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  1. Article ; Online: Diverging effects of host density and richness across biological scales drive diversity-disease outcomes.

    Johnson, Pieter T J / Stewart Merrill, Tara E / Dean, Andrew D / Fenton, Andy

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1937

    Abstract: Understanding how biodiversity affects pathogen transmission remains an unresolved question due to the challenges in testing potential mechanisms in natural systems and how these mechanisms vary across biological scales. By quantifying transmission of an ...

    Abstract Understanding how biodiversity affects pathogen transmission remains an unresolved question due to the challenges in testing potential mechanisms in natural systems and how these mechanisms vary across biological scales. By quantifying transmission of an entire guild of parasites (larval trematodes) within 902 amphibian host communities, we show that the community-level drivers of infection depend critically on biological scale. At the individual host scale, increases in host richness led to fewer parasites per host for all parasite taxa, with no effect of host or predator densities. At the host community scale, however, the inhibitory effects of richness were counteracted by associated increases in total host density, leading to no overall change in parasite densities. Mechanistically, we find that while average host competence declined with increasing host richness, total community competence remained stable due to additive assembly patterns. These results help reconcile disease-diversity debates by empirically disentangling the roles of alternative ecological drivers of parasite transmission and how such effects depend on biological scale.
    MeSH term(s) Animals ; Trematoda ; Parasites ; Biodiversity ; Amphibians ; Larva ; Host-Parasite Interactions
    Language English
    Publishing date 2024-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46091-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Labour market governance in England: devolution and localism

    Dean, Andrew

    The importance of governance in regional labour market monitoring for evidence-based policy-making , p. 95-113

    2017  , Page(s) 95–113

    Author's details Andrew Dean
    Keywords Arbeitsmarktpolitik ; Dezentralisierung ; Arbeitsmarktreform ; Großbritannien
    Language English
    Publisher Rainer Hampp Verlag
    Publishing place Augsburg
    Document type Article
    ISBN 978-3-95710-200-3 ; 3-95710-200-6
    Database ECONomics Information System

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  3. Article ; Online: Delayed migration of soft tissue fillers in the periocular area masquerading as eyelid and orbital pathology.

    Lin, Zhiheng / Dean, Andrew / Rene, Cornelius

    BMJ case reports

    2021  Volume 14, Issue 3

    Abstract: Soft tissue fillers used for facial rejuvenation can cause complications. We present two cases of late migration of injected fillers mimicking other pathology in the periocular area. Case 1 is a 52-year-old woman referred with chronic bilateral upper lid ...

    Abstract Soft tissue fillers used for facial rejuvenation can cause complications. We present two cases of late migration of injected fillers mimicking other pathology in the periocular area. Case 1 is a 52-year-old woman referred with chronic bilateral upper lid swelling, mimicking blepharochalasis syndrome, 5
    MeSH term(s) Cosmetic Techniques ; Eyelids/diagnostic imaging ; Female ; Humans ; Hyaluronic Acid ; Hyaluronoglucosaminidase ; Middle Aged ; Rejuvenation
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Hyaluronoglucosaminidase (EC 3.2.1.35)
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prior exposure of microbial communities to seawater reduces resilience but increases compositional and functional resistance to flooding events.

    Browett, Lewis C / Ruiz-Lopez, Sharon / Mossman, Hannah L / Dean, Andrew P / Rivett, Damian W

    The Science of the total environment

    2023  Volume 896, Page(s) 165040

    Abstract: Storm surges, flooding, and the encroachment of seawater onto agricultural land are predicted to increase with climate change. These flooding events fundamentally alter many soil properties and have knock-on effects on the microbial community composition ...

    Abstract Storm surges, flooding, and the encroachment of seawater onto agricultural land are predicted to increase with climate change. These flooding events fundamentally alter many soil properties and have knock-on effects on the microbial community composition and its functioning. The hypotheses tested in this study were (1) that the extent of change (resistance) of microbial community functioning and structure during seawater flooding is a factor of pre-adaptation to the stress, and (2) if structure and function are altered, the pre-adaptation will result in communities returning to previous state prior to flooding (resilience) faster than unexposed communities. We chose a naturally occurring saltmarsh-terrestrial pasture gradient from which three elevations were selected to create mesocosms. By selecting these sites, we were able to incorporate the legacy of differing levels of seawater ingress and exposure. Mesocosms were submerged in seawater for 0, 1, 96- and 192-h, with half of the mesocosms sacrificed immediately after flooding, and the other half taken after a 14 day "recovery" period. The following parameters were monitored: 1) changes in soil environmental parameters, 2) prokaryotic community composition, and 3) microbial functioning. Our results indicated that any length of seawater inundation significantly altered the physicochemical properties of all the soils, although a greater change is observed in the pasture site compared to the saltmarsh sites. These changes remained following a recovery period. Interestingly, our results indicated that for community composition, there was a high degree of resistance for the Saltmarsh mesocosms, with the Pasture mesocosm displaying higher resilience. Further, we observed a functional shift in the enzyme activities with labile hemicellulose being preferentially utilised over cellulose, with the effect increasing with longer floods. These results suggest that changing bacterial physiology is more critical to understanding the impact of storm surges on agricultural systems than bulk community change.
    MeSH term(s) Floods ; Soil/chemistry ; Agriculture ; Soil Microbiology ; Microbiota ; Seawater ; Ecosystem
    Chemical Substances Soil
    Language English
    Publishing date 2023-06-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.165040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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  5. Book ; Online: Ruth, Roger and Me

