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  1. Article ; Online: Technical modifications for cost optimization in robot-assisted ventral mesh rectopexy: an initial experience.

    Marra, A A / Campennì, P / De Simone, V / Parello, A / Litta, F / Ratto, C

    Techniques in coloproctology

    2023  Volume 27, Issue 7, Page(s) 551–557

    Abstract: Background: Robot-assisted ventral mesh rectopexy is considered a valid option in the treatment of rectal prolapse. However, it involves higher costs than the laparoscopic approach. The aim of this study is to determine if less expensive robotic surgery ...

    Abstract Background: Robot-assisted ventral mesh rectopexy is considered a valid option in the treatment of rectal prolapse. However, it involves higher costs than the laparoscopic approach. The aim of this study is to determine if less expensive robotic surgery for rectal prolapse can be safely performed.
    Methods: This study was conducted on consecutive patients who underwent robot-assisted ventral mesh rectopexy at Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, from 7 November 2020 to 22 November 2021. The cost of hospitalization, surgical procedure, robotic materials, and operating room resources in patients undergoing robot-assisted ventral mesh rectopexy with the da Vinci Xi Surgical Systems was analyzed before and after technical modifications, including the reduction of robotic arms and instruments, and the execution of a double minimal peritoneal incision at the pouch of Douglas and sacral promontory (instead of the traditional inverted J incision).
    Results: Twenty-two robot-assisted ventral mesh rectopexies were performed [21 females, 95.5%, median age 62.0 (54.8-70.0) years]. After an initial experience performing traditional robot-assisted ventral mesh rectopexy in four patients, we adopted technical modifications in other cases. No major complication or conversion to open surgery occurred. In total, mean cost of hospitalization, surgical procedure, robotic materials, and operating room resources was €6995.5 ± 1058.0, €5912.7 ± 877.0, €2797.6 ± 545.6, and €2608.3 ± 351.5, respectively. Technical modifications allowed a significant reduction in the overall cost of hospitalization (€6604.5 ± 589.5 versus €8755.0 ± 906.4, p = 0.001), number of robotic instruments (3.1 ± 0.2 versus 4.0 ± 0.8 units, p = 0.026), and operating room time (201 ± 26 versus 253 ± 16 min, p = 0.003).
    Conclusions: Considering our preliminary results, robot-assisted ventral mesh rectopexy with appropriate technical modifications can be cost-effective and safe.
    MeSH term(s) Female ; Humans ; Middle Aged ; Rectal Prolapse/surgery ; Robotics ; Laparoscopy/methods ; Surgical Mesh ; Treatment Outcome ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2023-02-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-023-02756-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5842: Show issues Location:
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  2. Article: Would Surgeons Like to Be Submitted to Anal Fistulotomy? An International Web-Based Survey.

    Ratto, Carlo / Marra, Angelo Alessandro / Parello, Angelo / De Simone, Veronica / Campennì, Paola / Litta, Francesco

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: Traditional fistulotomy is the most performed surgical procedure in anal fistula surgery. We conducted an international online survey to explore colorectal surgeons' opinions and preferences on fistulotomy. Considering the healing and continence ... ...

    Abstract Traditional fistulotomy is the most performed surgical procedure in anal fistula surgery. We conducted an international online survey to explore colorectal surgeons' opinions and preferences on fistulotomy. Considering the healing and continence impairment rates reported in the literature, surgeons were invited to answer as a hypothetic patient susceptible to being submitted to fistulotomy for low and high anal fistula. A total of 767 surgeons completed the survey from 72 countries. The majority of respondents were consultants, having treated more than 20 anal fistulas in the last year. Most of them declared that anal fistula would be able to negatively affect quality of life and would be worried/anxious about it. Taking into account all aspects, 87.5% and 37.8% of respondents would agree to be treated with a fistulotomy in case of a low and high fistula, respectively, with an acceptance rate that varied worldwide. At multivariate analysis, factors correlated to the acceptance of anal fistulotomy were male gender (
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030825
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  3. Article ; Online: Clear Aligners Treatment of Class III Subdivision with an Extraction of a Lower Bicuspid.

    D'Antò, Vincenzo / Valletta, Rosa / De Simone, Vittoria / Pisano, Massimo / Martina, Stefano

    International journal of environmental research and public health

    2023  Volume 20, Issue 4

    Abstract: The aim of this study was to show a case of a Class III subdivision adult patient treated with clear aligners (CA) and the extraction of a lower bicuspid. A 19-year-old male with a class III canine and molar relationship on the right side and a deviation ...

