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  1. Article ; Online: Patch Testing to Diphenylguanidine by the North American Contact Dermatitis Group (2013-2016).

    Warshaw, Erin M / Gupta, Rachit / Dekoven, Joel G / Fowler, Joseph F / Silverberg, Jonathan I / Atwater, Amber R / Taylor, James S / Reeder, Margo J / Maibach, Howard I / Sasseville, Denis / Belsito, Donald V / DeLeo, Vincent A / Pratt, Melanie D / Marks, James G / Zug, Kathryn A / Zirwas, Matthew J

    Dermatitis : contact, atopic, occupational, drug

    2020  Volume 31, Issue 6, Page(s) 350–358

    Abstract: Background/objectives: Carba mix (CM, 3% petrolatum) contains 1,3-diphenylguanidine (DPG, 1%), zinc diethyldithiocarbamate (1%), and zinc dibutyldithiocarbamate (1%). Because DPG is a component of CM, DPG is often not tested separately. The purpose of ... ...

    Abstract Background/objectives: Carba mix (CM, 3% petrolatum) contains 1,3-diphenylguanidine (DPG, 1%), zinc diethyldithiocarbamate (1%), and zinc dibutyldithiocarbamate (1%). Because DPG is a component of CM, DPG is often not tested separately. The purpose of this study was to determine the frequency of concomitant reactions to CM and DPG.
    Methods: A retrospective analysis of the 2013-2016 North American Contact Dermatitis Group data was conducted. The study group consisted of patients with final interpretation of "allergic" to either DPG or CM. Reactions coded as irritant or doubtful/macular erythema (+/- and not interpreted as allergic) were excluded.
    Results: A total of 10,457 patients were patch tested to both CM and DPG, and 610 (5.8%) had allergic reactions to either CM or DPG (CM only [n = 292, 47.9%], DPG only [n = 190, 31.1%], both [n = 128, 21.0%]). A total of 39.4% of CM-allergic patients reacted to DPG, and 59.7% of DPG-allergic patients reacted to CM. Analyses found that 25% (++/+++ subgroup) to 40% (all patients) of allergic reactions to DPG would have been missed by testing to CM alone. More than 70% of reactions to CM and DPG were +/- or +.
    Conclusions: Patch testing to CM will miss 25% to 40% of positive reactions to DPG. Both CM and DPG have a high frequency of +/- and + reactions.
    MeSH term(s) Adult ; Dermatitis, Allergic Contact/etiology ; Ditiocarb/adverse effects ; Female ; Guanidines/adverse effects ; Humans ; Male ; Patch Tests/methods
    Chemical Substances Guanidines ; carbamix (123618-05-3) ; diphenylguanidine (6MRZ85RNHQ) ; Ditiocarb (99Z2744345)
    Keywords covid19
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Cross-reactions to desoximetasone and mometasone furoate in a patient with multiple topical corticosteroid allergies.

    Donovan, Jeffrey C H / Dekoven, Joel G

    Dermatitis : contact, atopic, occupational, drug

    2006  Volume 17, Issue 3, Page(s) 147–151

    Abstract: A 60-year-old man developed a bullous contact dermatitis after topical corticosteroid treatment of dermatitis on his lower leg. Subsequent patch testing showed cross-reactions to numerous group B and group D corticosteroids as well as cross-reactions to ... ...

    Abstract A 60-year-old man developed a bullous contact dermatitis after topical corticosteroid treatment of dermatitis on his lower leg. Subsequent patch testing showed cross-reactions to numerous group B and group D corticosteroids as well as cross-reactions to group C desoximetasone and group D1 mometasone furoate. His patch-test result was negative for the group A corticosteroids hydrocortisone and tixocortol pivalate. We discuss the uncommon finding of cross-reactions to desoximetasone and mometasone furoate.
    MeSH term(s) Administration, Cutaneous ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Asthma ; Cross Reactions ; Dermatitis, Allergic Contact/drug therapy ; Desoximetasone/administration & dosage ; Desoximetasone/adverse effects ; Diagnosis, Differential ; Humans ; Leg ; Male ; Middle Aged ; Mometasone Furoate ; Patch Tests ; Pregnadienediols/administration & dosage ; Pregnadienediols/adverse effects ; Rhinitis, Allergic, Seasonal
    Chemical Substances Anti-Inflammatory Agents ; Pregnadienediols ; Mometasone Furoate (04201GDN4R) ; Desoximetasone (4E07GXB7AU)
    Language English
    Publishing date 2006-08-29
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.2310/6620.2006.05053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast.

    Rao, Jaggi / Dekoven, Joel G / Beatty, J David / Jones, Glenn

    Journal of the American Academy of Dermatology

    2003  Volume 49, Issue 3, Page(s) 532–538

    Abstract: Three cases of cutaneous angiosarcoma of the breast that arose in irradiated skin tissue in women who had previously undergone treatment for breast carcinoma are reported. A review of the literature identified 55 cases of cutaneous angiosarcoma following ...

