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Article ; Online: Cardiac Tuberculosis: A Case Series from Ethiopia, Italy, and Uganda and a Literature Review.

The American journal of tropical medicine and hygiene

2024 Volume 110, Issue 4, Page(s) 795–804

Abstract: Extrapulmonary tuberculosis (TB) is estimated to account for up to 20% of active cases of TB disease, but its prevalence is difficult to ascertain because of the difficulty of diagnosis. Involvement of the heart is uncommon, with constrictive ... ...

Abstract	Extrapulmonary tuberculosis (TB) is estimated to account for up to 20% of active cases of TB disease, but its prevalence is difficult to ascertain because of the difficulty of diagnosis. Involvement of the heart is uncommon, with constrictive pericarditis being the most common cardiac manifestation. Diagnostic research for cardiac disease is frequently lacking, resulting in a high mortality rate. In addition to direct cardiac involvement, instances of cardiac events during antitubercular therapy are described. This case series describes five cases of TB affecting the heart (cardiac TB) from Italy and high-burden, low-income countries (Ethiopia and Uganda), including a case of Loeffler syndrome manifesting as myocarditis in a patient receiving antitubercular therapy. Our study emphasizes how cardiac TB, rare but important in high-burden areas, is a leading cause of pericardial effusion or pericarditis. Timely diagnosis and a comprehensive approach, including imaging and microbiological tools, are crucial. Implementing high-sensitivity methods and investigating alternative samples, such as detection of tuberculosis lipoarabinomannan or use of the GeneXpert assay with stool, is recommended in TB control programs.
MeSH term(s)	Humans ; Ethiopia/epidemiology ; Uganda ; Antitubercular Agents/therapeutic use ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/complications ; Pericardial Effusion/diagnosis ; Pericardial Effusion/drug therapy ; Pericardial Effusion/etiology ; Mycobacterium tuberculosis
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0505
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Article ; Online: [No title information]

Farina, Umberto / Coppola, Cristina / Dall'Oglio, Giovanni / Alupu, Monica / Ogwang, Eric / Bingom, Christopher / Ogwal, Polycap / Di Gennaro, Francesco / Marotta, Claudia / Segala, Vladimiro Francesco / De Vita, Elda / Iacob, Giulio / Tognon, Francesca / Putoto, Giovanni / Martinelli, Domenico / Prato, Rosa / Fortunato, Francesca

Recenti progressi in medicina

2023 Volume 114, Issue 9, Page(s) 541–542

Title translation	Indagine conoscitiva sulla violenza di genere tra i giovani residenti nel distretto di Oyam, Uganda.
MeSH term(s)	Humans ; Adolescent ; Gender-Based Violence ; Uganda
Language	Italian
Publishing date	2023-08-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	138266-4
ISSN	2038-1840 ; 0034-1193
ISSN (online)	2038-1840
ISSN	0034-1193
DOI	10.1701/4088.40805
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Article ; Online: Efficacy and safety of therapies for COVID-19 in pregnancy: a systematic review and meta-analysis.

Di Gennaro, Francesco / Guido, Giacomo / Frallonardo, Luisa / Segala, Francesco Vladimiro / De Nola, Rosalba / Damiani, Gianluca Raffaello / De Vita, Elda / Totaro, Valentina / Barbagallo, Mario / Nicastri, Emanuele / Vimercati, Antonella / Cicinelli, Ettore / Liuzzi, Giuseppina / Veronese, Nicola / Saracino, Annalisa

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 776

Abstract: Background: Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they are at increased risk for disease progression and for obstetric complications, such as premature labor, miscarriage, preeclampsia, cesarean delivery, ... ...

