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  1. Article ; Online: Jaboticaba peel improves postprandial glucose and inflammation: A randomized controlled trial in adults with metabolic syndrome.

    Geraldi, Marina Vilar / de Souza, Ágatta Caroline / Norde, Marina Maintinguer / Berni, Paulo Roberto / Reguengo, Lívia Mateus / Geloneze, Bruno / Marostica, Mario Roberto

    Nutrition research (New York, N.Y.)

    2024  Volume 125, Page(s) 36–49

    Abstract: The modulation of glucose metabolism through dietary sources has been recognized as 1 of the most sustainable approaches for preventing of cardiometabolic diseases. Although fibers and phenolic compounds derived from jaboticaba (Plinia jaboticaba) peel ... ...

    Abstract The modulation of glucose metabolism through dietary sources has been recognized as 1 of the most sustainable approaches for preventing of cardiometabolic diseases. Although fibers and phenolic compounds derived from jaboticaba (Plinia jaboticaba) peel have demonstrated improvements in metabolic pathways in preclinical models, their beneficial effects in clinical trials remain to be fully determined. This study aimed to assess the impact of jaboticaba peel (JP) powder supplementation on glucose metabolism compared with a placebo in individuals with metabolic syndrome (MetS). A single-blind, parallel, randomized, placebo-controlled trial involving 49 individuals with MetS was conducted. Participants were assigned to receive either a JP supplement (15 g/day) or a matched placebo. Anthropometry measurements, body composition, blood pressure, metabolic and inflammatory parameters, and a mixed-meal tolerance test were assessed at weeks 0 and 5. Daily intake of JP improved the area under the curve of glucose (P = .025) and the interleukin-6 (IL-6) (P = .045). No significant time × treatment effects were observed for blood pressure, body weight, body composition, lipid metabolism, glucagon-like peptide-1, inflammatory cytokines (tumor necrosis factor-α, IL-1β), C-reactive protein, and insulin sensitivity and resistance indexes. JP supplementation may be a promising approach for managing MetS disorders, potentially by reducing the area under the curve for glucose and the proinflammatory cytokine IL-6. This research is registered at the Brazilian Registry of Clinical Trials (RBR-8wwq9t).
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 582432-1
    ISSN 1879-0739 ; 0271-5317
    ISSN (online) 1879-0739
    ISSN 0271-5317
    DOI 10.1016/j.nutres.2024.02.008
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    Zs.A 1686: Show issues Location:
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  2. Article ; Online: Rapid identification,fluconazole and micafungin susceptibility testing of Candida species from blood culture by a short incubation method.

    de Souza, Ândrea Celestino / Pereira, Dariane Castro / Barth, Patricia Orlandi / Roesch, Eliane Würdig / Lutz, Larissa / Aquino, Valério Rodrigues / Goldani, Luciano Zubaran

    Diagnostic microbiology and infectious disease

    2024  Volume 109, Issue 2, Page(s) 116271

    Abstract: This study aimed to develop and validate a rapid method for identification by MALDI-TOF system and determination of the susceptibility to Fluconazole and Micafungin by broth microdilution among Candidaspecies causing bloodstream infections. Subcultures ... ...

    Abstract This study aimed to develop and validate a rapid method for identification by MALDI-TOF system and determination of the susceptibility to Fluconazole and Micafungin by broth microdilution among Candidaspecies causing bloodstream infections. Subcultures from blood culture bottles were incubated for 5 hours (+/- 1h) and used to perform the tests, so that the turnaround time of rapid identification and susceptibility profile was about 5 and 24 hours, respectively. The rapid identification showed agreement of 92.05 %. Regarding the rapid broth microdilution for Fluconazole and Micafungin, the agreement was 97.06 % (p<0.001) and 100 % (p<0.001), and the Kappa coefficient was 0.91 (p<0.001) and 1.0 (p<0.001), respectively. To conclude, both rapid methods showed to be reproducible, inexpensive, easy to perform and time-saving. Thus, these methodologies could be useful to guide and adjust empirical antifungal therapy.
    MeSH term(s) Micafungin/pharmacology ; Humans ; Microbial Sensitivity Tests/methods ; Candida/drug effects ; Candida/classification ; Antifungal Agents/pharmacology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Blood Culture/methods ; Lipopeptides/pharmacology ; Echinocandins/pharmacology ; Fluconazole/pharmacology ; Candidemia/microbiology ; Candidemia/diagnosis ; Time Factors ; Reproducibility of Results
    Chemical Substances Micafungin (R10H71BSWG) ; Antifungal Agents ; Lipopeptides ; Echinocandins ; Fluconazole (8VZV102JFY)
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2024.116271
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    Zs.A 1845: Show issues Location:
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  3. Article ; Online: Forensic exploration of endodontic cements: Unveiling macroscopic and radiographic changes under high temperatures.

