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Book: Exoscope-Assisted Surgery in Otorhinolaryngology

de Virgilio, Armando / Spriano, Giuseppe

2021

Language	English
Size	154 p.
Publisher	Elsevier Science
Document type	Book
Note	PDA Manuell_11
Format	192 x 233 x 10
ISBN	9780323831680 ; 0323831680
Database	PDA

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Article ; Online: Comparison between the high-definition 3D exoscope and the operating microscope in head and neck reconstruction.

De Virgilio, A / Costantino, A / Russo, E / Festa, B M / Pirola, F / Spriano, G

International journal of oral and maxillofacial surgery

2023

Abstract: The purpose of this study was to compare the three-dimensional (3D) operating exoscope (OE) with the conventional operating microscope (OM) in head and neck reconstruction. A retrospective cohort study was performed including 50 consecutive patients with ...

Abstract	The purpose of this study was to compare the three-dimensional (3D) operating exoscope (OE) with the conventional operating microscope (OM) in head and neck reconstruction. A retrospective cohort study was performed including 50 consecutive patients with no history of previous surgery or irradiation (32 male, 18 female; mean age 59.2 ± 13.3 years), who underwent free flap head and neck reconstruction using a 3D OE (n = 25; OE group) or conventional OM (n = 25; OM group). The mean total operative time was 8.0 ± 1.53 h in the OE group and 7.6 ± 1.52 h in the OM group (P = 0.86). The median (interquartile range) anastomosis time was 78.0 (63.0-91.5) minutes in the OE group and 90.0 (75.5-115.0) minutes in the OM group (P = 0.06). The final free flap survival rate was 100%. Only seven patients experienced a free flap reconstruction-related complication, and they were similarly distributed between the two groups (four in the OE group, three in the OM group; P = 0.68). Secondary outcomes (length of hospital stay, tracheostomy dependence, feeding tube dependence) were comparable in the two groups (P > 0.05). The 3D OE is a viable alternative to the conventional OM for performing standard head and neck free flap reconstructive procedures.
Language	English
Publishing date	2023-12-04
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2023.11.004
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Article ; Online: Is the robot an instrument or an indication for transoral surgery?

De Virgilio, Armando / Virós Porcuna, David / Sampieri, Claudio / Costantino, Andrea

Oral oncology

2024 , Page(s) 106716

Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Editorial
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2024.106716
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Article ; Online: Theranostics of Thyroid Cancer.

Giovanella, Luca / Tuncel, Murat / Aghaee, Atena / Campenni, Alfredo / Petranović Ovčariček, Petra / De Virgilio, Armando

Seminars in nuclear medicine

2024

Abstract: Molecular imaging is pivotal in evaluating and managing patients with different thyroid cancer histotypes. The existing, pathology-based, risk stratification systems can be usefully refined, by incorporating tumor-specific molecular and molecular imaging ...

Abstract	Molecular imaging is pivotal in evaluating and managing patients with different thyroid cancer histotypes. The existing, pathology-based, risk stratification systems can be usefully refined, by incorporating tumor-specific molecular and molecular imaging biomarkers with theranostic value, allowing patient-specific treatment decisions. Molecular imaging with different radioactive iodine isotopes (ie, I
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2024.01.011
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Article ; Online: Reply to: Comment on "Transoral robotic surgery in oropharyngeal squamous cell carcinoma: A comparative study between da Vinci Single-Port and da Vinci Xi systems".

Costantino, Andrea / Sampieri, Claudio / Meliante, Piero Giuseppe / De Virgilio, Armando / Kim, Se-Heon

Oral oncology

2024 Volume 150, Page(s) 106700

MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck ; Robotic Surgical Procedures ; Head and Neck Neoplasms
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2024.106700
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Article ; Online: The Use of Machine Learning for Predicting Complications of Free Flap Head and Neck Reconstruction: Caution Needed.