Abstract	Background: Clinical evidence suggests that pregnant women are more vulnerable to COVID-19, since they are at increased risk for disease progression and for obstetric complications, such as premature labor, miscarriage, preeclampsia, cesarean delivery, fetal growth restriction and perinatal death. Despite this evidence, pregnant women are often excluded from clinical trials, resulting in limited knowledge on COVID-19 management. The aim of this systematic review and meta-analysis is to provide better evidence on the efficacy and safety of available COVID-19 treatment in pregnant women. Methods: Four authors searched major electronic databases from inception until 1 st November-2022 for controlled trials/observational studies, investigating outcomes after the administration of anti-SARS-CoV-2 treatments in pregnant women affected by COVID-19. The analyses investigated the cumulative incidence of delivery and maternal outcomes in pregnant women, comparing those taking active medication vs standard care. Risk ratios (RRs) with 95% confidence intervals were calculated. Statistical significance was assessed using the random effects model and inverse-variance method. This systematic review and meta-analysis was conducted in accordance with the updated 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The protocol has been registered in Prospero (number registration: CRD42023397445). Results: From initially 937 non duplicate records, we assessed the full texts of 40 articles, finally including ten studies. In six studies, including 1627 patients, the use of casirivimab/imdevimab (CAS/IMD), remdesivir, and IFN-alpha 2b significantly decreased the need of cesarean section ((RR = 0.665; 95%CI: 0.491-0.899; p = 0.008; I 2 = 19.5%;) (Table 1, (Fig. 1). Treatments did not decrease the risk of preterm delivery, admission to neonatal ICU, or stillbirth/perinatal loss (p-values > 0.50 for all these outcomes) and did not prevent the progression of disease towards severe degrees (k = 8; 2,374 pregnant women; RR = 0.778; 95%CI: 0.550-1.099; p = 0.15; I 2 = 0%). Moreover, the use of medications during pregnancy did not modify the incidence of maternal death in two studies (Table 2). Conclusions: To our analysis, CAS/IMD, remdesivir, and IFN alpha 2b reduced the number of cesarean sections but demonstrated no effect on disease progression and other obstetric and COVID-19 related outcomes. The inability to evaluate the influence of viral load on illness development in pregnant women was attributed to lack of data. In our systematic review, no major side effects were reported. Though, it is essential for the medical community to focus more on clinical trials and less on episodic case reports and case series, with standardization of fetal and maternal outcomes.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; COVID-19 ; Cesarean Section ; COVID-19 Drug Treatment ; Stillbirth/epidemiology ; Disease Progression ; Pregnancy Outcome
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08747-2
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Article ; Online: Stool Xpert MTB/RIF as a possible diagnostic alternative to sputum in Africa: a systematic review and meta-analysis.

Segala, Francesco Vladimiro / Papagni, Roberta / Cotugno, Sergio / De Vita, Elda / Susini, Maria Chiara / Filippi, Valeria / Tulone, Ottavia / Facci, Enzo / Lattanzio, Rossana / Marotta, Claudia / Manenti, Fabio / Bavaro, Davide Fiore / De Iaco, Giuseppina / Putoto, Giovanni / Veronese, Nicola / Barbagallo, Mario / Saracino, Annalisa / Di Gennaro, Francesco

Frontiers in public health

2023 Volume 11, Page(s) 1117709

Abstract: Introduction: Worldwide, COVID-19 pandemic lead to a large fall in the number of newly reported TB cases. In sub-Saharan Africa, microbiological diagnosis of TB is generally based on smear microscopy and Xpert MTB/RIF on sputum samples, but good quality ...

Abstract	Introduction: Worldwide, COVID-19 pandemic lead to a large fall in the number of newly reported TB cases. In sub-Saharan Africa, microbiological diagnosis of TB is generally based on smear microscopy and Xpert MTB/RIF on sputum samples, but good quality sputum samples are often difficult to obtain, leading clinicians to rely on more invasive procedures for diagnosis. Aim of this study was to investigate pooled sensitivity and specificity of Xpert MTB/RIF on stool samples compared to respiratory microbiological reference standards in African countries. Methods: Four investigators independently searched PubMed, SCOPUS, and Web of Science until 12th October 2022, then screened titles and abstracts of all potentially eligible articles. The authors applied the eligibility criteria, considered the full texts. All the studies reported the data regarding true positive (TP), true negative (TN), false positive (FP) and false negative (FN). Risk of bias and applicability concerns were assessed with the Quadas-2 tool. Results: overall, among 130 papers initially screened, we evaluated 47 works, finally including 13 papers for a total of 2,352 participants, mainly children. The mean percentage of females was 49.6%, whilst the mean percentage of patients reporting HIV was 27.7%. Pooled sensitivity for Xpert MTB/RIF assay for detecting pulmonary tuberculosis was 68.2% (95%CI: 61.1-74.7%) even if characterized by a high heterogeneity (I Conclusions: Our study confirms that, in Africa, stool Xpert MTB/RIF may be a useful rule-in test for children above and below 5 years of age under evaluation for pulmonary tuberculosis. Sensitivity increased substantially when using both sputum and nasogastric aspirate as reference samples.
MeSH term(s)	Child ; Female ; Humans ; Mycobacterium tuberculosis ; Sputum/microbiology ; Pandemics ; COVID-19 ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/microbiology ; Africa South of the Sahara ; COVID-19 Testing
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1117709
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Article ; Online: Immunogenicity and safety of the BNT162b2 COVID-19 mRNA vaccine in PLWH: A monocentric study in Bari, Italy.

