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  1. Article ; Online: Transcatheter management of mid-aortic syndrome secondary to myofibroma presenting in infancy with severe left ventricular dysfunction: a case report.

    Callahan, Ryan / Kreutzer, Jacqueline / Debrunner, Mark

    Cardiology in the young

    2016  Volume 26, Issue 4, Page(s) 799–801

    Abstract: In this study, we summarise a case of a myofibroma causing mid-aortic syndrome due to obstruction of the distal thoracic and abdominal aorta leading to severe left ventricular dysfunction. The patient was managed with percutaneous intervention via ... ...

    Abstract In this study, we summarise a case of a myofibroma causing mid-aortic syndrome due to obstruction of the distal thoracic and abdominal aorta leading to severe left ventricular dysfunction. The patient was managed with percutaneous intervention via balloon dilation and stent placement. On follow-up, the patient has normalisation of ventricular function, is off anti-hypertensives, and is being monitored for re-stenosis.
    MeSH term(s) Angioplasty, Balloon ; Aorta, Abdominal ; Aorta, Thoracic ; Aortic Diseases/etiology ; Catheterization ; Constriction, Pathologic/etiology ; Humans ; Infant ; Male ; Mediastinal Neoplasms/complications ; Myofibroma/complications ; Severity of Illness Index ; Stents ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/therapy
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951115001936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Left ventricular myocardial performance index change for detection of acute cellular rejection in pediatric heart transplantation.

    Flanagan, Ryan / Cain, Nicole / Tatum, Gregory H / Debrunner, Mark G / Drant, Stacey / Feingold, Brian

    Pediatric transplantation

    2013  Volume 17, Issue 8, Page(s) 782–786

    Abstract: EMB, the gold standard for diagnosis of ACR, poses unique risks in children. Limited cross-sectional data have associated LV MPI with ACR. We hypothesize that a relative change in MPI from baseline without ACR to the time of ACR will better detect ACR ... ...

    Abstract EMB, the gold standard for diagnosis of ACR, poses unique risks in children. Limited cross-sectional data have associated LV MPI with ACR. We hypothesize that a relative change in MPI from baseline without ACR to the time of ACR will better detect ACR than an absolute threshold LV MPI value. We identified 40 children with ACR ≥60 days post-transplant matching them by age and time from transplantation to 40 children without ACR. There was a significant increase in LV MPI at time of ACR vs. baseline (0.59 ± 0.17 vs. 0.41 ± 0.11; p < 0.001). There was no difference in LV MPI between baseline and follow-up (0.41 ± 0.11 vs. 0.42 ± 0.11; p = 0.65). An absolute increase in LV MPI of ≥0.47 had 82.5% sensitivity and 85% specificity for ACR, whereas an increase in LV MPI from baseline of ≥20.4% was 90% sensitive and 100% specific. Serial measurement of LV MPI appears to be a sensitive and specific marker of ACR. LV MPI shows good interobserver agreement and increases at the time of EMB-proven ACR with subsequent resolution to baseline measurements upon EMB-proven resolution of ACR. Future studies in larger, prospective cohorts should be undertaken to validate these findings.
    MeSH term(s) Adolescent ; Adult ; Biopsy ; Child ; Child, Preschool ; Diastole ; Echocardiography ; Female ; Graft Rejection/diagnosis ; Heart Failure/therapy ; Heart Transplantation ; Humans ; Infant ; Male ; Myocardium/pathology ; Observer Variation ; Prospective Studies ; ROC Curve ; Reperfusion Injury/pathology ; Risk ; Sensitivity and Specificity ; Time Factors ; Treatment Outcome ; Ventricular Dysfunction, Left/pathology ; Ventricular Function, Left/physiology ; Young Adult
    Language English
    Publishing date 2013-09-30
    Publishing country Denmark
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.12153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4947: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Acquired toxoplasmosis after orthotopic heart transplantation in a sulfonamide-allergic patient.

