Article: A multicenter, site-independent, blinded study to compare the diagnostic accuracy of contrast-enhanced magnetic resonance angiography using 1.0M gadobutrol (Gadovist) to intraarterial digital subtraction angiography in body arteries.
2007 Volume 61, Issue 2, Page(s) 315–323
Abstract: Purpose: Prospective evaluation of diagnostic accuracy of single field-of-view contrast-enhanced MR Angiography (ceMRA) with 1.0M gadobutrol compared to intraarterial DSA in body arteries.: Materials and methods: In an European multicenter study 179 ... ...
| Abstract | Purpose: Prospective evaluation of diagnostic accuracy of single field-of-view contrast-enhanced MR Angiography (ceMRA) with 1.0M gadobutrol compared to intraarterial DSA in body arteries. Materials and methods: In an European multicenter study 179 patients underwent ceMRA and DSA. For each indication five prospectively defined vessel segments were evaluated by local investigators onsite and by three site-independent blinded readers (BR) independently. Results: The agreement between ceMRA and DSA diagnosis was statistically significant in the onsite (96.6%) and blinded reader (86.6-90.2%) evaluation. Sensitivity, specificity, accuracy, positive (PPV) and negative predictive values (NPV) for detection of relevant stenosis (>50%) were calculated for the right and left internal carotid arteries, and common and external iliac arteries: Sensitivity was 95-98% (onsite) and 76-96% (BR), specificity 94-96% (onsite) and 86-94% (BR), accuracy 96% (onsite) and 87-93% (BR), NPV 98-99% (onsite) and 84-98% (BR), and PPV 79-93% (onsite) and 44-91% (BR), respectively. Conclusion: CeMRA of body arteries using 1.0M gadobutrol provides diagnostic information comparable to intraarterial DSA. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Angiography, Digital Subtraction ; Arteries/pathology ; Constriction, Pathologic/diagnosis ; Contrast Media ; Gadolinium ; Humans ; Magnetic Resonance Angiography/methods ; Male ; Middle Aged ; Organometallic Compounds ; Prospective Studies ; Sensitivity and Specificity ; Single-Blind Method | |||||
| Chemical Substances | Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L) ; Gadolinium (AU0V1LM3JT) | |||||
| Language | English | |||||
| Publishing date | 2007-02 | |||||
| Publishing country | Ireland | |||||
| Document type | Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 138815-0 | |||||
| ISSN | 1872-7727 ; 0720-048X | |||||
| ISSN (online) | 1872-7727 | |||||
| ISSN | 0720-048X | |||||
| DOI | 10.1016/j.ejrad.2006.09.002 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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