    Abstract Three cases of cutaneous angiosarcoma of the breast that arose in irradiated skin tissue in women who had previously undergone treatment for breast carcinoma are reported. A review of the literature identified 55 cases of cutaneous angiosarcoma following radiation therapy as part of the treatment of carcinoma of the breast. For all 58 assembled cases, the mean age at the time of adjuvant radiation therapy for breast carcinoma was 64 years (range 42-83). The mean time to subsequent diagnosis in irradiated skin was 75 months (range 12-192). The estimated 3-year overall survival for all 58 patients was only 20%, similar to that of patients with the general form of angiosarcoma. Postirradiation angiosarcoma of the breast has a variety of presentations; thus diagnosis is often delayed. Early diagnosis relies on a high index of suspicion and appropriate histopathologic studies, as the clinical and histopathologic findings may be confused with other conditions. Treatment should be aggressive and include local surgery with consideration of adjuvant systemic chemotherapy.
    MeSH term(s) Breast Neoplasms/pathology ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/radiotherapy ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Female ; Follow-Up Studies ; Hemangiosarcoma/etiology ; Hemangiosarcoma/pathology ; Humans ; Mastectomy, Segmental/methods ; Middle Aged ; Neoplasms, Radiation-Induced/pathology ; Radiation Dosage ; Radiotherapy, Adjuvant/adverse effects ; Risk Assessment ; Skin Neoplasms/etiology ; Skin Neoplasms/pathology
    Language English
    Publishing date 2003-08-20
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1067/s0190-9622(03)00428-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Occupationally related contact dermatitis in North American food service workers referred for patch testing, 1994 to 2010.

    Warshaw, Erin M / Kwon, Gina P / Mathias, C G Toby / Maibach, Howard I / Fowler, Joseph F / Belsito, Donald V / Sasseville, Denis / Zug, Kathryn A / Taylor, James S / Fransway, Anthony F / Deleo, Vincent A / Marks, James G / Pratt, Melanie D / Storrs, Frances J / Zirwas, Matthew J / Dekoven, Joel G

    Dermatitis : contact, atopic, occupational, drug

    2013  Volume 24, Issue 1, Page(s) 22–28

    Abstract: Background: Contact dermatoses are common in food service workers (FSWs).: Objectives: This study aims to (1) determine the prevalence of occupationally related contact dermatitis among FSWs patch tested by the North American Contact Dermatitis Group ...

    Abstract Background: Contact dermatoses are common in food service workers (FSWs).
    Objectives: This study aims to (1) determine the prevalence of occupationally related contact dermatitis among FSWs patch tested by the North American Contact Dermatitis Group (NACDG) and (2) characterize responsible allergens and irritants as well as sources.
    Methods: Cross-sectional analysis of patients patch tested by the NACDG, 1994 to 2010, was conducted.
    Results: Of 35,872 patients patch tested, 1237 (3.4%) were FSWs. Occupationally related skin disease was significantly more common in FSWs when compared with employed non-FSWs. Food service workers were significantly more likely to have hand (P < 0.0001) and arm (P < 0.0006) involvement. The rates for irritant and allergic contact dermatitis in FSWs were 30.6% and 54.7%, respectively. Although the final diagnosis of irritant contact dermatitis was statistically higher in FSWs as compared with non-FSWs, allergic contact dermatitis was lower in FSWs as compared with non-FSWs. The most frequent currently relevant and occupationally related allergens were thiuram mix (32.5%) and carba mix (28.9%). Gloves were the most common source of responsible allergens. The NACDG standard tray missed at least 1 occupationally related allergen in 38 patients (4.3%).
    Conclusions: Among FSWs patch tested by the NACDG between 1994 and 2010, the most common allergens were thiuram mix and carba mix. Gloves were the most common source of responsible allergens.
    MeSH term(s) Adult ; Aged ; Allergens/adverse effects ; Cross-Sectional Studies ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Occupational/etiology ; Female ; Food Handling ; Food Services ; Humans ; Male ; Middle Aged ; North America ; Occupational Exposure/adverse effects ; Patch Tests/methods
    Chemical Substances Allergens
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0b013e31827b14e1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of immunomodulatory agents on patch testing: expert opinion 2012.

    Fowler, Joseph F / Maibach, Howard I / Zirwas, Matthew / Taylor, James S / Dekoven, Joel G / Sasseville, Denis / Warshaw, Erin M / Belsito, Donald V / Storrs, Frances J / Zug, Kathryn A / Pratt, Melanie D / Mathias, C G Toby / Deleo, Vincent A / Fransway, Anthony F / Myers, Fort / Marks, James G

    Dermatitis : contact, atopic, occupational, drug

    2012  Volume 23, Issue 6, Page(s) 301–303

    MeSH term(s) Allergens/adverse effects ; Allergens/immunology ; Denmark ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/prevention & control ; Dermatology/standards ; Expert Testimony/standards ; Humans ; Immunologic Factors/adverse effects ; Immunologic Factors/immunology ; Patch Tests/methods ; Patch Tests/standards ; United Kingdom ; United States
    Chemical Substances Allergens ; Immunologic Factors
    Language English
    Publishing date 2012-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0b013e318275969f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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