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  1. Article ; Online: Skin manifestations in patients with COVID-19: a prospective observational study during the first wave of the pandemic in the UK and review of the recent literature.

    Parmar, Shivani / De Silva, Bernadette

    European journal of dermatology : EJD

    2022  Volume 32, Issue 1, Page(s) 77–85

    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Prospective Studies ; SARS-CoV-2 ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-02-16
    Publishing country France
    Document type Journal Article ; Observational Study
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2022.4202
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    Zs.A 3484: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Amelanotic subungual melanoma and chilblains.

    Manuelyan, Karen / De Silva, Bernadette / Singh-Raghunath, Rakhi

    BMJ case reports

    2023  Volume 16, Issue 1

    Abstract: A female patient in her 50s presented with blue discolouration of several toes and with single nail dystrophy affecting the little toenail. The nail changes were considered to be secondary to poor circulation and chilblains, which led to delay in the ... ...

    Abstract A female patient in her 50s presented with blue discolouration of several toes and with single nail dystrophy affecting the little toenail. The nail changes were considered to be secondary to poor circulation and chilblains, which led to delay in the diagnosis of amelanotic subungual melanoma.
    MeSH term(s) Humans ; Female ; Chilblains ; Skin Neoplasms/complications ; Skin Neoplasms/diagnosis ; Skin Neoplasms/surgery ; Melanoma, Amelanotic/diagnosis ; Melanoma, Amelanotic/surgery ; Nail Diseases/diagnosis ; Nail Diseases/surgery ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Atopic Polygenic Risk Score Is Associated with Paradoxical Eczema Developing in Patients with Psoriasis Treated with Biologics.

    Al-Janabi, Ali / Eyre, Steve / Foulkes, Amy C / Khan, Adnan R / Dand, Nick / Burova, Ekaterina / DeSilva, Bernadette / Makrygeorgou, Areti / Davies, Emily / Smith, Catherine H / Griffiths, Christopher E M / Morris, Andrew P / Warren, Richard B

    The Journal of investigative dermatology

    2023  Volume 143, Issue 8, Page(s) 1470–1478.e1

    Abstract: Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 patients with psoriasis, of whom 88 developed paradoxical eczema. Two lead ... ...

    Abstract Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pathogenesis is unknown. To identify risk variants, we conducted a GWAS of 3,212 patients with psoriasis, of whom 88 developed paradoxical eczema. Two lead SNPs reached genome-wide significance (P ≤ 5 × 10
    MeSH term(s) Humans ; Dermatitis, Atopic/complications ; Eczema/epidemiology ; Eczema/genetics ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/complications ; Risk Factors ; Biological Products ; Netrin Receptors
    Chemical Substances Biological Products ; UNC5B protein, human ; Netrin Receptors
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.01.021
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    Ui VI Zs.124: Show issues Location:
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  4. Article ; Online: Hanging on by a thread: a rare case of secondary pseudoainhum.

    Arkush, Leo / De Silva, Bernadette / Gordon, David

    BMJ case reports

    2016  Volume 2016

    Abstract: Pseudoainhum is a rare and poorly characterised phenomenon involving autoamputation of a digit associated with an identifiable or related disease process. We describe the case of a 19-year-old man with long-standing neurodisability, sensorineural hearing ...

    Abstract Pseudoainhum is a rare and poorly characterised phenomenon involving autoamputation of a digit associated with an identifiable or related disease process. We describe the case of a 19-year-old man with long-standing neurodisability, sensorineural hearing loss and severe keratoderma, presenting with painless rapidly-progressing autoamputation of his left little toe. Genetic analysis thus far has been inconclusive. The toe appeared to be hanging on by a thread, with no clinical signs of infection. Radiographs showed lysis with complete resorption of the proximal phalynx. Routine blood tests found an isolated neutropenia with normal C reactive protein and biochemistry. We report an unusual case of a young adult with a history of chronic neurological and dermatological problems presenting with secondary pseudoainhum and provide a valuable addition to the limited literature describing this rare condition.
    MeSH term(s) Ainhum/diagnosis ; Ainhum/genetics ; Constriction, Pathologic/diagnosis ; Constriction, Pathologic/genetics ; Developmental Disabilities/complications ; Hearing Loss, Sensorineural/complications ; Humans ; Keratoderma, Palmoplantar/complications ; Male ; Osteolysis/diagnostic imaging ; Toes/abnormalities ; Young Adult
    Language English
    Publishing date 2016-02-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-213854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: What syndrome is this? Rubenstein-Taybi syndrome.

    De Silva, Bernadette

    Pediatric dermatology

    2002  Volume 19, Issue 2, Page(s) 177–179

    MeSH term(s) Adult ; Female ; Humans ; Pruritus/diagnosis ; Rubinstein-Taybi Syndrome/diagnosis
    Language English
    Publishing date 2002-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1046/j.1525-1470.2002.00036.x
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    Zs.A 1882: Show issues Location:
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  6. Article ; Online: Local effects of TL01 phototherapy in psoriasis.

    DeSilva, Bernadette / McKenzie, Roddie C / Hunter, John A A / Norval, Mary

    Photodermatology, photoimmunology & photomedicine

    2008  Volume 24, Issue 5, Page(s) 268–269

    Abstract: The mechanisms whereby narrowband ultraviolet B (UVB) (311-313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy ... ...