    Dean, Andrew

    Debts and Legacies

    (BWB Texts)

    2015  

    Abstract: Andrew Dean explores the lives of the generation of young people brought up in the shadow of the economic reforms of the 1980s and 1990s, those whom he calls 'the children of the Mother of All Budgets' ...

    Series title BWB Texts
    Abstract Andrew Dean explores the lives of the generation of young people brought up in the shadow of the economic reforms of the 1980s and 1990s, those whom he calls 'the children of the Mother of All Budgets'
    Language English
    Size Online-Ressource (66 p)
    Publisher Bridget Williams Books
    Publishing place Wellington
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780908321216 ; 090832121X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Ruth, Roger and me

    Dean, Andrew

    debts and legacies

    (BWB texts)

    2015  

    Author's details Andrew Dean
    Series title BWB texts
    Keywords Wirtschaftsreform ; Finanzreform ; Haushaltskonsolidierung ; Neuseeland
    Language English
    Size 124 Seiten
    Publisher Bridget Williams Books
    Publishing place Wellington, New Zealand
    Document type Book
    ISBN 9780908321216 ; 9780908321230 ; 9780908321247 ; 9780908321254 ; 090832121X ; 0908321236 ; 0908321244 ; 0908321252
    Database ECONomics Information System

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  7. Article: A new regional labour market intervention

    Dean, Andrew / Neild, Ben

    Developing skills in a changing world of work : concepts, measurement and data applied in regional and local labour market monitoring across Europe , p. 347-363

    the creation and delivery of a "data analytics skills escalator" in the Exeter SUB-region of SW England

    2018  , Page(s) 347–363

    Author's details Andrew Dean and Ben Neild
    Keywords Regionaler Arbeitsmarkt ; Berufsbildungspolitik ; IT-Berufe ; E-Business ; Großbritannien
    Language English
    Publisher Rainer Hampp Verlag
    Publishing place Augsburg , München
    Document type Article
    ISBN 978-3-95710-215-7 ; 3-95710-215-4
    Database ECONomics Information System

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  8. Article ; Online: Multi-genomic analysis of the cation diffusion facilitator transporters from algae.

    Ibuot, Aniefon / Dean, Andrew P / Pittman, Jon K

    Metallomics : integrated biometal science

    2020  Volume 12, Issue 4, Page(s) 617–630

    Abstract: Metal transport processes are relatively poorly understood in algae in comparison to higher plants and other eukaryotes. A screen of genomes from 33 taxonomically diverse algal species was conducted to identify members of the Cation Diffusion Facilitator ...

    Abstract Metal transport processes are relatively poorly understood in algae in comparison to higher plants and other eukaryotes. A screen of genomes from 33 taxonomically diverse algal species was conducted to identify members of the Cation Diffusion Facilitator (CDF) family of metal ion transporter. All algal genomes contained at least one CDF gene with four species having >10 CDF genes (median of 5 genes per genome), further confirming that this is a ubiquitous gene family. Phylogenetic analysis suggested a CDF gene organisation of five groups, which includes Zn-CDF, Fe/Zn-CDF and Mn-CDF groups, consistent with previous phylogenetic analyses, and two functionally undefined groups. One of these undefined groups was algal specific although excluded chlorophyte and rhodophyte sequences. The majority of sequences (22 out of 26 sequences) from this group had a putative ion binding site motif within transmembrane domain 2 and 5 that was distinct from other CDF proteins, such that alanine or serine replaced the conserved histidine residue. The phylogenetic grouping was supported by sequence cluster analysis. Yeast heterologous expression of CDF proteins from Chlamydomonas reinhardtii indicated Zn
    MeSH term(s) Amino Acid Sequence ; Cation Transport Proteins/classification ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Charophyceae/classification ; Charophyceae/genetics ; Charophyceae/metabolism ; Chlorophyta/classification ; Chlorophyta/genetics ; Chlorophyta/metabolism ; Cobalt/metabolism ; Diatoms/classification ; Diatoms/genetics ; Diatoms/metabolism ; Genomics/methods ; Haptophyta/classification ; Haptophyta/genetics ; Haptophyta/metabolism ; Ion Transport ; Iron/metabolism ; Manganese/metabolism ; Phylogeny ; Rhodophyta/classification ; Rhodophyta/genetics ; Rhodophyta/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Zinc/metabolism
    Chemical Substances Cation Transport Proteins ; Cobalt (3G0H8C9362) ; Manganese (42Z2K6ZL8P) ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2020-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1039/d0mt00009d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Addition of organic acids to acid mine drainage polluted wetland sediment leads to microbial community structure and functional changes and improved water quality.

