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  1. Article ; Online: Incidence and outcomes of prosthetic valve endocarditis in adults with tetralogy of Fallot.

    Egbe, Alexander C / Kothapalli, Srikanth / Miranda, William R / Jadav, Raja / Banala, Keerthana / Vojjini, Rahul / Faizee, Faizan / Khalil, Fouad / Najam, Maria / Angirekula, Mounika / Desimone, Daniel C / Connolly, Heidi M

    Cardiology in the young

    2020  Volume 30, Issue 1, Page(s) 19–23

    Abstract: Background: The risk of endocarditis varies with CHD complexity and the presence of prosthetic valves. The purpose of the study was therefore to describe incidence and outcomes of prosthetic valve endocarditis in adults with repair tetralogy of Fallot.!# ...

    Abstract Background: The risk of endocarditis varies with CHD complexity and the presence of prosthetic valves. The purpose of the study was therefore to describe incidence and outcomes of prosthetic valve endocarditis in adults with repair tetralogy of Fallot.
    Methods: Retrospective review of adult tetralogy of Fallot patients who underwent prosthetic valve implantation, 1990-2017. We defined prosthetic valve endocarditis-related complications as prosthetic valve dysfunction, perivalvular extension of infection such abscess/aneurysm/fistula, heart block, pulmonary/systemic embolic events, recurrent endocarditis, and death due to sepsis.
    Results: A total of 338 patients (age: 37 ± 15 years) received 352 prosthetic valves (pulmonary [n = 308, 88%], tricuspid [n = 13, 4%], mitral [n = 9, 3%], and aortic position [n = 22, 6%]). The annual incidence of prosthetic valve endocarditis was 0.4%. There were 12 prosthetic valve endocarditis-related complications in six patients, and these complications were prosthetic valve dysfunction (n = 4), systemic/pulmonary embolic events (n = 2), heart block (n = 1), aortic root abscess (n = 1), recurrent endocarditis (n = 2), and death due to sepsis (n = 1). Three (50%) patients required surgery at 2 days, 6 weeks, and 23 weeks from the time of prosthetic valve endocarditis diagnosis. Altogether three of the six (50%) patients died, and one of these deaths was due to sepsis.
    Conclusions: The incidence, complication rate, and outcomes of prosthetic valve endocarditis in tetralogy of Fallot patients underscore some of the risks of having a prosthetic valve. It is important to educate the patients on the need for early presentation if they develop systemic symptoms, have a high index of suspicion for prosthetic valve endocarditis, and adopt a multi-disciplinary care approach in this high-risk population.
    MeSH term(s) Adult ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/etiology ; Female ; Heart Valve Prosthesis/adverse effects ; Humans ; Incidence ; Male ; Middle Aged ; Minnesota/epidemiology ; Prosthesis-Related Infections/epidemiology ; Prosthesis-Related Infections/etiology ; Retrospective Studies ; Risk Factors ; Sepsis/etiology ; Sepsis/mortality ; Tetralogy of Fallot/surgery ; Young Adult
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951119001975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4050: Show issues Location:
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  2. Article: Influence of Acetylsalicylic Acid Use on Risk and Outcome of Community-Acquired

    Smit, Jesper / Dalager-Pedersen, Michael / Adelborg, Kasper / Kaasch, Achim J / Thomsen, Reimar W / Frøslev, Trine / Nielsen, Henrik / Schønheyder, Henrik C / Sørensen, Henrik T / Desimone, Christopher V / Desimone, Daniel C / Søgaard, Mette

    Open forum infectious diseases

    2019  Volume 6, Issue 9, Page(s) ofz356

    Abstract: Objective: To investigate the influence of acetylsalicylic acid (ASA) use on risk and outcome of community-acquired : Method: We used population-based medical databases to identify all patients diagnosed in northern Denmark with first-time CA-SAB and ...