    Abstract The aim of this study was to show a case of a Class III subdivision adult patient treated with clear aligners (CA) and the extraction of a lower bicuspid. A 19-year-old male with a class III canine and molar relationship on the right side and a deviation of lower dental midline to the left asked for an aesthetic treatment. He refused orthognathic surgical procedures, so he was offered a camouflage orthodontic treatment with the extraction of lower right first premolar to achieve a canine Class I relationship and to center the lower midline. The treatment was performed with clear aligners and the use of Class III elastics to maintain distal anchorage on the right side during the canine distalization. At the end of the treatment, the occlusal objectives were achieved.
    MeSH term(s) Male ; Animals ; Bicuspid/surgery ; Treatment Outcome ; Orthognathic Surgical Procedures ; Tooth Extraction/methods ; Orthodontic Appliances, Removable
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20043550
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  4. Article: Estrogen-Mediated Effects Underlie Gender Bias in Inflammatory Bowel Disease.

    De Simone, Veronica / Matteoli, Gianluca

    Cellular and molecular gastroenterology and hepatology

    2018  Volume 5, Issue 4, Page(s) 638–639.e1

    Language English
    Publishing date 2018-02-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2819778-1
    ISSN 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2018.01.017
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  5. Book ; Online: Cartoon-texture evolution for two-region image segmentation

    Antonelli, Laura / De Simone, Valentina / Viola, Marco

    2022  

    Abstract: Two-region image segmentation is the process of dividing an image into two regions of interest, i.e., the foreground and the background. To this aim, Chan et al. [Chan, Esedo\=glu, Nikolova, SIAM Journal on Applied Mathematics 66(5), 1632-1648, 2006] ... ...

    Abstract Two-region image segmentation is the process of dividing an image into two regions of interest, i.e., the foreground and the background. To this aim, Chan et al. [Chan, Esedo\=glu, Nikolova, SIAM Journal on Applied Mathematics 66(5), 1632-1648, 2006] designed a model well suited for smooth images. One drawback of this model is that it may produce a bad segmentation when the image contains oscillatory components. Based on a cartoon-texture decomposition of the image to be segmented, we propose a new model that is able to produce an accurate segmentation of images also containing noise or oscillatory information like texture. The novel model leads to a non-smooth constrained optimization problem which we solve by means of the ADMM method. The convergence of the numerical scheme is also proved. Several experiments on smooth, noisy, and textural images show the effectiveness of the proposed model.

    Comment: 26 pages, 2 tables, 6 figures
    Keywords Mathematics - Numerical Analysis ; Computer Science - Computer Vision and Pattern Recognition ; 90C25 ; 65K05 ; 94A08
    Subject code 004
    Publishing date 2022-03-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Split Bregman iteration for multi-period mean variance portfolio optimization.

    Corsaro, Stefania / De Simone, Valentina / Marino, Zelda

    Applied mathematics and computation

    2020  Volume 392, Page(s) 125715

    Abstract: This paper investigates the problem of defining an optimal long-term investment strategy, where the investor can exit the investment before maturity without severe loss. Our setting is a multi-period one, where the aim is to make a plan for allocating ... ...

    Abstract This paper investigates the problem of defining an optimal long-term investment strategy, where the investor can exit the investment before maturity without severe loss. Our setting is a multi-period one, where the aim is to make a plan for allocating all of wealth among the
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1465428-3
    ISSN 0096-3003
    ISSN 0096-3003
    DOI 10.1016/j.amc.2020.125715
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  7. Article: Chitosan-Induced Activation of the Antioxidant Defense System Counteracts the Adverse Effects of Salinity in Durum Wheat.

    Quitadamo, Filippo / De Simone, Vanessa / Beleggia, Romina / Trono, Daniela

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 7

    Abstract: The present study was carried out with the aim of ( ...

    Abstract The present study was carried out with the aim of (
    Language English
    Publishing date 2021-07-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10071365
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  8. Article ; Online: Fistulotomy and primary sphincteroplasty for anal fistula: long-term data on continence and patient satisfaction.

    Litta, F / Parello, A / De Simone, V / Grossi, U / Orefice, R / Ratto, C

    Techniques in coloproctology

    2019  Volume 23, Issue 10, Page(s) 993–1001

    Abstract: Background: The aim of this study was to evaluate the safety and long-term efficacy of fistulotomy and primary sphincteroplasty (FIPS). Secondary endpoints were its impact on postoperative continence status and patients' satisfaction.: Methods: A ... ...