    Lima, Natalia Fernandes Cardoso / Ribeiro, Guilherme D / Visconti, Maria A / Verner, Francielle S / Breda de Souza, Andreia Cristina

    Forensic science international

    2024  Volume 356, Page(s) 111953

    Abstract: Objective: To evaluate macroscopically and radiographically the behavior of four endodontic sealers submitted to high temperatures, with forensic purposes.: Methods: Sixty-four lower anterior teeth were included. All teeth were endodontically treated, ...

    Abstract Objective: To evaluate macroscopically and radiographically the behavior of four endodontic sealers submitted to high temperatures, with forensic purposes.
    Methods: Sixty-four lower anterior teeth were included. All teeth were endodontically treated, and simulation of external cervical resorption (ECR) was performed. Half of the sample was filled with AH-Plus™ cement and had ECR sealed with Bio-C-Repair™. The other 32 teeth were filled with Bio-C-Sealer™ cement and had their respective ECR sealed with MTA-Repair™. Then, all teeth were introduced into a bovine bone block to simulate the alveolar bone. The teeth were submitted to incineration at temperatures of 600, 800, 1000, and 1140 °C. All teeth were radiographed before and after incineration. The pre-and post-incineration radiopacity of cements and dentin were evaluated using the ImageJ™ software and compared using a t-test for paired samples.
    Results: It was possible to confirm color change and appearance of cracks in the tissues and dental materials tested, varying according to the temperature. Radiographically, it was observed that the dental crowns completely detached at 1000 ° and 1140 °C, and, only at 1140 °C, the roots showed cracks. Regarding the radiopacity, there was a significant difference in the shades of gray in AH-Plus™ when subjected to 1000 ° and 1140 °C, and at 600 ° and 1000 °C in Bio-C-Sealer™. In Bio-C-Repair™ and MTA-Repair™, a difference was observed at 600 ° and 1140 °C.
    Conclusions: There were macroscopic and radiographic alterations of the materials. This data is important in Forensic Dentistry and may contribute to identifying carbonized victims.
    MeSH term(s) Animals ; Cattle ; Temperature ; Tooth ; Glass Ionomer Cements
    Chemical Substances Glass Ionomer Cements
    Language English
    Publishing date 2024-02-03
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 424042-x
    ISSN 1872-6283 ; 0379-0738
    ISSN (online) 1872-6283
    ISSN 0379-0738
    DOI 10.1016/j.forsciint.2024.111953
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  4. Article ; Online: The effect of seed-dispersal timing on seedling recruitment is modulated by environmental conditions that vary across altitude in a threatened palm.

    de Souza, Aline C / Donohue, Kathleen / de Mattos, Eduardo A

    Annals of botany

    2022  Volume 129, Issue 7, Page(s) 839–856

    Abstract: Background and aims: The timing of seed dispersal determines the environmental conditions that plants face during early life stages. In seasonal environments, selection is expected to favour dispersal timing that is matched to environmental conditions ... ...

    Abstract Background and aims: The timing of seed dispersal determines the environmental conditions that plants face during early life stages. In seasonal environments, selection is expected to favour dispersal timing that is matched to environmental conditions suitable for successful recruitment. Our aim here was to test whether the timing of seed dispersal influences seedling establishment success in two populations of Euterpe edulis that are located at contrasting altitudes, have different seed-dispersal phenologies and are subjected to distinct climatic conditions.
    Methods: We sowed E. edulis seeds in contrasting altitudes on different dates, and monitored seed germination, emergence and seedling establishment at each altitude over 4 years. At the high-altitude site, five seed-dispersal cohorts were established during the natural dispersal period. At the low-altitude site, three seed-dispersal cohorts were established during natural dispersal, and two were established either before or after natural dispersal.
    Key results: At the high-altitude site, seed-dispersal timing did not affect seed germination, seedling emergence or seedling establishment success. In contrast, at the low-altitude site, late seed dispersal near the end of the wet season resulted in a lower probability of seedling establishment, possibly due to the exposure of seeds, germinants and seedlings to unfavourable drought conditions. In addition, at the low-altitude site, the natural seed-dispersal period was poorly matched to favourable environmental conditions for seedling establishment.
    Conclusions: The greater effect of seed-dispersal timing on seedling establishment at the low-altitude site is probably related to a more seasonal and drought-prone environment that favours a restricted period of seed dispersal. The magnitude of the effect of dispersal timing on seedling establishment success was modulated by environmental conditions that vary across altitude. Furthermore, reproductive phenology appears to be subject to more intense selection at the lower limit of the altitudinal range, due to a more restrictive window of opportunity for successful seedling establishment.
    MeSH term(s) Altitude ; Germination ; Plants ; Seed Dispersal ; Seedlings ; Seeds
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcac038
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  5. Article ; Online: Paid Parental Leave: Different Scenarios Around the World.

    de Souza, Ana Claudia / Carbonera, Leonardo Augusto / Rocha, Eva

    Stroke

    2021  Volume 53, Issue 1, Page(s) e23–e25

    MeSH term(s) Behavior/physiology ; Employment ; Humans ; Parental Leave ; Parents
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.035919
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    Zs.A 448: Show issues Location:
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  6. Article ; Online: How did a tailings spill change the distribution of legacy organochlorine compounds in a Southeast Atlantic inner shelf area: Is a hidden danger being transferred to the ocean?