Milano, Eugenio / Ricciardi, Aurelia / Casciaro, Raffaella / Pallara, Elisabetta / De Vita, Elda / Bavaro, Davide F / Larocca, Angela Maria Vittoria / Stefanizzi, Pasquale / Tafuri, Silvio / Saracino, Annalisa

Journal of medical virology

2022 Volume 94, Issue 5, Page(s) 2230–2236

Abstract: In March, people living with HIV infection (PLWH) were included in the risk category of fragile people for severe COVID-19 receiving priority access to vaccination with BNT162b2 vaccine. The aim of the study was to evaluate the immunogenicity and safety ... ...

Abstract	In March, people living with HIV infection (PLWH) were included in the risk category of fragile people for severe COVID-19 receiving priority access to vaccination with BNT162b2 vaccine. The aim of the study was to evaluate the immunogenicity and safety of the two doses regimen. The antibodies titer for severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) was evaluated after 21 days since the first administration (Time 1), 1 (Time 2), and 3 (Time 3) months post-vaccination. Information regarding virological and immunological conditions at baseline, previous SARS-CoV-2 state of infection, other immunodeficiencies, current antiretroviral therapy (ART), comorbidities, and severe adverse events (SAE) to vaccination was collected. Six hundred and ninety-seven patients were tested for quantitative anti-spike antibodies at Time 1, 577 patients had a second detection at Time 2, and 491 patients had the third detection. Baseline characteristics of the study population are reported in Table 1. At the time of vaccine administration, all patients were on ART (except one long-term nonprogressor); 632 (90.7%) patients had undetectable HIV-RNA; 12 (1.7%) patients were immunosuppressed due to chemotherapy or other immunosuppressive drugs; 345 (49.5%) patients had at least one COVID-19 related comorbidity and 155 (22.2%) had two or more comorbidities. No SAEs were reported. Final serological results are available for 694 patients after the first dose, 577 and 491 after the second and third ones, respectively; positive titer (values ≥ 50 AU/ml) was demonstrated in 653 (94.1%), 576 (99.8%), 484 (98.6%) patients, respectively. Only one patient was a nonresponder after completing vaccination, who was a newly diagnosed one for HIV infection. All vaccinations were well tolerated, with no SAEs. BNT162b2 mRNA vaccine was immunogenic and safe in PLWH.
MeSH term(s)	Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; HIV Infections ; Humans ; Immunogenicity, Vaccine ; RNA, Messenger ; SARS-CoV-2 ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27629
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Article: Neurocysticercosis in Low- and Middle-Income Countries, a Diagnostic Challenge from Oyam District, Uganda.

Segala, Francesco Vladimiro / De Vita, Elda / Amone, James / Ongaro, Daniel / Nassali, Ritah / Oceng, Bonny / Okori, Samuel / Putoto, Giovanni / Lochoro, Peter / Ictho, Jerry / Fantoni, Massimo / Saracino, Annalisa / Di Gennaro, Francesco

Infectious disease reports

2022 Volume 14, Issue 4, Page(s) 505–508

Abstract: Background: In countries where : Methods: Here, we report the case of a 73-year-old woman admitted in a rural hospital in Northern Uganda, who presented with seizures and a progressive inability to walk. She was then diagnosed with NCC after a brain ... ...

Abstract	Background: In countries where Methods: Here, we report the case of a 73-year-old woman admitted in a rural hospital in Northern Uganda, who presented with seizures and a progressive inability to walk. She was then diagnosed with NCC after a brain CT scan. Conclusions: This case study represents a rare example of the detection of NCC in a rural district hospital, thus suggesting the potential feasibility of a CT-scan guided diagnostic approach in low resource settings.
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Case Reports
ISSN	2036-7430
ISSN	2036-7430
DOI	10.3390/idr14040054
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Article ; Online: Subacute Cardiac Tamponade Due to Tuberculous Pericarditis Diagnosed by Urine Lipoarabinomannan Assay in a Immunocompetent Patient in Oyam District, Uganda: A Case Report.

De Vita, Elda / Segala, Francesco Vladimiro / Amone, James / Samuel, Kabuga / Marotta, Claudia / Putoto, Giovanni / Nassali, Ritah / Lochoro, Peter / Bavaro, Davide Fiore / Ictho, Jerry / Okori, Samuel / Di Gennaro, Francesco / Saracino, Annalisa

International journal of environmental research and public health

2022 Volume 19, Issue 22

Abstract: Background: Uganda ranks among the countries with the highest burden of TB the world and tuberculous pericarditis (TBP) affects up to 2% of people diagnosed with pulmonary tuberculosis worldwide. In Africa, it represents the most common cause of ... ...

