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  1. Article ; Online: An overview of diagnosis and assessment methods for neuropathic pain.

    De Stefano, Gianfranco / Truini, Andrea

    Presse medicale (Paris, France : 1983)

    2024  Volume 53, Issue 2, Page(s) 104234

    Abstract: Neuropathic pain, defined as pain arising as a consequence of a lesion or disease affecting the somatosensory nervous system, requires precise diagnostic assessment. Different diagnostic tools have been devised for the diagnosis of neuropathic pain. This ...

    Abstract Neuropathic pain, defined as pain arising as a consequence of a lesion or disease affecting the somatosensory nervous system, requires precise diagnostic assessment. Different diagnostic tools have been devised for the diagnosis of neuropathic pain. This review offers insights into the diagnostic accuracy of screening questionnaires and different tests that investigate the somatosensory nervous system, in patients with suspected neuropathic pain. Thus, it illustrates how these tools can aid clinicians in accurately diagnosing neuropathic pain.
    Language English
    Publishing date 2024-04-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2024.104234
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  2. Article ; Online: Large-vessel vasculitis following the Pfizer-BioNTech COVID-19 vaccine.

    Gilio, Michele / De Stefano, Giulio

    Internal and emergency medicine

    2022  Volume 17, Issue 4, Page(s) 1239–1241

    MeSH term(s) BNT162 Vaccine/adverse effects ; COVID-19/prevention & control ; Humans ; Vasculitis/chemically induced
    Chemical Substances BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-01-24
    Publishing country Italy
    Document type Case Reports ; Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02908-4
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  3. Article ; Online: Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection and Escherichia coli Sepsis: The Role of Procalcitonin for Differential Diagnosis.

    Gilio, Michele / De Stefano, Giulio

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2021  Volume 27, Issue 8S, Page(s) S859–S860

    MeSH term(s) COVID-19/complications ; Child ; Diagnosis, Differential ; Escherichia coli ; Humans ; Procalcitonin ; SARS-CoV-2 ; Sepsis/diagnosis ; Sepsis/etiology ; Systemic Inflammatory Response Syndrome
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2021-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000001783
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  4. Article ; Online: Nerve ultrasound in Friedreich's Ataxia: enlarged nerves as a biomarker of disease severity.

    Di Pietro, G / Cioffi, E / Falco, P / Galosi, E / De Stefano, G / Di Stefano, G / Leone, C / Martines, V / Perotti, S / Casali, C / Truini, A

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2024  Volume 159, Page(s) 75–80

    Abstract: Objective: In Friedreich's ataxia research, the focus is on discovering treatments and biomarkers to assess disease severity and treatment effects. Our study examines high-resolution nerve ultrasound in these patients, seeking correlations with ... ...

    Abstract Objective: In Friedreich's ataxia research, the focus is on discovering treatments and biomarkers to assess disease severity and treatment effects. Our study examines high-resolution nerve ultrasound in these patients, seeking correlations with established clinical markers of disease severity.
    Method: Ten patients with Friedreich's Ataxia underwent a comprehensive clinical assessment with established scales (SARA, FARS, mFARS, INCAT, ADL 0-36, IADL). Additionally, they underwent nerve conduction studies and high-resolution nerve ultrasound. Quantitative evaluation of nerve cross-sectional area, conducted at 24 nerve sites using high-resolution nerve ultrasound, was compared with data obtained from 20 healthy volunteers.
    Results: All the patients had a severe sensory axonal neuropathy. High-resolution nerve ultrasound showed significant increase, in cross sectional area, of median and ulnar nerves at the axilla and arm. The cumulative count of affected nerve sites was directly associated with clinical disability, as determined by SARA, FARS, mFARS, ADL 0-36, and INCAT score, while displaying an inverse correlation with IADL.
    Conclusions: Our study shows that high-resolution ultrasound reveals notable nerve abnormalities, primarily in the upper limbs of patients diagnosed with Friedreich's Ataxia. The observed correlation between these nerve abnormalities and clinical disability scales indicates the potential use of this technique as a biomarker for evaluating disease severity and treatment effects.
    Significance: Nerve Ultrasound is a potential biomarker of disease severity in Friedreich's Ataxia.
    MeSH term(s) Humans ; Friedreich Ataxia/diagnostic imaging ; Neurosurgical Procedures ; Ultrasonography ; Biomarkers ; Patient Acuity
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2024.01.004
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  6. Article ; Online: Covid-19 and EU Competition Law

    De Stefano, Gianni

    Journal of European Competition Law & Practice

    Bring the Informal Guidance On

    2020  Volume 11, Issue 3-4, Page(s) 121–123

    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2538313-9
    ISSN 2041-7772 ; 2041-7764
    ISSN (online) 2041-7772
    ISSN 2041-7764
    DOI 10.1093/jeclap/lpaa024
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Posterior component separation with TAR: lessons learned from our first consecutive 52 cases.

