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  1. Article ; Online: Survival of the Fittest: Clonal Selection of Somatic Mutations Reveals Targets to Abate Chronic Liver Injury.

    Niemi, Natalie M / Debosch, Brian J

    Gastroenterology

    2024  Volume 166, Issue 5, Page(s) 936–937

    MeSH term(s) Humans ; Mutation ; Animals ; Chronic Disease ; Liver/pathology ; Liver Diseases/genetics
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2024.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 572: Show issues

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  2. Article ; Online: Bariatric Surgery for the Treatment of NASH-An Old Solution to a Newer Problem?

    Tica, Stefani / Debosch, Brian J

    Gastroenterology

    2023  Volume 165, Issue 4, Page(s) 1091

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/surgery ; Bariatric Surgery/adverse effects ; Obesity, Morbid/complications ; Obesity, Morbid/surgery
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
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  3. Article ; Online: Modeling the effect of cigarette smoke on hexose utilization in spermatocytes.

    Omurtag, Kenan / Esakky, Prabagaran / Debosch, Brian J / Schoeller, Erica L / Chi, Maggie M / Moley, Kelle H

    Reproductive sciences (Thousand Oaks, Calif.)

    2014  Volume 22, Issue 1, Page(s) 94–101

    Abstract: We set out to determine whether the addition of an aryl hydrocarbon receptor (AHR) antagonist has an effect on glucose/fructose utilization in the spermatocyte when exposed to cigarette smoke condensate (CSC). We exposed male germ cells to 5 and 40 μg/mL ...

    Abstract We set out to determine whether the addition of an aryl hydrocarbon receptor (AHR) antagonist has an effect on glucose/fructose utilization in the spermatocyte when exposed to cigarette smoke condensate (CSC). We exposed male germ cells to 5 and 40 μg/mL of CSC ± 10 μmol/L of AHR antagonist at various time points. Immunoblot expression of specific glucose/fructose transporters was compared to control. Radiolabeled uptake of 2-deoxyglucose (2-DG) and fructose was also performed. Spermatocytes utilized fructose nearly 50-fold more than 2-DG. Uptake of 2-DG decreased after CSC + AHR antagonist exposure. Glucose transporters (GLUTs) 9a and 12 declined after CSC + AHR antagonist exposure. Synergy between CSC and the AHR antagonist in spermatocytes may disrupt the metabolic profile in vitro. Toxic exposures alter energy homeostasis in early stages of male germ cell development, which could contribute to later effects explaining decreases in sperm motility in smokers.
    MeSH term(s) Adenosine Triphosphate/metabolism ; Animals ; Azo Compounds/toxicity ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Cell Line ; Deoxyglucose/metabolism ; Energy Metabolism/drug effects ; Fructose/metabolism ; Glucose Transport Proteins, Facilitative/metabolism ; Hexoses/metabolism ; Male ; Mice ; Pyrazoles/toxicity ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Receptors, Aryl Hydrocarbon/metabolism ; Smoke/adverse effects ; Smoking/adverse effects ; Spermatocytes/drug effects ; Spermatocytes/metabolism ; Time Factors
    Chemical Substances 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide ; Ahr protein, mouse ; Azo Compounds ; Basic Helix-Loop-Helix Transcription Factors ; Glucose Transport Proteins, Facilitative ; Hexoses ; Pyrazoles ; Receptors, Aryl Hydrocarbon ; Slc2a12 protein, mouse ; Slc2a9 protein, mouse ; Smoke ; Fructose (30237-26-4) ; Adenosine Triphosphate (8L70Q75FXE) ; Deoxyglucose (9G2MP84A8W)
    Language English
    Publishing date 2014-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2276411-2
    ISSN 1933-7205 ; 1933-7191
    ISSN (online) 1933-7205
    ISSN 1933-7191
    DOI 10.1177/1933719114533727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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