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Article ; Online: Hospital-Based Health Technology Assessment of Machine Perfusion Systems for Human Liver Transplantation.

De Simone, Paolo / Ghinolfi, Davide

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10405

Abstract: Based on published data, we have carried out a hospital-based health technology assessment of machine perfusion in adult liver transplantation using cold storage as a comparator, and within the perspective of a national health system-based hospital ... ...

Abstract	Based on published data, we have carried out a hospital-based health technology assessment of machine perfusion in adult liver transplantation using cold storage as a comparator, and within the perspective of a national health system-based hospital practice and disease-related group reimbursement policy. A systematic literature review on machine perfusion for adult liver transplantation was conducted exploring the Pubmed, CINAHL, Scopus, Embase, and Cochrane databases. The literature was analyzed with the intent to provide information on 6 dimensions and 19 items of the hospital-based health technology assessment framework derived from previous studies. Out of 705 references, 47 (6.7%) were retained for current analysis. Use of machine perfusion was associated with advantages over cold storage, i.e., a 10%-50% reduced risk for early allograft dysfunction, 7%-15% less ischemia reperfusion injury; 7%-50% fewer ischemic biliary complications, comparable or improved 1-year graft and patient survival, and up to a 50% lower graft discard rate. Hospital stay was not longer, and technical failures were anecdotal. Information on costs of machine perfusion is limited, but this technology is projected to increase hospital costs while cost-effectiveness analysis requires data over the transplant patient lifetime. No hospital-based health technology assessment study on machine perfusion in liver transplantation was previously conducted. From the hospital perspective, there is evidence of the clinical advantages of this novel technology, but strategies to counterbalance the increased costs of liver transplantation are urgently needed. Further studies should focus on the ethical, social, and organizational issues related to machine perfusion.
MeSH term(s)	Adult ; Hospitals ; Humans ; Liver Transplantation/methods ; Organ Preservation/methods ; Perfusion/methods ; Technology Assessment, Biomedical
Language	English
Publishing date	2022-05-27
Publishing country	Switzerland
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10405
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Article ; Online: Applicability of Patient-Reported Outcome Measures to Aesthetic Medicine Patient Archetypes.

Rauch, Simonne / De Simone, Patricia / Bertucci, Vince

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2023 Volume 50, Issue 1, Page(s) 86–92

Abstract: Background: Patient-reported outcome measures (PROMs) are valuable in understanding patient motivations, setting expectations, and ensuring satisfaction. As the aesthetic industry expands globally, factors that motivate the treatment goals of the ... ...

Abstract	Background: Patient-reported outcome measures (PROMs) are valuable in understanding patient motivations, setting expectations, and ensuring satisfaction. As the aesthetic industry expands globally, factors that motivate the treatment goals of the aesthetic patient reflect evolving social, cultural, and commercial influences. Objective: This article will assess the applicability of current PROMs used in aesthetic medicine to an increasingly diverse patient population and consider their ability to measure the underlying motives that drive different types of patients to pursue their specific goals. Methods: PubMed database was searched for studies using PROMs to evaluate the motivations and expectations of aesthetic patients. Results: Seven validated aesthetic PROM tools were reviewed against a backdrop of different patient segments as represented by the 4 patient archetypes: Positive Aging, Beautification, Correction, and Transformation. None of the tools could universally represent the individual motivations and expectations of all 4 patient archetypes. Conclusion: There is a need for updated PROMs in aesthetics that are applicable to patients with different motivations or expected outcomes than the traditional rejuvenation patient. PROMs that help decode patient motivations and that are developed with more diverse patient involvement will help aesthetic clinicians better understand the goals and expectations of new patient segments.
MeSH term(s)	Humans ; Esthetics ; Aging ; Rejuvenation ; Motivation ; Patient Reported Outcome Measures ; Quality of Life
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000003985
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Article: Optimal Use of Novel Immunotherapeutics in B-Cell Precursor ALL.

Lussana, Federico / Cavallaro, Gianluca / De Simone, Pantaleo / Rambaldi, Alessandro

Cancers

2023 Volume 15, Issue 4

Abstract: Novel immune therapies are currently being used for patients with R/R ALL based on their ability to induce not only hematologic but also molecular remission. Despite promising results, specific clinical conditions, such as high tumor burden or extra ... ...

