Maria / Selmi, Carlo

    Frontiers in medicine

    2023  Volume 10, Page(s) 1068402

    Abstract: Progressive pulmonary fibrosis is generally diagnosed when interstitial lung disease progression occurs in the absence of any other cause, and a subset of patients with myositis and associated interstitial lung disease may develop progressive pulmonary ... ...

    Abstract Progressive pulmonary fibrosis is generally diagnosed when interstitial lung disease progression occurs in the absence of any other cause, and a subset of patients with myositis and associated interstitial lung disease may develop progressive pulmonary fibrosis. Numerous autoantibodies (e.g., against tRNA-synthetase, MDA5, Ro52) increase the risk of this clinical feature in myositis and we speculate that serum biomarkers, sought using the most sensitive laboratory techniques available (i.e., immunoprecipitation) may predict pulmonary involvement and allow the early identification of progressive pulmonary fibrosis. We herein provide a narrative review of the literature and also present original data on pulmonary fibrosis in a cohort of patients with myositis and serum anti-Ro52 with interstitial lung disease. Our results fit into the previous evidence and support the association between anti-Ro52 and signs of pulmonary fibrosis in patients with inflammatory myositis. We believe that the combination of available and real-life data has significant clinical relevance as a paradigm of serum autoantibodies that prove useful in determining precision medicine in rare connective tissue diseases.
    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1068402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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