    Sanchez Mejia, Aura / Debrunner, Mark / Cox, Elaine / Caldwell, Randall

    Pediatric cardiology

    2010  Volume 32, Issue 1, Page(s) 91–93

    Abstract: We report the case of a young adult with a history of an allergic reaction to a sulfonamide antibiotic who developed toxoplasmosis after his second orthotopic heart transplant. As a result of this drug allergy, the patient did not receive prophylaxis ... ...

    Abstract We report the case of a young adult with a history of an allergic reaction to a sulfonamide antibiotic who developed toxoplasmosis after his second orthotopic heart transplant. As a result of this drug allergy, the patient did not receive prophylaxis with trimethoprim and sulfamethoxazole. He was successfully treated with clindamycin, pyrimethamine, and folic acid.
    MeSH term(s) Adult ; Antibiotic Prophylaxis ; Antiparasitic Agents/therapeutic use ; Clindamycin/therapeutic use ; Drug Hypersensitivity ; Folic Acid/therapeutic use ; Heart Transplantation ; Humans ; Male ; Pyrimethamine/therapeutic use ; Sulfonamides/adverse effects ; Sulfonamides/therapeutic use ; Toxoplasmosis/drug therapy
    Chemical Substances Antiparasitic Agents ; Sulfonamides ; Clindamycin (3U02EL437C) ; Folic Acid (935E97BOY8) ; Pyrimethamine (Z3614QOX8W)
    Language English
    Publishing date 2010-10-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-010-9812-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Midterm survival of infants requiring postoperative extracorporeal membrane oxygenation after Norwood palliation.

    Debrunner, Mark G / Porayette, Prashob / Breinholt, John P / Turrentine, Mark W / Cordes, Timothy M

    Pediatric cardiology

    2012  Volume 34, Issue 3, Page(s) 570–575

    Abstract: This study reports the mid-term survival for neonates undergoing extracorporeal membrane oxygenation (ECMO) after Norwood palliation at a single center. Limited data exist on the mid-term survival of patients undergoing ECMO after Norwood palliation. We ... ...

    Abstract This study reports the mid-term survival for neonates undergoing extracorporeal membrane oxygenation (ECMO) after Norwood palliation at a single center. Limited data exist on the mid-term survival of patients undergoing ECMO after Norwood palliation. We reviewed our ECMO experience from July 1994 to October 2008 and compared two groups: patients who required ECMO after Norwood palliation and patients who underwent Norwood palliation without ECMO. We analyzed 30-day survival, survival to hospital discharge, and survival to most recent follow-up. One hundred sixty patients underwent Norwood palliation for hypoplastic left heart syndrome (HLHS) and its variants. A total of 32 patients (20%) required postoperative ECMO. Using Kaplan-Meier analysis, the predicted survival rates for Norwood/non-ECMO patients to 30 days, 1 year, and 3 years after the procedure are 87.6% (CI 79.5-91.5%), 62.5% (CI 54.3-71.0%), and 59.9% (CI 50.8-67.8%), respectively. Survival to 30 days, 1 year, and 3 years after Norwood was significantly decreased in Norwood/ ECMO patients, with predicted survival rates of 50.0% (CI 31.9-65.7%), 24.6% (CI 11.4-40.4), and 13.2% (CI 3.9-28.3%), respectively (p < 0.0001). Risk factors for hospital mortality included nonelective or emergency placement onto ECMO, longer duration of ECMO support, and the development of acute renal failure while on ECMO. Of the original Norwood/ECMO hospital survivors, only half of these patients survived a mean of nearly 4 years. ECMO after Norwood palliation is associated with significant mortality. Our data suggest that neonates who require ECMO after Norwood palliation are prone to continued attrition once discharged from the hospital.
    MeSH term(s) Cohort Studies ; Confidence Intervals ; Extracorporeal Membrane Oxygenation/methods ; Extracorporeal Membrane Oxygenation/mortality ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Humans ; Hypoplastic Left Heart Syndrome/diagnosis ; Hypoplastic Left Heart Syndrome/mortality ; Hypoplastic Left Heart Syndrome/surgery ; Infant, Newborn ; Kaplan-Meier Estimate ; Male ; Norwood Procedures/methods ; Norwood Procedures/mortality ; Postoperative Care/methods ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Survival Rate ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2012-09-25
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-012-0499-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1528: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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