    Abstract Background: The aim of this study was to evaluate the safety and long-term efficacy of fistulotomy and primary sphincteroplasty (FIPS). Secondary endpoints were its impact on postoperative continence status and patients' satisfaction.
    Methods: A retrospective study was conducted on patients with cryptoglandular anal fistula (AF) who had FIPS between June 2006 and May 2017. Patients were evaluated with standardized telephone interviews and clinical/instrumental assessment. Main outcome measures included fistula healing rate, continence status, and patient satisfaction. Incontinence was defined as an inability to hold either gas, liquid, or solid stools, as well as postdefecation soiling, and was measured by the Cleveland Clinic fecal incontinence score. Patient satisfaction was evaluated by an 11-point numeric rating scale.
    Results: There were 203 patients (139 males; mean age: 48.7 years) who had FIPS. The overall healing rate was 93% (188 patients) with a mean follow-up period of 56 ± 31 months. Half of the total cohort (51%) had a complex fistula. Preoperatively, 8 (4%) patients complained of postdefecation soiling and 2 (1%) of gas incontinence. Postoperatively, 26 (13%) patients had continence impairment (de novo n = 24), mainly consisting of postdefecation soiling (10%). In univariate analysis, patients with recurrent (RR 6.153 95% CI 2.097-18.048; p = 0.002) or complex (RR 3.005 95% CI 1.203-7.506; p = 0.012) AF and those with secondary tracts (RR 8.190 95% CI 2.188-30.654; p = 0.004) or previous set on drainage (RR 5.286 95% CI 2.235-12.503; p = 0.0001) were at higher risk of incontinence. In multivariate analysis, no significant predictors were found, although fistula complexity approached statistical significance (RR 5.464 95% CI 0.944-31.623; p = 0.050). The mean patient satisfaction numeric rating scale was 9.3 ± 1.6. Lower satisfaction rates were found in patients with transphincteric (p = 0.011) or complex (p = 0.0001) AF, with secondary tracts (p = 0.041) or previous seton drainage (p = 0.008), and in those with postoperative continence impairment (p = 0.0001). Postoperative onset of incontinence was the only significant factor in multivariate analysis (p = 0.0001).
    Conclusions: FIPS should be considered a valid therapeutic option for selected AF. However, the risk of postoperative minor fecal incontinence exists, and should be discussed during preoperative patient counselling.
    MeSH term(s) Adult ; Anal Canal/surgery ; Fecal Incontinence/epidemiology ; Fecal Incontinence/etiology ; Female ; Humans ; Male ; Middle Aged ; Patient Satisfaction/statistics & numerical data ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Period ; Reconstructive Surgical Procedures/adverse effects ; Reconstructive Surgical Procedures/methods ; Rectal Fistula/complications ; Rectal Fistula/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2019-09-19
    Publishing country Italy
    Document type Evaluation Study ; Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-019-02093-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5842: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Comparative Analysis of Qualitative and Bioactive Compounds of Whole and Refined Flours in Durum Wheat Grains with Different Year of Release and Yield Potential.

    Menga, Valeria / Giovanniello, Valentina / Savino, Michele / Gallo, Antonio / Colecchia, Salvatore Antonio / De Simone, Vanessa / Zingale, Silvia / Ficco, Donatella Bianca Maria

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Durum wheat varieties are important sources of nutrients and provide remarkable amounts of phytochemicals. Especially, phenolics, which are mostly located in external layers of grains, have recently gained increased interest due to their high antioxidant ...

    Abstract Durum wheat varieties are important sources of nutrients and provide remarkable amounts of phytochemicals. Especially, phenolics, which are mostly located in external layers of grains, have recently gained increased interest due to their high antioxidant power. This study aimed to evaluate the differences in the quality traits and phenolic compounds' concentration (e.g., phenolic acids) of different durum wheat genotypes, namely four Italian durum wheat cultivars and a USA elite variety, in relation to their yield potential and year of release. Phenolic acids were extracted both from wholemeal flour and semolina and analysed through HPLC-DAD analysis. Ferulic acid was the most represented phenolic acid, both in the wholemeal flour (438.3 µg g
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12061350
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  10. Article ; Online: The Ketogenic Diet in Children with Epilepsy: A Focus on Parental Stress and Family Compliance.

    Operto, Francesca Felicia / Labate, Angelo / Aiello, Salvatore / Perillo, Cristina / de Simone, Valeria / Rinaldi, Rosetta / Coppola, Giangennaro / Pastorino, Grazia Maria Giovanna

    Nutrients

    2023  Volume 15, Issue 4

    Abstract: 1) Background: The aim of our study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables (epilepsy type, epilepsy duration, seizure number, antiseizure medications, comorbidities, ... ...

    Abstract (1) Background: The aim of our study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables (epilepsy type, epilepsy duration, seizure number, antiseizure medications, comorbidities, efficacy, and adverse events). (2) Methods: We consecutively enrolled 36 children aged between 3 and 10 years who had been diagnosed with various types of drug-resistant epilepsy and who were in therapy with a ketogenic diet for better seizure control. A standardized neuropsychological questionnaire (Parenting Stress Index-PSI) was administered to the parents evaluating parental stress at baseline (T0), after 6 (T1) months, and after 12 months (T2). (3) Results: After 6 and 12 months of dietary treatment, Parental Distress and Total Stress mean scores were statistically significantly increased. Post hoc analysis showed no significant changes in the scores between T0 and T1, although there was a significant increase between T1 and T2. We did not find statistically significant relationships between parental stress and the other variables considered. (4) Conclusions: The ketogenic diet can be challenging for parents and can affect the perception of parental stress, especially in the long term. Parents may feel inadequate in their role; therefore, they should be helped and encouraged through additional supports in order to maximize the adherence to diet therapy.
    MeSH term(s) Humans ; Child ; Child, Preschool ; Diet, Ketogenic/adverse effects ; Treatment Outcome ; Epilepsy ; Seizures ; Parents
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15041058
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