    Aguinaga, Oscar E / White, Keith N / Dean, Andrew P / Pittman, Jon K

    Environmental pollution (Barking, Essex : 1987)

    2021  Volume 290, Page(s) 118064

    Abstract: Acid mine drainage (AMD) is a serious environmental problem worldwide that requires efficient and sustainable remediation technologies including the use of biological mechanisms. A key challenge for AMD bioremediation is to provide optimal conditions for ...

    Abstract Acid mine drainage (AMD) is a serious environmental problem worldwide that requires efficient and sustainable remediation technologies including the use of biological mechanisms. A key challenge for AMD bioremediation is to provide optimal conditions for microbial-mediated immobilisation of trace metals. Although organic carbon and oxygen can enhance treatment efficiency, the effect on microbial communities is unclear. In this study, surface sediments from a natural wetland with proven efficiency for AMD bioremediation were artificially exposed to oxygen (by aeration) and/or organic carbon (in the form of mixed organic acids) and incubated under laboratory conditions. In addition to measuring changes in water chemistry, a metagenomics approach was used to determine changes in sediment bacterial, archaeal and fungal community structure, and functional gene abundance. The addition of organic carbon produced major changes in the abundance of microorganisms related to iron and sulfur metabolism (including Geobacter and Pelobacter) and increased levels of particulate metals via sulfate reduction. Aeration resulted in an increase in Sideroxydans abundance but no significant changes in metal chemistry were observed. The study concludes that the utilisation of organic carbon by microorganisms is more important for achieving efficient AMD treatment than the availability of oxygen, yet the combination of oxygen with organic carbon addition did not inhibit the improvements to water quality.
    MeSH term(s) Acids ; Microbiota ; Mining ; Water Quality ; Wetlands
    Chemical Substances Acids
    Language English
    Publishing date 2021-08-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2021.118064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Molecular and neurological features of MELAS syndrome in paediatric patients: A case series and review of the literature.

    Seed, Lydia M / Dean, Andrew / Krishnakumar, Deepa / Phyu, Poe / Horvath, Rita / Harijan, Pooja Devi

    Molecular genetics & genomic medicine

    2022  Volume 10, Issue 7, Page(s) e1955

    Abstract: Background: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is one of the most well-known mitochondrial diseases, with most cases attributed to m.3243A>G. MELAS syndrome patients typically present in the first ... ...

    Abstract Background: Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is one of the most well-known mitochondrial diseases, with most cases attributed to m.3243A>G. MELAS syndrome patients typically present in the first two decades of life with a broad, multi-systemic phenotype that predominantly features neurological manifestations--stroke-like episodes. However, marked phenotypic variability has been observed among paediatric patients, creating a clinical challenge and delaying diagnoses.
    Methods: A literature review of paediatric MELAS syndrome patients and a retrospective analysis in a UK tertiary paediatric neurology centre were performed.
    Results: Three children were included in this case series. All patients presented with seizures and had MRI changes not confined to a single vascular territory. Blood heteroplasmy varied considerably, and one patient required a muscle biopsy. Based on a literature review of 114 patients, the mean age of presentation is 8.1 years and seizures are the most prevalent manifestation of stroke-like episodes. Heteroplasmy is higher in a tissue other than blood in most cases.
    Conclusion: The threshold for investigating MELAS syndrome in children with suspicious neurological symptoms should be low. If blood m.3243A>G analysis is negative, yet clinical suspicion remains high, invasive testing or further interrogation of the mitochondrial genome should be considered.
    MeSH term(s) Acidosis, Lactic/genetics ; Child ; Humans ; MELAS Syndrome/diagnosis ; MELAS Syndrome/genetics ; MELAS Syndrome/pathology ; Retrospective Studies ; Seizures ; Stroke/genetics
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2734884-2
    ISSN 2324-9269 ; 2324-9269
    ISSN (online) 2324-9269
    ISSN 2324-9269
    DOI 10.1002/mgg3.1955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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