Article ; Online: Ex Vivo Uniaxial Tensile Properties of Rat Uterosacral Ligaments.
Annals of biomedical engineering
2023 Volume 51, Issue 4, Page(s) 702–714
Abstract: This manuscript presents new experimental methods for testing the ex vivo tensile properties of the uterosacral ligaments (USLs) in rats. The USL specimens ([Formula: see text]) were carefully dissected to preserve their anatomical attachments, and they ... ...
| Abstract | This manuscript presents new experimental methods for testing the ex vivo tensile properties of the uterosacral ligaments (USLs) in rats. The USL specimens ([Formula: see text]) were carefully dissected to preserve their anatomical attachments, and they were loaded along their main in vivo loading direction (MD) using a custom-built uniaxial tensile testing device. During loading, strain maps in both the MD and the perpendicular direction (PD) were collected using the digital image correlation technique. The mean (± S.E.M.) maximum load and displacement at the maximum load were [Formula: see text] N and [Formula: see text] mm, respectively. The USLs were found to be highly heterogeneous structures, with some specimens experiencing strains in the MD that were lower than [Formula: see text] and others reaching strains that were up to [Formula: see text] in the intermediate region. At 0.5 kPa stress, a value reached by all the specimens, the mean strain in the MD was [Formula: see text] while at 5 kPa stress, a value achieved only by 9 out of the 21 specimens, the mean strain increased to [Formula: see text]. Under uniaxial loading, the specimens also elongated in the PD, with strains that were one order of magnitude lower than the strains in the MD; at the 0.5 kPa stress, the mean strain in the PD was recorded to be [Formula: see text] and, at the 5 kPa stress, the strain in the PD was [Formula: see text]. The directions of maximum principal strains remained almost unchanged with the increase in stress, indicating that little microstructural re-organization occurred due to uniaxial loading. This study serves as a springboard for future investigations on the supportive function of the USLs in the rat model by offering guidelines on testing methods that capture their complex mechanical behavior. |
|---|---|
| MeSH term(s) | Female ; Animals ; Rats ; Biomechanical Phenomena ; Stress, Mechanical ; Uterus ; Ligaments |
| Language | English |
| Publishing date | 2023-01-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 185984-5 |
| ISSN | 1573-9686 ; 0191-5649 ; 0090-6964 |
| ISSN (online) | 1573-9686 |
| ISSN | 0191-5649 ; 0090-6964 |
| DOI | 10.1007/s10439-023-03135-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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