    Abstract Objective: To investigate the influence of acetylsalicylic acid (ASA) use on risk and outcome of community-acquired
    Method: We used population-based medical databases to identify all patients diagnosed in northern Denmark with first-time CA-SAB and matched population controls from 2000-2011. Categories for ASA users included current users (new or long-term users), former users, and nonusers. The analyses were adjusted for comorbidities, comedication use, and socioeconomic indicators.
    Results: We identified 2638 patients with first-time CA-SAB and 26 379 matched population controls. Compared with nonusers, the adjusted odds ratio (aOR) for CA-SAB was 1.00 (95% confidence interval [CI], 0.88-1.13) for current users, 1.00 (95% CI, 0.86-1.16) for former users, 2.04 (95% CI, 1.42-2.94) for new users, and 0.95 (95% CI, 0.84-1.09) for long-term users. Thirty-day cumulative mortality was 28.0% among current users compared with 21.6% among nonusers, yielding an adjusted hazard rate ratio (aHRR) of 1.02 (95% CI, 0.84-1.25). Compared with nonusers, the aHRR was 1.10 (95% CI, 0.87-1.40) for former users, 0.60 (95% CI, 0.29-1.21) for new users, and 1.06 (95% CI, 0.87-1.31) for long-term users. We observed no difference in the risk or outcome of CA-SAB with increasing ASA dose or by presence of diseases commonly treated with ASA.
    Conclusions: Use of ASA did not seem to influence the risk or outcome of CA-SAB. The apparent increased risk among new users may relate to residual confounding from the circumstances underlying ASA treatment initiation. Our finding of no association remained robust with increasing ASA dose and across multiple patient subsets.
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofz356
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  3. Article ; Online: Cardiovascular Implantable Electronic Device Infections due to Propionibacterium Species.

    El Rafei, Abdelghani / Desimone, Daniel C / Sohail, M Rizwan / Desimone, Christopher V / Steckelberg, James M / Wilson, Walter R / Baddour, Larry M

    Pacing and clinical electrophysiology : PACE

    2016  Volume 39, Issue 6, Page(s) 522–530

    Abstract: Introduction: Propionibacterium species are part of the normal skin flora and often considered contaminants when identified in cultures. However, they can cause life-threatening infections, including prosthetic cardiovascular device infections. Clinical ...

    Abstract Introduction: Propionibacterium species are part of the normal skin flora and often considered contaminants when identified in cultures. However, they can cause life-threatening infections, including prosthetic cardiovascular device infections. Clinical presentation and management of cardiovascular implantable electronic device (CIED) infection due to Propionibacterium species has not been well described.
    Methods: Retrospective review of all cases of CIED infection due to Propionibacterium species admitted to Mayo Clinic between January 1, 1990 and December 31, 2014. Patient charts were reviewed for clinical, microbiological, and imaging data. Descriptive analysis was performed.
    Results: We identified 14 patients with CIED infection due to Propionibacterium species, accounting for 2.3% of all CIED infections. Patients were predominantly male (n = 12, 86%). The median age at admission was 58.5 years (range 22-83). Twelve patients had implantable cardioverter defibrillators (ICDs) and two had permanent pacemaker systems. Twelve patients had generator pocket infection (86%). Two patients met clinical criteria for CIED-related infective endocarditis. Median time between last device manipulation and infection was 9 months (range 1-98). All patients were treated with complete device removal and antibiotic therapy. Six-month follow-up data were available for 10 patients (71%), with no relapses documented.
    Conclusion: CIED infections due to Propionibacterium species accounted for 2.3% of all device infections over a 25-year period. The most common infectious syndrome was generator pocket infection with delayed onset. There was an unanticipated predominance of ICDs in this cohort. Cure was achieved in all cases with complete device removal and antibiotic therapy.
    MeSH term(s) Actinomycetales Infections/etiology ; Adult ; Aged ; Aged, 80 and over ; Defibrillators, Implantable/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Pacemaker, Artificial/adverse effects ; Propionibacterium ; Prosthesis-Related Infections/etiology ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.12845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1466: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 399: Show issues

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  4. Article: An approach to the stepwise management of severe mitral regurgitation with optimal cardiac pacemaker function.