Abstract	Novel immune therapies are currently being used for patients with R/R ALL based on their ability to induce not only hematologic but also molecular remission. Despite promising results, specific clinical conditions, such as high tumor burden or extra medullary relapse, are still associated with a remarkably poor clinical outcome. Therefore, how to optimize the choice and the timing of such new treatments within different clinical settings remains a matter of debate. In addition, with the aim of increasing the rate and depth of molecular remission, clinical studies are currently evaluating the combination of these immunotherapies with chemotherapy in the contest of frontline treatment. The preliminary data suggest that this approach may increase the cure rate and perhaps reduce the use of allogeneic stem cell transplantation (alloHSCT) in first remission. In Ph-positive ALL, reproducible results are showing that frontline treatment programs, based on the combination of tyrosine kinase inhibitors and immunotherapy, can achieve unprecedented rates of hematologic and molecular remission as well as a long-term cure, even in the absence of chemotherapy and alloHSCT. The results from these studies have led to the development of potentially curative treatment modalities, even for older ALL patients who cannot be treated with conventional intensive chemotherapy. The present review examined the evidence for an appropriate use of the new immunotherapies in ALL patients and provided some appraisal of the current and future possible uses of these drugs for achieving further therapeutic improvement in the treatment of this disease.
Language	English
Publishing date	2023-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041349
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Article: Everolimus versus mycophenolate mofetil in liver transplantation: every improvement in renal function matters.

De Simone, Paolo / Bronzoni, Jessica / Martinelli, Caterina

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2022 Volume 114, Issue 6, Page(s) 312–313

Abstract: The current edition of the journal features a Spanish, nationwide, multi-institutional study by Gomez Bravo MA et al. exploring the advantages of everolimus (EVR)-facilitated tacrolimus (TAC) minimization versus TAC in combination with mycophenolate ... ...

Abstract	The current edition of the journal features a Spanish, nationwide, multi-institutional study by Gomez Bravo MA et al. exploring the advantages of everolimus (EVR)-facilitated tacrolimus (TAC) minimization versus TAC in combination with mycophenolate mofetil (MMF) after liver transplantation (LT).
MeSH term(s)	Drug Therapy, Combination ; Everolimus/therapeutic use ; Humans ; Kidney/drug effects ; Kidney/physiology ; Liver Transplantation ; Multicenter Studies as Topic ; Mycophenolic Acid/therapeutic use ; Tacrolimus/therapeutic use
Chemical Substances	Everolimus (9HW64Q8G6G) ; Mycophenolic Acid (HU9DX48N0T) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2022-05-12
Publishing country	Spain
Document type	Introductory Journal Article ; Editorial ; Comment
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2022.8902/2022
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Article ; Online: Data mining of key genes expression in hepatocellular carcinoma: novel potential biomarkers of diagnosis prognosis or progression.

Cabiati, Manuela / Gaggini, Melania / De Simone, Paolo / Del Ry, Silvia

Clinical & experimental metastasis

2022 Volume 39, Issue 4, Page(s) 589–602

Abstract: Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death worldwide. The study aimed to perform a data mining analysis of the expression and regulatory role of key genes in HCC to reveal novel potential biomarkers of diagnosis ... ...

Abstract	Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death worldwide. The study aimed to perform a data mining analysis of the expression and regulatory role of key genes in HCC to reveal novel potential biomarkers of diagnosis prognosis, or progression since their availability is still almost lacking. Starting from data of our cohort of patients (HCV-positive HCC pts undergoing liver transplantation (LR, n = 10) and donors (LD, n = 14), deeply analyzed previously, in which apelin, osteopontin, osteoprotegerin, NOTCH-1, CASP-3, Bcl-2, BAX, PTX3, and NPTX2 were analyzed, we applied statistical analysis and in-silico tools (Gene Expression Profiling Interactive Analysis, HCCDB database and GeneMania, UALCAN) to screen and identify the key genes. Firstly, we performed a stepwise regression analysis using our mRNA-datasets which revealed that higher expression levels of apelin and osteopontin were positively associated with the HCC and identified that the most consistently differentially expressed gene across multiple HCC expression datasets was only OPN. This comprehensive strategy of data mining evidenced that OPN might have a potential function as an important tumor marker-driven oncogenesis being associated with poor prognosis of HCC patients.
MeSH term(s)	Apelin/genetics ; Apelin/metabolism ; Biomarkers, Tumor/genetics ; Carcinoma, Hepatocellular/metabolism ; Data Mining ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Liver Neoplasms/pathology ; Osteopontin/genetics ; Prognosis
Chemical Substances	Apelin ; Biomarkers, Tumor ; Osteopontin (106441-73-0)
Language	English
Publishing date	2022-04-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-022-10164-9
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Article: Aging with a Liver Graft: Analysis of Very Long-Term Survivors after Liver Transplantation.

De Simone, Paolo / Bronzoni, Jessica / Martinelli, Caterina / Ducci, Juri / Campani, Daniela / Gitto, Stefano / Marchetti, Piero / Biancofiore, Giandomenico

Journal of clinical medicine

2024 Volume 13, Issue 4

Abstract: Background: In Italy, data on long-term survivors after liver transplantation are lacking.: Materials and methods: We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify ... ...