    Marte, Gianpaolo / Tufo, A / Ferronetti, A / Di Maio, V / Russo, R / Sordelli, I F / De Stefano, G / Maida, P

    Updates in surgery

    2022  Volume 75, Issue 3, Page(s) 723–733

    Abstract: Patients with complex incisional hernia (IH) is a growing and challenging category that surgeons are facing in daily practice and represent indeed a technical challenge for most of them. The posterior component separation with TAR (PCS-TAR) has become ... ...

    Abstract Patients with complex incisional hernia (IH) is a growing and challenging category that surgeons are facing in daily practice and represent indeed a technical challenge for most of them. The posterior component separation with TAR (PCS-TAR) has become the procedure of choice to repair most complex abdominal wall defects, including those with loss of domain, subxiphoid, subcostal, parastomal or after trauma and sepsis treated initially with "open abdomen" and in those scenarios in which the fascia closure was not performed to avoid an abdominal compartment syndrome. Most recent studies showed that the PCS-TAR represents a valid procedure in recurrent IH. The purpose of our study is to evaluate the reproducibility of the PCS-TAR, describing our experience, our surgical technique and the rate of postoperative complications and recurrences in a cohort of consecutive patients. 52 consecutive patients with complex IH, who underwent PCS-TAR at "Betania Hospital and Ospedale del Mare Hospital" in Naples between May 2014 and November 2019 were identified from a prospectively maintained database and reviewed retrospectively. There were 36 males (69%) and 16 females (31%) with a mean age of 57.88 (range 39-76) and Body mass index (BMI kg/m
    MeSH term(s) Male ; Humans ; Female ; Animals ; Horses ; Middle Aged ; Abdominal Muscles ; Hernia, Ventral/surgery ; Hernia, Ventral/etiology ; Retrospective Studies ; Reproducibility of Results ; Treatment Outcome ; Incisional Hernia/surgery ; Herniorrhaphy/methods ; Surgical Mesh ; Recurrence ; Abdominal Wall/surgery
    Language English
    Publishing date 2022-11-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01418-y
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  8. Article: Considerations When Using Gabapentinoids to Treat Trigeminal Neuralgia: A Review.

    De Stefano, Gianfranco / Di Pietro, Giuseppe / Truini, Andrea / Cruccu, Giorgio / Di Stefano, Giulia

    Neuropsychiatric disease and treatment

    2023  Volume 19, Page(s) 2007–2012

    Abstract: Despite the exemplary efficacy of voltage-gated sodium channel blockers as a first-line treatment of trigeminal neuralgia, the pharmacological management of this excruciating facial pain condition remains a major issue, as these first-line drugs produce ... ...

    Abstract Despite the exemplary efficacy of voltage-gated sodium channel blockers as a first-line treatment of trigeminal neuralgia, the pharmacological management of this excruciating facial pain condition remains a major issue, as these first-line drugs produce intolerable side effects in a significant portion of patients. In addition, in patients with concomitant continuous pain, the efficacy of these drugs may drop, thus suggesting the opportunity to test the efficacy of different drug categories. The aim of this review is to provide current, evidence-based, knowledge about the use of gabapentin and other α2δ ligands in patients with trigeminal neuralgia. We searched for relevant papers within PubMed, EMBASE, the Cochrane Database of Systematic Reviews and the Clinical Trials database (ClinicalTrials.gov), considering publications up to April 2023. Two authors independently selected studies for inclusion and data extraction. The efficacy of α2δ ligands, gabapentin and pregabalin, has been assessed in seven controlled or open-label studies. Despite the low quality of evidence, the favorable tolerability profile and the possible action on concomitant continuous pain make this drug category of interest for future trials in trigeminal neuralgia.
    Language English
    Publishing date 2023-09-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S407543
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  9. Article ; Online: Anti-LGI1 encephalitis: A family affair.