    Cabral, Ana Caroline / de Souza, Amanda Câmara / Sá, Fabian / Neto, Renato Rodrigues / C Martins, César

    The Science of the total environment

    2023  Volume 905, Page(s) 166939

    Abstract: Polychlorinated biphenyls (PCBs) and dichloro-diphenyl-trichloroethane (DDT) were evaluated in water and sediments from the Espírito Santo Inner Shelf (ESIS), Brazil, three years after the Fundão dam failure (FDF). We discuss the levels, sources, fate, ... ...

    Abstract Polychlorinated biphenyls (PCBs) and dichloro-diphenyl-trichloroethane (DDT) were evaluated in water and sediments from the Espírito Santo Inner Shelf (ESIS), Brazil, three years after the Fundão dam failure (FDF). We discuss the levels, sources, fate, and current environmental risks of these contaminants on temporal and spatial scales. In addition, the associated coastal dispersion patterns, water-sediment exchange trends, and environmental alterations were also discussed. Low contributions and no environmental risks were verified for PCBs after FDF. However, the low concentrations and frequency of occurrence in the samples did not allow for further reliable conclusions regarding the source of this contaminant. In contrast, hazard risk has been detected for DDTs in water and sediments. In sediments, there were a significant increase in level (up to 13.42 ng g
    Language English
    Publishing date 2023-09-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.166939
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    Zs.A 949: Show issues Location:
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  7. Article ; Online: Mental Health in Stroke Neurology: Facing Challenges and Building Solutions.

    Borelli, Wyllians Vendramini / de Souza, Ana Claudia / Reckziegel, Estela / Lioutas, Vasileios-Arsenios

    Stroke

    2022  Volume 53, Issue 10, Page(s) e457–e460

    MeSH term(s) Humans ; Mental Health ; Neurology ; Stress, Psychological ; Stroke/therapy ; Workload
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.122.037783
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    Zs.A 448: Show issues Location:
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  8. Article ; Online: Novel yeasts with potential probiotic characteristics isolated from the endogenous ferment of artisanal Minas cheese.

    de Miranda, Nayara Martins Zille / de Souza, Angélica Cristina / de Souza Costa Sobrinho, Paulo / Dias, Disney Ribeiro / Schwan, Rosane Freitas / Ramos, Cíntia Lacerda

    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

    2023  Volume 54, Issue 2, Page(s) 1021–1033

    Abstract: Artisanal Minas cheese (QMA) is traditionally elaborate using raw milk and endogenous ferment (pingo - whey or rala - grated ripened cheese). In the present study, 91 yeast strains were isolated and identified from pingo and rala. Eight yeast species ... ...

    Abstract Artisanal Minas cheese (QMA) is traditionally elaborate using raw milk and endogenous ferment (pingo - whey or rala - grated ripened cheese). In the present study, 91 yeast strains were isolated and identified from pingo and rala. Eight yeast species were identified by the MALDI-TOF mass spectrometry and confirmed by sequencing of the ITS region. The yeasts' protease and lipase activities were evaluated in addition to probiotic properties such as tolerance to low pH and bile salts, hydrophobicity, autoaggregation, co-aggregation with pathogens, and antimicrobial susceptibility. The rala ferment showed a greater variety of species. Yarrowia lipolytica was the dominant specie (52.7% of isolates), followed by the Kluyveromyces lactis and Kodamaea ohmeri (9.9 and 6.6%, respectively). From the total yeasts evaluated, 74 strains showed positive enzymatic activity: 52 strains showed lipolytic (51 Y. lipolytica and one Trichosporon japonicum) and 44 proteolytic activities (18 Y. lipolytica, 13 K. ohmeri, 11 K. lactis, and 2 Wickerhamiella sp.). All evaluated isolates demonstrated tolerance to pH 2.0, and 69 isolates supported the presence of bile salts. From them, 12 isolates showed the capacity of autoaggregation (> 30%) and hydrophobicity (> 90.0%) and were then selected for co-aggregation and antibiotic resistance assays. All selected isolates showed co-aggregation with Salmonella Enteritidis, Escherichia coli, and Listeria monocytogenes greater than 30%. None of the yeast showed sensibility to the evaluated antibiotics and antagonistic activity against the evaluated pathogens. The results demonstrated that pingo and rala have different yeast composition with different enzymatic activity, which may affect the characteristics of the cheese. Furthermore, some yeast strains: Y. lipolytica (9 strains isolated from rala) and K. ohmeri (3 strains isolated from pingo) demonstrated attractive probiotic potential.
    MeSH term(s) Cheese/microbiology ; Yeasts ; Peptide Hydrolases ; Probiotics
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2023-05-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2017175-4
    ISSN 1678-4405 ; 1517-8382
    ISSN (online) 1678-4405
    ISSN 1517-8382
    DOI 10.1007/s42770-023-01002-5
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  9. Article ; Online: Navigating the PAH maze: Bioaccumulation, risks, and review of the quality guidelines in marine ecosystems with a spotlight on the Brazilian coastline.