    Desimone, Christopher V / Nkomo, Vuyisile T / Desimone, Daniel C / Keenan, Lawrence R / Enriquez-Sarano, Maurice / Asirvatham, Samuel J

    Indian pacing and electrophysiology journal

    2014  Volume 14, Issue 2, Page(s) 75–78

    Abstract: Right ventricular apical pacing may cause or worsen mitral regurgitation (MR). Potential mechanisms for this adverse sequelae include intraventricular dyssynchrony, altered papillary muscle function, pacing-induced cardiomyopathy with left ventricular ... ...

    Abstract Right ventricular apical pacing may cause or worsen mitral regurgitation (MR). Potential mechanisms for this adverse sequelae include intraventricular dyssynchrony, altered papillary muscle function, pacing-induced cardiomyopathy with left ventricular dilation, and annular dilation. In contrast, biventricular (BiV) pacing may improve MR presumably by opposing the negative effects. Whether or not left ventricular lead location is important in treating mitral regurgitation in patients with pacemakers is unknown. We report a case of severe MR and left ventricular (LV) systolic failure in a patient with right ventricular pacing. Multiple potential etiologies for the worsening valve function were noted, and a stepwise iterative optimizing scheme that included basal lateral LV pacing improved mitral valve function and ameliorated heart failure symptoms.
    Language English
    Publishing date 2014-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2123606-9
    ISSN 0972-6292
    ISSN 0972-6292
    DOI 10.1016/s0972-6292(16)30732-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Incidence of infective endocarditis caused by viridans group streptococci before and after publication of the 2007 American Heart Association's endocarditis prevention guidelines.

    Desimone, Daniel C / Tleyjeh, Imad M / Correa de Sa, Daniel D / Anavekar, Nandan S / Lahr, Brian D / Sohail, Muhammad R / Steckelberg, James M / Wilson, Walter R / Baddour, Larry M

    Circulation

    2012  Volume 126, Issue 1, Page(s) 60–64

    Abstract: Background: The American Heart Association published updated guidelines for infective endocarditis (IE) prevention in 2007 that markedly restricted the use of antibiotic prophylaxis in certain at-risk patients undergoing dental and other invasive ... ...

    Abstract Background: The American Heart Association published updated guidelines for infective endocarditis (IE) prevention in 2007 that markedly restricted the use of antibiotic prophylaxis in certain at-risk patients undergoing dental and other invasive procedures. The incidence of IE caused by viridans group streptococci (VGS) in the United States after publication of the 2007 American Heart Association guidelines has not been reported.
    Methods and results: We performed a population-based review of all definite or possible cases of VGS-IE using the Rochester Epidemiology Project of Olmsted County, Minnesota. Patient demographics and microbiological data were collected for all VGS-IE cases diagnosed from January 1, 1999, through December 31, 2010. We also examined the Nationwide Inpatient Sample hospital discharge database to determine the number of VGS-IE cases included between 1999 and 2009. We identified 22 cases with VGS-IE in Olmsted County over the 12-year study period. Rates of incidence (per 100 000 person-years) during time intervals of 1999-2002, 2003-2006, and 2007-2010 were 3.19 (95% confidence interval, 1.20-5.17), 2.48 (95% confidence interval, 0.85-4.10), and 0.77 (95% confidence interval, 0.00-1.64), respectively (P=0.061 from Poisson regression). The number of hospital discharges with a VGS-IE diagnosis in the Nationwide Inpatient Sample database during 1999-2002, 2003-2006, and 2007-2009 ranged between 15 318 to 15 938, 16 214 to 17 433, and 14 728 to 15 479, respectively.
    Conclusions: On the basis of data complete through 2010, there has been no perceivable increase in the incidence of VGS-IE in Olmsted County, Minnesota, since the publication of the 2007 American Heart Association endocarditis prevention guidelines.
    MeSH term(s) American Heart Association ; Endocarditis/epidemiology ; Endocarditis/prevention & control ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/prevention & control ; Female ; Humans ; Incidence ; Male ; Population Surveillance/methods ; Practice Guidelines as Topic/standards ; Streptococcal Infections/epidemiology ; Streptococcal Infections/prevention & control ; United States/epidemiology ; Viridans Streptococci
    Language English
    Publishing date 2012-06-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.112.095281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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