    De Stefano, Gianfranco / Pulitano, Patrizia / Di Bonaventura, Carlo / Zuliani, Luigi / Morano, Alessandra

    Journal of neuroimmunology

    2023  Volume 378, Page(s) 578084

    Abstract: Here we describe the second ever-reported case of familial anti-leucine-rich glioma-inactivated protein 1 (LGI1) limbic encephalitis (LE). Two elderly Caucasian sisters presented with psychiatric symptoms and cognitive impairment, followed by ... ...

    Abstract Here we describe the second ever-reported case of familial anti-leucine-rich glioma-inactivated protein 1 (LGI1) limbic encephalitis (LE). Two elderly Caucasian sisters presented with psychiatric symptoms and cognitive impairment, followed by faciobrachial dystonic seizures. Anti-LGI1 antibodies were detected in their serum. Considering they had been living in distant regions for decades, environmental factors could be ruled out. Human leukocyte antigen (HLA) genotyping revealed that both carried HLA-DRB1*07, found in 90% of anti-LGI1 encephalitis patients, HLA-DQA1*02:01 and HLA-DQB1*03:03, commonly associated with DRB1*07:01. Considering the exceptional nature of familial cases, as-yet-unknown genetic contributors other than HLA might play a role in our siblings.
    MeSH term(s) Humans ; Aged ; Intracellular Signaling Peptides and Proteins ; Encephalitis/genetics ; Encephalitis/complications ; Limbic Encephalitis ; Seizures ; HLA-DRB1 Chains/genetics ; Autoantibodies
    Chemical Substances Intracellular Signaling Peptides and Proteins ; HLA-DRB1 Chains ; Autoantibodies
    Language English
    Publishing date 2023-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2023.578084
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  10. Article ; Online: Predicting value for incomplete recovery in Bell's palsy of facial nerve ultrasound versus nerve conduction study.

    Di Pietro, G / Falco, P / D'Elia, C / Cavalcanti, L / De Stefano, G / Di Stefano, G / Fabiano, E / Galosi, E / Leone, C / Vicenzini, E / Truini, A / Mancini, P

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    2023  Volume 158, Page(s) 35–42

    Abstract: Objective: This longitudinal study aims at assessing the predictive value of facial nerve high-resolution ultrasound (HRUS) for incomplete clinical recovery in patients with Bell's palsy, the most common facial nerve disease.: Methods: We ... ...

    Abstract Objective: This longitudinal study aims at assessing the predictive value of facial nerve high-resolution ultrasound (HRUS) for incomplete clinical recovery in patients with Bell's palsy, the most common facial nerve disease.
    Methods: We prospectively enrolled 34 consecutive patients with Bell's palsy. All patients underwent neurophysiological testing (including facial nerve conduction study) and HRUS evaluations 10-15 days (T1), one month (T2), and three months (T3) after the onset of Bell's palsy. Patients who did not experience complete recovery within three months were also evaluated after six months (T4). We have then compared the accuracy of HRUS with that of the facial nerve conduction study in predicting incomplete clinical recovery at three and six months.
    Results: At T1, the facial nerve diameter, as assessed with HRUS, was larger on the affected side than on the normal side, particularly in patients with incomplete recovery at T2, T3 and T4. ROC curve analysis, however, showed that the facial nerve diameter at T1 had a lower predictive value than the facial nerve conduction study for an incomplete clinical recovery at three (T3) and six (T4) months. Still, the facial nerve diameter asymmetry, as assessed with HRUS, had a relatively high negative predictive value (thus indicating a strong association between normal HRUS examination and a good prognosis).
    Conclusions: Although HRUS shows abnormally increased facial nerve diameter in patients in the acute phase of Bell's palsy, the predictive value of this technique for incomplete clinical recovery at three and six months is lower than that of the nerve conduction study.
    Significance: Nerve ultrasound has a low predictive value for incomplete clinical recovery in patients with Bell's Palsy.
    MeSH term(s) Humans ; Bell Palsy/diagnostic imaging ; Facial Nerve/diagnostic imaging ; Nerve Conduction Studies ; Longitudinal Studies ; Facial Paralysis
    Language English
    Publishing date 2023-12-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1463630-x
    ISSN 1872-8952 ; 0921-884X ; 1388-2457
    ISSN (online) 1872-8952
    ISSN 0921-884X ; 1388-2457
    DOI 10.1016/j.clinph.2023.11.020
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