Costantino, Andrea / Festa, Bianca Maria / Spriano, Giuseppe / De Virgilio, Armando

Annals of surgical oncology

2023 Volume 30, Issue 7, Page(s) 4232–4233

MeSH term(s)	Humans ; Free Tissue Flaps/adverse effects ; Free Tissue Flaps/surgery ; Plastic Surgery Procedures/adverse effects ; Neck/surgery ; Machine Learning ; Head and Neck Neoplasms/surgery ; Retrospective Studies ; Postoperative Complications/etiology ; Postoperative Complications/surgery
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13428-0
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Article ; Online: Neo-adjuvant chemotherapy and transoral robotic surgery in locoregionally advanced oropharyngeal cancer.

Costantino, Andrea / Sampieri, Claudio / De Virgilio, Armando / Kim, Se-Heon

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 12, Page(s) 107121

Abstract: Purpose: To analyze the oncological outcomes and patterns of recurrence of patients with locoregionally advanced oropharyngeal squamous cell carcinoma (OPSCC) who underwent neo-adjuvant chemotherapy (NCT) with subsequent transoral robotic surgery (TORS). ...

Abstract	Purpose: To analyze the oncological outcomes and patterns of recurrence of patients with locoregionally advanced oropharyngeal squamous cell carcinoma (OPSCC) who underwent neo-adjuvant chemotherapy (NCT) with subsequent transoral robotic surgery (TORS). Methods: A single-center retrospective cohort study was performed, including 198 patients (mean age: 58.6, SD: 9.2). The primary outcome was disease-free survival (DFS). Results: The median follow-up time was 26.5 months (IQR: 16.0-52.0). Estimated DFS rates (95 % CI) at 1 and 3 years were 86.6 % (81.9-91.7), and 81.4 % (75.7-87.6), respectively. Estimated DSS rates (95 % CI) at 1 and 3 years were 96.7 % (94.1-99.3), and 92.6 % (88.4-97.0), respectively. Estimated OS rates (95 % CI) at 1 and 3 years were 96.2 % (93.4-99.0), and 88.7 % (83.4-94.2), respectively. A total of 31 (15.6 %) patients showed a disease relapse after a median time of 8 months (IQR: 4.0-12.0), but only 12 (6 %) patients died of the disease during the study period. Conclusions: This study demonstrates that NCT and TORS can obtain excellent tumor control and survival in locoregionally advanced OPSCC. NCT might reduce the need for adjuvant treatments, and randomized clinical trials should be conducted to better define this aspect.
MeSH term(s)	Humans ; Middle Aged ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/surgery ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Squamous Cell Carcinoma of Head and Neck ; Oropharyngeal Neoplasms/drug therapy ; Oropharyngeal Neoplasms/surgery ; Head and Neck Neoplasms
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.107121
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Article ; Online: Caution Regarding Assessment of Toxic Effects and Survival in Treatment De-escalation With Radiotherapy vs Transoral Surgery for Human Papillomavirus-Associated Oropharyngeal Cancer.

De Virgilio, Armando / Costantino, Andrea / Spriano, Giuseppe

JAMA oncology

2022 Volume 8, Issue 10, Page(s) 1511–1512

MeSH term(s)	Humans ; Papillomaviridae ; Alphapapillomavirus ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/surgery ; Papillomavirus Infections/surgery
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.3458
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Article ; Online: Infrahyoid myocutaneous flap in head and neck reconstruction: a systematic review and meta-analysis.

Di Maio, P / De Virgilio, A / Mincione, A / Zocchi, J / Boriani, F / Spriano, G / Deganello, A / Iocca, O

International journal of oral and maxillofacial surgery

2022 Volume 51, Issue 10, Page(s) 1279–1288

Abstract: The aim of this systematic review and meta-analysis was to analyse the literature on the infrahyoid myocutaneous flap (IHMCF) and evaluate its clinical outcomes. The MEDLINE, Embase, Web of Science, Cochrane Library, and Scopus databases were searched ( ... ...