Abstract	Background: In Italy, data on long-term survivors after liver transplantation are lacking. Materials and methods: We conducted a hybrid design study on a cohort of 359 adult recipients who received transplants between 1996 and 2002 to identify predictors of survival and the prevalence of co-morbidities among long-term survivors. Results: The actuarial (95% CI) patient survival was 96% (94.6-98.3%), 69% (64.2-73.6%), 55% (49.8-59.9%), 42.8% (37.6-47.8%), and 34% (29.2-38.9%) at 1, 5, 10, 15, and 20 years, respectively. The leading causes of death were hepatitis C virus recurrence (24.6%), extrahepatic malignancies (16.9%), infection (14.4%), and hepatocellular carcinoma recurrence (14.4%). The factors associated with the survival probability were younger donor and recipient ages ( Conclusions: Aging with a liver graft is associated with an increased risk of complications and requires ongoing care to reduce the long-term attrition rate resulting from chronic immunosuppression.
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13041087
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Article ; Online: Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes.

Papaccio, Federica / Caputo, Silvia / Iorio, Alessandra / De Simone, Paola / Ottaviani, Monica / Del Brocco, Antonella / Frascione, Pasquale / Bellei, Barbara

Cells

2024 Volume 13, Issue 5

Abstract: Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major ... ...

Abstract	Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major clinical risk factors for melanoma include fair skin, an increased number of nevi, the presence of dysplastic nevi, and a family history of melanoma. However, several external inducers seem to be associated with melanoma susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol consumption, and heavy metals. In recent years, epidemiological studies have highlighted a potential risk of β-hexachlorocyclohexane (β-HCH), the most studied organochlorine pesticide, causing cancer induction including melanoma. Methods: We evaluated in vitro the impact of this pollutant on epidermal and dermal cells, attempting to describe mechanisms that could render cutaneous cells more prone to oncogenic transformation. Results: We demonstrated that β-HCH impacts melanocyte biology with a highly cell-type specific signature that involves perturbation of AKT/mTOR and Wnt/β-catenin signaling, and AMPK activation, resulting in lowering energy reserve, cell proliferation, and pigment production. Conclusions: In conclusion, long-term exposure to persistent organic pollutants damages melanocyte metabolism in its function of melanin production with a consequent reduction of melanogenesis indicating a potential augmented skin cancer risk.
MeSH term(s)	Humans ; Melanoma/pathology ; Skin Neoplasms/pathology ; Melanocytes/metabolism ; Hexachlorocyclohexane/metabolism
Chemical Substances	beta-hexachlorocyclohexane (YM80ODM9PD) ; Hexachlorocyclohexane (59NEE7PCAB)
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13050374
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Article: Everolimus Mitigates the Risk of Hepatocellular Carcinoma Recurrence after Liver Transplantation.

De Simone, Paolo / Precisi, Arianna / Lai, Quirino / Ducci, Juri / Campani, Daniela / Marchetti, Piero / Gitto, Stefano

Cancers

2024 Volume 16, Issue 7

Abstract: To obtain long-term data on the use of everolimus in patients who underwent liver transplantation for hepatocellular carcinoma, we conducted a retrospective, single-center analysis of adult recipients transplanted between 2013 and 2021. Patients on ... ...

Abstract	To obtain long-term data on the use of everolimus in patients who underwent liver transplantation for hepatocellular carcinoma, we conducted a retrospective, single-center analysis of adult recipients transplanted between 2013 and 2021. Patients on everolimus-incorporating immunosuppression were matched with those on tacrolimus using an inverse probability of treatment weighting methodology. Two propensity-matched groups of patients were thus compared: 233 (45.6%) receiving everolimus versus 278 (54.4%) on tacrolimus. At a median (interquartile range) follow-up of 4.4 (3.8) years after transplantation, everolimus patients showed a reduced risk of recurrence versus tacrolimus (7.7% versus 16.9%; RR = 0.45;
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16071243
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Article ; Online: Viability testing during normothermic machine perfusion requires both hepatocellular and cholangiocellular criteria.

Melandro, Fabio / De Simone, Paolo / Ghinolfi, Davide

Updates in surgery

2021 Volume 73, Issue 2, Page(s) 781–783

MeSH term(s)	Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Organ Preservation ; Perfusion
Language	English
Publishing date	2021-01-21
Publishing country	Italy
Document type	Letter
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-021-00976-x
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Article ; Online: The pursuit of happiness: The thin line between rights and duties.

Ghinolfi, Davide / De Simone, Paolo

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2018 Volume 18, Issue 7, Page(s) 1826–1827

MeSH term(s)	Aged ; Happiness ; Humans ; Liver ; Liver Transplantation ; Tissue and Organ Procurement
Language	English
Publishing date	2018-03-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14686
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