    Abstract The mechanisms whereby narrowband ultraviolet B (UVB) (311-313 nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non-lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole-body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53-positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53-positive epidermal cells, a 12-fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non-lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy.
    MeSH term(s) Adult ; Aged ; Apoptosis/radiation effects ; Cell Count ; Female ; Humans ; Keratinocytes/metabolism ; Keratinocytes/pathology ; Langerhans Cells/metabolism ; Langerhans Cells/pathology ; Male ; Middle Aged ; Psoriasis/metabolism ; Psoriasis/pathology ; Psoriasis/therapy ; Skin/metabolism ; Skin/pathology ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Therapy/methods
    Chemical Substances TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2008-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/j.1600-0781.2008.00366.x
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    Zs.A 1951: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article: Lack of effect of oral selenite on p53 associated gene expression during TL01 therapy of psoriasis patients.

    DeSilva, Bernadette / Beckett, Geoffrey J / McLean, Steven / Arthur, John R / Hunter, John A A / Norval, Mary / McKenzie, Roddie C

    Photodermatology, photoimmunology & photomedicine

    2007  Volume 23, Issue 2-3, Page(s) 98–100

    Abstract: Selenium (Se) has protective properties against ultraviolet (UV)-induced changes in skin cells in vitro but little is known about such activity in human subjects. In the present study, seven patients with psoriasis ingested 400 microg of sodium selenite ... ...

    Abstract Selenium (Se) has protective properties against ultraviolet (UV)-induced changes in skin cells in vitro but little is known about such activity in human subjects. In the present study, seven patients with psoriasis ingested 400 microg of sodium selenite daily during a 4 week course of whole-body narrow-band UVB (TL01) therapy while six more psoriasis patients, similarly irradiated, ingested a placebo. Skin biopsies, collected at the start and end of the phototherapy were analysed for phosphorylated p53, Fas, Bcl-2, Bax and oxidized guaninosine, and for numbers of Langerhans and sunburn cells. Following the TL01 therapy, no significant difference was observed for any of these markers when the Se group was compared with the placebo group of patients, although p53 and Bcl-2 expression decreased in the Se supplemented group.
    MeSH term(s) Administration, Oral ; Adult ; Combined Modality Therapy ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Psoriasis/drug therapy ; Psoriasis/metabolism ; Psoriasis/pathology ; Psoriasis/radiotherapy ; Severity of Illness Index ; Sodium Selenite/administration & dosage ; Sodium Selenite/therapeutic use ; Treatment Outcome ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ultraviolet Rays ; Ultraviolet Therapy
    Chemical Substances Tumor Suppressor Protein p53 ; Sodium Selenite (HIW548RQ3W)
    Language English
    Publishing date 2007-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0905-4383 ; 0108-9684
    ISSN (online) 1600-0781
    ISSN 0905-4383 ; 0108-9684
    DOI 10.1111/j.1600-0781.2007.00277.x
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    Zs.A 1951: Show issues Location:
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  8. Article: Inhibition of TCR-mediated shedding of L-selectin (CD62L) on human and mouse CD4+ T cells by metalloproteinase inhibition: analysis of the regulation of Th1/Th2 function.

    Savage, Nigel D L / Harris, Stephen H / Rossi, Adriano G / De Silva, Bernadette / Howie, Sarah E M / Layton, Guy T / Lamb, Jonathan R

    European journal of immunology

    2002  Volume 32, Issue 10, Page(s) 2905–2914

    Abstract: The generation of a productive primary immune response is dependent on the ability of naïve T lymphocytes to recirculate through peripheral lymph organs to encounter specific antigen. The process of naïve CD4(+) T cell entry into lymph nodes correlates ... ...

    Abstract The generation of a productive primary immune response is dependent on the ability of naïve T lymphocytes to recirculate through peripheral lymph organs to encounter specific antigen. The process of naïve CD4(+) T cell entry into lymph nodes correlates with cell surface expression of L-selectin (CD62L), which mediates early tethering and rolling events to endothelium prior to entry. Here, we demonstrate that surface expression of CD62L enhances CD4(+) T cell activation in vitro. The synthetic hydroxamate metalloproteinase inhibitor (BB-3103), specifically inhibits activation-induced shedding of CD62L from CD4(+) T cells by TCR cross-linking and lowers proliferation in part by reducing rapid tyrosine phosphorylation of zeta-associated protein 70 kDa (ZAP-70) and by increasing cytosolic free Ca(2+) concentration mobilization. BB-3103 also inhibited the proliferative response of both murine CD4(+) Th1 and Th2 subsets in vitro but the inhibitory effects were sustained only in Th2-type cells. Similarly, BB-3103 mediated prolonged inhibition of allergen-dependent peripheral T cell proliferation in atopic dermatitis patients but not in healthy controls. Analysis of CD62L expression on murine CD4(+) T cell subsets revealed that surface expression was maintained on Th1 cells but not Th2 cells. The differential effects of BB-3103 on primed effector CD4(+) T cells may provide new insights into generating therapeutic agents capable of redressing the Th2/Th1 imbalance in allergic diseases.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/physiology ; Calcium/metabolism ; Cytokines/biosynthesis ; Humans ; Hydroxamic Acids/pharmacology ; L-Selectin/analysis ; L-Selectin/physiology ; Lymphocyte Activation ; Metalloendopeptidases/antagonists & inhibitors ; Mice ; Mice, Inbred C57BL ; Receptors, Antigen, T-Cell/physiology ; Th1 Cells/physiology ; Th2 Cells/physiology
    Chemical Substances BB 3103 ; Cytokines ; Hydroxamic Acids ; Receptors, Antigen, T-Cell ; L-Selectin (126880-86-2) ; Metalloendopeptidases (EC 3.4.24.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2002-10
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/1521-4141(2002010)32:10<2905::AID-IMMU2905>3.0.CO;2-6
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    Zs.MG 85: Show issues

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