Abstract	The aim of this systematic review and meta-analysis was to analyse the literature on the infrahyoid myocutaneous flap (IHMCF) and evaluate its clinical outcomes. The MEDLINE, Embase, Web of Science, Cochrane Library, and Scopus databases were searched (inception to December 31, 2021). Meta-analyses were then conducted to estimate the overall rates of partial flap loss, total flap loss, salivary fistula, and surgical revision. The 21 studies that met the inclusion criteria included 768 patients undergoing head and neck reconstruction with 773 IHMCF. The oral cavity (77.7%) and oropharynx (13.0%) were the most reconstructed sites. The meta-analyses estimated a pooled partial flap loss rate of 10.4% (99% confidence interval (CI) 5.4-16.7%), total loss rate of 1.8% (99% CI 0.8-3.2%), salivary fistula rate of 3.0% (99% CI 1.3-5.3%), and surgical revision rate of 1.9% (99% CI 0.7-3.7%). Fast flap harvesting and low donor site morbidity were other flap features. Previous thyroid surgery or neck dissection and advanced lymph nodal stage were considered contraindications to IHMCF reconstruction by most authors, while prior neck radiotherapy was reported as a relative contraindication. This pedicled cervical flap is a versatile and reliable reconstructive option for medium-sized head and neck defects. Careful preoperative assessment of the neck condition allows for its safe use.
MeSH term(s)	Head and Neck Neoplasms/surgery ; Humans ; Myocutaneous Flap ; Neck Dissection ; Postoperative Complications ; Reconstructive Surgical Procedures ; Retrospective Studies
Language	English
Publishing date	2022-05-19
Publishing country	Denmark
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2022.04.012
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Article ; Online: Transoral robotic surgery in oropharyngeal squamous cell carcinoma: A comparative study between da Vinci Single-Port and da Vinci Xi systems.

Costantino, Andrea / Sampieri, Claudio / Meliante, Piero Giuseppe / De Virgilio, Armando / Kim, Se-Heon

Oral oncology

2023 Volume 148, Page(s) 106629

Abstract: Background: The recently developed da Vinci single-port (SP) system offers potential advantages in maneuverability within narrower surgical spaces. This study aims to compare intra- and post-operative outcomes, technical advantages, and limitations of ... ...

Abstract	Background: The recently developed da Vinci single-port (SP) system offers potential advantages in maneuverability within narrower surgical spaces. This study aims to compare intra- and post-operative outcomes, technical advantages, and limitations of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). Methods: A single-center retrospective cohort study included patients with OPSCC who underwent transoral robotic surgery (TORS) after neoadjuvant chemotherapy (NCT). Data on pre-operative variables, intraoperative data, postoperative complications, and functional outcomes were collected. Results: A total of 209 patients (males: 175; mean age: 59.0 ± 9.3) were included (SP: n = 136; Xi: n = 73). A significantly lower docking time was measured for the SP group (5.7 ± 2.5 min vs. 10.0 ± 4.4 min; p <.001). Similarly, the console time was reduced for the SP group though not reaching statistical significance (76.3 ± 30.7 min vs. 88.1 ± 36.9 min; p =.06). A greater proportion of patients showed wide negative resection margins in the SP group (71 % vs. 56 %; p =.10), although not statistically significant. No significant differences were observed in complication rates or postoperative functional outcomes. Discussion: This study demonstrates the safety and efficacy of the da Vinci SP system in oropharyngeal surgery, with potential advantages in terms of reduced docking and console times. The findings suggest that the SP system offers improved maneuverability and instrument placement compared to the da Vinci Xi system.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Squamous Cell Carcinoma of Head and Neck ; Retrospective Studies ; Robotic Surgical Procedures ; Postoperative Complications ; Head and Neck Neoplasms ; Treatment Outcome
Language	English
Publishing date	2023-11-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106629
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