Abstract	Background: Uganda ranks among the countries with the highest burden of TB the world and tuberculous pericarditis (TBP) affects up to 2% of people diagnosed with pulmonary tuberculosis worldwide. In Africa, it represents the most common cause of pericardial disease. Here, we present the case of a 21-year-old male patient who was diagnosed of cardiac tamponade due to tuberculous pericarditis with a positive urine LF-LAM. Case report: We report a case of a 21-year-old male living in Oyam district, Uganda, who presented to the emergency department with difficulty in breathing, easy fatigability, general body weakness, and abdominal pain. A chest X-ray showed the presence of right pleural effusion and massive cardiomegaly. Thus, percutaneous pericardiocentesis was performed immediately and pericardial fluid resulted negative both for gram staining and real-time PCR test Xpert MTB/RIF. The following day's urine LF-LAM test resulted positive, and antitubercular therapy started with gradual improvement. During the follow-up visits, the patient remained asymptomatic, reporting good compliance to the antitubercular therapy. Conclusion: Our case highlights the potential usefulness of a LF-LAM-based diagnostic approach, suggesting that, in low-resource settings, this test might be used as part of routine diagnostic workup in patients with pericardial disease or suspected extra-pulmonary tuberculosis.
MeSH term(s)	Male ; Humans ; Young Adult ; Adult ; Pericarditis, Tuberculous/complications ; Pericarditis, Tuberculous/diagnosis ; Cardiac Tamponade/etiology ; Uganda ; Sensitivity and Specificity ; Tuberculosis, Pulmonary/complications ; Antitubercular Agents
Chemical Substances	lipoarabinomannan ; Antitubercular Agents
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192215143
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Article ; Online: Predictors for Pulmonary Tuberculosis Outcome and Adverse Events in an Italian Referral Hospital: A Nine-Year Retrospective Study (2013-2021).

Di Gennaro, Francesco / Lattanzio, Rossana / Guido, Giacomo / Ricciardi, Aurelia / Novara, Roberta / Patti, Giulia / Cotugno, Sergio / De Vita, Elda / Brindicci, Gaetano / Mariano, Michele Fabiano / Ronga, Luigi / Santoro, Carmen Rita / Romanelli, Federica / Stolfa, Stefania / Papagni, Roberta / Bavaro, Davide Fiore / De Iaco, Giusi / Saracino, Annalisa

Annals of global health

2022 Volume 88, Issue 1, Page(s) 26

Abstract: Background: The COVID-19 pandemic has undone years of progress in providing essential TB services and controlling the TB burden. Italy, a low TB burden country, has an incidence of 7.1 cases per 100,000 people. To control the TB spreading in Italy is ... ...

Abstract	Background: The COVID-19 pandemic has undone years of progress in providing essential TB services and controlling the TB burden. Italy, a low TB burden country, has an incidence of 7.1 cases per 100,000 people. To control the TB spreading in Italy is critical to investigate the characteristics of patients with the worst outcomes and the highest risk of adverse events related to antituberculosis therapy. Therefore, we conducted a large retrospective study in TB patients admitted to the Clinic of Infectious Diseases University of Bari, Italy, in order to describe the clinical presentation and the factors associated with adverse events and outcomes. Methods: We retrospectively evaluated the patients admitted to the Clinic of Infectious Diseases from January 2013 to 15 December 2021. We stratified our cohort into two groups: <65 years of age and ≥65 years in order to assess any differences between the two groups. Two logistic regression models were implemented considering the dependent variables as: (I) the adverse events; and (II) the unsuccessful treatments. Results: In total, 206 consecutive patients [60% (n = 124) M, median age 39 years, range 16-92] were diagnosed and admitted with TB at Clinic of Infectious Diseases. Of the whole sample, 151 (74%) were <65 years and 55 (26%) were ≥65. Statistically significant differences between the two groups were detected ( Conclusions: The pharmacological approach alone seems insufficient to treat and cure a disease whose ethiopathogenesis is not only due to the
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents/adverse effects ; COVID-19 ; Delayed Diagnosis ; Hospitals ; Humans ; Middle Aged ; Pandemics ; Referral and Consultation ; Retrospective Studies ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/epidemiology ; Young Adult
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821756-1
ISSN	2214-9996 ; 2214-9996
ISSN (online)	2214-9996
ISSN	2214-9996
DOI	10.5334/aogh.3677
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Article ; Online: Regulatory and Effector Cell Disequilibrium in Patients with Acute Cellular Rejection and Chronic Lung Allograft Dysfunction after Lung Transplantation: Comparison of Peripheral and Alveolar Distribution.