    Lourenço, Rafael André / Lube, Gabrielle Vieira / Jarcovis, Raphael De Lucca Marcello / da Silva, Josilene / de Souza, Amanda Câmara

    Marine pollution bulletin

    2023  Volume 197, Page(s) 115764

    Abstract: This review delves into the intricate world of Polycyclic Aromatic Hydrocarbons (PAHs) and their bioaccumulation in marine organisms. It explores how physicochemical attributes of individual compounds, along with metabolic oxidation and elimination ... ...

    Abstract This review delves into the intricate world of Polycyclic Aromatic Hydrocarbons (PAHs) and their bioaccumulation in marine organisms. It explores how physicochemical attributes of individual compounds, along with metabolic oxidation and elimination processes, influence this bioaccumulation. The review further investigates the risks and toxicity associated with PAHs in marine organisms. Subsequently, sediment and water quality guidelines used to assess the potential for adverse effects from PAH exposure are discussed exposing significant differences in the methodological approaches used to establish the guidelines, which can lead to discrepancies in the values used to compare PAH concentrations and limitations to their use. Emphasis is placed on the criteria employed in establishing these guidelines, rooted in adverse effects data linked to PAHs, and efforts to establish local quality guidelines for a tropical area are described. This exploration serves to enhance our understanding of the complex interplay between PAHs and marine ecosystems, informing more effective environmental management strategies.
    MeSH term(s) Environmental Monitoring ; Ecosystem ; Bioaccumulation ; Brazil ; Water Pollutants, Chemical/analysis ; Aquatic Organisms/metabolism ; Polycyclic Aromatic Hydrocarbons/analysis ; Geologic Sediments/chemistry
    Chemical Substances Water Pollutants, Chemical ; Polycyclic Aromatic Hydrocarbons
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2023.115764
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  10. Article: Low levels of persistent organic pollutants in sediments of the Doce River mouth, South Atlantic, before the Fundão dam failure

    de Souza, Amanda Câmara / Cabral, Ana Caroline / da Silva, Josilene / Neto, Renato Rodrigues / Martins, César C.

    Science of the total environment. 2022 Jan. 01, v. 802

    2022  

    Abstract: The Doce River mouth (DRM) was severely impacted by the rupture of the Fundão Dam in 2015, considered the greatest Brazilian environmental tragedy in terms of tailings volume released (>40 million m³) and traveled distance (~600 km until the Atlantic ... ...

    Abstract The Doce River mouth (DRM) was severely impacted by the rupture of the Fundão Dam in 2015, considered the greatest Brazilian environmental tragedy in terms of tailings volume released (>40 million m³) and traveled distance (~600 km until the Atlantic Ocean). Environmental monitoring has been performed since then, but background levels are scarce or absent to Persistent Organic Pollutants (POPs), making impact assessments difficult. In the current study, we presented the baseline levels, inventories, and risk assessment of the POPs polychlorinated biphenyl (PCBs) and organochlorinated pesticides (OCPs), in surface sediment of the DRM. Samples were collected in December 2010 and July 2011, i.e., four years before the Fundão dam failure. The total PCBs and the OCPs (Aldrin, HCHs, and Chlordanes) were detected in both sampling campaigns, with levels up to 9.50 and 1.64, 0.28, and 0.63 ng g⁻¹, respectively. The decrease of the Doce River flow was the main factor contributing to seasonal variations in the spatial distribution, and to a slight decline in the levels and frequency of the analyzed POPs in sediments collected in the dry season (July 2011). Environmental risk assessment, inventories, and total mass results suggest a low potential of PCBs and OCPs accumulation before the dam failure. This is the first POPs assessment in the study area that helped identify some unexpected impacts of the Fundão dam failure and contributed to the understanding of POPs cycles in the Southern Atlantic, data that are still scarce in the region.
    Keywords dry season ; environment ; environmental assessment ; polychlorinated biphenyls ; risk assessment ; river flow ; sediments ; Atlantic Ocean
    Language English
    Dates of publication 2022-0101
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.149882
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