Article ; Online: Breast Cancer Treatment Delay in SafetyNet Health Systems, Houston Versus Southeast Brazil.
2022 Volume 27, Issue 5, Page(s) 344–351
Abstract: Background: Breast cancer outcomes among patients who use safety-net hospitals in the highly populated Harris County, Texas and Southeast Brazil are poor. It is unknown whether treatment delay contributes to these outcomes.: Methods: We conducted a ... ...
| Abstract | Background: Breast cancer outcomes among patients who use safety-net hospitals in the highly populated Harris County, Texas and Southeast Brazil are poor. It is unknown whether treatment delay contributes to these outcomes. Methods: We conducted a retrospective cohort analysis of patients with non-metastatic breast cancer diagnosed between January 1, 2009 and December 31, 2011 at Harris Health Texas and Unicamp's Women's Hospital, Barretos Hospital, and Brazilian National Institute of Cancer, Brazil. We used Cox proportional hazards regression to evaluate association of time to treatment and risk of recurrence (ROR) or death. Results: One thousand one hundred ninety-one patients were included. Women in Brazil were more frequently diagnosed with stage III disease (32.3% vs. 21.1% Texas; P = .002). Majority of patients in both populations had symptom-detected disease (63% in Brazil vs. 59% in Texas). Recurrence within 5 years from diagnosis was similar 21% versus 23%. Median time from diagnosis to first treatment defined as either systemic therapy (chemotherapy or endocrine therapy) or surgery, were comparable, 9.9 weeks versus 9.4 weeks. Treatment delay was not associated with increased ROR or death. Higher stage at diagnosis was associated with both increased ROR and death. Conclusion: Time from symptoms to treatment was considerably long in both populations. Treatment delay did not affect outcomes. Impact: Access to timely screening and diagnosis of breast cancer are priorities in these populations. |
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| MeSH term(s) | Brazil/epidemiology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Female ; Humans ; Mass Screening ; Retrospective Studies ; Time-to-Treatment | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2022-04-30 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 1409038-7 | ||||||||||
| ISSN | 1549-490X ; 1083-7159 | ||||||||||
| ISSN (online) | 1549-490X | ||||||||||
| ISSN | 1083-7159 | ||||||||||
| DOI | 10.1093/oncolo/oyac050 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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