Bergantini, Laura / d'Alessandro, Miriana / De Vita, Elda / Perillo, Felice / Fossi, Antonella / Luzzi, Luca / Paladini, Piero / Perrone, Anna / Rottoli, Paola / Sestini, Piersante / Bargagli, Elena / Bennett, David

Cells

2021 Volume 10, Issue 4

Abstract: Background: The immune mechanisms occurring during acute rejection (AR) and chronic lung allograft dysfunction are a challenge for research and the balance between effector and regulatory cells has not been defined completely. In this study, we aimed to ...

Abstract	Background: The immune mechanisms occurring during acute rejection (AR) and chronic lung allograft dysfunction are a challenge for research and the balance between effector and regulatory cells has not been defined completely. In this study, we aimed to elucidate the interaction of effector cells, mainly Th17, Th1 and Th2, and regulatory cells including (CD4 Methods: Bronchoalveolar lavage cells (BAL) and peripheral blood mononuclear cells (PBMCs) from stable lung transplanted (LTx )subjects ( Results: A predominance of Th17 cells subtypes in the PBMCs and BAL and a depletion of Tregs, that resulted in decrease Treg/Th17 ratio, was observed in the AR group. CD19 Conclusions: In AR, BOS and stable lung transplant, regulatory and effector cells clearly demonstrated different pathways of activation. Understanding of the balance of T cells and T and B regulatory cells can offers insights into rejection.
MeSH term(s)	Acute Disease ; Allografts/immunology ; Allografts/physiopathology ; B-Lymphocytes, Regulatory/immunology ; Biomarkers/metabolism ; Bronchoalveolar Lavage ; Chronic Disease ; Female ; Graft Rejection/blood ; Graft Rejection/etiology ; Graft Rejection/immunology ; Humans ; Leukocytes, Mononuclear/metabolism ; Lung Transplantation/adverse effects ; Lymphocyte Subsets/immunology ; Male ; Middle Aged ; Multivariate Analysis ; Principal Component Analysis ; Pulmonary Alveoli/immunology ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-04-01
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10040780
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Article ; Online: COVID Perceptions among Pregnant Women Living in a Malaria Hyperendemic Rural Region in Uganda: A Cross-Sectional Study.

The American journal of tropical medicine and hygiene

2023 Volume 109, Issue 6, Page(s) 1363–1367

Abstract: Both SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, ...

Abstract	Both SARS-CoV2 and Plasmodium falciparum infection during pregnancy increases the risk for adverse maternal and fetal outcomes, including abortion, severe disease, and death. Indeed, although malaria and COVID-19 show an overlapping clinical presentation, they require a profoundly different approach. The aim of this study was to explore COVID-19 awareness among pregnant women living in a P. falciparum hyperendemic region in rural Uganda. This cross-sectional, prospective study was conducted in one Hospital and two Health Centers (HC) in Lango region, Uganda, from July 14, 2022, to March 14, 2023. Data about demographics, COVID-19 history, and COVID-19 and malaria perceptions were collected using RedCap mobile app platform. Study endpoint was a context-specific COVID-19 awareness score, accounting for the most common disease misconceptions. Association between study variables and good COVID-19 awareness was assessed by χ2 and t test, as appropriate, and variables found to be statistically significant were further explored in multivariate logistic regression analysis. A total of 888 pregnant women were recruited. Median age was 24 (interquartile range: 20-29) years, whereas 79% (n = 704) attained only primary education and 66.6% (n = 591) were used in agriculture. SARS-CoV2 vaccination rate was 92%. In multivariate analysis (Table 3), variables associated with high COVID knowledge were presenting at antenatal care visit in Atipe HC (adjusted odds ratio [aOR]: 8.1, 95% CI: 4.1-16.48) having a previous good knowledge about malaria (aOR: 1.76, 95% CI: 1.21-2.56). Among pregnant women living in rural Uganda, COVID-19 awareness relies on the overall educational level, malaria knowledge and reference HC. Among pregnant women living in P. falciparum endemic areas, community-level malaria awareness might guide educational interventions during future pandemics.
MeSH term(s)	Female ; Pregnancy ; Humans ; Young Adult ; Adult ; Pregnant Women ; Cross-Sectional Studies ; Prospective Studies ; RNA, Viral ; Uganda/epidemiology ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Malaria/epidemiology ; Malaria/complications ; Malaria, Falciparum/epidemiology
Chemical Substances	RNA, Viral
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.23-0464
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